Clinical trials: Implant Therapy
Local Anesthesia, Dental Implants
Comparison of Anesthetic Efficacy and Safety Between Inferior Alveolar Nerve Block and the Infiltrative Technique for the Treatment of Peri-implant Diseases in Posterior Mandibular Implants
This triple-blind randomized clinical trial aims to compare the anesthetic efficacy and safety of two local anesthesia techniques for the surgical treatment of peri-implantitis in posterior mandibular implants: inferior alveolar…
- Conditions
- Local Anesthesia, Dental Implants, Periimplantitis
- Trial name
- NCT07590037
- Testing
- Comparison of anesthetic efficacy and safety between nerve block and infiltrative technique for periimplantitis surgical treatment in poosterior mandibular implants
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Peri-implant Mucositis, Peri-Implantitis
Peri-implant Phenotype, Calprotectin and Mmp-8 Levels in Cases Diagnosed With Peri-implant Disease
Following the implantation procedures; The peri-implant mucosa may begin to show signs of inflammation depending on the patient (bruxism, lack of oral hygiene) or other factors (planning errors, iatrogenic factors).
- Trial name
- NCT06173739
- Testing
- Non-surgical mechanical treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Beliz Önder
Coronary Artery Disease
1-month vs 12-month DAPT for ACS Patients Who Underwent PCI Stratified by IVUS: IVUS-ACS and ULTIMATE-DAPT Trials
Prospective, multicenter, randomized, double-blind, placebo-controlled trials.
- Trial name
- NCT03971500
- Testing
- AntiPlatelet therapy, Percutaneous coronary intervention
- Where
- China
- Volunteers
- 3,710 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
High Ischemic Risk
24-month Ticagrelor-based Dual-antiplatelet Therapy Versus Clopidogrel-based Dual-antiplatelet theRapy aftEr 12 Months of DrUg-eluting Stent Implantation in High isChEmic Risk Patients: P-REDUCE Trial
The purpose of this prospective randomized clinical trial is to compare the clinical outcomes between aspirin with ticagrelor versus aspirin with clopidogrel in high ischemic risk patients beyond 12 months after percutaneous…
- Trial name
- NCT04989257
- Testing
- Ticagrelor-based dual-antiplatelet therapy, Clopidogrel-based dual-antiplatelet therapy
- Where
- South Korea
- Volunteers
- 3,488 people
- Sponsor
- Yonsei University
Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
YK-029A as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations
The purpose of this study is to compare the effectiveness of YK-029A as first-line treatment with that of platinum-based chemotherapy in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose…
- Trial name
- NCT05767892
- Testing
- YK-209A tablet, Pemetrexed+carboplatin/Cisplatin
- Where
- 52 sites in China
- Volunteers
- 350 people
- Sponsor
- Suzhou Puhe Pharmaceutical Technology Co., LTD
Neoplasms
Efficacy and Safety of FLEXIPORT Implantable Port in Chemotherapeutic Treatments
The goal of this clinical trial is to assess, in a clinical setting, the efficacy and the safety of FLEXIPORT, a totally implantable venous access device (TIVAD) designed to provide a repeated access to the vascular system, in…
- Trial name
- PTC (NCT07856745)
- Testing
- FLEXIPORT
- Where
- Dominican Republic
- Volunteers
- 40 people
- Sponsor
- Portal Access Ltd.
Shoulder Pain
Physical Therapy Program for Prevention of Shoulder Pain After Device Implant
This is a clinical research study to determine if a prescribed physical therapy intervention after subcutaneous implantation of an implanted cardioverter-defibrillator (ICD) or pacemaker reduces the incidence of rotator cuff…
- Trial name
- NCT00680537
- Testing
- Exercises
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Peri-Implantitis, Sinusitis
"Association of Peri-implantitis and Maxillary Sinusitis: a Case-control Study".
Scientific evidence regarding the influence of peri-implantitis on Schneider's membrane thickening is scarce and limited. Similarly, to date, there is no literature documenting the resolution of implant-associated maxillary…
- Conditions
- Peri-Implantitis, Sinusitis, Sinusitis, Acute, Sinusitis, Chronic
- Trial name
- NCT05924711
- Testing
- Retrospective analysis of demographic and radiographic data previously obtained from the patient.
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Universitat Internacional de Catalunya
Nasolabial Fold Wrinkles
DL6049 Versus Cosmoplast in the Treatment of Nasolabial Fold Wrinkles, Long Term Follow-up
This study is being undertaken to: evaluate the degree of correction attainable with DL6049 (injectable poly-L-lactic acid)compared to a commercially available CosmoPlast™ Collagen Implant in the treatment of dermal nasolabial…
- Trial name
- NCT00444353
- Testing
- DL6049 (injectable poly-L-lactic acid)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Bausch Health Americas, Inc.
Brachytherapy, Non-small Cell Lung Cancer
I-125 Seeds Implantation in the Treatment of Recurrent Lung Cancer After Radiotherapy
Patients with recurrence after radiotherapy are often encountered in clinical practice.Patients with recurrence after radiotherapy are less likely to undergo surgery or secondary radiotherapy, and the guidelines recommend only…
- Trial name
- RISIRLC (NCT04071418)
- Testing
- 3D-printing Template-assisted CT-guided I-125 Seeds Implantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Profound Congenital Deafness, Cochlear Implantation
Analysis of Parental Support in Families Using the LENA After Early Cochlear Implantation
The language environment that influences the child's language development has been studied using different subjective tools, mainly audio and/or video recording and manual transcriptions.
- Trial name
- ACLEIC (NCT05917496)
- Testing
- LENA tool: Language ENvironment Analysis, Return of the analysis of the data of LENA
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peri-implant Mucositis
Limosilactobacillus Reuteri as an Adjuvant in the Treatment of Peri-implant Mucositis
Mechanical debridement is the traditional method for the treatment of peri-implant mucositis and its success depends on the patient's correct oral hygiene.
- Trial name
- LRRCT (NCT05758103)
- Testing
- Limosilactobacillus reuteri Prodentis® (combining L. reuteri DSM 17938 and L. reuteri ATCC PTA 5289 strains)
- Where
- Portugal
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Malo Clinic
Levels of Pain
Effect of Low Level Laser Therapy on Pain Induced by Placement of Orthodontic Separators in Pediatric Patients
The primary goal of the study is to determine if there is a difference in pain levels following the use of low level laser therapy versus placebo and control after placement of elastomeric orthodontic separators in pediatric…
- Trial name
- NCT02211547
- Testing
- Epic 10 Diode Laser by Biolase Inc.
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Aggressive Periodontitis, Generalized
Subgingival Microbiota Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Periodontitis Patients
The investigators planed to observe the microbiome of an aggressive periodontitis patient, during mechanical treatment, surgery(if indicated) and implant placement.
- Trial name
- NCT03090282
- Testing
- mechanical treatment(mainly scaling and root planing), periodontal surgery(if indicated), implant placement.
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Peking University
Heart Failure With Reduced Ejection Fraction, HFrEF
VisONE Heart Failure Study: Pilot
The VisONE HF pilot is a feasibility pilot for evaluating the benefits and risks of chronically delivering Asymptomatic Diaphragmatic Stimulation in medical refractory heart failure patients using the VisONE™ implantable system…
- Trial name
- NCT03484780
- Testing
- VisONE ADS
- Where
- 3 sites in Georgia, Ukraine
- Volunteers
- 15 people
- Sponsor
- VisCardia Inc.
Chronic Pain, Intractable Pain
Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation Therapy
The PERSIST study is being conducted within Medtronic's active post-market surveillance platform, the Product Surveillance Registry (PSR).
- Trial name
- PERSIST (NCT07507422)
- Testing
- Commercially available Inceptiv™ neurostimulation systems
- Where
- 6 sites in United States, France
- Volunteers
- 970 people
- Sponsor
- Medtronic
Edentulous
The Treatment of Implant-retained Mandibular Overdentures for Edentulous Patients
The purpose of this study is to investigate to what extent IOs improve the functionality of edentulous patients and changes in quality of life and overall patient satisfaction following treatment with IOs.
- Trial name
- TIMOEP (NCT02846805)
- Testing
- implant-retained overdentures
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Chufan Ma
Implant Therapy, Biological Width
Histological Analysis of Peri-implant Soft Tissue
The aim of this study is to evaluate the histologically analysis in humans and the orientation of collagen fibers around screw-less, morse taper implant-abutment connection.
- Trial name
- NCT06862505
- Testing
- Biopsy
- Where
- Italy
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Sassari
Severe Aortic Valve Stenosis, Aortic Valve Stenosis
Single Antiplatelet Treatment With Ticagrelor or Aspirin After Transcatheter Aortic Valve Implantation
The optimal pharmacological therapy after transcatheter aortic valve implantation (TAVI) to prevent valve thrombosis and reduce thromboembolic complications without significantly increasing the risk of bleeding is not yet fully…
- Conditions
- Severe Aortic Valve Stenosis, Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement (TAVR), Transcatheter Aortic Valve Implantation (TAVI)
- Trial name
- REAC-TAVI2 (NCT05283356)
- Testing
- Ticagrelor 60mg
- Where
- Spain
- Volunteers
- 1,206 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Coronary Artery Disease
Intravascular Optical Coherence Tomography Imaging - Length of Anti-Platelet Therapy After Drug Eluting Stent Placement
Patients who receive drug-coated stents (as opposed to the less frequently used bare metal stents) are currently recommended aspirin plus a thienopyridine such as Plavix, Effient, or Ticlid for one year.
- Trial name
- FDI-DAPT-ZES (NCT01219894)
- Sponsor
- Emory University