Clinical trials: Implementation, open to volunteers
Knee Injuries, Anterior Cruciate Ligament Rupture
Stopping OsteoARthritis After an ACL Tear
By 2040, 25% of Canadians will have osteoarthritis, a disabling joint condition. Most people think osteoarthritis only affects older adults, but 50% of the 700,000 Canadian youth who hurt their knee playing sports annually will…
- Conditions
- Knee Injuries, Anterior Cruciate Ligament Rupture, Osteoarthritis, Knee
- Trial name
- SOAR (NCT06195423)
- Testing
- Stop OsteoARthritis (SOAR) program, Living Well after ACLR program
- Where
- 2 sites in Canada
- Volunteers
- 210 people
- Sponsor
- University of British Columbia
Osteoarthritis, Osteoarthritis (OA) of the Knee
Feasibility of Choose to Move Replacement Ready
Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada.
- Conditions
- Osteoarthritis, Osteoarthritis (OA) of the Knee, Osteoarthritis, Hip, Total Knee Arthroplasty; Total Hip Arthroplasty
- Trial name
- CTM-RR (NCT07069179)
- Testing
- Choose to Move Replacement Ready
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Information Dissemination
Implementation of a Caregiver-Report Suicide-Risk Screener in Children Under Age 8 in a Behavioral Health Center
This project addresses the pressing need for tools to identify suicidal thoughts and behaviors in children aged 4-7. Although young children can experience STBs, current screening tools and guidelines often overlook this age…
- Trial name
- NCT07350161
- Testing
- SITB information
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Washington University School of Medicine
Uptake of Systematic Review Evidence
Place Activation in Urban Peripheries: the 'Comunidades y Espacios Activos" Project (CEA)
This study will use a Hybrid III Cluster-Randomized Controlled Trial to test an 'active dissemination and implementation' intervention in peripheral urban neighborhoods, designed to accelerate the uptake of evidence-based…
- Trial name
- CEA (NCT06999382)
- Testing
- Active Dissemination and Implementation, Passive Dissemination
- Where
- Mexico
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Deborah Salvo
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Digital Patient-Reported Assessment in Older Adults With Acute Leukemia
This pilot study will evaluate the feasibility of implementing a structured digital patient-reported assessment pathway in adults aged 65 years or older with acute leukemia at Hospital Universitario Central de Asturias, Oviedo…
- Trial name
- NCT07597590
- Testing
- Digital Patient-Reported Assessment Pathway
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Healthy
Health4Life a Digital Intervention to Promote Healthy Lifestyle Behaviours From the Start of Life
The overall aim of this project is to evaluate the effectiveness and implementation of a digital intervention to support parents to create healthy lifestyle behaviours from the start of their infant's life, in order to prevent…
- Trial name
- Health4Life (NCT06798597)
- Testing
- Health4Life app
- Where
- Sweden
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Low Back Pain
MyBack - A Behavior Change Informed Exercise Program to Prevent Low Back Pain Recurrences
Low Back Pain is a common heath condition with high rates of recurrence and huge associated costs. Research has focused its efforts on analysing the effects of interventions while knowledge about effective secondary prevention…
- Trial name
- MyBack (NCT05841732)
- Testing
- Usual Care, MyBack Program
- Where
- Portugal
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Instituto Politécnico de Setúbal
Asthma Management, Asthma
eAMS-Eco: Implementation of a Tool for Climate Conscious Inhaler Prescribing
The goal of this study is to determine whether an 'eco' version of the Electronic Asthma Management System (eAMS) can reduce inhaler carbon emissions in primary care, in patients with asthma.
- Conditions
- Asthma Management, Asthma, Computerized Decision Support System, Primary Care
- Trial name
- NCT07638735
- Testing
- Climate-Conscious Clinical Decision Support System for Asthma Management
- Where
- 2 sites in Canada
- Volunteers
- 95 people
- Sponsor
- University of Toronto
Colorectal Cancer, Significant Bowel Pathology
Optimising Colorectal Cancer Patient Pathways
Bowel cancer (colorectal cancer) is the 4th most common cancer in Scotland. Approximately 4,000 cases are diagnosed annually. Cancer-related deaths in Scotland are higher than other UK nations.
- Trial name
- NCT07430540
- Testing
- Additional FIT testing
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Embolic Stroke of Undetermined Source
AI-Based Prediction of Atrial Fibrillation in ESUS Patients With ICM
This study investigates patients with Embolic Stroke of Undetermined Source (ESUS) who have received an Implantable Cardiac Monitor (ICM).
- Trial name
- SMART-ESUS (NCT07347691)
- Where
- 5 sites in South Korea
- Volunteers
- 92 people
- Sponsor
- Inha University Hospital
Cancer, Palliative Treatment
Cognitive Behavioral Therapy for Cancer-related Fatigue in Patients With Cancer Receiving Palliative Systemic Treatment
Cancer-related fatigue is highly prevalent in patients receiving treatment for gliomas or palliative systemic treatment for cancer and is experienced as one of the most burdensome symptoms affecting patients' daily functioning…
- Trial name
- TIRELESS (NCT06511518)
- Testing
- Cognitive behavioral therapy
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Frailty, Intrinsic Capacity
Implementation of Decade of Healthy Ageing Action Plan to Screen and Prevent Decline in Intrinsic Capacity in Elders (SPICE) Through Multisectoral Collaboration in Singapore
This study evaluates the implementation of a structured community-based pathway to screen, risk stratify, and prevent decline in intrinsic capacity (IC) among adults aged 60 years and above in Singapore.
- Conditions
- Frailty, Intrinsic Capacity, Lifestyle
- Trial name
- SPICE (NCT07525583)
- Testing
- ICOPE-Based Digital Intrinsic Capacity Monitoring and Triggered Follow-up (SPICE Pathway)
- Where
- Singapore
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Spinal Metastases, Spinal Tumors
SBRT Technique Implementation for Spinal Metastases Irradiation
Stereotactic body radiotherapy (SBRT) is a highly precise, image-guided radiotherapy technique delivering 1-5 high-dose fractions to spinal metastases.
- Conditions
- Spinal Metastases, Spinal Tumors, Bone Metastases
- Trial name
- NCT07429422
- Testing
- Stereotactic Body Radiotherapy (SBRT) for Spinal Metastases
- Where
- 2 sites in Slovenia
- Volunteers
- 100 people
- Sponsor
- Institute of Oncology Ljubljana
Pain, Acute
Impact of Virtual Reality in Cardiac Electrophysiology
Pain during pacemaker or defibrillator implantation can increase patient discomfort, anxiety, and the need for deeper sedation. Using virtual reality (VR) as a non-pharmacological distraction tool may help reduce perceived pain…
- Trial name
- NCT07009951
- Testing
- Virtual reality
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Calabria
Total Hip Arthroplasty (THA), Antibiotic Prophylaxis
Infection-related Revision Rates After Single-dose Versus Multiple-dose Antibiotic Prophylaxis in Primary Hip and Knee Arthroplasty: a Comparative Implementation Study.
Prosthetic Joint Infection (PJI) is a significant issue in joint replacement surgeries, causing additional surgeries and substantial healthcare costs.
- Conditions
- Total Hip Arthroplasty (THA), Antibiotic Prophylaxis, Revision Arthroplasty, Total Knee Arthroplasty
- Trial name
- REVISE (NCT07053943)
- Where
- Netherlands
- Volunteers
- 70,000 people
- Sponsor
- JointResearch
All-cause Mortality, Cardiovascular Disease
The Global Cardiovascular Risk Consortium
The Global Cardiovascular Risk Consortium (GCVRC) brings together harmonized individual-level data from currently more than 2 million (anticipated: approximately 3 million) individuals across 133 cohorts, 40 countries, and 6…
- Trial name
- NCT05466825
- Where
- Germany
- Volunteers
- 3,000,000 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Heart Failure (HF)
Early Detection and IntervenTion in Heart Failure
Heart failure (HF) occurs when the heart is no longer able to pump blood effectively throughout the body. This leads to symptoms that gradually worsen over time and are often mistaken for normal signs of aging.
- Trial name
- EDIT-HF (NCT07731490)
- Testing
- Intervention bundle comprising increased awareness, early diagnostics, and early treatment to improve HF prognosis.
- Where
- 21 sites in Austria, Bulgaria and 7 more
- Volunteers
- 18,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Hypertension, Primary Care
Fixed-Dose Combinations Pragmatic Randomized Implementation Trial for Blood Pressure Control
The proposed study is an effectiveness-implementation hybrid type II trial designed to evaluate the impact of provider- and patient-directed interventions on FDC use.
- Trial name
- NCT07228065
- Testing
- Provider nudge, Patient nudge, Pharmacist Virtual Visit
- Where
- United States
- Volunteers
- 720 people
- Sponsor
- Brigham and Women's Hospital
Endometriosis
Evaluating the Feasibility of elleFA App Implementation
Endometriosis is a chronic incurable disease where endometrial-like tissue grows outside of the uterus, and causes symptoms such as debilitating menstrual pain, pain during intercourse, infertility, constipation, and bloating…
- Trial name
- elleFA (NCT06452407)
- Testing
- Implementation of elleFA smartphone application
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Opioid Use Disorder
Real World Evaluation of the Effectiveness and Implementation of a Digital Health Therapeutic for OUD
The researchers will study the KIOS app, a digital health tool made to help people recovering from opioid addiction take better care of themselves.
- Trial name
- NCT07348796
- Testing
- KIOS App
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
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