Clinical trials: Immunomodulation
Healthy
Increased Salt Intake in Healthy Men
To study the effects of an increased salt intake on metabolic, cardiovascular and immunoregulatory functions in healthy men.
- Trial name
- BSALT (NCT02509962)
- Testing
- Slow sodium tablets
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Drug Related Side Effects and Adverse Reactions, Infusion Reactions
Retrospective Kinetic Safety Evaluation of an Intravenous Micellar Excipient Platform
Protocol PICO-RWE-001: The goal of this observational study is to evaluate the kinetic safety and tolerability of an investigational intravenous micellar delivery platform.
- Trial name
- NCT07609069
- Testing
- PIV-850 (850-picometer Dual-NCE Acidic Matrix), Legacy Heterogeneous Payload (Micellar Vehicle)
- Where
- United States
- Volunteers
- 625 people
- Sponsor
- PICO IV, Inc.
Immunotherapy, Head and Neck Neoplasms
ImmunoModulation by the Combination of Ipilimumab and Nivolumab Neoadjuvant to Surgery In Advanced or Recurrent Head and Neck Carcinoma
This is a phase IB/II trial to examine feasibility and safety of checkpoint blockade (aPD1 with or without aCTLA4) neoadjuvant to standard of care (SOC) in advanced stage head and neck squamous cell carcinoma (HNSCC), a patient…
- Trial name
- IMCISION (NCT03003637)
- Testing
- Nivolumab, Ipilimumab
- Where
- Netherlands
- Volunteers
- 33 people
- Sponsor
- The Netherlands Cancer Institute
Idiopathic Pulmonary Fibrosis, Cough
Azithromycin in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a devastating disease with no cure available. Patients suffer from respiratory symptoms including dyspnea and cough.
- Trial name
- NCT02173145
- Testing
- azithromycin
- Where
- 4 sites in Switzerland
- Volunteers
- 27 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cutaneous Leishmaniasis
Add-on Study of Pentoxifylline in Cutaneous Leishmaniasis
The purpose of this study is to determine whether adding pentoxifylline to treatment of American cutaneous leishmaniasis with meglumine antimoniate increases the rate and speed of clinical response without diminishing safety, and…
- Trial name
- GT (NCT01464242)
- Testing
- Meglumine antimonate, Pentoxifylline
- Where
- Colombia
- Volunteers
- 75 people
- Sponsor
- Centro Internacional de Entrenamiento e Investigaciones Médicas
Psoriasis, Immunomodulation
Multiple Dose Escalation Study In Medically Stable Subjects With Psoriasis
This study was conducted in subjects with psoriasis to evaluate drug activity in this patient population by analysis of changes in psoriatic lesion biopsy characteristics.
- Trial name
- NCT01736696
- Testing
- tofacitinib
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Pfizer
Head and Neck Carcinoma
Pembrolizumab Plus Docetaxel for the Treatment of Recurrent or Metastatic Head and Neck Cancer
Squamous cell carcinoma of the head and neck, which accounts for 90% of head and neck cancers, is the tenth most common cancer worldwide with over 650000 new cases per year.
- Trial name
- NCT02718820
- Testing
- Docetaxel, Pembrolizumab
- Where
- Austria
- Volunteers
- 22 people
- Sponsor
- Medical University of Vienna
Immunologic Deficiency Syndromes
Effects of Orally Administered Beta-glucan on Leukocyte Function in Humans
The purpose of this study is to test wether orally administered Beta-glucan has systemic effects in humans.
- Trial name
- BG (NCT01727895)
- Testing
- Beta-glucan (Glucan #300®)
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Low Dose Methotrexate in Severe Chronic Asthma
Low-dose Methotrexate for Change in Global Initiative for Asthma Step 5 Medications in Chronic Severe Asthma
Patients with chronic severe asthma (CSA) have a crippling disease and current available treatments are not satisfactory. Thus, management of CSA remains a major unmet need.
- Trial name
- NCT02124226
- Testing
- Methotrexate
- Volunteers
- 102 people
- Sponsor
- University of Catania
COVID-19 Pneumonia, COVID-19 Respiratory Infection
A Proof-of-Concept Study Evaluating EOM613 in COVID-19 Infected Patients With Severe Symptoms
The purpose of this study is to evaluate the safety, tolerability and preliminary efficacy of EOM613, a peptide nucleic acid with novel immune-modulating properties, in treating patients with severe COVID-19 infections.
- Conditions
- COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05212532
- Testing
- EOM613
- Where
- 4 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- EOM Pharmaceuticals