Clinical trials: Impaired Quality of Life
Brain Metastases, Brain Metastasis
Feasibility of a Cognitive Stepped Care Program for Adults With Brain Metastases
Background: Cognitive symptoms are common and often severe in patients with brain metastases, significantly impacting their quality of life and ability to manage cancer care.
- Trial name
- NCT07355348
- Testing
- Cognitive Stepped Care Program (CSCP)
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- University Health Network, Toronto
Hearing Loss, Cognitive Impairment, Mild
ENACT Program on Auditory Perception and Function, Cognitive Function and Health-related Quality of Life
Although previous studies indicated that tackling hearing loss may have a secondary benefit in improving cognitive function and delaying the onset of dementia, a more integrated care approach to optimize both hearing and…
- Trial name
- NCT06955494
- Testing
- Empowerment Network for Auditory-Cognitive Training (ENACT) Program, Usual Care
- Where
- Hong Kong
- Volunteers
- 62 people
- Sponsor
- The University of Hong Kong
Schizophrenia; Psychosis, Cognitive Impairment
A Study Evaluating the Efficacy of Xanomeline/Trospium (XT) on Cognitive Impairment After 24 and 52 Weeks of Treatment in Adult Participants With Schizophrenia
Schizophrenia is a long-lasting and serious mental health disorder that affects about 1% of people worldwide. It can cause symptoms such as hallucinations and delusions (called positive symptoms), confused or disorganized…
- Trial name
- SHINE (NCT07084831)
- Testing
- Xanomeline/trospium
- Where
- 16 sites in Austria, Belgium and 8 more
- Volunteers
- 171 people
- Sponsor
- European Group for Research In Schizophrenia
Neurocognitive Disorders, Dementia
Care at 360º: A Long-term Individual Cognitive Stimulation Program
The aim of the intervention proposed in the present study is to assess the effect of a cognitive stimulation (CS) intervention program in an individual and long-term format, for non-institutionalized elderly people with…
- Conditions
- Neurocognitive Disorders, Dementia, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT04417751
- Testing
- Cognitive Stimulation
- Where
- Portugal
- Volunteers
- 59 people
- Sponsor
- CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas
Attention Deficit Disorder With Hyperactivity, Sleep Disorders, Circadian Rhythm
Sleep Disorders, Chronotype, and Functional Impairment in the Restrictive ADHD Phenotype
This study aims to explore chronotype and sleep disturbances in ADHD subtypes and their relation to functional impairment.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Sleep Disorders, Circadian Rhythm, Quality of Life, Morningness Eveningness Preference
- Trial name
- NCT06970418
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Dr. Behcet Uz Children's Hospital
Dementia, Cognitive Impairment
Motion-based Interactive Technology for Improved Quality of Life in Individuals With Cognitive Impairment
The aging population is growing in Sweden and worldwide, highlighting the urgent need to address their needs using available societal resources.
- Trial name
- WakeIT (NCT06466460)
- Testing
- Motion based - Virtual cycling
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Marie Matérne
Stroke
Effects of Mobile Application-Based Cognitive Training Along With Aerobic Training
This randomized controlled trial will determine the effects of combining mobile application-based cognitive training with aerobic exercise on cognitive function and the effects of combining mobile application-based cognitive…
- Trial name
- NCT07148453
- Testing
- Experimental Group, Control Group
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Low Vision Blindness, Visual Impairment
Development of a Multi-sensory Rehabilitation Program for People With Ultra Low Vision
This research is aimed to address one of the big gaps in the current vision rehabilitation protocols for people with profound visual impairment by evaluating a multisensory approach.
- Conditions
- Low Vision Blindness, Visual Impairment, Quality of Life, Functional Visual Loss
- Trial name
- NCT05028712
- Testing
- Visual Information Training, Multimodal training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- State University of New York College of Optometry
Type 2 Diabetes, Impaired Glucose Tolerance
Exercise Effects on Cardiovascular Risk Factors, Quality of Life, Muscle Function in Type 2 Diabetes and Healthy Persons
A sedentary lifestyle is known to be a risk factor to developing type 2 diabetes. The aim of this study was to determine the effects of adding regular Nordic walking to daily physical activity.
- Trial name
- SMIDIG (NCT00852982)
- Testing
- Exercise
- Where
- Sweden
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Traumatic Brain Injury, Aging
The Long-term Consequences After Traumatic Brain Injury in the Elderly
A better understanding of the injury patterns, injury severity, risk profiles, consequences and impact of Traumatic Brain Injury (TBI) in the elderly population is necessary due to the increasing incidence and prevalence of TBI…
- Conditions
- Traumatic Brain Injury, Aging, Cognitive Impairment, Quality of Life
- Trial name
- NCT04074850
- Where
- Belgium
- Volunteers
- 47 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Mild Cognitive Impairment
Evaluating a Digital Memory Notebook App to Improve Functional Independence
This study will investigate the efficacy of a smart home / digital memory notebook (DMN) partnership that will allow for real-time intervention and thereby facilitate acquisition and use of the DMN to support everyday…
- Trial name
- NCT03453554
- Testing
- Digital Notebook app, Smart Home Prompting
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington State University
Schizophrenia
Compensatory Strategies Applied to Cognitive Impairment in Schizophrenia
The purpose of this study is to determine whether Cognitive Adaptation Training are effective in comparison with conventional treatment, focusing on social functions, symptoms, relapse, re-hospitalisation, and quality of life in…
- Trial name
- CAT-Denmark (NCT01055509)
- Testing
- Cognitive Adaptation Training
- Where
- 3 sites in Denmark
- Volunteers
- 65 people
- Sponsor
- University of Southern Denmark
Multiple Sclerosis, Cognitive Ability, General
Trial of Ginkgo as a Treatment for Cognitive Problems in Multiple Sclerosis
The purpose of this study is to see if treatment with Ginkgo improves cognitive function in people with multiple sclerosis who have cognitive problems.
- Trial name
- NCT00841321
- Testing
- Ginkgo biloba
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- US Department of Veterans Affairs
Substance Use Disorders, Mental Health Impairment
Homeless Care Management App
There is a significant revolving door of incarceration among homeless adults, a population with substantial health disparities. Homeless adults who receive the professional coordination of individualized care (i.e., case…
- Conditions
- Substance Use Disorders, Mental Health Impairment, Health Behavior, Adherence, Patient
- Trial name
- Link2Care (NCT03399500)
- Testing
- In-Person Case Management at Homeless Recovery Program, Unlimited Smartphone, Smartphone Based Case Management (SPCM) app
- Where
- 2 sites in United States
- Volunteers
- 403 people
- Sponsor
- University of Oklahoma
Haemophilia A, Haemophilia B
Management of Health-Related QoL Impairment, Including Pain, Depression and Anxiety, in People With Haemophilia A and B
The puropse of this non-interventional register and survey study is to identify the patterns of prescribed pain, anti-depressive and anti-anxiety medication and management of pain, depression and anxiety for people with…
- Trial name
- MIND (NCT03276130)
- Where
- 5 sites in Denmark, Finland and 1 more
- Volunteers
- 2,300 people
- Sponsor
- Swedish Orphan Biovitrum
Cognitive Impairment, Postoperative Delirium
Cognitive Impairment Following Elective Spine Surgery
Older people are a rapidly growing proportion of the world's population and their number is expected to increase twofold by 2050.
- Conditions
- Cognitive Impairment, Postoperative Delirium, Spine Fusion
- Trial name
- CONFESS (NCT03486288)
- Where
- Germany
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Hematopoietic Stem Cell Transplantation, Breast Cancer
Treating Cancer-Related Fatigue Through Systematic Light Exposure
Cancer related fatigue (CRF) - a persistent sense of exhaustion related to cancer or cancer treatment - can severely interfere with activities of daily living, and has even been reported to be a factor in patient requests for…
- Conditions
- Hematopoietic Stem Cell Transplantation, Breast Cancer, Fatigue, Mild Cognitive Impairment
- Trial name
- NCT01873794
- Testing
- Bright white light, Dim red light
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Breast Cancer Female, Side Effects
Rehabilitation Through Hippotherapy for the Management of Women After Primary Treatment of Breast Cancer
Breast cancer is the most common women's cancer and the third leading cause of death. Advances in prevention, detection and primary treatment have improved overall survival leading to its growing acceptance as a long-term…
- Conditions
- Breast Cancer Female, Side Effects, Psychological Distress, Physical Disability
- Trial name
- HippoBreastCa (NCT04350398)
- Testing
- Hippotherapy, Conventional therapy
- Where
- France
- Volunteers
- 83 people
- Sponsor
- Alliance Equiphoria
Mild Cognitive Impairment
Effects of Tai Chi on Cognition, I-ADLs, and HRQOL in Older People With MCI
The prevalence of older people with cognitive decline is increasing since the aging population is growing substantially worldwide. Cognitive impairment places older adults at high risk for functional disability.
- Trial name
- NCT03404765
- Testing
- Tai Chi
- Where
- Hong Kong
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Multiple Sclerosis, Fatigue
The Impact of Exercise Training on Living Quality in Multiple Sclerosis Individuals
The most common symptom displayed in patients with multiple sclerosis (MS) is a pronounced sense of fatigue that can have negative effect on functional ability and quality of life (QOL).
- Conditions
- Multiple Sclerosis, Fatigue, Mental Status Change, Physical Disability
- Trial name
- NCT03222596
- Testing
- Exercise training
- Where
- Croatia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rijeka