Clinical trials: Impairment
Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter
Combination Chemotherapy in Treating Patients With Advanced Bladder or Kidney Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003342
- Testing
- filgrastim, carboplatin, doxorubicin hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Stroke, Acute
The Oslo Study of Visual Impairment After Stroke (StrokeVIS)
Longitudinal, prospective, single-center observational study of visual impairment after stroke. Population: Patients admitted with acute ischemic stroke at the Regional Stroke Unit at Oslo University Hospital who are assessed to…
- Trial name
- StrokeVIS (NCT05809973)
- Testing
- VISA tool
- Where
- Norway
- Volunteers
- 127 people
- Sponsor
- Oslo University Hospital
Participants With Moderate and Severe Renal Impairment and Healthy Participants
A Study to Investigate the Pharmacokinetics and Safety of PKN605 in Participants With Moderate and Severe Renal Impairment Compared to Matched Control Subjects With Normal Renal Function
The purpose of this trial is to assess any potential exposure increases of PKN605 in participants with reduced renal function to support decisions on participant eligibility and dosing in subsequent clinical trials of PKN605.
- Trial name
- NCT07797322
- Testing
- PKN605
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Impaired Health
Dental Hygienist Support Promotes Good Oral Health in Nursing Homes
Objective: The aim of this study was to evaluate the effects of dental hygienist support on oral health and attitudes to oral healthcare in nursing homes for older people.
- Trial name
- NCT02676453
- Testing
- Intervention
- Volunteers
- 31 people
- Sponsor
- Public Dental Health, Varmland
Cerebral Palsy, Bilateral Cerebral Palsy
Stepping to Understand Lower Limb Impairments in Bilateral Cerebral Palsy
The purpose of this study is to investigate lower limb impairments in children with bilateral cerebral palsy during stepping tasks.
- Conditions
- Cerebral Palsy, Bilateral Cerebral Palsy, Diplegic Cerebral Palsy
- Trial name
- NCT04957277
- Testing
- load modulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Alzheimer Disease, Mild Cognitive Impairment
The PREVENTION Trial: Precision Recommendations to Optimize Neurocognition
The PREVENTION Trial is a 12-month, two-arm randomized clinical trial (RCT) in adults 50-80 years old experiencing cognitive decline.
- Trial name
- PREVENTION (NCT04082611)
- Testing
- Data-Driven Clinical Recommendations, Coached Data-Driven Clinical Recommendations
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Saint John's Cancer Institute
Aging
Gait Adaptation Study
This pilot study proposes a clinical trial to target treatment of sensorimotor and cognitive deficits in persons with Multiple Sclerosis (pwMS).
- Trial name
- NCT07660601
- Testing
- Gait Adaptation Training, Basic Physical Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Type 2 Diabetes Mellitus
Mind-motor Exercise in Older Adults With Type 2 Diabetes and Self-reported Cognitive Complaints
The purpose of this study is to determine if a 6 month mind-motor intervention will help to improve overall brain health in adults over the age of 55 with type 2 diabetes and a self-reported complaint about memory or thinking…
- Trial name
- NCT02292511
- Testing
- Square-stepping exercise
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Mild Cognitive Impairment
Biodistribution of [11C]Acetoacetate/[18F]Fluorodeoxyglucose in Subjects With Risk Factors for Alzheimer's Disease
This is a single center imaging study that will recruit 60 participants who are enrolled in the Effect of a Ketogenic Diet on Alzheimer's Disease Biomarkers and Symptoms: Brain Energy for Amyloid Transformation in AD (BEAT-AD)…
- Trial name
- AcAc PET (NCT03130036)
- Testing
- [11C]Acetoacetate[18F]Fluorodeoxyglucose positron emission tomography scan
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Effects of Chemotherapy, Cognitive Impairment
Cognitive Changes in Adult Cancer Survivors
This study will document the cognitive (mental) and functional abilities of newly diagnosed cancer patients. The study will also examine the changes in cognitive and functional abilities during and after chemotherapy (your cancer…
- Trial name
- CFCC (NCT01569932)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Washington University School of Medicine
Parkinson Disease, Dysphagia
Effortful Swallow Maneuver for Swallowing Impairment in People With Parkinson Disease
Context: Many people with Parkinson Disease (PwPD) experience swallowing difficulties, particularly with food/liquid going down the wrong way or remaining in the throat after swallowing.
- Trial name
- NCT05319795
- Testing
- Effortful Swallow Maneuver
- Where
- 2 sites in Canada
- Volunteers
- 5 people
- Sponsor
- University Health Network, Toronto
Mild Cognitive Impairment
Calorie Restriction and Brain Function in Mild Cognitive Impairment
Problems with blood sugar metabolism (i.e., metabolic dysfunction) progressively develop through old age, which is primarily due to obesity and lack of physical activity.
- Trial name
- 5-2CR (NCT03872375)
- Testing
- Meal-Replacement Therapy, Dietary Counseling
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- Iowa State University
Elderly Population, Cognitive Dysfunction
Effects of Balance Training with and Without Gaze Stability Exercises on Cognitive Function Balance and Dynamic Postural Stability in Older Adults with Mild Cognitive Impairment
The study aims to evaluate the effects of balance training, with and without gaze stability exercises, on cognitive function, balance, and postural stability in older adults with mild cognitive impairment (MCI).
- Trial name
- NCT06672367
- Testing
- Balance training group, Balance training combined with gaze stability exercises
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Foundation University Islamabad
Healthy, Renal Insufficiency
A Single-Dose, Pharmacokinetic/Pharmacodynamic (PK/PD), & Safety Study of BIIB017 in Participants With Renal Impairment & Healthy Volunteers
The primary objective of the study is to evaluate the pharmacokinetics (PK) of a single dose of PEGylated Interferon Beta-1a (BIIB017) administered subcutaneous in participants with renal impairment and in participants with…
- Trial name
- NCT01119781
- Testing
- BIIB017(peginterferon beta-1a)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Biogen
Cognitive Impairment
Virtual Reality-Assisted Reminiscence Therapy in Older Adults With Cognitive Impairment
This study evaluated whether immersive virtual reality (VR) could enhance the effects of reminiscence therapy in older adults with cognitive impairment attending day-care services.
- Trial name
- NCT07825909
- Testing
- Virtual Reality-Assisted Reminiscence Therapy, Traditional Reminiscence Therapy
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Universitario Salesiano Venezia-Mestre (IUS)
Mild Cognitive Impairment
Neurofeedback Improves Cognitive Performance and EEG Activity in Elderly With Mild Cognitive Impairment
This is a non-pharmacological pilot study showing the improvement of a SMR/theta neurofeedback training program on cognitive performance and EEG activity in Elderly with Mild Cognitive Impairment.
- Trial name
- Neurofeedel (NCT03855319)
- Testing
- SMR neurofeedback training to MCI
- Volunteers
- 20 people
- Sponsor
- Fabienne Marlats
Alzheimer Disease, Mild Cognitive Impairment
Enriching Clinical Trials Requiring Amyloid Positivity With Practice Effects
The primary objective of this study is to demonstrate that individuals with low short-term practice effects (STPE) on cognitive testing are more likely to be identified as "positive" on amyloid imaging than individuals with high…
- Trial name
- APPE (NCT03466736)
- Testing
- [18F]flutemetamol PET scan
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Utah
Heart Failure, Kidney Failure
Safety and Efficacy Study of Add On Aliskiren in Patients With Heart Failure and Renal Impairment
The main purpose of this study is to examine the effect of add-on therapy with the direct renin inhibitor Aliskiren in comparison to placebo on renal blood flow in patients with heart failure and reduced renal function.
- Trial name
- ARIANA-CHF-RD (NCT00881439)
- Testing
- Aliskiren
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- University Medical Center Groningen
Chronic Fatigue Syndrome, Cognitive Impairments
Efficacy and Safety of Lisdexamfetamine Dimesylate in Adults With Chronic Fatigue Syndrome
Over the past decade, the Rochester Center for Behavioral Medicine (RCBM) has evaluated many patients with attention deficit hyperactivity disorder (ADHD).
- Trial name
- NCT01071044
- Testing
- Lisdexamfetamine Dimesylate
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rochester Center for Behavioral Medicine
Attention Deficit Hyperactivity Disorder, Dyslexia
Implementation of Climb Up Program for Children With Attention Deficit Hyperactivity Disorder (ADHD) and Dyslexia in a School in India
A multimodal intervention was rolled out at a large public school in Najibabad, Uttar Pradesh (UP). The program identified elementary school children with ADHD and Dyslexia using standard screening of all children who had…
- Trial name
- ClimbUp (NCT01012778)
- Testing
- Climb Up ADHD and Dyslexia Program
- Where
- India
- Volunteers
- 76 people
- Sponsor
- Climb Up Kids
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