Clinical trials: Impaired Physical Function
Cognition, Brain Injuries
Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator
Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are common combat-related conditions that can result in impairments in cognition, including memory, attention and multi-tasking.
- Conditions
- Cognition, Brain Injuries, Stress Disorders, Post-Traumatic
- Trial name
- NCT07414537
- Testing
- Transcranial direct current stimulation (tDCS), Cognitive training
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- VA Office of Research and Development
Renal Impairment
Study of ISIS 681257 in Patients With Renal Impairment Compared to Healthy Patients
This is a Phase 1, Multicenter, Open-Label, Parallel Group Adaptive Pharmacokinetic Single Dose Study of ISIS 681257 Subcutaneous Injections in Male And Female Subjects with Normal and Impaired Renal Function
- Trial name
- NCT03506854
- Testing
- ISIS 681257
- Where
- 3 sites in United States, Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Akcea Therapeutics
Moderate Renal Impairment
Clofutriben Pharmacokinetics in Patients With Impaired Renal Function
This is a Phase 1, single-center, open-label, single-dose trial. Sixteen participants are planned: 8 participants with moderate renal impairment and 8 matched control participants with normal renal function.
- Trial name
- RENAL (NCT07227922)
- Testing
- 12mg clofutriben
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sparrow Pharmaceuticals
Renal Insufficiency, Healthy
A Study of LY3819469 in Participants With Impaired and Normal Renal Function
The main purpose of this study is to assess the amount of study drug (LY3819469) that reaches the bloodstream and the time it takes for the body to get rid of it when given to participants with renal (kidney) impairment compared…
- Trial name
- NCT05841277
- Testing
- LY3819469
- Where
- 4 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
PreDiabetes, Impaired Glucose Tolerance
Almonds and Health Effects on Metabolism, Vascular Function and Cognition
The primary objective of the proposed study is to examine and understand the impact of long-term almond consumption on chronic glucose metabolism in subjects with impaired glucose tolerance and/or impaired fasting glucose.
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Impaired Fasting Glucose, Overweight and Obesity
- Trial name
- NCT03419702
- Testing
- Almonds
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Maastricht University Medical Center
Cognitive Impairment, Preoperative Cognitive Impairment
Reliability In Neurocognitive Telemedicine Screening (RING)
Perioperative neurocognitive disorders are common after surgery and pre-existing cognitive impairment is an important risk factor.
- Conditions
- Cognitive Impairment, Preoperative Cognitive Impairment, Perioperative Neurocognitive Disorders, Neurocognitive Function
- Trial name
- NCT07760545
- Testing
- Modified Mini-Cog Telephone Assessment
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University of British Columbia
Stroke, Hemiplegia
Combined Mirror Therapy and Soft Robotic Glove for Hand Recovery After Stroke
Post-stroke hemiplegia frequently results in impaired upper limb function, which significantly affects independence and quality of life.
- Conditions
- Stroke, Hemiplegia, Upper Limb Motor Impairment
- Trial name
- MT-SRG (NCT07467915)
- Testing
- Conventional Rehabilitation, Mirror Therapy, Soft Robotic Glove
- Where
- Iraq
- Volunteers
- 104 people
- Sponsor
- University of Baghdad
Dynapenia, Aging
Protein Supplementation and Mixed Power Training on Muscle Function and Functional Capacities in Elderly Men
Investigate the effect of 12 weeks mixed power training (power and functional exercises) combined with a protein supplementation (30g/d) or not (placebo) on physiological characteristics of muscle and functional capacities in…
- Conditions
- Dynapenia, Aging, Physical Impairment
- Trial name
- PROMU (NCT03393650)
- Testing
- Exercise + Protein group
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université du Québec a Montréal
Growth Hormone Disorder, Adult Growth Hormone Deficiency
Investigation of Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Multiple Doses of Somapacitan in Subjects With Various Degrees of Impaired Renal Function Compared to Subjects With Normal Renal Function
The trial is conducted in Europe. The aim of the trial is to investigate the steady state exposure of somapacitan in subjects with various degrees of renal impairment (mild, moderate, severe renal impairment, requiring…
- Conditions
- Growth Hormone Disorder, Adult Growth Hormone Deficiency, Growth Hormone Deficiency in Children
- Trial name
- NCT03186495
- Testing
- Somapacitan
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Novo Nordisk A/S
Physical Function, Executive Function (Cognition)
Effects of Resistance and Dual-Task Training on Physical, Oculomotor, and Executive Functions in Older Adults With MCI
The goal of this clinical trial is to determine the effect of a combined therapeutic intervention program with anaerobic exercises (resistance exercises) and dual tasks on the physical, oculomotor, and executive functions of…
- Conditions
- Physical Function, Executive Function (Cognition), Saccadic Eye Movements
- Trial name
- NCT07278141
- Testing
- Anaerobic therapeutic exercises (resistance exercise), Anaerobic therapeutic exercises (resistance exercise) plus Dual Task
- Where
- 2 sites in Chile, Spain
- Volunteers
- 66 people
- Sponsor
- Universidad Santo Tomas, Chile
Schizophrenia
A Study Evaluating the of OPC-34712 in Subjects With Normal Hepatic Function and Hepatically Impaired Subjects
The purpose of this study is to evaluate how much of the investigational product gets into the blood stream and how long the body takes to get rid of it when given to subjects with a range of liver impairment compared to subjects…
- Trial name
- NCT01299454
- Testing
- OPC-34712
- Where
- 3 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Obstructive Sleep Apnea, Mild Cognitive Impairment
Mild Cognitive Impairment and Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) has been linked to increased risk for Alzheimer's disease (AD), but little prospective evidence exists on the effects of OSA treatment in preclinical AD.
- Trial name
- MEMORIES (NCT01482351)
- Testing
- CPAP adherence intervention, Attention control intervention
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- George Mason University
Diabetes Mellitus, Type 2, Cognitive Dysfunction
Tai Chi Chuan as Rehabilitation Program for Mild Cognitive Impairment in Type 2 Diabetes Mellitus Patients
The patients with type 2 diabetes mellitus (T2DM) is expected to rise to 439 million in 2030, accounting for 7.7% the population in the world.
- Trial name
- NCT04416841
- Testing
- Tai Chi Chuan, Fitness Walking, Standard Diabetic Care Education
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Jing Tao
Cerebral Small Vessel Diseases
Visit-to-Visit Variability in Blood Pressure as a Predictor of Poor Cognitive Function
Hypertension in midlife is an independent risk factor of late life cognitive dysfunction or dementia. Chronic hypertension cause vascular damage and cerebral ischemia, which ultimately gives rise to the cognitive dysfunction or…
- Trial name
- BPV-COG (NCT01688505)
- Where
- 5 sites in South Korea
- Volunteers
- 140 people
- Sponsor
- Hallym University Medical Center
Hepatic Insufficiency
A Study of Tirzepatide in Participants With Impaired Liver Function
The purpose of this study is to assess how fast tirzepatide gets into the blood stream and how long it takes the body to remove it in participants with impaired liver function compared to healthy participants.
- Trial name
- NCT03940742
- Testing
- Tirzepatide
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Hemiplegic Cerebral Palsy, Mirror Movement Therapy
Effectiveness of the Mirror Therapy for Improving Bimanual Performance, Somatosensory Function of the Impaired Upper Limb and Quality of Life in Children With Unilateral Spastic Cerebral Palsy
Background: Unilateral Spastic Cerebral Palsy (USPC) is caused by an injury in one brain hemisphere in the immature brain, and affects the contralateral side of the body, especially on the upper limb.
- Trial name
- NCT05244083
- Testing
- Mirror Therapy, Program without Mirror Therapy
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Universitat Internacional de Catalunya
Renal Failure
A Pharmacokinetics and Safety Study of Naproxcinod in Subjects With Impaired Renal Function
To study the pharmacokinetics and safety of naproxcinod in patients with impaired renal function
- Trial name
- HCT3012-X-106 (NCT00674856)
- Testing
- naproxcinod
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- NicOx
Generalized Anxiety Disorder
Pharmacokinetic Study of Buagafuran Capsules in Participants With Hepatic Impairment and Normal Hepatic Function
This study adopts a non-randomized, open label, parallel, single-dose design to evaluate the safety and pharmacokinetic characteristics of Buagafuran capsules in participants with hepatic impairment.
- Trial name
- NCT07457190
- Testing
- Buagafuran
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Beijing Union Pharmaceutical Factory Ltd
Mild Cognitive Impairment
Effects of Combined Physical-cognitive Training on Cognitive Function in MCI
The present study aims to investigate the effects of combined physical-cognitive training on cognitive function as well as peripheral BDNF level and mitochondrial function of individuals with MCI.
- Trial name
- NCT03805620
- Testing
- Combined physical-cognitive training, Physical training, Cognitive training
- Where
- Thailand
- Volunteers
- 128 people
- Sponsor
- Chiang Mai University
PK of FG-4592, Hepatic Insufficiency
A Study to Investigate the Exposure and Safety and Tolerability of a Single Dose of FG-4592 in Subjects With Moderately Diminished Liver Function Compared to Those With Normal Liver Function
The effect of moderately diminished liver function on the exposure, safety and tolerability of a single dose of FG-4592 is studied in male and female subjects.
- Conditions
- PK of FG-4592, Hepatic Insufficiency, Healthy Subjects
- Trial name
- NCT02161224
- Testing
- FG-4592
- Where
- Bulgaria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.