Clinical trials: Impairment
Mild Cognitive Impairment, Mild Dementia
Shanghai Non-pharmacological Intervention for Mild Cognitive Impairment and Mild Alzheimer's Disease
This study is a multicentre, randomized, double-blind, controlled trial that aims to investigate the efficacy of multi-domain life-style intervention including low inflammatory-index diet, exercise, and cognitive training in…
- Trial name
- SIM-2 (NCT05887674)
- Testing
- Diet intervention, Exercise, Cognitive training
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Ruijin Hospital
Chemo-brain
Treatment of Post-Chemo Cognitive Impairment w/Transcranial Magnetic Stimulation (Chemobrain TMS)
In this pilot study, the investigators propose to test the efficacy of rTMS for the treatment of PCCI. Efficacy measures will include baseline and post-rTMS neuropsychological testing, functional MRI and biometry data using body…
- Trial name
- NCT04295720
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arizona
Treatment, Active Control
Cognitive Training Delivered Remotely to Individuals With Psychosis (ROAM)
Primary study: This study is a single-site, double-blind, randomized, controlled clinical trial to compare an evidence-based structured program of 30-35 hours of on-line cognitive and social cognitive training exercises performed…
- Conditions
- Treatment, Active Control, Schizophrenia, Psychosis
- Trial name
- NCT02782442
- Testing
- Structured Cognitive Training & PRIME, Computer Games Control & PRIME
- Where
- 2 sites in United States
- Volunteers
- 109 people
- Sponsor
- University of Minnesota
Bipolar Disorder
Functional Remediation for Bipolar Disorder
Bipolar Disorder is a major mood disorder with periodic mood episodes that may be very distressing, both to the individual and to others.
- Trial name
- NCT03403179
- Testing
- Functional Remediation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Language Disorders in Children
Let's Know!2: Language-focused Intervention for Children at Risk of Comprehension Difficulties
In the proposed project, the investigators will conduct a multisite randomized controlled trial (RCT) to determine the efficacy of Let's Know!2, a small-group, language focused comprehension intervention, on children's lower- and…
- Trial name
- LK!2 (NCT05133479)
- Testing
- Let's Know! small-group or TierL 2 Intervention
- Where
- 2 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Parkinson Disease, Parkinson
Evaluation of a Computer Game Based Rehabilitation System for Assessment and Treatment of Balance and Gait Impairments in Individuals With Parkinson's Disease.
Examining the feasibility and acceptability of the computer game based rehabilitation system for improving balance, gait and executive function in individuals with PD.
- Trial name
- NCT03232996
- Testing
- Computer game based balance and walking rehabilitation for individuals with Parkinson's Disease
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Thermoregulation Impairment
Glucocorticoid Long-term Administration: Effect on Cold Induced Energy Expenditure and Resting Metabolic Rate
The aim of the study is to investigate whether treatment with glucocorticoids leads to a change in heat production of the human body at mild cold conditions.
- Trial name
- GLACIER (NCT03949361)
- Testing
- Indirect calorimetry, Skin Temperature, Dual energy X-ray Absorptiometry (DXA)
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- University Hospital, Basel, Switzerland
Mental Health Impairment
National Survey of Mental Health After COVID-19 Outbreak
The Serbian national survey - acronym CoV2Soul.RS - has been launched to document mental health (MH) status and understand needs of the population in relation to the prolonged global public health crisis.
- Trial name
- CoV2SoulRS (NCT04896983)
- Where
- 3 sites in Serbia
- Volunteers
- 1,200 people
- Sponsor
- University of Belgrade
Mild Cognitive Impairment
Effects of Multimodal Music Intervention on Mild Cognitive Impairment Elderly
The goal of this clinical trial is to learn about whether music therapy can ameliorate cognitive function, physical fitness and psychology in mild cognitive impairment and mild dementia population.
- Trial name
- NCT06324227
- Testing
- multimodal music therapy, no intervention
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Yang Ming Chiao Tung University
Pituitary Adenoma
OCT-angiography as a Pronostic Marker for Visual Impairment in Patients Undergoing Neurosurgery for Compressive Macroadenoma : a Prospective Study.
The aim of the study is to assess accurancy of OCT angiography as a pronostic marker for patients undergoing neurosurgery for compressiver macroadenoma as compared with visual acuity, visual field and OCT.
- Trial name
- FIRST (NCT04074642)
- Testing
- Neurosurgery
- Where
- 2 sites in France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Epilepsy
An Open-label, Multiple-dose, Single-centre Study, Investigating the Pharmacokinetics of BIA 2-093
Open-label, multiple-dose, single-centre study in 2 groups of subjects: subjects with moderate hepatic impairment and healthy controls. The trial consisted of a screening visit, a treatment phase and a follow-up visit.
- Trial name
- NCT02281526
- Testing
- BIA 2-093
- Where
- South Africa
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Behavioral Dynamics, Visual Impairment
Video Screening for Visual Impairment of Infants
An individual senses the world and reflects feedbacks via independent behaviors. Such precise collaboration of the sensory and behavioral systems is fundamental to survival and evolution.
- Trial name
- NCT04237350
- Testing
- Video recording for behaviors
- Where
- China
- Volunteers
- 3,652 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Impaired Glucose Tolerance
Glycemic and Insulinemic Impact of Selected Canadian Beans
The objective of this study is to compare the glycemic and insulinemic response elicited by ½ cup servings of 6 beans to those elicited by ½ cup servings of mashed potato, macaroni, rice and corn.
- Trial name
- MED-beans (NCT02907190)
- Testing
- Bean Type, Starchy Foods
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Guelph Food Research Centre
Obesity
The Effects of Aronia Melanocarpa Extract on Obese Individuals With Impaired Fasting Blood Glucose
Obesity is closely related to many chronic diseases such as hypertension, coronary heart disease, hyperlipidemia, type 2 diabetes, fatty liver, certain types of tumors, etc, which are associated with adverse health outcomes.
- Trial name
- NCT06057389
- Testing
- aronia melanocarpa extract
- Volunteers
- 72 people
- Sponsor
- Peking Union Medical College Hospital
Diabete Mellitus
Effectiveness of a Multimodal Cognitive Rehabilitation Protocol Combined With Mechanical Periodontal Therapy in Diabetic Patients With Cognitive Impairment
Type 2 diabetes mellitus (T2DM) is strongly associated with an increased risk of cognitive impairment via multiple, converging pathways chronic hyperglycemia, insulin resistance, and vascular injury leading to deficits in memory…
- Trial name
- NCT07870291
- Testing
- Group A, Group B, Group C
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Emad Eldin Mohamed
Alzheimer Disease, Mild Cognitive Impairment
Biomarker Study to Diagnose Alzheimer's Disease
The purpose of our study is to investigate CSF and blood biomarkers among the subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) as well as normal controls.
- Trial name
- ADAM (NCT01874418)
- Testing
- Biomarker
- Where
- South Korea
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Dementia, Mild Cognitive Impairment (MCI)
Dementia and Mild Cognitive Impairment: Assessment of Cognitive Functioning, Functional Autonomy, and Neuropsychiatric Symptoms.
Dementia, in its various forms, is characterized by a generalized cognitive decline that can significantly compromise personal autonomy and quality of life.
- Trial name
- RE-MIDA (NCT07287410)
- Testing
- none - observational study
- Where
- Italy
- Volunteers
- 151 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Breast Cancer
A Combined Exercise Training Program for Women Living With Breast Cancer
Women living with and beyond breast cancer are at a heightened risk for experiencing adverse mental health outcomes and declines in cognitive function following chemotherapy treatment.
- Trial name
- NCT05704855
- Testing
- Combined Exercise + Behavioural Counselling, Active Control
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University of Toronto
Healthy, Renal Insufficiency
Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Kidney Function and Healthy Participants
The main purpose of this study is to measure how much of pirtobrutinib (LOXO-305) gets into the bloodstream and how long it takes the body to eliminate it in participants with impaired kidney function and healthy participants.
- Trial name
- NCT06190678
- Testing
- Pirtobrutinib
- Where
- 5 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
PTSD, Cognitive Impairment
(Neuro)Cognitive Remediation for Adults With OSIs
(Neuro)Cognitive remediation (CR) is an intervention for people experiencing cognitive impairments that interfere with their daily functioning.
- Conditions
- PTSD, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT06813378
- Testing
- (Neuro)Cognitive Remediation
- Volunteers
- 20 people
- Sponsor
- Nova Scotia Health Authority
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