Clinical trials: Impairment
Sleep Wake Disorders, Sleep Disturbance
Optimizing Cardiac Rehabilitation by Integrating Sleep Therapeutics
The study aims are to: 1) optimize the Transdiagnostic Sleep and Circadian Intervention (TranS-C) for delivery to Veterans in cardiac rehabilitation, 2) test and refine the adapted TranS-C treatment manual and protocol, and 3)…
- Conditions
- Sleep Wake Disorders, Sleep Disturbance, Sleep-Related Impairment
- Trial name
- NCT04506112
- Testing
- Transdiagnostic Sleep and Circadian Intervention (TranS-C), adapted for cardiac rehabilitation
- Where
- United States
- Sponsor
- VA Office of Research and Development
Cerebral Palsy
Investigation of Relations Between Edinburgh Visual Gait Score and Selective Motor Control for Children With CP
Children with Cerebral Palsy have generally limited selective motor control which affects their ability to complete functional tasks Selective Motor Control has been shown to correlate with specific characteristics of gait…
- Trial name
- NCT04686630
- Testing
- Video based observational gait analysis and SCALE Test
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Yeditepe University
Cognitive Impairment
Harmonization of Teleneuropsychological Assessment in Dementia
The prevention and management of cognitive decline and dementia represent major healthcare challenges. Neuropsychological assessment is a key component of current diagnostic criteria for Mild Neurocognitive Disorder (mNCD) due to…
- Trial name
- NCT07664865
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Diabetic Macular Edema
A Trial to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Participants With Diabetic Macular Edema (DME)
This Phase 3 study will evaluate the efficacy, durability, and safety of KSI-301 compared to aflibercept in participants with treatment-naïve DME.
- Trial name
- GLEAM (NCT04611152)
- Testing
- KSI-301, Aflibercept
- Where
- 75 sites in United States, Germany and 6 more
- Volunteers
- 460 people
- Sponsor
- Kodiak Sciences Inc
Vascular Cognitive Impairment
PROMOTE: Promotion of the Mind Through Exercise
The investigators will conduct a proof-of-concept study to provide preliminary evidence of efficacy of aerobic-based exercise training for maintaining cognitive function, executive function, and everyday function in adults with…
- Trial name
- NCT01027858
- Testing
- Aerobic-based exercise training, CON (control; usual care)
- Where
- Canada
- Volunteers
- 71 people
- Sponsor
- University of British Columbia
Hepatic Impairment, Healthy Participants
An Investigational Study of SHR3680 in Participants With Mild to Moderate Liver Impairment and Healthy Participants
The purpose of this study is to investigate SHR3680 in participants with different levels of liver function
- Trial name
- NCT04631549
- Testing
- SHR3680
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Mild to Moderate Alzheimer Disease, Cognitive Impairment
An Efficacy and Safety Study of Sodium Oligo-mannurarate (GV-971) Capsule for the Treatment of Alzheimer's Disease
The primary purpose of this study is to determine the efficacy and safety of Sodium Oligo-mannurarate (GV-971) in 36-week treatment of mild to moderate Alzheimer's disease.
- Trial name
- NCT02293915
- Testing
- Sodium oligo-mannurarate 900mg
- Where
- 16 sites in China
- Volunteers
- 818 people
- Sponsor
- Shanghai Greenvalley Pharmaceutical Co., Ltd.
Cognitive Impairment, Parkinson Disease
Impact of Individual Cognitive Remediation for Parkinson's Disease
This is an interventional clinical trial that will be conducted as a pilot project. Investigators hope to conduct the study to obtain at least 10 study completers.
- Trial name
- NCT03622840
- Testing
- Cognitive Remediation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New York Institute of Technology
Brain Injuries
Lariboisière Cognitive Assessment: Evaluation of the 1-year Outcomes
Cognitive sequelae are common following acquired brain injuries. However, their detection can be challenging, particularly in acute care units such as neurosurgery.
- Trial name
- ECOG (NCT06171568)
- Testing
- Tests and questionnaires
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Delirium, Postoperative Delirium
Stanford PIPRA Validation Study in an Elderly Orthopedic Population
The purpose of this study is to determine the accuracy of an AI-based tool in the prediction of postoperative delirium (POD), in a population at moderately high risk of developing this syndrome (i.e., elderly orthopedic…
- Conditions
- Delirium, Postoperative Delirium, Cognitive Impairment
- Trial name
- PIPRA-ORTHO (NCT06567574)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Stanford University
Dementia, Mild Cognitive Impairment
Evaluation of the Effect of Cataract Surgery on Cognitive Function in Very Elderly Patients
The study intends to measure the evolution over time of the cognitive capacity of patients undergoing cataract surgery in relation to the opaque lens removal surgery (cataract) in a population considered to be at risk of…
- Conditions
- Dementia, Mild Cognitive Impairment, Cataract Senile, Cataract
- Trial name
- NCT04047485
- Testing
- Visual Acuity, CAM (Confusion Assesment Method), CATQUEST 9-SF
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Cognitive Impairment
Cognitive Functions During Thyrotropin Suppressive Therapy in Patients With Differentiated Thyroid Carcinoma
Thyroid carcinoma is the common endocrine system malignant neoplasm. At present it has become the malignant neoplasm of fastest growing incidence rate. More than 90% thyroid carcinoma is thyroid differentiated carcinoma（DTC）.
- Trial name
- NCT02665325
- Testing
- TSH-suppressive therapy
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Inner Mongolia Medical University
Mild Cognitive Impairment, Aging
Tau PET in Imaging and Cognition: Healthy Adults From 55-90
The investigators aim to use the new PET radioligand, 18F-MK-6240, to detect tau pathology in cognitive healthy and mild cognitive impairment (MCI) elders.
- Trial name
- NCT03372317
- Testing
- 18F-MK-6240
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Yaakov Stern
Sensory Impairments, Cognitive Impairment
Development of an Ensemble Learning-based, Multi-dimensional Sensory Impairment Score to Predict Cognitive Impairment in an Elderly Cohort of Southern Italy
There is now strong scientific literature showing a relationship between sensory loss and cognitive performance and between sensory loss and incident dementia.
- Conditions
- Sensory Impairments, Cognitive Impairment, Artificial Intelligence
- Trial name
- DEMETRA (NCT06783010)
- Volunteers
- 30 people
- Sponsor
- Azienda Sanitaria Locale Bari
Cerebral White Matter Lesions
MRI,Gene And Cognitive Performance Study of Patients With Cerebral White Matter Lesions(WMLs)
The purpose of this study is:1)to observe topological organization in brain structural and functional networks in cerebral white matter lesion patients and to evaluate the association between impairment of cognitive function and…
- Trial name
- NCT02276976
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wei Wang
Diabetes Mellitus, Type 1, Hypoglycemia
Exenatide and Impaired Hypoglycaemic Awareness in Type 1 Diabetes
Approximately 25% of patients with type 1 diabetes have lost the capacity to timely detect hypoglycaemia, a condition referred to as impaired hypoglycaemic awareness (IHA) that causes a six-fold higher risk of severe, potentially…
- Trial name
- NCT02735031
- Testing
- Exenatide
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Arthritis, Pain
Non-cancer Pain and Cognitive Impairment: A Disabling Relationship
To compare the efficacy of long-acting oxycodone to extended-release acetaminophen in older persons with no and mild to moderate cognitive impairment and persistent moderate or higher intensity non-cancer lower extremity…
- Conditions
- Arthritis, Pain, Cognitive Impairment
- Trial name
- NCT01264965
- Testing
- long acting oxycodone, extra strength acetaminophen
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Chicago
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Mitigating Chronic Respiratory Disease Through the Lens of Multimorbidity (MARES3)
The investigators aim to investigate how individuals attending primary healthcare (PHC) services in Brazil for treatment of non-communicable diseases (NCDs), identified there as having abnormal spirometry or as being at high risk…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Preserved Ratio Impaired Spirometry (PRISM)
- Trial name
- NCT07134855
- Where
- 2 sites in Brazil
- Volunteers
- 473 people
- Sponsor
- University College, London
Vocal Cord Dysfunction, Vocal Cord Paralysis
Detection of Vocal Fold Motion Impairment on Noninvasive Positive Pressure
The goal of this prospective, observational study is to evaluate for the presence of vocal fold motion impairment (VFMI) in the children admitted to the pediatric intensive care unit on noninvasive positive pressure ventilation…
- Conditions
- Vocal Cord Dysfunction, Vocal Cord Paralysis, Vocal Cord Paresis, Recurrent Laryngeal Nerve Palsy
- Trial name
- NCT06406725
- Testing
- Point-of-Care Ultrasound of the Airway
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Mild Cognitive Impairment (MCI)
The Effect of Melatonin on Cognitive Function in Patients Diagnosed With Mild Cognitive Impairment
Recent studies have described the role of melatonin as a sleep regulator and as an anti- oxidative neuroprotective agent in improving sleep quality and delaying cognitive decline in Alzheimer's disease (AD).
- Trial name
- MCI (NCT00544791)
- Testing
- melatonin
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
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