Clinical trials: Immunotherapy, Allergen
Allergy
A Trial of the ALK Grass Tablet in Subjects With Hayfever
This trial is performed to assess the efficacy and safety of the ALK Grass tablet for treatment of grass pollen induced rhinoconjunctivitis (hayfever).
- Trial name
- NCT00227279
- Testing
- ALK Grass tablet
- Where
- Denmark
- Volunteers
- 634 people
- Sponsor
- ALK-Abelló A/S
Severe Asthma, Allergy to House Dust Mites
Potency of HDM Sublingual AIT Tablets in Assuring the Persistency of Asthma Control in HDM Allergic Patients With Severe Asthma, Treated With Tezepelumab
The aim of this drug trial is to evaluate the annualized asthma exacerbation rate under treatment with Acarizax versus placebo. The trial is intended for adults aged 18 to 65 with severe uncontrolled asthma and a house dust mite…
- Trial name
- TEZEPAIT (NCT07013123)
- Testing
- Tezepelumab, Acarizax
- Volunteers
- 38 people
- Sponsor
- University Hospital, Montpellier
Rhinoconjunctivitis
Evaluation of Safety and Efficacy of Specific Immunotherapy With Recombinant Major Allergens of Timothy Grass Pollen Adsorbed Onto Aluminium-hydroxide in Patients With IgE-mediated Allergic Rhinoconjunctivitis +/- Controlled Asthma
Efficacy and Safety from a high-dosed subcutaneous recombinant preparation
- Trial name
- AMETHYST (NCT00671268)
- Testing
- AL0704rP
- Where
- Germany
- Volunteers
- 256 people
- Sponsor
- Allergopharma GmbH & Co. KG
Allergy;Food, Allergy to Shrimp
Food Allergen OIT for Shrimp and Cashew
A prospective Phase 2, single-center, single-allergen OIT of cashew or shrimp in participants with proven allergies to either cashew or shrimp, respectively.
- Conditions
- Allergy;Food, Allergy to Shrimp, Allergy to Cashew Nut (Disorder)
- Trial name
- MOTIF (NCT03504774)
- Testing
- Cashew or Shrimp Oral Immunotherapy
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Sayantani B. Sindher
Peanut Hypersensitivity, Food Hypersensitivity
Peanut Epicutaneous Phase II Immunotherapy Clinical Trial
Food allergy occurs when the immune system reacts against foods. The immune system is the part of the body that protects us from illness and germs, but it can also cause allergies.
- Conditions
- Peanut Hypersensitivity, Food Hypersensitivity, Hypersensitivity, Hypersensitivity, Immediate
- Trial name
- NCT01904604
- Testing
- Low-dose DBV712 Viaskin® Patch, High-dose DBV712 Viaskin® Patch
- Where
- 5 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Allergy to Grass Pollen
Biological Standardization of Poa Pratensis Allergen Extract
The objective of this study is to determine the biologic activity of a Poa pratensis allergen extract in histamine equivalent prick (HEP) units, in order to be used as in-house reference preparation (IHRP).
- Trial name
- NCT01430117
- Testing
- Four different concentrations of Poa pratensis allergen extract, positive control and negative control
- Where
- 2 sites in Spain
- Volunteers
- 31 people
- Sponsor
- Laboratorios Leti, S.L.
Hymenoptera Sting Allergy
Frequency of Hymenoptera-stings in Patients Under Allergen-Specific Immunotherapy (SIT)
In Switzerland, 3.5% of the population are suffering from hymenoptera venom allergy. The only causal treatment of hymenoptera alelrty is venom specific immunotherapy.
- Trial name
- ZU-HVA-001 (NCT00742794)
- Testing
- Observation
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Rhinitis or Rhinoconjunctivitis With or Without Asthma Induced by Hypersensitivity to Olea Europea Pollen
Subcutaneous Immunotherapy Treatment for Patients With Hypersensitivity to Olea Europaea Pollen
The objective of this trial is to assess the clinical efficacy of a modified allergen extract of Olea europaea pollen in the treatment of patients affected by allergic rhinitis/rhinoconjunctivitis (with or without episodic…
- Trial name
- OLEA (NCT00831025)
- Testing
- Immunotherapy with modified extract of Olea europaea pollen
- Where
- 7 sites in Spain
- Volunteers
- 158 people
- Sponsor
- Laboratorios Leti, S.L.
Allergic Rhinitis Due to Grass Pollens
Study of Efficacy and Safety of 300 IR Sublingual Immunotherapy (SLIT) Tablets in Adult Patients With Allergic Grass Pollen Rhinoconjunctivitis
The purpose of the study is to assess the efficacy and safety of 300 IR sublingual tablet of grass pollen allergen extract compared to placebo in adult patient with allergic rhinoconjunctivitis.
- Trial name
- NCT00955825
- Testing
- 300 IR
- Where
- 19 sites in United States
- Volunteers
- 473 people
- Sponsor
- Stallergenes Greer
Allergic Rhinitis
Grass Pollen Allergen Immunotherapy Tablet (AIT) Time Course Study
About 45 million people in Europe have allergic rhinitis (hay fever) - inflammation of the nasal passages causing sneezing, runny nose, nasal congestion, itching and tearing of the eyes.
- Trial name
- Pollen+ (NCT02005627)
- Testing
- Grazax
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Food Allergy
Open-label Extension Study of ADP101
This is an open-label, safety extension study for participants who participated in the Harmony study (protocol ADP101-MA-01).
- Trial name
- NCT05243719
- Testing
- ADP101
- Where
- 14 sites in United States
- Volunteers
- 45 people
- Sponsor
- Alladapt Immunotherapeutics, Inc.
Immunologic Desensitization
Desensitization and Cross-Desensitization During Oral Grass or Ragweed Pollen Immunotherapy
The purpose of this study is to determine if sublingual allergen immunotherapy tablets work by inducing a state of desensitization in mast cells and basophils.
- Trial name
- NCT02676765
- Testing
- allergen extract tablet
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Allergic Rhinitis, Asthma
The Effect of Pollen Season on Subcutaneous Allergen Immunotherapy Reactions
Subcutaneous allergen immunotherapy (SCIT) is a widely used and effective treatment modality for allergic rhinoconjunctivitis and asthma.
- Conditions
- Allergic Rhinitis, Asthma, Allergic Conjunctivitis
- Trial name
- SCIT (NCT01878929)
- Testing
- Allergen(Tree, Grass, Weeds)
- Where
- United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Allergic Reactions
Study Evaluating the Safety and Efficacy of Neffy or Intramuscular Adrenalin in Patients With Allergic Reactions After Oral Food Challenge or Allergen Immunotherapy
The study is to assess the safety of neffy or IM Adrenalin in patients who are experiencing allergic reactions after an OFC, allergen Immunotherapy (AIT), or other allergy challenge that may require epinephrine intervention.
- Trial name
- NCT06834165
- Testing
- Neffy, Adrenaline
- Where
- 6 sites in United States
- Volunteers
- 600 people
- Sponsor
- ARS Pharmaceuticals, Inc.
Allergy to Grass Pollen (Secale Cereale)
Biological Standardization of Secale Cereale Allergen Extract
The objective of this study is to determine the biologic activity of a Secale cereale allergen extract in histamine equivalent prick (HEP) units, in order to be used as in-house reference preparation (IHRP).
- Trial name
- NCT01408238
- Testing
- Four different concentrations of Secale cereale allergen extract, positive control and negative control
- Where
- 2 sites in Spain
- Volunteers
- 35 people
- Sponsor
- Laboratorios Leti, S.L.
Food Allergy
E-B-FAHF-2, Multi OIT and Xolair (Omalizumab) for Food Allergy
The purpose of this study is testing the use E-B-FAHF-2 Chinese herbal therapy in combination with multi-food oral immunotherapy (OIT) and Xolair® (Omalizumab) to help children and adults who are allergic to foods be able to…
- Trial name
- NCT02879006
- Testing
- Chinese Herbal Medication, Omalizumab, Multi OIT
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Xiu-Min Li
Allergic Asthma, Allergic Rhinitis
The Effect of Allergen Immunotherapy on Exhaled Nitric Oxide in Adult Patients With Asthma and Allergic Rhinitis
This study will evaluate whether exhaled nitric oxide levels are affected by allergen immunotherapy ("allergy shots"). The investigators' hypothesis is that successful allergen immunotherapy may be accompanied by decreased…
- Trial name
- NCT01318954
- Testing
- Allergen immunotherapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Rohr and Columbo Asthma, Allergy and Immunology Specialists, P.C.
Rhinitis, Allergic, Seasonal
Factors Predicting Efficacy of Allergen Injection Immunotherapy for Grass Pollen Hayfever
The purpose of this study is to determine at which point in the dosing regime grass pollen immunotherapy causes a significant reduction in the late skin response to allergen challenge.
- Trial name
- NCT00135629
- Testing
- Active injections of alum-adsorbed grass pollen vaccine (Alutard SQ)., Venepuncture: 100ml blood sample taken on 12 separate visits
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Imperial College London
Asthma, Allergic
Biologics and Sublingual Immunotherapy
Most current studies involve using a biological drug to increase the safety of allergen immunotherapy (AIT) especially in the treatment of food allergies, to avoid the risk of anaphylaxis.
- Trial name
- BSIPL (NCT06027073)
- Testing
- omalizumab
- Volunteers
- 150 people
- Sponsor
- Medical University of Silesia
Allergic Asthma
Combination Therapy of Omalizumab and Allergen Immunotherapy for Moderate to Severe Asthma
The combined treatment of anti-IgE monoclonal antibody and standardized allergen immunotherapy has good efficacy and safety in allergic diseases.
- Trial name
- NCT06771934
- Testing
- Allergen-specific immunotherapy(AIT), omalizumab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Qianfoshan Hospital