Clinical trials: Implantable Cardioverter-defibrillators (ICDs)
Implantable Defibrillator User
Plexa ICD Lead Registry
The purpose of this registry is to confirm the long-term safety and reliability of BIOTRONIK's Plexa ICD lead.
- Trial name
- NCT03103503
- Where
- 28 sites in United States
- Volunteers
- 901 people
- Sponsor
- Biotronik, Inc.
Myocarditis, Ventricular Arrythmia
Role of Endomyocardial Biopsy and Aetiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management
Myocarditis is a complex inflammatory disease, usually occurring secondary to viral infections, autoimmune processes or toxic agents.
- Conditions
- Myocarditis, Ventricular Arrythmia, Inflammatory Cardiomyopathy, Genetic Predisposition
- Trial name
- MYOCAR (NCT04521790)
- Testing
- support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Scientific Institute San Raffaele
Congestive Heart Failure, Atrial Arrhythmia, Atrial Tachyarrhythmia, Atrial Fibrillation
Clinical Investigation of the Medtronic Concerto™ Device
Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes.
- Trial name
- NCT00268320
- Testing
- Cardiac Resynchronization Therapy+Implantable Cardioverter Defibrillator
- Where
- 51 sites in United States, Austria and 10 more
- Volunteers
- 270 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Arrhythmia
Exercise Training in Patients With Cardioverter-Defibrillators
Exercise therapy has proven to be an effective additive therapy in patients with cardiovascular diseases. The prognostic value of physical activity is well established in patients with congestive heart failure.
- Trial name
- BETA (NCT00754663)
- Testing
- exercise training
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Implantable Cardioverter Defibrillator (ICD)
Patient-Reported Quality of Life in Patients With an Implantable-Cardioverter Defibrillator - A Cross-Sectional Observational Study
Patients at risk for life-threatening arrhythmias are eligible for the implantation of an implantable cardioverter-defibrillator (ICD), which has repeatedly shown improved survival.
- Trial name
- QoL-ICD I (NCT06654232)
- Testing
- quality of life questionnaires
- Where
- Belgium
- Volunteers
- 731 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
ICD, Pacemaker DDD
Postcards to Improve Remote Monitoring Adherence Among Veterans
We tested the effect of informational postcards on improving remote monitoring adherence among Veterans with pacemakers and implantable cardioverter-defibrillators in a stepped-wedge randomized controlled trial.
- Conditions
- ICD, Pacemaker DDD, Adherence, Patient
- Trial name
- NCT06068699
- Testing
- Postcard
- Where
- United States
- Volunteers
- 6,351 people
- Sponsor
- US Department of Veterans Affairs
Implantable Cardiac Device. Patients With a NMR Indication
Patients With Implantable Cardiac Devices Requiring a Nuclear Magnetic Resonance
The general objective of this registry is to study the number of patients carrying an implantable cardiac device that have an indication for an imaging diagnosis based on nuclear magnetic resonance.
- Trial name
- RESONANCE (NCT04330898)
- Testing
- Biotronik peacemakers, implantable cardioverter-defibrillators and cardiac resynchronizers
- Where
- 20 sites in Spain
- Volunteers
- 1,248 people
- Sponsor
- Trialance SCCL
Anxiety, Depression
REmote Web Assisted Care for Heart Failure Patients With Implantable Cardioverter Defibrillators
Aim and Background: Although implantable cardioverter defibrillators (ICD) save lives, many ICD-patients experience psychosocial complications such as anxiety disorders, depression and reduced quality of life after…
- Conditions
- Anxiety, Depression, Quality of Life
- Trial name
- REACH-ICD (NCT01589913)
- Testing
- ICD-Forum
- Where
- 7 sites in Germany
- Volunteers
- 118 people
- Sponsor
- Wuerzburg University Hospital
Cardiac Arrhythmia
SJM MRI Diagnostic Imaging Registry (IDE)
This study is a prospective, non-randomized, multi-center study of subjects implanted with an SJM pacemakers, implantable cardioverter defibrillator (ICD), and cardiac resynchronization therapy (CRT) devices who are clinically…
- Trial name
- NCT02807948
- Testing
- Pacemaker, ICD, or CRT device
- Where
- 58 sites in United States
- Volunteers
- 189 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Dilated Cardiomyopathy
Efficacy of Implantable Cardioverter Defibrillator in Patients With Non-ischemic Systolic Heart Failure on Mortality
Primary objective: The primary objective of this study is to determine the efficacy of ICD therapy compared with control on the endpoint of death from any cause.
- Conditions
- Heart Failure, Dilated Cardiomyopathy, Reduced LVEF
- Trial name
- DANISH (NCT00541268)
- Testing
- ICD, Optimal medical treatment
- Where
- 4 sites in Denmark
- Volunteers
- 1,116 people
- Sponsor
- Danish Study Group
Arrhythmias, Cardiac, Heart Diseases
Efficacy and Safety Study of Azimilide on the Incidence of Cardiovascular Hospitalizations/Emergency Department Visits or Cardiovascular Death in Patients With an Implantable Cardioverter Defibrillator (ICD) (SHIELD-2)
This study will evaluate the efficacy and safety of Azimilide on the incidence of cardiovascular hospitalizations, cardiovascular emergency department visits or cardiovascular death in patients with Implantable Cardioverter…
- Conditions
- Arrhythmias, Cardiac, Heart Diseases, Cardiovascular Diseases, Implantable Cardioverter Defibrillator
- Trial name
- SHIELD-2 (NCT01464476)
- Testing
- Azimilide Dihydrochloride
- Where
- 138 sites in United States, Belgium and 11 more
- Volunteers
- 240 people
- Sponsor
- Forest Laboratories
Chest Pain, Pain, Procedural
Evaluation of the Effectiveness of Two Methods of Regional Anesthesia During S-ICD Implantation Procedure.
Our study consists of a combination of regional blockade ('local' anesthesia) of the anterior and lateral chest wall in the form of a thin needle prick and the supply of local anesthetic drugs to the area of the relevant chest…
- Conditions
- Chest Pain, Pain, Procedural, Pain, Postoperative, Analgesia
- Trial name
- NCT06520150
- Testing
- Regional anaesthetic combined fascial plane block, Ropivacaine 0.125% Injectable Solution +Lignocaine 0,25% Injectable Solution
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Arrhythmia, Cardiovascular Diseases
Antiarrhythmics Versus Implantable Defibrillators (AVID)
To evaluate if use of an implantable cardiac defibrillator (ICD) results in reduction in total mortality, when compared with conventional pharmacological therapy, in patients resuscitated from sudden cardiac death who are…
- Conditions
- Arrhythmia, Cardiovascular Diseases, Death, Sudden, Cardiac, Heart Diseases
- Trial name
- NCT00000531
- Testing
- defibrillators, implantable, amiodarone amiodarone, sotalol
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ventricular Tachyarrhythmias
Initial Chronic Human Validation Study: Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) System
Primary objective is to evaluate the safety and performance of the implanted Subcutaneous implantable cardioverter defibrillator (S-ICD) system.
- Trial name
- Chronic II (NCT00853645)
- Testing
- Subcutaneous Implantable Defibrillator (S-ICD) System
- Where
- 2 sites in New Zealand
- Volunteers
- 6 people
- Sponsor
- Boston Scientific Corporation
Sleep Apnoea
Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in Implantable Cardioverter-Defibrillator (ICD) Patients
The purpose of this study is to report the incidence of ventricular arrhythmias correlated to the SAS and to focus on the interest of diagnosing Sleep-disorders breathing in ICD patients.
- Trial name
- NCT00708786
- Testing
- ICD, CRT-D
- Where
- 31 sites in France, Germany and 2 more
- Volunteers
- 755 people
- Sponsor
- LivaNova
Post Procedural Infection, Pacemaker Electrode Infection
Post-procedure Antibiotic Prophylaxis for Cardiac Electrical Device Implantation: ABxFREE Study
This study is a multi-center open-label randomized study, and we sought to investigate the redundancy of post-procedural prophylactic antibiotics in cardiac implantable electronic device implantation.
- Conditions
- Post Procedural Infection, Pacemaker Electrode Infection, Antibiotics, Implantable Defibrillator User
- Trial name
- ABxFREE (NCT04146883)
- Testing
- Antibiotics
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- National Cheng-Kung University Hospital
Cardiovascular Disease
Technology Dependency and Health-Related Quality of Life
This study will explore how people with an implanted cardioverter defibrillator (ICD) feel that dependence on this life-saving technology affects their health-related quality of life.
- Trial name
- NCT00022984
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Sudden Cardiac Death
Ovatio DR and VR Implantable Cardioverter Defibrillators Post-approval Study
The purpose of this post-approval study is to confirm the safety and effectiveness of Ovatio DR and VR ICDs
- Trial name
- Post-Ovatio (NCT00586378)
- Testing
- Ovatio DR and Ovatio VR
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- ELA Medical, Inc.
Sudden Cardiac Death, Implantable Defibrillator User
Implantable Cardioverter Defibrillators - Improving Risk Stratification
Worldwide three million people a year die from sudden cardiac death (SCD). In most cases there is no warning and the heart is stopped by a sudden arrhythmia.
- Conditions
- Sudden Cardiac Death, Implantable Defibrillator User, Myocardial Infarction, Arrhythmias, Cardiac
- Trial name
- ICD-IRS (NCT01944514)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Ventricular Tachycardia, Monomorphic, Cardiomyopathies
Stereotactic Radioablation as First-Line Therapy for Scar-Related Ventricular Tachycardia
Ventricular tachycardia (VT) is a dangerous fast heart rhythm originating from scarred areas of the heart muscle, often after a heart attack or in patients with cardiomyopathy.
- Trial name
- START-VT (NCT07618780)
- Testing
- Stereotactic Arrhythmia Radioablation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Southlake Health