Clinical trials: Impairment
Prediabetic State
A Study of Attitudes About the Risk of Developing Type 2 Diabetes
Diabetes mellitus (DM) type 2 is well recognized as a major cause of morbidity and mortality in the United States, as well as a significant contributor to health disparities within the population.
- Trial name
- NCT00323349
- Testing
- Oral Glucose Tolerance Testing, Education tailored to learning style preferences
- Where
- 2 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Hepatic Insufficiency
A Study of Abemaciclib in Participants With Varying Degrees of Liver Impairment
The study involves a single dose of a study drug called abemaciclib taken by mouth. The purpose of this study will be to measure how much study drug gets into the blood stream and how long the body takes to get rid of it when…
- Trial name
- NCT02387814
- Testing
- Abemaciclib
- Where
- 5 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Traumatic Brain Injury (TBI) Patients, Cognitive Impairment
Mindfulness-Integrated Neuropsychotherapy for Traumatic Brain Injury: A Mixed-Methods Evaluation of Cognitive and Psychosocial Recovery
The goal of this clinical trial is to test the effectiveness of Integrative Mindfulness Enhanced Neuropsychotherapy (IMENP) in improving neurocognitive functioning and wellbeing among adults aged 18 to 44 years with mild to…
- Conditions
- Traumatic Brain Injury (TBI) Patients, Cognitive Impairment, Depression Disorder, Fatigue Severity Scale
- Trial name
- IMENP (NCT07874685)
- Testing
- Integrative Mindfulness Enhanced Neuropsychotherapy (IMENP)
- Where
- India
- Volunteers
- 68 people
- Sponsor
- University of Madras
Depression, Incontinence
A Casefinding and Referral System for Older Veterans Within Primary Care
Underdiagnosis and undertreatment of elderly persons remains a widespread problem. While many innovative geriatric care programs exist within VHA, we still lack a systematic process for identifying at-risk elders from the larger…
- Conditions
- Depression, Incontinence, Cognitive Impairment
- Trial name
- NCT00012740
- Testing
- Casefinding and Referral System
- Where
- United States
- Volunteers
- 792 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Handwriting, Graphomotor Impairment
Evaluation of Grip'n'Play
The goal of this study is to evaluate Grip'n'Play, a set of tablet games controlled with the SensoGrip pen, which provides visual feedback on grip and writing pressure.
- Trial name
- NCT07846449
- Testing
- Grip'n'Play, Workbook
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Hochschule Campus Wien (University of Applied Sciences Campus Vienna)
Parkinson Disease, Mild Cognitive Impairment
Financial Abilities in Neurological Diseases. Development of a Telerehabilitation Program: FINAGE
Financial Abilities (FA) are a set of capacities that allow a person to independently manage her/his financial affairs in a manner consistent with personal self-interests and values.
- Conditions
- Parkinson Disease, Mild Cognitive Impairment, Stroke
- Trial name
- FINAGE (NCT05826548)
- Testing
- Telerehabilitation group, Conventioanl treatment group
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Overactive Bladder, Voiding Dysfunction
A Follow-net Investigation of a Randomised Study of Cystoscopy and Urethral Dilatation Versus Cystoscopy Alone in Women With Overactive Bladder Syndrome and Impaired Voiding
Urinary incontinences is a highly prevalent and distressing condition which has a significant impact on health related quality of life in millions of women worldwide.
- Conditions
- Overactive Bladder, Voiding Dysfunction, Urinary Incontinence
- Trial name
- NCT02297178
- Testing
- Cystoscopy only, Cystoscopy and Urethral dilatation
- Sponsor
- Medway NHS Foundation Trust
Diabetic Macular Edema
Efficacy and Safety of Ranibizumab in Two "Treat and Extend" Treatment Algorithms Versus Ranibizumab As Needed in Patients With Macular Edema and Visual Impairment Secondary to Diabetes Mellitus
The purpose of this study is to demonstrate that two investigational treatment regimens have the potential to result in a superior visual acuity improvement as compared to a ranibizumab pro re nata (PRN=as needed) treatment…
- Trial name
- RETAIN (NCT01171976)
- Testing
- Ranibizumab
- Where
- 68 sites in Belgium, Czechia and 11 more
- Volunteers
- 373 people
- Sponsor
- Novartis Pharmaceuticals
Hepatic Impairment and Healthy Female
GS1-144 in Participants With Hepatic Impairment and Healthy Female
GS1-144 in Participants with Hepatic Impairment and Healthy Female
- Trial name
- NCT07491289
- Testing
- GS1-144 tablet
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Subclinical Hypothyroidism
Subclinical Hypothyroidism and Mind in the Elderly
Some recommendations of expert consensus on subclinical hypothyroidism (SH) are controversial in those areas with not enough information to reach a conclusion, such as not recommending treatment with thyrotrophic hormone of 4-10…
- Trial name
- NCT00921050
- Testing
- levothyroxine sodium
- Where
- 2 sites in Mexico
- Volunteers
- 70 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Obesity
resVida and Fat Oxidation
There is now a general consensus that the combination of excessive energy intake and a low capacity to oxidize fat will lead to muscular fat accumulation and insulin resistance.
- Trial name
- NCT00998504
- Testing
- resVida
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sepsis, Cognitive Impairment
Systems Biology Approach to Cognitive Impairment After SepsiS
This study will use systems biology techniques, especially RNA-seq, to understand cognitive impairment after sepsis requiring an intensive care unit (ICU) admission.
- Trial name
- CASS (NCT03015584)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Intermountain Health Care, Inc.
Impairment of Gastric Emptying, Acute Phase of Myocardial Infarction
Impairment of Gastric Emptying During Acute Phase of Myocardial Infarction. Impact on Oral Antiplatelet Treatment Efficacy. The GASTRIM Study.
Oral antiplatelet therapy is a key treatment of the STEMI (ST elevation myocardial infarction). Delayed action isn't suitable and has to be elucidated.
- Trial name
- GASTRIM (NCT02251249)
- Testing
- Paracetamol concentration time curve from 0 to 120 min
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Bordeaux
Hepatic Impairment, Healthy Volunteers
A Study of Fostamatinib in Subjects With Impaired Hepatic (Liver) Function
A study to evaluate the amount of fostamatinib in the blood in subjects with impaired hepatic (liver) function compared with healthy volunteers with normal liver function.
- Conditions
- Hepatic Impairment, Healthy Volunteers, Pharmacokinetics, Amount of R406 in Blood
- Trial name
- NCT01222455
- Testing
- Fostamatinib
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
A Dangerous Triad in Ageing and in Chronic Obstructive Pulmonary Disease (COPD) - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition
The investigators have taken part in the development of simple muscle function tests and studied physical training and energy turnover in patients with chronic obstructive pulmonary disease, COPD.
- Trial name
- NCT01179178
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Göteborg University
Ventilation Therapy; Complications
Physiological Dead Space Measured by Volumetric Capnography in BiPAP and APRV .
Background and Rationale : Mechanical ventilation is an essential component of the care of patients with respiratory failure.Biphasic positive Airway Pressure (BiPAP) and Airway Pressure release ventilation (APRV) are relatively…
- Trial name
- NCT03218943
- Testing
- APRV ventilation mode, BIPAP ventilation moood
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Advanced Solid Tumors
A Phase I Study of TAS-102 in Patients With Advanced Solid Tumors With Renal Impairment
Study to evaluate the safety, tolerability, and pharmacokinetics of TAS-102 in patients with advanced solid tumors and varying degrees of renal impairment.
- Trial name
- NCT02301117
- Testing
- TAS-102
- Where
- 14 sites in United States, Czechia and 1 more
- Volunteers
- 43 people
- Sponsor
- Taiho Oncology, Inc.
Ischemic Stroke Hospitalized, Impairment, Cognitive
A Study Testing How Well the Drug Extract of Ginkgo Biloba Leaves Tablets Works for People With Memory or Thinking Problems After a Stroke When Added to Standard Treatment
The goal of this clinical trial is to learn if Extract of Ginkgo Biloba Leaves Tablets help improve thinking and memory in people aged 55 years and older who had an ischemic stroke (a type of stroke caused by a blocked blood…
- Trial name
- GiCIIS (NCT07220538)
- Testing
- Extract of Ginkgo Biloba Leaves Tablets 240 mg (2 x 40 mg, t.i.d.), Standard of care (SoC) Group
- Where
- 34 sites in China
- Volunteers
- 400 people
- Sponsor
- Dr. Willmar Schwabe GmbH & Co. KG
Hepatic Impairment
A Study to Evaluate the Pharmacokinetics and Safety of DBPR108 in Subjects With Hepatic Impairment
This is an open-label, single-dose study to evaluate the pharmacokinetics and safety of DBPR108 in subjects with mild or moderate hepatic impairment (HI) compared to the matched control subjects with normal hepatic function.
- Trial name
- NCT04859426
- Testing
- DBPR108 tablets
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Hepatic Impairment, Healthy Volunteers
A Study of HDM1002 in Subjects With And Without Varying Degrees Of Hepatic Impairement
The current study is proposed to evaluate whether there is any clinically meaningful effect of hepatic impairment on the plasma Pharmacokinetic (PK) of HDM1002
- Trial name
- NCT06985615
- Testing
- Single dose of HDM1002 on Day 1
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
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