Clinical trials: Immunological Tolerance
Hemophilia A With Inhibitor
The Hemophilia Inhibitor Eradication Trial
This is a multi-center randomized phase III clinical trial, the Inhibitor Eradication Trial, in which Eloctate ITI plus Emicizumab will be compared with Eloctate ITI alone to eradicate inhibitors in severe hemophilia A.
- Trial name
- NCT04303572
- Testing
- Eloctate ITI, Emicizumab
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Margaret Ragni
Health, Subjective
Clinical Study of ALT-BB4 to Determine Tolerance, Safety and Pharmacokinetics in Healthy Volunteer
A Phase I Study to Evaluate the Tolerance, Safety and Pharmacokinetics of ALT-BB4 in Healthy Volunteers
- Trial name
- NCT05232175
- Testing
- ALT-BB4, 0.9%NaCl
- Where
- South Korea
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Alteogen, Inc.
Pancreatic Metastatic Cancer, Toxicity
Efficacy and Tolerance Evaluation in FOLFIRINOX Dose Adjusted in Elderly Patients With a Metastatic Pancreatic Cancer
Metastatic pancreatic carcinomas represent the 5th cause of cancer death in France (#8000 per year). The median age at diagnosis is 69 and 74 in male and female respectively.
- Trial name
- PAMELA70 (NCT02143219)
- Testing
- Oxaliplatine, Folinic acid, Irinotecan
- Where
- 6 sites in France
- Volunteers
- 72 people
- Sponsor
- Institut Cancerologie de l'Ouest
Metabolic Syndrome
Study of TNF-Antagonism in the Metabolic Syndrome (II)
This study will investigate whether etanercept will result in improved inflammatory indices, glucose tolerance and endothelial function in patients with the metabolic syndrome.
- Trial name
- NCT00413400
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Hemorrhage, Healthy
Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Ketamine
The purpose of this project is to test how ketamine, an analgesics currently employed in the pre-hospital setting by the US Army, alters the capacity to tolerate a hemorrhagic insult in humans.
- Trial name
- NCT03621085
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center