Clinical trials: Impairment
Neuromotor Impairments, Walking Impairment
Clinical Impacts of Structured Robotic Gait Training Programs
Background and Rationale: Walking impairments impacts the 2-3/1000 children who have cerebral palsy1,2, and others unable to walk due to other central nervous system disorders such as a traumatic brain injury.
- Trial name
- NCT07405450
- Testing
- Clinical Impacts of Structured Robotic Gait Training Programs
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of Calgary
Liver Diseases
A Study to Learn How the Body Processes the Study Medicine Called Osivelotor (PF-07940367) in People With Loss of Liver Function
The purpose of this study is to understand how Osivelotor is processed in people with loss of liver function. This study is seeking participants that are: stable loss of liver function with mild or moderate severity none of…
- Trial name
- NCT06340347
- Testing
- Osivelotor
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- Pfizer
Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene
Evaluation of Impaired Mobility in Chronic Illness Constitution of a Cohort
Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern.
- Conditions
- Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene, Parkinson Disease, Chronic Obstructive Pulmonary Disease, Unspecified
- Trial name
- EVALMOB (NCT04375280)
- Testing
- Development of a screening algorithm designed to determine a "dysmobility" profile in patients with chronic illness.
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
ALS (Amyotrophic Lateral Sclerosis), Postpoliomyelitis Syndrome
Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised Diagnosis
Motor neuron disease (MND) or ALS is a nervous system disease. ALS leads to a loss of movement ability that eventually leads to death. At the moment, there is no known treatment for ALS.
- Conditions
- ALS (Amyotrophic Lateral Sclerosis), Postpoliomyelitis Syndrome, Spinal Muscular Atrophy
- Trial name
- MotorMarker (NCT05663008)
- Testing
- 128 electrode electroencephalography (EEG), Bipolar surface electromyography (sEMG), High-density electromyography (HD-EMG)
- Where
- Ireland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Healthy, Hepatic Impairment
Effect of Hepatic Impairment on the Pharmacokinetics of Mirdametinib
The purposes of this study are to determine: The pharmacokinetics (the amount of study drug in your blood and how long it takes the body to get rid of it) of the study drug and its metabolites (substances produced as the body…
- Trial name
- NCT06997276
- Testing
- Mirdametinib (MEK Inhibitor)
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany
Thrombin, Hemostatic Disorder
Thrombin in Cardiac Surgery
Coagulopathy, bleeding, and transfusion are common in cardiac surgical patients. Our collaborator has developed a novel point of care device that can be used to assess thrombin generation in real-time in cardiac surgical…
- Conditions
- Thrombin, Hemostatic Disorder, Surgical Blood Loss, Coagulation Disorder
- Trial name
- NCT04762576
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Vision, Low, Mobility Limitation
Evaluating Stairway Designs for Individuals With Vision Impairment
The goal of this study is to learn if contrast frequency on step tread-edges influences foot clearance measures, a marker of fall risk, in older adults with and without visual impairments.
- Trial name
- NCT07337317
- Testing
- Frequency of contrast marking on stair steps
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The University of Alabama in Huntsville
Deaf, Hard of Hearing
Effectiveness of Integrative Therapy on Psychological Hardiness Among Hard-of-Hearing Female Students
The goal of this clinical trial (quasi-experimental study) is to learn whether an integrative therapeutic program can enhance psychological hardiness among hard-of-hearing (HOH) female students in Saudi Arabia (Al-Ahsa…
- Conditions
- Deaf, Hard of Hearing, Hearing Disability
- Trial name
- Integrative (NCT07514468)
- Testing
- Integrative Therapeutic Program
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- King Faisal University
Cognitive Impairment
Effect of Memantine on Radiotherapy-related Cognitive Impairment
Purpose: This randomized, double-blind, placebo-controlled clinical trial aims to evaluate the therapeutic effects of thalidomide in radiotherapy-related cognitive impairment.
- Trial name
- NCT03342443
- Testing
- Memantine
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Impaired Driving, Sleep Driving
Objective Assessment of the Effects of Shift Work on Drowsiness and Driving Impairment in Hospital Staff
The purpose of this protocol is to assess the risk of drowsy driving amongst shift workers using objective measures of drowsiness and driving performance in an instrumented research vehicle.
- Trial name
- NCT01672489
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hepatic Impairment
Pharmacokinetics (PK) of 20 mg Teduglutide in Participants With Moderately Impaired Hepatic Function Compared to Healthy Participants
This is a study to compare the pharmacokinetic profile of teduglutide in healthy participants with normal hepatic function with participants who have moderate hepatic impairment.
- Trial name
- NCT00819468
- Testing
- Teduglutide
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Shire
Amnestic Mild Cognitive Impairment
Outcome Predictors of a Cognitive Intervention in aMCI
Cognitive training has been shown to be successful in patients with amnestic mild cognitive impairment (aMCI), a group at high-risk for Alzheimer's disease (AD).
- Trial name
- OutPreC MCI (NCT01525368)
- Testing
- cognitive intervention
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Mild Cognitive Impairment
Measuring the Impact of Cognitive and Psychosocial Interventions in Persons With Mild Cognitive Impairment
Memory interventions are training programs that provide a variety of cognitive and psychological strategies meant to improve memory.
- Trial name
- NCT01448148
- Testing
- Cognitive intervention, Psychosocial intervention
- Where
- 2 sites in Canada
- Volunteers
- 145 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Health Services for the Aged, Frailty
e-GAB: Electronic Geriatric Assessment Bundle: Development of an Arabic Self-administered Android CGA Application
The aim of this study is to design and assess the accuracy of administering the electronic Geriatric Assessment Bundle (e-GAB) compared to geriatrician performed comprehensive geriatric assessment (CGA) in a group of Egyptian…
- Conditions
- Health Services for the Aged, Frailty, Cognitive Impairment, Depression
- Trial name
- NCT04211285
- Testing
- e-GAB, standard physician performed CGA
- Where
- Egypt
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Stroke, Cognition Disorders
Dual-site Cross-frequency Coupled Transcranial Electrical Stimulation Modulates Working Memory of Patients With Post-stroke Cognitive Impairment
This clinical trial aims to explore the effect of dual-site theta-gamma cross-frequency coupled transcranial alternating current stimulation in the frontal and parietal region on the working memory ability of patients with…
- Trial name
- NCT07573501
- Testing
- occupational therapy, real tACS
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Ke Dong, MD
Mental Health Impairment, Mental Health Disorder
Youth FORWARD Phase 2 YRI and EPP Study
Objectives: The objectives of this research proposal are to study the delivery of an evidence-based mental health intervention in the alternate setting of youth employment programs tied to regional economic development and to…
- Conditions
- Mental Health Impairment, Mental Health Disorder, Psychosocial Problem
- Trial name
- NCT03542500
- Testing
- Youth Readiness Intervention (YRI), Entrepreneurship Training
- Where
- 3 sites in Sierra Leone
- Volunteers
- 1,783 people, healthy volunteers welcome
- Sponsor
- Boston College
Irritable Bowel Syndrome, Disorders of Gut-brain Interaction
Audio-recorded Gut-Hypnotherapy for Sleep and Pain in Pediatric Abdominal Pain Disorders
Children with irritable bowel syndrome (IBS) and functional abdominal pain- not otherwise specified (FAP-NOS) have higher rates of poor sleep quality.
- Trial name
- NCT07216092
- Testing
- Gut-directed Hypnotherapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Children's Hospital at Montefiore
Mild Cognitive Impairment
Neurofeedback Training for Older Adults With Mild Cognitive Impairment: a Protocol Study
This is a non-pharmacological study evaluating the effects of SMR/delta ratio and beta1/theta ratio neurofeedback trainings on cognitive performance and electrical brain activity in elderly with mild cognitive impairment.
- Trial name
- NCT03526692
- Testing
- Neurofeedback
- Volunteers
- 60 people
- Sponsor
- Fabienne Marlats
Cognitive Dysfunction
Flutemetamol F 18 Injection Formulation Comparison
VIZAMYL (flutemetamol F 18 injection) is a drug used during Positron Emission Tomography (PET) brain scans. It helps doctors detect the presence of amyloid protein, which is associated with Alzheimer's disease and other…
- Trial name
- NCT07873463
- Testing
- GE-287, Vizamyl
- Where
- 6 sites in United States
- Volunteers
- 20 people
- Sponsor
- GE Healthcare
Heroin Dependence, Sleep Impairment
Methadone Maintenance Outcome Study in Taiwan: 5-year Follow-up
Methadone maintenance treatment (MMT) has been one of the most effective treatment choices for opioid addicts to reduce their heroin use, criminality and spread of HIV. In Taiwan, MMT has been introduced since 2006.
- Conditions
- Heroin Dependence, Sleep Impairment, Mortality, Quality of Life
- Trial name
- NCT02524912
- Volunteers
- 1,200 people
- Sponsor
- National Health Research Institutes, Taiwan
The first 5,000 results can be paged through. Add a filter or change the sort order to reach the rest.