Clinical trials: Impairment Upper Limb
Chronic Hepatitis C Virus (HCV) Infection
A Study to Evaluate the Efficacy and Safety of ABT-493/ABT-530 in Renally Impaired Adults With Chronic Hepatitis C Virus Genotype 1 - 6 Infection
The purpose of this study is to assess the efficacy and safety of 12 weeks of treatment with the ABT-493/ABT-530 combination regimen in adults with chronic HCV genotype 1 - 6 infection and chronic severe renal impairment.
- Trial name
- EXPEDITION-4 (NCT02651194)
- Testing
- ABT-493/ABT-530
- Volunteers
- 104 people
- Sponsor
- AbbVie
Neuromuscular Disease
Safety and Efficacy Study of A0001 in Patients With the A3243G Mitochondrial DNA Point Mutation
This is a phase 2a, double-blind, placebo-controlled, single-center study. Twenty-one patients who qualify for the study will be randomly assigned to either active drug or placebo.
- Trial name
- NCT01074359
- Testing
- A0001 (alpha-tocopherolquinone)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Penwest Pharmaceuticals Co.
Alzheimer Disease, Dementia
A Bridging Study on Efficacy and Safety of [18F]Florbetaben PET for Diagnosis of Alzheimer Disease Subjects in Chinese Population
This is a bridging study to visually and quantitatively assess PET images obtained after single application of 300 MBq [18F]florbetaben and PET scanning of patients with Alzheimer disease.
- Conditions
- Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT05527288
- Testing
- Drug: [18F]florbetaben
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sinotau Pharmaceutical Group
Hypertension, Impaired Glucose Tolerance
Clinical Trial To Evaluate The Effect Of Valsartan On Insulin Sensitivity In Subjects With Impaired Glucose Tolerance
THE PURPOSE OF THIS STUDY IS TO DETERMINE IF 24 WEEKS OF TREATMENT WITH VALSARTAN (80 MG - 320 MG) IMPROVES INSULIN SENSITIVITY IN SUBJECTS WITH HIGHER THAN NORMAL GLUCOSE LEVELS USING A TEST CALLED THE EUGLYCEMIC CLAMP.
- Trial name
- NCT00241072
- Testing
- valsartan
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Novartis
Musculoskeletal Complication, Recurrent Breast Carcinoma
Questionnaires in Identifying Upper Extremity Function and Quality of Life After Treatment in Patients With Breast Cancer
This pilot clinical trial studies questionnaires in identifying arms, shoulder, and neck (upper extremity) function and quality of life after treatment in patients with breast cancer.
- Conditions
- Musculoskeletal Complication, Recurrent Breast Carcinoma, Stage IA Breast Cancer, Stage IB Breast Cancer
- Trial name
- NCT02370264
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Medical Chart Review
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Southern California
Stroke, Multiple Sclerosis
Upper Limb Muscle Strength Models for Patients With Motor Impairment.
Upper limb motor impairments are common. They affect quality of life and can lead to dependency. They are mainly due to neurological conditions such as stroke, multiple sclerosis, and traumatic spinal cord injury.
- Conditions
- Stroke, Multiple Sclerosis, Spinal Cord Injuries
- Trial name
- MusMapS (NCT06608121)
- Testing
- Upper limb isokinetic forces measurements
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Pôle Saint Hélier
PARKINSON DISEASE (Disorder), Postural Instability
Postural Sway of Trunk and Upper Extremity Functional Skills in Atient With Parkinson Disease (pwPD)
Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized clinically by motor and non-motor symptoms, including bradykinesia, resting tremor, and/or rigidity.
- Conditions
- PARKINSON DISEASE (Disorder), Postural Instability, Trunk Stability Impairment, Upper Extremity
- Trial name
- NCT07182487
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Stroke
Personalized Upper Extremity Rehabilitation for Persons With Stroke
Approximately 80% of individuals with chronic stroke present with long lasting upper extremity (UE) impairments. Advances in rehabilitation technology, such as robotics, virtual reality (VR) and neuromuscular electrical…
- Trial name
- SUPER (NCT03903770)
- Testing
- Upper extremity rehabilitation
- Where
- 2 sites in Canada
- Volunteers
- 32 people
- Sponsor
- McGill University
Stroke, Upper Limb Motor Impairment
tDCS Combined With Constraint-Induced Therapy in Post-Stroke Upper Limb Rehabilitation
The objective of this clinical trial is to evaluate the effects of transcranial direct current stimulation (tDCS) combined with constraint-induced therapy (CIT) on upper limb motor recovery in individuals after stroke.
- Conditions
- Stroke, Upper Limb Motor Impairment, Post-Stroke Hemiparesis
- Trial name
- tDCS-CIT Strok (NCT07458503)
- Testing
- transcranial direct current stimulation (tDCS), Constraint-induced movement therapy
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade do Estado do Pará
Stroke, TBI
Assessment of Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments
This study will evaluate the safety and performance of the Spatial StimeMD (SSMD) medical device in people with multiple sclerosis (MS). The SSMD device is intended to support patients through a non-invasive stimulation program.
- Conditions
- Stroke, TBI, Spinal Cord Injury, Peripheral Nerve Damage
- Trial name
- NCT07396922
- Testing
- SSMD, Functional Electrical Stimulation (FES)
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Motion Informatics LTD
Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease
Post-Market Registry of AURYON Atherectomy Device in Subjects Affected With Infrainguinal Peripheral Artery Disease
The PATHFINDER Registry is a prospective, non-randomized, single arm, multicenter observational study. This pilot registry is aimed to evaluate the performance (peri-procedural) and clinical outcomes (intermediate and long-term)…
- Conditions
- Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease, PAD
- Trial name
- PATHFINDER (NCT04229563)
- Testing
- AURYON Atherectomy System
- Where
- 10 sites in United States
- Volunteers
- 102 people
- Sponsor
- Angiodynamics, Inc.
Cerebral Palsy
Effects of Forms of Modified CIT on Upper Extremity Performance in Cerebral Palsy
The purpose of this study will employ clinical assessment tools to examine the effects of modified constraint-induced therapy (mCIT) on the more affected upper extremity of children with cerebral palsy.
- Trial name
- NCT01643239
- Testing
- Hospital-based mCIT restraint of the unaffected arm and practice of the affected arm, Hospital-based mCIT, Hospital-based TR
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
The Effectiveness of Novel Rehabilitation Device on Upper Limb Impairment Among Patients With Stroke
Usability and Effectiveness of a Novel Bilateral Upper Limb Training Device for Stroke Patients With Hemiparesis: A Preliminary Study
Background and Study Aims Stroke is a leading cause of long-term disability worldwide, affecting millions of individuals each year.
- Trial name
- Synslai (NCT06956677)
- Testing
- Novel UE rehabilitation device training, The UE functional training, Conventional occupational therapy
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- Chang Gung Memorial Hospital
Ictus, Stroke
Motor and Cognitive Telerehabilitation in a Virtual Environment in Patients With Post-stroke Sequelae and Parkinson's Disease
The goal of this interventional pilot trial is to evaluate whether a telerehabilitation protocol based on immersive virtual reality (VR) is effective and feasible for the recovery of cognitive and/or motor functions in patients…
- Conditions
- Ictus, Stroke, Parkinson Disease
- Trial name
- HOME VR REHAB (NCT07582497)
- Testing
- VR-based Telerehabilitation with Home Kit, Standard Rehabilitation (Conventional Care)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Usl di Bologna
Stroke
Brain-behavior Associations of Sensorimotor Therapy Post Stroke
Stroke survivors often encounter impairments in the upper limb after stroke. Sensorimotor impairments are present in 67% of the stroke patients, resulting in problems with independency and performance of activities of daily life.
- Trial name
- NCT03236376
- Testing
- additional sensorimotor therapy for the upper limb, additional motor therapy for the upper limb after stroke
- Where
- Belgium
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cognitive Decline, Mild Cognitive Impairment
The Effects of Chicken Extract and a Peptide Supplement for the Prevention of Cognitive Decline in Non-demented Elderly Adults
This trial investigates the effect of a chicken extract supplement and a peptide supplement on cognitive function and potential mechanisms of action of cognitive decline during ageing, among non-demented elderly adults using a…
- Conditions
- Cognitive Decline, Mild Cognitive Impairment, Aging
- Trial name
- NCT04555655
- Testing
- Chicken extract supplement, Peptide Supplement
- Where
- 3 sites in Taiwan
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Brand's Suntory Asia
Stroke
A Study Exploring Brain Activity in Relation to Sensory Arm Impairments in the Early Stages of Stroke
This clinical study is organized for people with stroke often experience difficulties with their sensation in their upper limb. New technologies may be able to help these important problems.
- Trial name
- NCT03407547
- Testing
- Electroencephalography
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Assessment of Arm and Hand Sensorimotor Functions in Multiple Sclerosis Subjects
Validation of a Novel Instrument Task for Assessing Upper Limb
The aim of this study i to investigate a new approach (Physical Peg Insertion Test, PPIT) to measure sensorimotor function in the arm and hand.
- Trial name
- NCT04868370
- Testing
- Assessment of the upper limb (VPIT + PPIT)
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Stroke
Robot Mediated Therapy-Feasibility Study and Preliminary Effects
The goal of this clinical trial is to investigate the feasibility of the application of robot mediated impairment-training (RMIT) and robot mediated task-specific training (RMTT) in acute stroke patients with upper limb…
- Trial name
- NCT05729633
- Testing
- Robot mediated upper limb therapy
- Volunteers
- 4 people
- Sponsor
- Changi General Hospital
Type 2 Diabetes Mellitus, Chronic Kidney Disease Stage 4
A Study to Evaluate Safety and Effects of Sotagliflozin 400 and 200 mg on Glucose Control in Participants With Type 2 Diabetes, Severe Impairment of Kidney Function and Inadequate Blood Sugar Control
Primary Objective: To demonstrate the superiority of sotagliflozin 400 milligrams (mg) versus placebo with respect to hemoglobin A1c (HbA1c) reduction at Week 26 in participants with Type 2 diabetes who have inadequate glycemic…
- Trial name
- SOTA-CKD4 (NCT03242018)
- Testing
- Sotagliflozin
- Where
- 106 sites in United States, Argentina and 13 more
- Volunteers
- 277 people
- Sponsor
- Lexicon Pharmaceuticals