Clinical trials: Immunosuppressive Treatment
Rheumatoid Arthritis, Psoriatic Arthritis
Integration of Remote Monitoring in the Management of Chronic Immunosuppressive Therapy
Systemic autoimmune and chronic inflammatory diseases are a group of chronic illnesses whose treatment is usually very prolonged, often lifelong, and is essential to keep the disease under control, thus reducing the risk of…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Systemic Lupus Erythematosus, Systemic Sclerosis
- Trial name
- TEMPLATE (NCT06544343)
- Testing
- Remote Monitoring, On site monitoring
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- University Of Perugia
Severe Seborrheic Dermatitis
Tacrolimus Ointment Interest (PROTOPIC ®) in the Maintenance Treatment of Severe Seborrheic Dermatitis
Seborrheic dermatitis is a chronic inflammatory dermatological disease, evolving by relapses, affecting mainly the face and scalp.
- Trial name
- Disease (NCT02004860)
- Testing
- Protopic (R), Mycoster (R)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Rouen
Colorectal Cancer
Phase I/II Study of KRN330 Plus Irinotecan in Patients With Metastatic Colorectal Cancer
The primary objective of the Phase II portion of this study is to assess the efficacy of KRN330 in combination with irinotecan after first-line or adjuvant FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin)/CapOx (capecitabine…
- Trial name
- NCT00838578
- Testing
- KRN330, Irinotecan
- Where
- 12 sites in United States
- Volunteers
- 65 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Dysplasia in IBD
Dysplasia in Inflammatory Chronic Idiopathic Colitis Long-standing
Chronic intestinal inflammation produce dysplasia more frequently than the normal population. The therapies protect against these changes, but do not rule out dysplasia.
- Trial name
- NCT03096717
- Testing
- colonoscopy and histology
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Parkinson Disease
Relationship Between Immunosuppressive Treatment Status and Clinical Course of Parkinson's Disease
The goal of this observational study is to learn if immunosuppressive drug treatment influences the clinical course of Parkinson's disease. Recent research suggests that Parkinson's disease may have an inflammatory background.
- Trial name
- NCT06834191
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Warsaw
Chronic Kidney Disease
Study Evaluating the Benefit of Two Immunosuppressive Strategies on Renal Function
Prospective, multicenter, randomized and open label study evaluating the benefit on renal function at 12 months post-transplantation, with an immunosuppression without calcineurin inhibitor at 3 months and combining mycophenolate…
- Trial name
- NCT02334488
- Testing
- Everolimus, Tacrolimus, Mycophenolate sodium
- Where
- 14 sites in France
- Volunteers
- 329 people
- Sponsor
- Poitiers University Hospital
Severe Aplastic Anemia
Retrospective Study of Patients With Severe Aplastic Anemia Who Relapsed After Immunosuppressive Therapy
Background: Severe aplastic anemia (SAA) is a form of bone marrow failure. It usually results from a cytotoxic T cell attack on the marrow stem cell. Two treatments can be used for most people with SAA.
- Trial name
- NCT04436380
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Giant Cell Arteritis
Abatacept for the Treatment of Giant Cell Arteritis
This randomized, double-blind, placebo-controlled trial will seek to determine the efficacy of abatacept in GCA. To examine this objective, 62 eligible patients who have newly diagnosed or relapsing GCA within 8 weeks prior to…
- Trial name
- NCT04474847
- Testing
- Abatacept
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 78 people
- Sponsor
- University of Pennsylvania
Aplastic Anemia
Anti-thymocyte Globulin and Cyclosporine as First-Line Therapy in Treating Patients With Severe Aplastic Anemia
RATIONALE: Immunosuppressive therapies, such as anti-thymocyte globulin and cyclosporine, may improve bone marrow function and increase blood cell counts.
- Trial name
- NCT01231841
- Testing
- cyclosporine, anti-thymocyte globulin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Liver Transplantation
Immunosuppressive Therapy Optimization: Development of a Population Pharmacokinetic-pharmacodynamic (PK-PD) Model in Liver Transplantation
Prospective, non-randomized, open Pharmacokinetic-Pharmacogenetic-Pharmacodynamic monocentric study. Donor and recipient CYP3A5 genotype and recipient ABCB1 will not be communicate to clinicians or patients during the study.
- Trial name
- OPTILTH (NCT02877628)
- Testing
- Pharmacokinetic-pharmacodynamic model in liver transplantation
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Rennes University Hospital
Dry Eye Disease (DED)
Photobiomodulation in Combination With Topical Cyclosporine A or Tacrolimus
The objective of the study is to evaluate the effectiveness of Low-level light therapy (LLLT) in combination with either topical Cyclosporine A (CsA) or topical Tacrolimus, using each non-steroidal immunosuppressant as an active…
- Trial name
- NCT07239128
- Testing
- Low-level light therapy (LLLT), Topical Cyclosporine A, Topical tacrolimus
- Where
- 2 sites in Italy
- Volunteers
- 160 people
- Sponsor
- University of Seville
Lupus Nephritis
A Pharmacoeconomic Study Comparing the Use of Mycophenolate Mofetil or Cyclophosphamide as Induction Therapy in Lupus Nephritis Patients in Egypt
The aim of this study is to conduct a pharmacoeconomic analysis to compare the use of Mycophenolate Mofetil or i.v. Cyclophosphamide as induction therapy from a third party payer perspective in LN patients in the Egyptian context
- Trial name
- NCT05195086
- Testing
- endoxan, cellcept
- Where
- Egypt
- Volunteers
- 122 people
- Sponsor
- Nada Magdy Mansour