Clinical trials: Impaired Glucose Tolerance
Impaired Glucose Tolerance, Type 2 Diabetes
Impact of 3-year Lifestyle Intervention on Postprandial Glucose Metabolism: the SLIM Study
To evaluate the effect of a 3-year diet- and exercise lifestyle intervention, based on general public health recommendations, on glucose tolerance, insulin resistance and metabolic cardiovascular risk factors in Dutch subjects…
- Trial name
- NCT00381186
- Testing
- diet- and exercise intervention
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
PreDiabetes, Prediabetic State
Mobile Health Application of Screening and Early Intervention for Prediabetic Patient at Primary Health Cares Setting
Background: Preventing type-2 diabetes mellitus begins with early screening and intervention of prediabetic participants. Until now, prediabetes screening and early intervention have not been optimal.
- Trial name
- NCT04979559
- Testing
- Mobile health apps, Standard care
- Where
- Indonesia
- Volunteers
- 350 people
- Sponsor
- Gadjah Mada University
Glucose Intolerance, Diabetes Mellitus, Type 2
Lifestyle Interventions to Reduce Diabetes Risk
Type 2 diabetes is more frequent in Japanese Americans than in Japan or the U.S. non-Hispanic white population. This appears to be due to the effects of ''westernization'' to bring out metabolic changes that lead to diabetes.
- Trial name
- NCT00006162
- Testing
- exercise and diet
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Prediabetes
Modulating Effects of Oil Palm Phenolics in Subjects With Pre-diabetes
Study reported that providing Oil Palm Phenolics to Nile rats blocked diabetes progression in this spontaneous diabetes model. The present study aims to determine the beneficial effects of Oil Palm Phenolics in subjects with…
- Trial name
- PREDOPP (NCT02532088)
- Testing
- Oil Palm Phenolics
- Where
- Malaysia
- Sponsor
- Universiti Sains Malaysia
Diabetes Mellitus, Cancer
Diabetes Prevention Program Outcomes Study
The Diabetes Prevention Program (DPP) was a multi-center trial examining the ability of an intensive lifestyle or metformin to prevent or delay the development of diabetes in a high risk population due to the presence of impaired…
- Conditions
- Diabetes Mellitus, Cancer, CVD
- Trial name
- DPPOS (NCT00038727)
- Testing
- DPPOS Group Lifestyle, Metformin, DPPOS Boost Lifestyle
- Where
- United States
- Volunteers
- 2,779 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pre-Diabetes, Weight, Body
Prevention of Progression of Prediabetes, Obesity and CV Risk
The investigators are studying how to help people with prediabetes (Pre-DM) and obesity. The goal is to use new and affordable treatments to bring blood sugar levels back to normal and help participants to lose weight.
- Conditions
- Pre-Diabetes, Weight, Body, Cardiovascular Diseases
- Trial name
- Pre-DM (NCT06446531)
- Testing
- Rybelsus Tablet, Jardiance 25Mg Tablet, Metformin
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Prediabetes
Almond Effects on Glucose Intolerance Study
Diabetes is a major cause of morbidity and mortality worldwide. Prevention of diabetes is an important goal. The progression from impaired glucose tolerance to diabetes is thought to be promoted by the toxic effects of…
- Trial name
- AEGIS (NCT02260895)
- Testing
- Almond pre-test snack
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Memorial Hermann Health System
Prediabetes, Type 2 Diabetes
Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and Diabetes
The objective of this study is to investigate the impact of hypocaloric time-restricted eating (TRE) at different day times (early versus late TRE) on glucose metabolism and other cardiometabolic parameters in individuals with…
- Conditions
- Prediabetes, Type 2 Diabetes, Obesity &Amp; Overweight
- Trial name
- GLYCOTIME (NCT07171281)
- Testing
- Early Time-Restricted Eating, Late Time-Restricted Eating
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Overweight, Obesity
Meta-analysis of Fructose-Containing Sugar Sweetened Beverages (SSBs) and Weight Change
Since uncontrolled observational studies first linked fructose to the epidemic of obesity almost a decade ago, it has become a focus of intense concern regarding its role in the obesity epidemic.
- Conditions
- Overweight, Obesity, Diabetes, Prediabetes
- Trial name
- NCT01608607
- Testing
- Fructose-containing sugar sweetened beverages
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
PreDiabetes, Overweight and Obesity
Family Diabetes Prevention Program Pilot Study
This study will examine the feasibility and acceptability of a family-oriented augmentation of the Diabetes Prevention Program lifestyle intervention (DPP), called the Family DPP.
- Conditions
- PreDiabetes, Overweight and Obesity, Type 2 Diabetes, Overweight, Childhood
- Trial name
- NCT05358444
- Testing
- National Diabetes Prevention Program Lifestyle Intervention (DPP), Family Diabetes Prevention Program (Family DPP)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Diabetes, Prediabetes
Maintaining Resistance Training in Older Prediabetic Adults
The aim of this Phase II Clinical Trial is to demonstrate the efficacy of social cognitive theory (SCT) based intervention for initiating, and most importantly, maintaining resistance training in older adults with pre-diabetes…
- Trial name
- NCT01112709
- Testing
- SCT-based Resistance Training exercise program, Standard Intervention with minimal contact
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Virginia Polytechnic Institute and State University
Pre Diabetic, Obesity & Overweight
The Impact of Continuous Glucose Monitoring on Glucose Variability and Weight Loss in Individuals With Prediabetes and Obesity
This randomized, crossover interventional study evaluates the effects of real-time (open) versus blinded continuous glucose monitoring (CGM) on glycemic variability, lifestyle behaviors, and metabolic outcomes in adults with…
- Trial name
- CGM (NCT07423065)
- Testing
- Continuous Glucose Monitoring (CGM)
- Where
- 3 sites in Slovenia
- Volunteers
- 34 people
- Sponsor
- University of Primorska
Postprandial Hypoglycemia
Empagliflozin and Anakinra for the Treatment of Postprandial Hypoglycemia in Patients With Prediabetes
This study is to analyze whether the SGLT2-inhibitor empagliflozin or the IL-1 receptor antagonist anakinra may improve postprandial hypoglycemia in subjects with prediabetes.
- Trial name
- Hypo-PrEA (NCT05174507)
- Testing
- empagliflozin, anakinra
- Sponsor
- University Hospital, Basel, Switzerland
PreDiabetes, Impaired Glucose Tolerance
Effect of Probiotics Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes.
Pre diabetes (PD) is a term that refers to alterations in blood glucose levels, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both, and increase in glycated hemoglobin (HbA1c), all this factors…
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Hyperglycemia, Resistance, Insulin
- Trial name
- NCT04341571
- Testing
- Probiotics, Metformin
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- University of Guadalajara
PreDiabetes
Continuous Glucose Monitoring as Adjunct to Lifestyle Modification in Prediabetes
This is a 12-month prospective, open-label, non-masked, two arm randomized controlled trial comparing intermittently-viewed continuous glucose monitoring (iCGM) in addition to lifestyle modification programme (LMP) as compared…
- Trial name
- FlashLMP (NCT04588896)
- Testing
- Continuous glucose monitoring, Lifestyle modification programme
- Where
- Hong Kong
- Volunteers
- 177 people
- Sponsor
- Chinese University of Hong Kong
NAFLD, Pre-diabetes
Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis
Oxidative stress is produced by imbalance between reactive oxygen species and antioxidant systems. This state is frequently associated with chronic diseases like obesity, insulin resistance, metabolic syndrome and hepatic…
- Trial name
- NCT02051842
- Testing
- Metadoxine
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Type 2 Diabetes Mellitus
Effect of Probiotics on Pre-diabetes and Diabetes in China
This study is aimed at verifying the effects of probiotics (KAWAI:dead S.thermophilus) on glucos management among T2DM and pre-diabetes Chinese adult.
- Trial name
- NCT03377946
- Testing
- probiotics
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Chinese PLA General Hospital
Diabetes Mellitus, Type 2, HIV Infections
Food as Medicine for HIV and Diabetes
This is a single-site, open-label, Phase II, community-based randomized controlled explanatory trial to test the efficacy of a medically tailored meal + intensive lifestyle intervention (MTM + ILI) intervention for adults with…
- Conditions
- Diabetes Mellitus, Type 2, HIV Infections, PreDiabetes
- Trial name
- FAME-H (NCT05026723)
- Testing
- MTM + ILI, Standard MTM
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of North Carolina, Chapel Hill
Diabetes Prevention in Women After GDM Who Are at High-risk
Dapagliflozin and Metformin,Alone and in Combination, in Overweight/Obese Prior GDM Women
Women with a history of gestational diabetes (GDM) are at substantially increased risk of type 2 diabetes mellitus (T2DM). Compared with the general population, these women are more likely to be overweight or obese.
- Trial name
- DAPA-GDM (NCT02338193)
- Testing
- DAPA/MET XR, DAPA, MET XR
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Woman's
Obesity, PreDiabetes
The Effect of Time-Restricted Eating in Cardiometabolic Health
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no energy intake the rest of the day.
- Trial name
- TRE (NCT05866406)
- Testing
- Time restricted eating, Extended eating window, Healthy diet
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust