Clinical trials: Immunosuppressive Treatment
Renal Transplant
A Randomized Study Assess the Safety and Efficacy of Tacrolimus vs Prograf® in Renal Transplantation Treatment
Comparison of safety and efficacy of immunosuppressive regiments using tacrolimus from EMS and Prograf® in post renal transplanted patients.
- Trial name
- NCT01244659
- Testing
- Tacrolimus from EMS, Prograf
- Where
- Brazil
- Sponsor
- EMS
Lung and Heart-lung Transplantation
Bayesian Dose Adjustment of Immunosuppressants After Lung Transplantation
The purpose of this study is to evaluate in lung or heart-lung transplant patients on tacrolimus and mycophenolate the impact of optimized mofetil (MMF) therapeutic drug monitoring and dose adjustment of both drugs on the…
- Trial name
- BASALT (NCT00975663)
- Testing
- Tacrolimus and MMF
- Where
- 9 sites in Belgium, France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Limoges
Liver Transplantation, Medication Adherence
Effect of Digital Follow-up Supported Patient Education on Immunosuppressive Medication Adherence and Quality of Life After Liver Transplantation
This randomized controlled study aimed to evaluate the effect of digital follow-up supported patient education on immunosuppressive medication adherence and quality of life in adult liver transplant recipients.
- Trial name
- NCT07728604
- Testing
- Digital Follow-up Supported Patient Education, Standard Care
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Cansu Yıldız
Renal Insufficiency
De Novo Everolimus-based Therapy for Renal Transplantation Using Rituximab Induction
The investigators hypothesized that everolimus-based immunosuppressive therapy combined with rituximab induction could provide comparable safety profiles for renal transplant patients, as compared to standard immunosuppressive…
- Trial name
- NCT01312064
- Testing
- rituximab and everolimus, thymoglobulin and tacrolimus
- Where
- Taiwan
- Volunteers
- 2 people
- Sponsor
- National Taiwan University Hospital
Multiple Sclerosis
Prospective Stratification of Infectious Risks in Multiple Sclerosis
This monocentric study is to identify factors that increase the susceptibility for infections and establish a questionnaire-based infection score that allows a prospective stratification for infectious risks in patients with…
- Trial name
- InRIMS (NCT04036097)
- Testing
- MS-adapted AWIS questionnaire (MS-AWIS), infection diary (MS-AWIS diary)
- Where
- Switzerland
- Volunteers
- 298 people
- Sponsor
- University Hospital, Basel, Switzerland
Idiopathic Pulmonary Fibrosis(IPF)
CAR-DC for End-Stage IPF
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal interstitial lung disease characterized by irreversible scarring, leading to respiratory failure.
- Trial name
- NCT07329959
- Testing
- Leukapheresis, CAR-DC
- Volunteers
- 8 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Dilated Cardiomyopathy (DCM), Heart Failure
Safety and Efficacy of Second Infusion of FAP iCDC in End-stage Dilated Cardiomyopathy
This study aims to evaluate the safety and preliminary efficacy of a second administration of fibroblast activation protein (FAP)-targeted immunosuppressive chimeric antigen receptor dendritic cells (CAR-DC) in patients with…
- Trial name
- NCT07516288
- Testing
- FAP immunosuppressive CAR-DC
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Primary or Secondary Immune Deficiency Including Immunosuppressive Therapy, Chemotherapy, HIV Infection
Performance of Clinical Metagenomics in Stool and Urine Samples for Unexplained Diseases Diagnostic and Emerging Diseases Surveillance in Immunocompromised Patients
The study is based on the hypothesis that the concomitant use of mNGS in non-invasive samples (stool, urine) could improve the rate of detected pathogens in immunodeficient patients compared with mNGS performed in an invasive…
- Trial name
- SENTINEL (NCT07603453)
- Testing
- Metagenomics
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Transplantation, Medication Adherence
Intervention to Improve Adherence in Teen Kidney Transplant
The broad aim of the proposed study is to improve medication adherence in adolescent kidney transplant recipients. The investigators hypothesize that a multi-component intervention will improve medication adherence in the…
- Trial name
- TAKE-IT (NCT01356277)
- Testing
- Action-focused problem-solving, Electronic pillbox monitoring, dose reminders, and feedback
- Where
- 8 sites in United States, Canada
- Volunteers
- 170 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Vasculitis, Wegener's Granulomatosis
Comparison of Treatments to Maintain Disease Remission in Patients With Wegener's Granulomatosis and Related Vasculitis Syndromes
This study will compare the safety and effectiveness of two drugs-methotrexate and mycophenolate mofetil (MPM)-in preventing disease recurrence in patients with Wegener's granulomatosis and related inflammatory blood vessel…
- Trial name
- NCT00004567
- Testing
- Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Behcet Disease
Phase III Study in Refractory Behcet's Disease
The purpose of this pivotal trial is to evaluate subcutaneous (SQ) AIN457 as an adjunctive therapy to reduce the rate of exacerbations of posterior uveitis or panuveitis secondary to Behçet's disease during the 24 weeks of study…
- Trial name
- SHIELD (NCT00995709)
- Testing
- AIN457
- Where
- 49 sites in United States, Egypt and 15 more
- Volunteers
- 118 people
- Sponsor
- Novartis Pharmaceuticals
Severe Aplastic Anemia
Retrospective Study of Patients With Severe Aplastic Anemia Who Developed High Risk Clonal Evolution With Chromosome 7 Abnormalities After Immunosuppressive Therapy
Background: Severe aplastic anemia (SAA) is a form of bone marrow failure. It usually results from a cytotoxic T cell attack on the marrow stem cell. Two treatments can be used for SAA.
- Trial name
- NCT04436367
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Kidney Transplant, Drug-Related Side Effects and Adverse Reactions (MeSH Term)
The Effect of the 5th Sign Intervention on Medication Adherence in Kidney Transplant Recipients
The goal of this randomized controlled trial is to evaluate the effectiveness of the "5th Sign" intervention program-a multi-component strategy based on the Socio-Ecological Model that incorporates goal setting, action planning…
- Conditions
- Kidney Transplant, Drug-Related Side Effects and Adverse Reactions (MeSH Term), Medication Adherence, Mobile Applications
- Trial name
- NCT07851142
- Testing
- 5th Sign Intervention Program
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dokuz Eylul University
Cardiogenic Shock, Cardiogenic Shock Post Myocardial Infarction
Safety and Efficacy of FAP iCDC in Acute Myocardial Infarction With Cardiogenic Shock
To study the safety and efficacy of fibroblast activation protein (FAP)-targeted allogeneic immunosuppressive chimeric antigen receptor-dendritic cell (CAR-DC) in the treatment of acute myocardial infarction with cardiogenic…
- Conditions
- Cardiogenic Shock, Cardiogenic Shock Post Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT07380659
- Testing
- FAP allogeneic immunosuppressive CAR-DC
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
De Novo Kidney Transplant
MYPROMS-ES02: Safety and Efficacy of Basiliximab, Cyclosporine Microemulsion and Enteric-coated Mycophenolate Sodium (EC-MPS) Versus EC-MPS and Steroid Therapy in Kidney Transplant Recipients Who Are Hepatitis C Positive
To prospectively evaluate in de novo kidney transplant recipients, hepatitis C positive, the clinical outcomes of an immunosuppressive regimen of EC-MPS free of steroids in comparison with a regimen of EC-MPS with standard…
- Trial name
- NCT00284921
- Testing
- Enteric-coated Mycophenolate sodium (EC-MPS)
- Volunteers
- 60 people
- Sponsor
- Novartis Pharmaceuticals
Evidence of Liver Transplantation, Effects of Immunosuppressant Therapy
Determining Equivalence Dose for Oral Versus Sublingual Administration of Tacrolimus in Hepatic Receptors
After liver transplantation one of the most important cost, for both patients and their health insurance system, is immunosuppressive drug therapy.
- Trial name
- FKosl (NCT02608606)
- Testing
- Tacrolimus
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Disorder Related to Renal Transplantation
Anti-thymocyte Globulin-induced Immune Senescence
The aim of the study is to investigate the impact of Anti-Thymocyte Globulin (ATG) on immune senescence. Markers of immune senescence expression is assessed in a prospective cohort of renal transplant recipients the day of…
- Trial name
- SIGAL (NCT02857907)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Heart Transplantation, Kidney Transplantation
A Study to Compare How the Body Absorbs and Processes Two Different Formulations of the Anti-rejection Medication Tacrolimus (Advagraf® or Prograf®) in Children Receiving an Organ Transplant, and How Safe and Effective They Are Over a Longer Period of Time
The purpose of this study is to compare how the body absorbs and processes two different formulations of the anti-rejection medication tacrolimus (Advagraf® or Prograf®) in children receiving an organ transplant, and how safe and…
- Conditions
- Heart Transplantation, Kidney Transplantation, Liver Transplantation
- Trial name
- NCT01614665
- Testing
- Tacrolimus, Tacrolimus prolonged release
- Where
- 10 sites in Czechia, France and 3 more
- Volunteers
- 44 people
- Sponsor
- Astellas Pharma Europe Ltd.
Idiopathic Membranous Nephropathy
Different Immunosuppressive Treatment in iMN
The primary objective of this study is to compare the 24 month remission of different immunosuppressive therapies in the treatment of idiopathic membranous nephropathy (iMN)
- Trial name
- NCT04745728
- Testing
- Prednisone, Cyclophosphamide, Rituximab
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Aplastic Anemia, Pure Red Cell Aplasia
A Study to Determine Whether Therapy With Daclizumab Will Benefit Patients With Bone Marrow Failure
Participants in this study are suffering from rare and serious blood disorders. In aplastic anemia, the bone marrow stops producing red blood cells, platelets, and white blood cells.
- Conditions
- Aplastic Anemia, Pure Red Cell Aplasia, Diamond Blackfan Anemia
- Trial name
- NCT00001962
- Testing
- Daclizumab
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)