Clinical trials: Implant Therapy
Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants
Effect of Photodynamic Treatment on Skin Microbiome. Single Center Study
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if photodynamic therapy has an effect on bacterial skin colonization and decrease number of…
- Conditions
- Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection
- Trial name
- PHOMIC (NCT04067843)
- Testing
- Photodynamic treatment
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Syncope
Guideline-based Pacing Therapy for Reflex Syncope
Study hypothesis: Dual-chamber pacemaker therapy with rate-hysteresis features is effective in preventing syncopal recurrences in patients affected by cardioinhibitory (CI) forms of reflex syncope diagnosed by means of carotid…
- Trial name
- SUP2 (NCT01509534)
- Where
- 8 sites in Italy
- Volunteers
- 281 people
- Sponsor
- Gruppo Italiano Multidisciplinare per lo Studio della Sincope
Pain During Intrauterine Device Insertion, Anxiety
Virtual Reality for Pain Reduction During IUD Insertion
This study aims to evaluate the effectiveness of virtual reality (VR) as a non-pharmacological distraction intervention during intrauterine device (IUD) insertion.
- Trial name
- NCT07648134
- Testing
- Virtual Reality
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Generalized Dystonia, Segmental Dystonia
Validation of the Implantation of a New Electrode for the Treatment of Dystonia
The main objective of the trial is to study the technical feasibility of the implantation of a new electrode Monocontact deep brain stimulation electrode in dystonia.
- Conditions
- Generalized Dystonia, Segmental Dystonia, Tardive Dystonia
- Trial name
- MONOCONTACT (NCT02509338)
- Testing
- Electrode deep brain stimulation (Monopolar DBS Lead Model 09064-40cm)
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Montpellier
Coronary Artery Disease
Short-Term Dual Antiplatelet and Maintenance CloPidogrel Therapy After Drug-Eluting Stent Implantation
The purpose of this study is to compare short-term (6-month Dual Anti Platelet Therapy(DAPT) followed by clopidogrel monotherapy) vs.
- Trial name
- STAMP-DES (NCT02494284)
- Testing
- Clopidogrel, Aspirin plus clopidogrel
- Where
- 12 sites in South Korea
- Volunteers
- 364 people
- Sponsor
- CHEOL WHAN LEE, M.D., Ph.D
Prepectoral Breast Reconstruction, Breast Reconstruction
Data Collection of Prepectoral Breast Reconstruction With Polyurethane Implantes
The goal of this observational study is to learn about correct surgical indications and long-term complications in patient with immediate prepectoral breast reconstruction with polyurethane implants.
- Conditions
- Prepectoral Breast Reconstruction, Breast Reconstruction, Radiation Therapy Complication
- Trial name
- IBR-PPBR (NCT06216106)
- Testing
- Prepectoral breast reconstruction with polyurethane implants
- Where
- Italy
- Volunteers
- 237 people
- Sponsor
- European Institute of Oncology
Aortic Stenosis, Mitral Regurgitation
Transcatheter Treatment for Combined Aortic and Mitral Valve Disease. The Aortic+Mitral TRAnsCatheter (AMTRAC) Valve Registry
an international multicentre registry designed to answer 3 clinical questions: 1. Describing the characteristics and outcomes of current patients undergoing aortic + mitral transcatheter heart valve procedures. 2.
- Trial name
- AMTRAC (NCT04031274)
- Testing
- TAVI, TMVR/r
- Where
- Israel
- Volunteers
- 10,000 people
- Sponsor
- Rabin Medical Center
Heart Failure
REmote MOnitoring of paTiEnts witH pacEmaker or implAntable cardioverteR defibrillaTor
However, the current guidelines recommend the use of remote monitoring (RM) in patients with cardiac implantable electronic devices (CIED) to reduce inappropriate shocks or early detection of atrial fibrillation, data is…
- Trial name
- REMOTE-HEART (NCT06173089)
- Testing
- Remote monitoring
- Where
- Hungary
- Volunteers
- 800 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Heart Failure, Congestive
HEAL-HF: A Cardiac Resynchronization Therapy (CRT) Outcomes Study
The literature shows that approximately 40% of individuals who receive a cardiac resynchronization therapy (CRT) device for symptomatic congestive heart failure (CHF) do not have a clinical benefit from the device.
- Trial name
- NCT00370526
- Testing
- Acute hemodynamic assessment using PV Loops (CD Leycom, The Netherlands) during LV lead placement
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- Stereotaxis
Symptomatic Cervical Disc Disease
Safety and Efficacy Study Comparing ProDisc-C to ACDF Surgery to Treat SCDD
The objective of this clinical investigation is to compare the safety and effectiveness of ProDisc-C to anterior cervical discectomy and fusion (ACDF) surgery in the treatment of symptomatic cervical disc disease (SCDD).
- Trial name
- NCT00291018
- Testing
- Total Disc Replacement, ACDF
- Volunteers
- 368 people
- Sponsor
- Synthes USA HQ, Inc.
Ventricular Tachycardia, Ischemic
Early Ablation Therapy for the Treatment of Ischemic Ventricular Tachycardia in Patients With Implantable Cardioverter Defibrillators
The purpose of this study is to determine if early ablation (i.e., ablation of ventricular tachycardia in patients with infrequent VT episodes) is more effective than medical therapy alone for the treatment of ischemic…
- Trial name
- ASPIRE (NCT01557842)
- Testing
- Drug Treatment, Catheter Ablation
- Where
- 23 sites in United States
- Volunteers
- 15 people
- Sponsor
- Biosense Webster, Inc.
Hearing Loss
Evaluation of the Benefits for Overall Health Following Cochlear Implant Treatment in the Elderly Population
The purpose of this study is to show that cochlear implant treatment improves the overall health related quality of life and general well-being in elderly individuals.
- Trial name
- NCT03072862
- Testing
- Commercial Nucleus Cochlear Implant Systems
- Where
- 8 sites in France, Israel and 2 more
- Volunteers
- 100 people
- Sponsor
- Cochlear
Tachyarrhythmias, Sudden Cardiac Death
SJ4 Post Approval Study in Implantable Cardioverter-Defibrillator and Cardiac Resynchronization Therapy Defibrillator Patients
The purpose of this study is to characterize the chronic performance of the St. Jude Medical SJ4 connector and RV high voltage SJ4 leads.
- Conditions
- Tachyarrhythmias, Sudden Cardiac Death, Heart Failure
- Trial name
- NCT00940888
- Testing
- SJ4 connector and RV high voltage SJ4 lead
- Where
- United States
- Volunteers
- 1,701 people
- Sponsor
- Abbott Medical Devices
Brachytherapy, Squamous Cell Carcinomas
RISI in the Treatment of Recurrent Metastatic SCC of Thoracic Inlet Lymph Nodes
The malignant tumor at the thoracic entrance is difficult to be surgically removed, and radiotherapy or radiotherapy based comprehensive treatment is often chosen at the initial diagnosis.
- Trial name
- NCT04266327
- Testing
- 3D-printing Template-assisted CT-guided I-125 Seed Implantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Cataract and IOL Surgery, IOL Implantation
Head-to-Head Comparison of Five Enhanced Depth of Focus IOLs and One Monofocal IOL
Study Goal The goal of this clinical trial is to compare how well four different types of artificial lenses (called intraocular lenses or IOLs) help people see after cataract surgery.
- Conditions
- Cataract and IOL Surgery, IOL Implantation, Presbyopia Correction, Extended Depth of Focus
- Trial name
- AKA-Reports (NCT07051720)
- Testing
- Bilateral implantation of CT ASPHINA 409M, Bilateral implantation of TECNIS Eyhance ICB00, Bilateral implantation of AcrySof® IQ Vivity®
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Augenklinik Ahaus G + H GmbH & Co. KG
Osteoarthritis
Safety and Efficacy of Autologous Bone Marrow Stem Cells for Treating Osteoarthritis
Osteoarthritis is a leading cause of chronic disability in elderly and the risk of disability attributed to osteoarthritis is as great as or greater than due to any other medical condition in that age group.
- Trial name
- NCT01152125
- Testing
- Autologous bone marrow stem cells
- Where
- India
- Volunteers
- 10 people
- Sponsor
- International Stemcell Services Limited
Primary Breast Cancer
Clip Marker Placement in Primary Lesions of Breast Cancer Patients Receiving Neoadjuvant Therapy
Neoadjuvant systemic therapy (NST) is increasingly recommended for patients with early breast cancer, and the rate of patients with pathological complete remission (pCR) is increasing due to the use of modern chemotherapy…
- Trial name
- Ultra3Detect (NCT04468113)
- Testing
- Tumark® Vision clip
- Where
- Germany
- Volunteers
- 339 people
- Sponsor
- Kliniken Essen-Mitte
Chronic Total Occlusion of Coronary Artery
To Evaluate Whether IVUS-guided Drug-eluting Stent (DES) Implantation Leads to Better Clinical Outcomes Compared to Conventional Angiography in the Treatment of Chronic Complete Occlusion (CTO) Disease.
This study aims to evaluate the treatment of Chronic total occlusion (CTO) disease. Whether Intravascular Ultrasonography (IVUS) guiding the implantation of drug-eluting stents (DES) will provide better long-term clinical…
- Trial name
- CRUISE-CTO (NCT04944615)
- Testing
- The guidewire successfully passed the CTO lesion
- Where
- China
- Volunteers
- 1,448 people
- Sponsor
- CCRF Inc., Beijing, China
Peri-implant Mucositis, Mucositis Oral
Treatment of Peri-implant Mucositis by Sodium Hypochlorite Gel and Cross-linked Hyaluronic Acid Gel
The aim of the study is to evaluate the potential of the combination of a sodium hypochlorite-based gel and a hyaluronic acid-based gel as an adjuvant to Non-Surgical Mechanical Debridement (NSMD) in the treatment of mucositis…
- Trial name
- NCT05926297
- Testing
- Application NaOCl gel + HA gel, Non-surgical mechanical debridement
- Where
- 2 sites in Hungary, Italy
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Federico II University
Alcohol Use Disorder (AUD)
Evaluate the Efficacy and Safety of Naltrexone Hydrochloride Implant in Patients With Alcohol Use Disorder
This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical trial. The study plans to enroll 240 adult patients with Alcohol Use Disorder (AUD).
- Trial name
- AUD (NCT07433413)
- Testing
- Naltrexone
- Volunteers
- 240 people
- Sponsor
- Shenzhen Sciencare Medical Industries Co., Ltd.