Clinical trials: Immunosenescence, open to volunteers
Immunosenescence, Uninfected Older
Interferon Reference for Older People - REFIPA Study
The diagnosis of respiratory viral infections is mainly based on PCR tests targeting the DNA or RNA of suspected viruses, including SARS-CoV-2, RSV and influenza viruses.
- Trial name
- REFIPA (NCT07239830)
- Testing
- Uninfected older adults
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Myeloma Multiple
Immune Fitness in Older Patients With Relapsed and Refractory Multiple Myeloma
Relapsed/refractory multiple myeloma (RRMM) predominantly affects older adults, who exhibit marked heterogeneity in treatment outcomes despite receiving the same therapies.
- Trial name
- PRIME (NCT07674498)
- Testing
- immunophenotyping of lymphocyte
- Where
- 3 sites in Belgium
- Volunteers
- 31 people
- Sponsor
- Jules Bordet Institute
Influenza, Immunosenescence
Effect of Oral Supplement on Influenza Vaccine Long-term Response
This is a follow-up study of a previously completed randomized controlled trial (NCT06827873) that investigated the effects of oral supplements on influenza vaccine response in adults aged 60-70 years.
- Trial name
- EOSIIVE-F (NCT07357467)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Cancer Survivors, Healthy Participant
A Study to Evaluate the Effects of the Combination of GI-102 With GIB-7 on Biomarkers of Aging in Healthy Adults and Cancer Survivors
This Phase 2a clinical study (GIANTS-1) aims to evaluate a novel dual-combination strategy using GI-102 and GIB-7 to address key pathological features of aging, including immunosenescence (the aging of the immune system)…
- Conditions
- Cancer Survivors, Healthy Participant, Elderly
- Trial name
- GIANTS-1 (NCT07363057)
- Testing
- GI-102 in combination with GIB-7
- Where
- 2 sites in Australia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- GI Innovation, Inc.
Diabetes Mellitus, Type 2
The Effects of Henagliflozin on Glucose Fluctuation and Immunosenescence in Type 2 Diabetes Patients on Insulin Therapy
The goal of this clinical trial is to learn if SGLT2 inhibitor Henggliflozin works to improve glucose variability in type 2 diabetes and if Henggliflozin can benefit immunosenescence.
- Trial name
- HOLIDYA (NCT06818851)
- Testing
- Henggliflozin
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Axial Spondyloarthrithis, Inflammatory Diseases
EXercise Therapy in Axial SpA, Inflammation and Biologic Therapy (ExTASI-B)
The goal of this randomised controlled trial study is to investigate whether exercise (brisk walking, equal to 13 on a rating of perceived exertion scale; somewhat hard) can be used as an adjuvant therapy for people living with…
- Conditions
- Axial Spondyloarthrithis, Inflammatory Diseases, Arthritis
- Trial name
- ExTASI-B (NCT06669702)
- Testing
- 12-week home based exercise, Routine care
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Loughborough University
HIV Infections, Alcohol Drinking
Precision Microbiota Interventions for Senoreduction Trial
People with HIV who drink alcohol are at increased risk for accelerated aging biology, including increased immune senescence. This randomized, double-blind, crossover clinical trial evaluates two generally recognized as safe…
- Conditions
- HIV Infections, Alcohol Drinking, Aging, Immunosenescence
- Trial name
- PreMIS (NCT07462767)
- Testing
- Limosilactobacillus reuteri, Blueberry extract
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Aging, High-intensity Interval Training
Can Exercise Ameliorate Immunosenescence and Thereby Reduce Relapse in Head and Neck Cancer Patients
Through the implementation of this three-year project, investigators expect to find a safe and effective exercise prescription for patients with oral cancer after surgery.
- Conditions
- Aging, High-intensity Interval Training, Head and Neck Cancers - Tonsils
- Trial name
- NCT06851988
- Testing
- HIIT & Record of physical activities at home., HIIT only
- Where
- Taiwan
- Volunteers
- 290 people
- Sponsor
- Chang Gung Memorial Hospital
Fasting, Diet, Healthy
Therapeutic Fasting and Immune Aging
Immunosenescence is the age-related decline of the immune system, involving a state of chronic inflammation and a decrease in the diversity/adaptability of the lymphocyte repertoire.
- Trial name
- JÛVENILE (NCT05857241)
- Testing
- Fasting mimicking diet (FMD)
- Where
- 5 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Vaccine Immune Response, Haemodialysis Patients
Vaccination Response Modulation With a Targeted Rapamycin Protocol Study
This study will investigate dialysis recipients' responses to important vaccines. Research suggests that a medication commonly used by transplant recipients may improve vaccine responses.
- Conditions
- Vaccine Immune Response, Haemodialysis Patients, Older Adults
- Trial name
- VON TRAPP (NCT07587801)
- Testing
- Sirolimus (RAPAMUNE), Influenza vaccine (Sequiris Fluad Quad), RSV vaccine (Pfizer Abrysvo)
- Where
- 3 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Central Adelaide Local Health Network Incorporated
Vaccination, Immunosenescence
VITAL: Vaccination, Immunity, Time-restricted Eating, Aging and Lifestyle
The aim of this study is to investigate the effects of a four-week time-restricted eating (TRE) intervention on autophagy, immune function, and vaccine response to a seasonal influenza and COVID-19 vaccines in older healthy…
- Conditions
- Vaccination, Immunosenescence, Metabolism
- Trial name
- VITAL (NCT07000708)
- Testing
- TRE: Time-restricted eating
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Brain, Aging
Biobank and Brain Health in Bordeaux.
B cube is a new generation cohort to study the determinants and natural history of brain aging, using molecular epidemiology, in a representative sample (N=2000) of the general population from the age of 55 (the approximate age…
- Conditions
- Brain, Aging, Cognitive Aging, Immunosenescence
- Trial name
- B-cube (NCT05322343)
- Testing
- Questionnaires, Fasting blood sampling., Saliva collection and nasal or nasopharyngeal swab
- Where
- France
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Epigenetic Aging, Immunosenescence
Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial
The TRIIM-X trial is an expanded pilot clinical study that will evaluate a personalized combination treatment regimen for thymus regeneration.
- Trial name
- TRIIM-X (NCT04375657)
- Testing
- TRIIM Treatment, Active Control
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Intervene Immune, Inc.
Infectious Diseases, Immunosenescence
Research Project on the Interaction Between Immune Function and Infectious Diseases in Older Adults and the Development of Prevention and Control Strategies
As population aging accelerates, infectious diseases have become a major factor affecting the health, quality of life, and survival outcomes of older adults.
- Conditions
- Infectious Diseases, Immunosenescence, Aging
- Trial name
- NCT07644962
- Volunteers
- 23,000 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Influenza Vaccination, Older Adults (65 Years and Older)
Influenza Vaccine Immunogenicity in Repeatedly Vaccinated Older Adults
The goal of this clinical trial is to compare immune responses to different influenza vaccine formulations in older adults and to understand how immune aging and repeated annual influenza vaccination affect these responses.
- Conditions
- Influenza Vaccination, Older Adults (65 Years and Older), Immunosenescence, Immunogenicity
- Trial name
- NCT07838298
- Testing
- Standard dose influenza vaccine, MF59 adjuvanted influenza vaccine, High dose influenza vaccine
- Where
- South Korea
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Immunosenescence
Exploratory Study on Infection and Immunosenescence Based on an Elderly Clinical Cohort
This prospective observational cohort study aims to investigate the relationship between immunosenescence and infectious diseases in older adults.
- Trial name
- NCT07672522
- Where
- China
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Skin Inflammation, Immunosenescence
Skin Inflammation in (Peri)Menopause: A Probiotic Intervention Proof of Concept Trial
This study will explore whether a daily probiotic drink containing Lactobacillus casei Shirota (LcS) can help improve immune function and reduce inflammation in women going through the menopausal transition.
- Conditions
- Skin Inflammation, Immunosenescence, Inflammation, Skin Health
- Trial name
- SIPPI (NCT07341087)
- Testing
- Lactobacillus casei Shirota (LcS) Probiotic Drink, Skimmed Milk Control Drink
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College London
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty
Immune Aging and Advanced Therapy Outcomes in Older Adults With IBD
The goal of this observational study is to learn whether signs of immune aging and frailty can help predict the balance of benefits and risks of advanced therapies in adults aged 60 years or older with inflammatory bowel disease…
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty, Immunosenescence
- Trial name
- NCT07828886
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Immune Deficiency
Efficacy of QBKPN Site-Specific Immunomodulator in Improving Innate Immune Function & Reducing Respiratory Tract Infection in Older Adults
This study is designed to test whether QBKPN SSI can improve immune function in older adults, including how well it can protect against respiratory and other infections, whether it improves the body's response to COVID-19…
- Trial name
- RESILIENCE (NCT05421325)
- Testing
- QBKPN SSI
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Qu Biologics Inc.
Immunosenescence, Aging
The Impact of Aerobic Exercise Program on Immunosenescence Institutionalized Older Adults
Background: Immunosenescence is an age-related decline in immune function, associated with chronic low-grade inflammation, increased morbidity, and functional impairment in older adults.
- Trial name
- NCT07476911
- Testing
- Aerobic exercise program
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto Politécnico de Castelo Branco