Clinical trials: Impaired Social Functioning
Adverse Childhood Experience, Endothelial Function (FMD)
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction.
- Conditions
- Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function
- Trial name
- PROMISE (NCT07244809)
- Testing
- Mitoquinone mesylate (MitoQ)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Existential Suffering, Meaning of Life
Reminiscence-Based Life Review on Copying With Existential Suffering Among Older Cancer Survivors
Target Issue: Cognitive impairment in older cancer survivors is highly prevalent and the co-existing neuro-psychiatric symptoms, particularly depression, would further complicate the psychosocial consequence of existential…
- Conditions
- Existential Suffering, Meaning of Life, Cognitive Function, Psychological Distress
- Trial name
- NCT05525299
- Testing
- Reminiscence-Based Life Review
- Where
- Hong Kong
- Volunteers
- 116 people
- Sponsor
- The University of Hong Kong
COVID-19 Pandemic, Depression, Anxiety
Older Adults' Perceptions of the Impact COVID-19 Pandemic
This multicentre study will be conduct in several Portuguese institutions, which provide care and supporting services for older adults, with aim to assess the impact of COVID-19 pandemic on the cognitive, emotional and social…
- Conditions
- COVID-19 Pandemic, Depression, Anxiety, Cognitive Impairment, Quality of Life
- Trial name
- NCT05379426
- Testing
- Impact COVID-19 pandemic
- Where
- 58 sites in Portugal
- Volunteers
- 880 people
- Sponsor
- Rsocialform - Geriatria, Lda
Psychosis, Prodromal Schizophrenia
Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk
This 10 week intervention, Specific Cognitive Remediation with Surround (or SCORES), is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability…
- Conditions
- Psychosis, Prodromal Schizophrenia, Prodromal Symptoms
- Trial name
- SCORES (NCT05131035)
- Testing
- SCORES (Specific COgnitive Remediation with Support)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwell Health
COPD
COPD and Socially Vulnerable Individuals
The trial investigates and describes the prevalence of COPD in patients who are in the social nurses' target group and investigates the effect of opportunistic screening for COPD in these vulnerable patients.
- Trial name
- NCT04754308
- Testing
- Spirometry
- Where
- 10 sites in Denmark
- Volunteers
- 513 people
- Sponsor
- Hvidovre University Hospital
Cognitive Function 1, Social
Evaluating Cognitive and Functional Impairment in Alzheimer's Dementia With a Ketogenic Diet.
The present study is being done in a scientifically rigorous manner, using readily available MCT oil (refined from coconut oil) versus a placebo oil to assess any cognitive and functional benefits for AD patients.
- Trial name
- NCT04396015
- Testing
- Bulletproof Brain Octane
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Autism Spectrum Disorder, Social Communication Disorder
Virtual Group Social ABCs - Multi-site Randomized Controlled Trial
The goal of this randomized control trial is to test the efficacy of the Social ABCs 6 week, group-based model using a virtual delivery platform.
- Conditions
- Autism Spectrum Disorder, Social Communication Disorder, Autism or Autistic Traits, Autism Spectrum Disorder With Impaired Functional Language
- Trial name
- NCT05663970
- Testing
- VG Social ABCs
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Social Isolation, SCD
The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
The goal of this clinical trial is to learn about the effects of social isolation and social interaction on the risk of dementia progression and brain function in SCD 1.
- Conditions
- Social Isolation, SCD, Subjective Cognitive Decline, MCI
- Trial name
- NCT06335836
- Testing
- social isolation
- Where
- China
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Depression, Functional Impairment
The Health and Social Consequences of Depression Among the Elderly
Mental illnesses often go undiagnosed or untreated in low-income settings. Mental health care may be especially important for the elderly - events in the lives of the elderly, like illnesses or deaths of peers, may put these…
- Trial name
- NCT05856552
- Testing
- CBT, Group Activities
- Where
- 2 sites in India
- Volunteers
- 5,370 people, healthy volunteers welcome
- Sponsor
- National Bureau of Economic Research, Inc.
Cognitive Change, Memory; Disturbance, Mild
The Influence of Food for Special Dietary Use - Spread Enriched With 5-hydroxytryptophan, Theanine and Gamma-aminobutyric Acid on Psychophysiological Functions of Subjects Without Meaningful Organic and Cognitive Pathology
This is a single-centre, single-blind, two-arms, controlled study to assess the efficacy and safety of food for special dietary use enriched with 5-hydroxytryptophan, L-theanine and Gamma-aminobutyric acid in generally healthy…
- Conditions
- Cognitive Change, Memory; Disturbance, Mild, Emotional Regulation, Concentration Ability Impaired
- Trial name
- Spread Bogatyr (NCT05543811)
- Testing
- Food for special dietary use
- Where
- Russia
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution
Alzheimer Disease, Stroke
Assessment of Social-emotional Functioning in Neurological Diseases
Empathy, defined as the ability to understand others emotions, is a fundamental concept in social interactions. It is a psychological phenomenon involving various separable components : (i) the ability to feel and imagine the…
- Conditions
- Alzheimer Disease, Stroke, Parkinson's Disease, Lewy Body Dementia
- Trial name
- Emotion (NCT01339130)
- Testing
- Computerized tests and Electrophysiological measurements
- Where
- France
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Multiple Sclerosis
Study of Social Cognition by Morphological and Functional Imaging in Multiple Sclerosis Patients
In recent years, studies have brought knowledge of the difficulties of social cognition in Multiple Sclerosis (MS). The brain tissue alteration at the origin of these difficulties in social cognition mechanisms remain poorly…
- Trial name
- SOCOG-MS (NCT02290587)
- Testing
- Brain MRI - Clinical and cognitive evaluation, MRI
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Mild Cognitive Impairment, Insomnia
A Mixed Method Pilot Study for Patients With Mild Cognitive Impairment and Insomnia.
Dementia is irreversible, incurable and devastating. It is thus imperative to preserve cognition at the pre-dementia stage. Mild cognitive impairment (MCI) refers to the reversible intermediate clinical state between normal…
- Trial name
- NCT04635085
- Testing
- Empowerment-based Cognitive behavioral therapy for insomnia for MCI
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Social Anhedonia, Social Function Impairment
Clinical and Neurocomputational Effects of Behavioral Activation in Veterans With Impaired Social Functioning
Poor psychosocial functioning, including social disconnection, is common and disabling among Veterans, and often fails to improve following the best available evidence-based treatments, particularly if more severe pathology is…
- Trial name
- NCT07697001
- Testing
- Behavioral Activation (BA), Supportive Care Therapy (SCT)
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- VA Office of Research and Development
Mental Health (Depression), Mental Health and General Well-being
Thrive at Home: A Virtual Reality Social Intervention for Older Adults
The goal of this clinical trial is to evaluate whether a virtual reality (VR) based social platform can improve mental health and social connection for older adults who receive in-home care.
- Conditions
- Mental Health (Depression), Mental Health and General Well-being, Loneliness, Well Being
- Trial name
- Thrive at Home (NCT07835568)
- Testing
- Full Virtual Reality Social Intervention, Abbreviated Virtual Reality Social Intervention
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of California, Santa Barbara
Psychological Distress, Impaired Social Functioning
A Scalable Psychological Intervention for Earthquake Survivors in Türkiye
This will be the first pilot randomized controlled trial (RCT) study that investigate the potential effectiveness of individual PM+ among earthquake survivors residing in container cities in Türkiye.
- Conditions
- Psychological Distress, Impaired Social Functioning, Depressive Symptoms
- Trial name
- NCT06026306
- Testing
- Problem Management Plus (PM+)
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Koç University
Personality Disorders, Social Withdrawal of Childhood or Adolescence
Child and Adolescent Psychiatric Personality Structure
The study plan outlined here represents an investigation of instruments on the patients treated in the acute ward of child and adolescent psychiatry at the University Medical Center Hamburg Eppendorf (UKE).
- Conditions
- Personality Disorders, Social Withdrawal of Childhood or Adolescence, Psychosocial Impairment
- Trial name
- CAPPS (NCT05162287)
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf