Clinical trials: Impairment
Stroke, Post-Stroke Cognitive Impairment
Immune-Inflammatory Biomarkers in Predicting Early Cognitive Impairment in Adults With Acute Basal Ganglionic Stroke
Post-stroke cognitive impairment (PSCI) is a common and disabling complication that affects memory, thinking, and daily functioning after a stroke.
- Conditions
- Stroke, Post-Stroke Cognitive Impairment, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT07837466
- Volunteers
- 100 people
- Sponsor
- Assiut University
Neoplasms
A Study of The Impact of Severe Hepatic Impairment on the Pharmacokinetics and Safety of Vemurafenib in BRAF V600 Mutation-Positive Cancer Participants
This open-label, Phase I study will evaluate the impact of severe hepatic impairment on the pharmacokinetics and safety of vemurafenib in participants with BRAF V600 mutation positive cancer.
- Trial name
- NCT01767623
- Testing
- Vemurafenib
- Where
- 8 sites in United States, Australia and 5 more
- Volunteers
- 8 people
- Sponsor
- Hoffmann-La Roche
Mental Health Impairment
National Survey of Mental Health After COVID-19 Outbreak
The Serbian national survey - acronym CoV2Soul.RS - has been launched to document mental health (MH) status and understand needs of the population in relation to the prolonged global public health crisis.
- Trial name
- CoV2SoulRS (NCT04896983)
- Where
- 3 sites in Serbia
- Volunteers
- 1,200 people
- Sponsor
- University of Belgrade
Schizophrenia
Once Weekly D-cycloserine for Schizophrenia
This is a parallel-group, placebo-controlled trial examining the cognitive effects at weeks 1, 4, \& 8 of once-weekly oral D-cycloserine 50 mg added to a stable dose of antipsychotic for 8 weeks in adult outpatients with…
- Trial name
- NCT00964041
- Testing
- D-cycloserine
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Solid Tumors, Hepatic Impairment
Pharmacokinetics (PK) of TKI258 in Cancer Patients With Normal and Impaired Hepatic Function
This is a multi-center, open label study to assess pharmacokinetics (PK) of TKI258 at single-dose and steady state in adult cancer patients either with mild, moderate or severe hepatic impairment or with normal hepatic function.
- Trial name
- NCT01443481
- Testing
- Dovitinib
- Where
- 12 sites in United States, Belgium and 4 more
- Volunteers
- 38 people
- Sponsor
- Novartis Pharmaceuticals
Subjects With Liver Function Injury, Normal Liver Function Subject
A Study in Subjects With Liver Function Injury and Subjects With Normal Liver Function
Evaluate the pharmacokinetic differences of the main metabolite 116-N1 of JT001 in subjects with mild and moderate liver function impairment and those with normal liver function, providing a basis for formulating clinical…
- Trial name
- NCT06093230
- Testing
- Deuremidevir Hydrobromide Tablets
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Shanghai Vinnerna Biosciences Co., Ltd.
Mild Cognitive Impairment, Dementia, Mild
Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment
The goal of this clinical trial is to compare a precision medicine approach to the standard-of-care for people with mild cognitive impairment or early-stage dementia.
- Trial name
- EVANTHEA (NCT05894954)
- Testing
- Precision Medicine Approach, Hormones and Medications tailored to lab tests, combined with devices that support stress management and brain exercises, Standard-of-Care
- Where
- 6 sites in United States
- Volunteers
- 73 people
- Sponsor
- Alzheimer's Prevention and Reversal Project, Inc.
Eating Disorders in Children, Psychomotor Development Impaired
Study of Psychomotor Development and Attachment in Children Aged 6 to 30 Months With Oral Disorder
Dietary difficulties and eating disorders of the child are a common reason for consulting infants and young children. There is currently little data on the psychomotor development of these children and their association with…
- Trial name
- TODEVA (NCT03671551)
- Where
- 2 sites in France
- Volunteers
- 1 people
- Sponsor
- Camille JUNG
Social Anhedonia, Social Function Impairment
Clinical and Neurocomputational Effects of Behavioral Activation in Veterans With Impaired Social Functioning
Poor psychosocial functioning, including social disconnection, is common and disabling among Veterans, and often fails to improve following the best available evidence-based treatments, particularly if more severe pathology is…
- Trial name
- NCT07697001
- Testing
- Behavioral Activation (BA), Supportive Care Therapy (SCT)
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- VA Office of Research and Development
Healthy, Renal Dysfunction
Study of Danicopan in Participants With Normal Kidney Function and Participants With Kidney Dysfunction
This was an open-label, nonrandomized, multi-center, single-dose, parallel group study to evaluate the effect of severe renal impairment (RI) on the safety, tolerability, pharmacokinetics, and pharmacodynamics of danicopan…
- Trial name
- NCT04935294
- Testing
- Danicopan
- Where
- 4 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.
Hepatic Impairment
Study to Assess the Effect of Hepatic Impairment on the Pharmacokinetics of CTP-543
This is an open-label, single-dose, single-period, parallel group designed study to determine the effect of mild and moderate hepatic impairment on the pharmacokinetics (PK) of CTP-543 and its major metabolites following…
- Trial name
- NCT05467722
- Testing
- CTP-543
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Concert Pharmaceuticals
Developmental Language Disorder, Speech Sound Disorder
A Framework For Linking Sequential Pattern Rules in DLD: Perception in Adults
This broad aim of this clinical study is to assess the hypothesis that morphological and phonological deficits are linked by a broader deficit in sequential pattern learning.
- Conditions
- Developmental Language Disorder, Speech Sound Disorder, Specific Language Impairment
- Trial name
- NCT04996472
- Testing
- Sensitivity to phonological rules: Adults, Sensitivity to semantic category cues: Adults
- Where
- 2 sites in United States
- Volunteers
- 933 people, healthy volunteers welcome
- Sponsor
- Father Flanagan's Boys' Home
Children With Motor Impairments
Utilizing an EEG-Based BCI Game to Evaluate Cognitive Skills in Children With Motor Impairments
This project aims to validate an EEG-based brain-computer interface (BCI) game as a cognitive assessment tool for children with motor impairments.
- Trial name
- NCT07109830
- Testing
- Cognitive assessment, NEPSY-II
- Where
- 2 sites in Canada
- Volunteers
- 73 people
- Sponsor
- University of Alberta
Subjective Cognitive Decline (SCD), Olfactory Dysfunction
The Efficacy of Modified Olfactory Training for MCI High-Risk Individuals
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can delay the progression of MCI in older…
- Conditions
- Subjective Cognitive Decline (SCD), Olfactory Dysfunction, Mild Cognitive Impairment (MCI), ELDERLY PEOPLE
- Trial name
- NCT06821828
- Testing
- Modified olfactory training device, Conventional olfactory training device
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Peking University Third Hospital
Prediabetes, Type 2 Diabetes
Effect of Totum-63, Active Ingredient of Valedia, on Glucose and Lipid Homeostasis on Subjects With Prediabetes
Given the data on the active ingredients of Totum-63, this research aims to evaluate the effect of its chronic consumption (24 weeks) on glucose and lipid homeostasis and especially on fasting plasma glucose in volunteers with…
- Conditions
- Prediabetes, Type 2 Diabetes, Hypertriglyceridemia, Obesity
- Trial name
- TOTUM-63 TWO (NCT02868177)
- Testing
- Totum-63
- Where
- 6 sites in France, Ireland and 2 more
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Subjective Cognitive Complaints, Mild Cognitive Impairment
Electronic Memory and Management Aid
This study will evaluate the effectiveness of a personalized, web-based training intervention that was developed to teach use of an Electronic Memory and Management Aid (EMMA) application.
- Trial name
- EMMA (NCT05696756)
- Testing
- Personalized Web-based training for EMMA app, Motivational Interviewing: Clinician Support
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington State University
Internal Carotid Artery Dolichoarteriopathy, Carotid Artery Tortuosity
Clinical Significance of Internal Carotid Artery Dolichoarteriopathy
This observational study aims to investigate the clinical significance of internal carotid artery dolichoarteriopathy, including tortuosity, kinking, and coiling, and to identify factors associated with cerebral dysfunction and…
- Trial name
- DALISTA (NCT07882875)
- Where
- Russia
- Volunteers
- 560 people
- Sponsor
- Kuban State Medical University
Aging, Mild Cognitive Impairment
SMART: Somatotrophics, Memory, and Aging Research Trial
The purpose of the SMART study was to better understand whether the body's own production of growth hormone (GH) would improve memory and problem solving ability, or cognitive function.
- Trial name
- NCT00257712
- Testing
- TH9507 human growth hormone releasing hormone (GHRH)
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dementia; Degenerative, Dementia Mixed
Longitudinal Study to Investigate Different Transcranial Electrical Stimulation
This research investigates the effect of different frequencies of tACS (0 Hz, 30 Hz, 50 Hz, 70 Hz, 90 Hz) and tRNS with cognitive exercises in a regimen protocol of 4 weeks, everyday (Monday to Friday).
- Trial name
- tES (NCT06877312)
- Testing
- Transcranial Direct Current Stimulation (tDCS), 30 Hz Transcranial Alternating Current Stimulation (tACS), 50 Hz Transcranial Alternating Current Stimulation (tACS)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Insulin Resistance
The Effect of Tea on Vascular Function and Insulin Sensitivity
The aim of this research is to explore changes in peripheral/cerebrovascular function and insulin sensitivity after a 7-day combination of physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day…
- Trial name
- NCT02777853
- Testing
- Green tea
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.