Clinical trials: Impairment
NEC - Necrotizing Enterocolitis, Complications
Long-term Consequences of Necrotizing Enterocolitis in the Newborn Period
Aim The aim of this study is to determine consequences at school age of the diagnosis of NEC in the neonatal period. Methods This is a case-control study, with case-group being children born in Denmark with a history of NEC and…
- Trial name
- NCT03091907
- Where
- 2 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- Gorm Greisen
Developmental Language Disorder and Language Impairment, Specific Language Impairment
Retrieval-Based Word Learning in Developmental Language Disorder During Book Reading II
Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and…
- Conditions
- Developmental Language Disorder and Language Impairment, Specific Language Impairment, Language Development
- Trial name
- NCT07048392
- Testing
- Retrieval-based word learning: Repeated Spaced Retrieval condition, Retrieval-based word learning: Repeated Study condition
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Purdue University
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Multimodal Risk Factor Graph Mapping, Metabolic Subtyping, and Digital Intelligent Chronic Disease Management for Prediabetes: An Integrated Cohort and Case-Control Clinical Study
This observational study aims to understand the metabolic characteristics and long-term changes in adults with prediabetes and to identify risk and protective factors associated with progression to diabetes or return to normal…
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Impaired Fasting Glucose, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- DM-PIONEER (NCT07854002)
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Sarcopenia, Osteoporosis
Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
The purpose of this study is to determine if taking the pain reliever acetaminophen (ACET) interferes with some of the benefits of weight lifting on muscles and bone density in older men.
- Conditions
- Sarcopenia, Osteoporosis, Aging
- Trial name
- NCT01083901
- Testing
- Resistance training
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alzheimer Disease
Low-Intensity Focused Ultrasound (LIFU) Neuromodulation
This study is a prospective, single-center, single-arm early feasibility study, to establish safety and tolerability of LIFU for neuromodulation in patients with mild cognitive impairment ( MCI) due to Alzheimer's disease.
- Trial name
- NCT05997030
- Testing
- low intensity focused ultrasound (LIFU)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Ali Rezai
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Brain Concussion, Post-Concussion Syndrome
Early Intervention Programme for Young Patients (Aged 15 - 30 Years) With Symptoms Following Concussion.
Background: Five - 15 % of patients with concussion continue to experience impairing physical, cognitive and emotional symptoms longer than 3 months post-injury.
- Trial name
- NCT02337101
- Testing
- Enhanced Usual Care (EUC), EUC + Early intervention programme
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Aarhus
Implementation Science, Women Health
REmote Virtual Inspiration: Vitality and Energy
REVIVE is a randomized controlled trial designed to evaluate the effects of a remotely delivered seated Tai Chi/Qigong (TCQ) intervention on cardiometabolic health, stress, sleep, and psychological well-being among women with…
- Conditions
- Implementation Science, Women Health, Disability Physical, Meditation
- Trial name
- REVIVE (NCT07675681)
- Testing
- Accesible Tai Chi/Qigong (TCQ), Health Education Videos (HEV)
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Arizona State University
Type 2 Diabetes, Mild Cognitive Impairment
Care Partner-Assisted Diabetes Self-Management Through Linking Continuous Glucose Monitoring With Mobile Health: Improving Outcomes for Older Adults With Mild Cognitive Impairment
Eligible older adults with Type 2 Diabetes-Mild Cognitive Impairment (T2D-MCI) will be provided a Continuous Glucose Monitoring (CGM) device and asked to share CGM data with their care partners for daily decision-making for…
- Trial name
- CP-CGMH (NCT05601583)
- Testing
- Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- NYU Langone Health
Impaired
A Study on Effects of Acupressure Among the Frail Elderly in the Community Dwellings
Acupressure has been used for thousands of years in China. Through applying pressure on the specific acupoints based on TCM theory, acupressure could promote relaxation and wellness, balance yin-yang and treat diseases.
- Trial name
- NCT02369094
- Testing
- acupressure
- Where
- China
- Volunteers
- 106 people
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment, Alzheimer Disease
Study of the Efficacy and Safety of Various Anti-inflammatory Agents in Participants With Mild Cognitive Impairment or Mild Alzheimer's Disease
The purpose of this platform study was to evaluate the effect of anti-inflammatory agents on cognition in early Alzheimer's disease.
- Trial name
- NCT04795466
- Testing
- Canakinumab
- Where
- 10 sites in United States, Finland and 2 more
- Volunteers
- 34 people
- Sponsor
- Novartis Pharmaceuticals
Mild Cognitive Impairment
Keeping on Course: A Communication-Focused Psychoeducational Program
The goal of Keeping on Course is to develop and test a psychoeducation program to provide dyads facing mild cognitive impairment (MCI) with communication skills and strategies that will establish or restore a sense of agency as…
- Trial name
- NCT05423912
- Testing
- Keeping on Course Program
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Emory University
Healthy, Hepatic Impairment
Pharmacokinetics of Favipiravir in Volunteers With Hepatic Impairment
This study is designed to determine the pharmacokinetics of favipiravir in volunteers with hepatic impairment and in healthy control volunteers.
- Trial name
- NCT01419457
- Testing
- Favipiravir
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- MDVI, LLC
Mild Cognitive Impairment
Magnetic Brain Stimulation in the Treatment of Mild Cognitive Impairment
This is a pilot study to test the efficacy of repetitive transcranial magnetic stimulation (rTMS) on cognitive improvement in individuals with mild cognitive impairment (MCI).
- Trial name
- NCT02420522
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of Manitoba
Hepatic Impairment
Pharmacokinetic Study of Alpelisib in Subjects With Hepatic Impairment.
To characterize the pharmacokinetics and safety of alpelisib in subjects with hepatic impairment compared to matched healthy control subjects.
- Trial name
- NCT02624557
- Testing
- Alpelisib
- Where
- 4 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Type 2 Diabetes Mellitus
Specified Drug-Use Survey of Alogliptin and Metformin Hydrochloride Combination Tablets "Survey on Long-term Use in Type 2 Diabetes Mellitus Patients With Renal or Hepatic Impairment or Advanced Age"
The purpose of this survey is to evaluate the long-term safety and efficacy of the alogliptin and metformin hydrochloride combination tablet in type 2 diabetes mellitus patients with renal impairment (mild), hepatic impairment…
- Trial name
- NCT03555565
- Testing
- Alogliptin and Metformin hydrochloride
- Where
- Japan
- Volunteers
- 1,026 people
- Sponsor
- Takeda
Memory Disorder, Retention Disorder, Cognitive
Investigation of Memantine in the Treatment of Memory, Concentration or Attention Problems
In this study, memantine will be tested in a new indication: in the treatment of subjective memory, concentration, or attention problems (subjective cognitive impairment) in the absence of dementia.
- Conditions
- Memory Disorder, Retention Disorder, Cognitive, Subjective Cognitive Impairment, Memory, Concentration or Attention Problems
- Trial name
- NCT01261741
- Testing
- Memantine
- Where
- 14 sites in Germany, United Kingdom
- Volunteers
- 299 people
- Sponsor
- Merz Pharmaceuticals GmbH
Multiple Sclerosis, Relapsing-Remitting
Study on the Effectiveness of EGb 761® vs Placebo Used for Cognitive Impairment in Patients With Multiple Sclerosis
The purpose of this study is to determine whether the use of EGb 761 by patients with Relapsing-Remitting Multiple Sclerosis is effective in improving cognition, when compared to placebo.
- Trial name
- NCT00276341
- Testing
- EGb 761® (Tanakan®)
- Where
- 30 sites in France
- Volunteers
- 47 people
- Sponsor
- Ipsen
Mild Cognitive Impairment
Effect of Vitamin D and Folic Acid on Mild Cognitive Impairment
The purpose of this study is to investigate the effects of Vitamin D3 combined with Folic Acid on mild cognitive impairment (MCI).
- Trial name
- NCT07486141
- Testing
- Vitamin D3 (800 IU/d) and Folic Acid(0.4mg/d), Vitamin D3 (1600 IU/d) and Folic Acid(0.4mg/d)
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Capital Medical University
Stroke, Stroke Rehabilitation
Effects of Sensory Training Application in Addition to Bobath Training
The primary purpose of this study is to investigate the effects of sensory training, which will be applied to the trunk in addition to Bobath-based and trunk-focused exercises on trunk functions, sense, balance and gait.
- Trial name
- NCT04753931
- Testing
- Sensory Training in addition to Bobath Training, Bobath Training
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- KTO Karatay University
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