Clinical trials: Implant Therapy
Keratoconus
First in Human Study to Assess Safety and Efficacy of an Implantable Nitinol Device in the Treatment of Keratoconus
This Study is a First In Human clinical investigation addressed to evaluate the safety and efficacy of a novel intra-corneal nitinol device (Investigational Medical Device: GROSSO® implant) for the treatment of advanced…
- Trial name
- NCT06451718
- Testing
- Nitinol net for intracorneal implant for keratoconus treatment
- Where
- 2 sites in Italy, Spain
- Volunteers
- 12 people
- Sponsor
- Recornea Srl
Articular Cartilage Lesion of Knee
Study to Assess the Safety of Treatment of Articular Cartilage Lesions With CartiLife®
The purpose of this study is to assess the safety and efficacy of implanting bead-type autologous chondrocytes (CartiLife®) obtained by culturing expanded costal chondrocytes of the patient with a chondral defect in the knee.
- Trial name
- NCT03517046
- Testing
- CartiLife
- Volunteers
- 6 people
- Sponsor
- Biosolution Co., Ltd.
Arthritis
Post Market Clinical Follow-Up KeriFuse®
The general objective of this study is to evaluate the performances and the safety related to the KeriFuse® intramedullary arthrodesis implant and associated instrumentation used in accordance with their approved labelling and…
- Trial name
- NCT06546332
- Testing
- KeriFuse®
- Where
- 6 sites in France
- Volunteers
- 97 people
- Sponsor
- Keri Medical SA
Coronary Artery Disease, Coronary Restenosis
Systemic Treatment With Everolimus for the Prevention of MACE After Bare Metal Stent Implantation
The purpose of the present study is to provide the first in-human safety and efficacy evaluations of systemic oral anti-proliferative Everolimus therapy compared to placebo in patients treated by bare metal stents for significant…
- Trial name
- NCT00426049
- Testing
- Everolimus
- Where
- Germany
- Volunteers
- 484 people
- Sponsor
- German Heart Institute
Sedative Adverse Reaction, Analgesic Adverse Reaction
The Use of Midazolam and Remifentanil During Dialysis Access Procedures
BACKGROUND: Sedation and analgesia are related to unexpected adverse events in chronic renal failure patients undergoing arteriovenous fistula placement procedures under monitored anesthesia care (MAC).
- Conditions
- Sedative Adverse Reaction, Analgesic Adverse Reaction, Midazolam Adverse Reaction, Adverse Reaction to Drug
- Trial name
- NCT04226443
- Testing
- Midazolam intravenous injection, Remifentanil intravenous bolus dose
- Volunteers
- 99 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Chondral or Osteochondral Lesion of Medial Femoral Condyle, Chondral or Osteochondral Lesion of Lateral Femoral Condyle
BiPhasic Cartilage Repair Implant (BiCRI) IDE Clinical Trial - Taiwan
The purpose of this trial is to evaluate the safety and effectiveness of the Biphasic Cartilage Repair Implant (BiCRI) compared to marrow stimulation in the treatment of chondral and osteochondral lesions located on the medial…
- Conditions
- Chondral or Osteochondral Lesion of Medial Femoral Condyle, Chondral or Osteochondral Lesion of Lateral Femoral Condyle, Chondral or Osteochondral Lesion of Trochlea
- Trial name
- NCT01477008
- Testing
- BiPhasic Cartilage Repair Implant, Marrow Stimulation
- Where
- 11 sites in Taiwan
- Volunteers
- 92 people
- Sponsor
- BioGend Therapeutics Co.Ltd
Prostate Cancer
Ability of a New Design of Iodine 125 Seed to Maintain Intended Position When Implanted in the Prostate
This study compares the ability of a new design of brachytherapy seed for prostate seed implants for treatment of prostate cancer to maintain their intended position in the prostate after being deposited.
- Trial name
- FAST (NCT01174017)
- Testing
- Iodine 125 standard loose brachytherapy seeds, AnchorSeed Iodine 125 brachytherapy prostate implant
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- British Columbia Cancer Agency
Femoral Fractures
Observational Retrospective and Prospective Study on the Treatment of Femoral Fractures With EBA2
This is an observational, retrospective and prospective study where subjects who have undergone surgery with EBA2 medical device for lateral proximal femoral fractures will be followed for data collection since the day before…
- Trial name
- NCT01599221
- Testing
- EBA2
- Where
- 3 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Citieffe S.r.l
Periodontal Diseases
Treatment of Periodontal Disease With Two Different Bioactive Gels for Home Oral Care
This study is an open-label split-mouth study in which periodontal patients will be treated in order to obtain periodontal health.
- Trial name
- NCT04781478
- Testing
- Application of Biorepair Gel, Irrigation of Chlorhexidine 1.00% gel
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pavia
Peri-Implantitis
Therapeutic Peri-implant Maintenance with Laser Therapy
The present study represents an extension of the previously concluded randomized clinical trial "Laser-Assisted Regenerative Surgical Therapy for Peri-implantitis" (HUM00124386).
- Trial name
- NCT04251793
- Testing
- Observation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Michigan
Chronic, Intractable Pain of the Trunk and/or Lower Limbs
Evaluating Anatomic Versus Targeted Lead Placement for Burst Stimulation Therapy During the Trial
Prospective, multi-center, randomized, single blind study
- Trial name
- DELIVERY (NCT03277378)
- Testing
- lead placement followed by BurstDR stimulation
- Where
- 25 sites in United States, Australia and 5 more
- Volunteers
- 270 people
- Sponsor
- Abbott Medical Devices
Effect of Putty Form Bone Graft in Immediate Implant Placment
Evaluation of Hyaluronic Acid in Addition to Xenograft in Immediate Implant Placement Within Maxillary Esthetic Zone
Study design: The present study will be carried out on twenty patients selected from the department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Mansoura University for replacement of non…
- Trial name
- NCT06783517
- Testing
- cerabone, cerabone®plus
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Heart Failure With Reduced Ejection Fraction (HFrEF)
Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Patients Receiving LBBp or Conventional BiVp for Cardiac Resynchronization Therapy (Echo LBBp)
The present study is a multicenter interventional non randomised study in patients requiring an implantable device for cardiac resynchronization therapy.
- Trial name
- ECHO-LBBp (NCT06689111)
- Testing
- Left bundle branch pacing lead, CRT with the standard method through cs
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University Hospital of Patras
Dental Implant, Osseointegration
Assessment of Early Healing Period of Dental Implants
This prospective cohort study aimed to evaluate, clinically, radiographically, and digitally, the volumetric changes occurring during the early healing period after implant treatment in patients with tooth loss in the posterior…
- Conditions
- Dental Implant, Osseointegration, Biological Width
- Trial name
- NCT06554444
- Testing
- Dental Implant Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Hallux Rigidus
Synthetic Cartilage Implant Versus Interposition Arthroplasty in Hallux Rigidus Treatment: A Randomized Clinical Trial
A minimum of 100 patients with grade III hallux rigidus will be randomized in two parallel groups for surgical care. The first group will be submitted to the insertion of a synthetic cartilage implant at the metatarsophalangeal…
- Trial name
- NCT05518721
- Testing
- Hallux Rigidus Treatment
- Where
- United States
- Sponsor
- John Femino
Non-squamous NSCLC
Pembrolizumab Plus Bevacizumab and Chemotherapy for Non-Squamous NSCLC Patients
This study is designed to evaluate the efficacy and safety of Pembrolizumab in combination with Bevacizumab and chemotherapy in advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion…
- Trial name
- NCT05751187
- Testing
- Pembrolizumab, Bevacizumab, Pemetrexed
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Shanghai Chest Hospital
Cardiovascular Diseases, Arrhythmias, Cardiac
Multicenter Evaluation of Patients Using LATITUDE Monitoring System
The Multitude is a registry of patients who receive commercially available CIEDs that remotely communicate through the LATITUDE monitoring system and transfer data to a central database.
- Conditions
- Cardiovascular Diseases, Arrhythmias, Cardiac, Heart Failure, Sudden Cardiac Death
- Trial name
- Multitude (NCT06311149)
- Where
- 3 sites in Italy
- Volunteers
- 20,000 people
- Sponsor
- University Hospital of Ferrara
Malocclusion, Angle Class II, Division 1
Low-Level Laser Therapy and Flapless Corticopuncture Effect on Accelerating Six Maxillary Anterior Teeth Retraction
The long time needed for orthodontic treatment is considered one of the biggest obstacles that make patients refuse to undergo orthodontic treatment.
- Trial name
- NCT03999307
- Testing
- Low-Level Laser Therapy (LLLT), Flapless Corticopunture, Control
- Where
- Syria
- Volunteers
- 36 people
- Sponsor
- Damascus University
Cardiac Pacing, Cardiac Pacemaker
BIO|STREAM.CSP Study
The registry is designed to assess outcome, performance and residual safety aspects of BIOTRONIK products which are used in the context of CSP based on long-term data from an unselected, real-life clinical set-up.
- Conditions
- Cardiac Pacing, Cardiac Pacemaker, Implantable Cardioverter Defibrillator, Cardiac Resynchronization Therapy Devices
- Trial name
- NCT07393009
- Testing
- Implantation of the Solia CSP S pacing lead for LBBAP
- Where
- 46 sites in Australia, Austria and 11 more
- Volunteers
- 1,000 people
- Sponsor
- Biotronik SE & Co. KG
In-stent Restenosis
Diffuse Type In-Stent Restenosis After Drug-Eluting Stent
To evaluate the best therapeutic option for the treatment of diffuse type post-drug-eluting stent restenosis.
- Trial name
- DES-ISR (NCT00485030)
- Testing
- Cypher, Xience-V
- Where
- 15 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seung-Jung Park