Clinical trials: Implementation, open to volunteers
Embolic Stroke of Undetermined Source
AI-Based Prediction of Atrial Fibrillation in ESUS Patients With ICM
This study investigates patients with Embolic Stroke of Undetermined Source (ESUS) who have received an Implantable Cardiac Monitor (ICM).
- Trial name
- SMART-ESUS (NCT07347691)
- Where
- 5 sites in South Korea
- Volunteers
- 92 people
- Sponsor
- Inha University Hospital
Colorectal Cancer Screening, Diabetes Mellitus, Type 2
Aim 3, Optimizing CRC Screening in Patients With Diabetes in Safety-net Primary Care Settings
This mixed methods study evaluates the effectiveness and feasibility of a multi-level (patient, team, organizations) intervention to optimize CRC screening for patients with diabetes in primary care safety-net settings.
- Trial name
- NCT05785780
- Testing
- Targeted CRC Screening Toolkit
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Hearing Loss, Bilateral or Unilateral, Otitis Media With Effusion in Children
Towards Implementation of Universal Newborn Hearing Screening in Kenya
The goal of this observational study is to learn if smartphone hearing screening devices can help to understand the role of ear infections in hearing loss in infants with HIV exposure.
- Trial name
- mTUNE-R33 (NCT07879326)
- Testing
- Hearing and ear health screening
- Where
- Kenya
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hiv
Resilient HIV Implementation Science With SGM Youths Using Evidence
The Resilient HIV Implementation Science with SGM Youths using Evidence (RISE) Clinical Research Center will use a Type 2 hybrid-effectiveness-implementation study to evaluate the effectiveness and implementation of HMP, a…
- Trial name
- RISE (NCT06350682)
- Testing
- HealthMPowerment (HMP)
- Where
- 3 sites in Nigeria, Zambia
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
HEPATITIS C (HCV), Incarceration
Implementing Low-Barrier HCV Treatment in a Jail Setting
The goal of this clinical trial is to learn whether a low-barrier treatment program can help people with hepatitis C virus (HCV) who are in jail start and complete treatment more easily.
- Conditions
- HEPATITIS C (HCV), Incarceration, Injection Drug Use, Implementation Science
- Trial name
- MINMON-J (NCT06953479)
- Testing
- Sofosbuvir / Velpatasvir Oral Tablet [Epclusa], Community Health Worker
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Lifespan
Lung Cancer Screening
Lung Cancer Screening With Low-dose CT Scan in Women : Implementation Study
The purpose of this study is to determine whether reading of low-dose thoracic CT scans can be done by a single general radiologist who has been trained to lung cancer screening, and will evaluate the performance in comparison…
- Trial name
- CASCADE (NCT05195385)
- Testing
- Low-dose computed tomography of the chest
- Where
- France
- Volunteers
- 2,635 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autosomal Dominant Polycystic Kidney Disease
Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)
This study will investigate if a medication (metformin) widely used in the treatment of diabetes could be re-purposed for the treatment of patients with a diagnosis of early stage ADPKD to slow the rate of kidney function…
- Trial name
- NCT04939935
- Testing
- Metformin XR, Control
- Where
- 49 sites in Australia, New Zealand and 1 more
- Volunteers
- 1,174 people
- Sponsor
- The University of Queensland
Breast Ductal Carcinoma In Situ, Hematopoietic and Lymphatic System Neoplasm
Addressing Financial Hardship in AYA Cancer Survivors Through the Use of the New LIFT UP Intervention
This clinical trial addresses the financial hardship among adolescent and young adult (AYA) survivors using the new Lessening the Impact of Financial Toxicity (LIFT) UP intervention.
- Conditions
- Breast Ductal Carcinoma In Situ, Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT07909525
- Testing
- Best Practice, Educational Intervention, Informational Intervention
- Volunteers
- 448 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Genetic Predisposition, Paraganglioma
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
Given the expansion of indications for genetic testing and our understanding of conditions for which the results change medical management, it is imperative to consider novel ways to deliver care beyond the traditional genetic…
- Conditions
- Genetic Predisposition, Paraganglioma, Pheochromocytoma, ALS
- Trial name
- NCT06377033
- Testing
- Behavioral nudge
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
Obstructive Sleep Apnea (OSA)
Telehealth for Sleep Apnea: Effectiveness, Implementation, and Cost in the Military Health System
The long-term goal of this research is to improve military health and operational readiness among military service members with sleep disorders.
- Trial name
- TS OSA (NCT07121452)
- Testing
- Sleep Navigator
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Uniformed Services University of the Health Sciences
Antimicrobial Stewardship
Evidence Based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU)
The goal of this observational study is to learn about the implementation of a process to review antimicrobial prescriptions for adult patients in Intensive Care Unit (ICU).
- Trial name
- EQUIPS-ICU (NCT06666738)
- Testing
- Structured antimicrobial review
- Where
- Vietnam
- Volunteers
- 6,300 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Breast Cancer
Breast Cancer Implementation Science Study With Educational Intervention
A study uniquely focused on system-based practice change, measuring the impact of educational interventions on both patients and clinicians for the recognition and management of treatment-related adverse effects for HER2+/HER2…
- Trial name
- NCT06927895
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Chronic Dermatological Conditions, Eczema
A Randomised Controlled Trial of ePROM-Guided Flexible Scheduling in Dermatology
The goal of this clinical trial is to evaluate whether an electronic patient-reported outcome measure (ePROM)-guided flexible scheduling system can improve outpatient clinic resource utilisation in patients attending dermatology…
- Conditions
- Chronic Dermatological Conditions, Eczema, Urticaria, Psoriasis
- Trial name
- NCT07481019
- Testing
- Flexible ePROM-guided Scheduling System, electronic patient reported outcome measures (ePROMs)
- Volunteers
- 250 people
- Sponsor
- National University Hospital, Singapore
HIV, HIV Antiretroviral Therapy (ART) Adherence
Transitional Housing and HIV Health
The goal of this pilot study is to evaluate the implementation and outcomes of the Arms Around You (AAY) program, a supportive housing initiative launched by the Philadelphia Department of Public Health (PDPH) in 2024.
- Conditions
- HIV, HIV Antiretroviral Therapy (ART) Adherence, Housing Instability
- Trial name
- NCT06829394
- Testing
- Program Assignment
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Pennsylvania
PrEP, HIV
HOTSPOT Study: Implement and Evaluate the PrEP (Pre-exposure Prophylaxis) Implementation Strategy
The goal of this study is to measure the implementation and effectiveness of a multicomponent strategy for PrEP for people who are incarcerated at the Dallas County Jail.
- Conditions
- PrEP, HIV, Incarceration
- Trial name
- Hotspot (NCT06919419)
- Testing
- Multicomponent strategy
- Where
- United States
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Lipoprotein(a), Lipoprotein(a), Hyper-Lp(a)-Emia
Implementation Research on the LILAC Method to Educate Management of Elevated Lipoprotein(a).
The goal of this observational study is to assess the if short educational videos about #LILAC-for-Lpa are feasible and accepted in improving the confidence, testing, and management on Lipoprotein(a).
- Trial name
- LILAC-UNI (NCT07177612)
- Where
- 3 sites in Australia, Malaysia and 1 more
- Volunteers
- 20,000 people
- Sponsor
- Changi General Hospital
HIV Prevention, HIV Risk
Evaluating an Interactive Digital Toolkit for Women's PrEP Implementation
The goal of this study is to test if a Digital PrEP Toolkit helps cisgender women learn about and access PrEP in Alabama and Mississippi. PrEP is a medication that prevents HIV infection.
- Conditions
- HIV Prevention, HIV Risk, Sexual and Reproductive Health
- Trial name
- NCT07292584
- Testing
- Interactive Digital PrEP Toolkit
- Where
- 4 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Aortic Stenosis
Transfemoral Transcatheter Aortic Valve Implementation at Hospital Without On-site Cardiac Surgery: Early Clinical Outcome in Patients With Prohibitive Surgical Risk.
Study design: single arm, interventional and multicenter study. The objectives are evaluate Safety and efficacy of TAVI in Department of Cardiology without on site cardiac Surgery for symptomatic severe aortic valve stenosis by…
- Trial name
- NCT05886517
- Testing
- Transfemoral transcatheter aortic valve implementation
- Where
- 4 sites in Italy, Spain
- Volunteers
- 200 people
- Sponsor
- AUSL Romagna Rimini
Cardio-vascular Disease, Depression Disorders
Supporting Patients Starting New Medicines: Evaluating the myCare Start Service in Switzerland
In Phase B, the aim is to evaluate the myCare Start service in routine care within the ambulatory primary care medicine and community pharmacy setting in Switzerland.
- Conditions
- Cardio-vascular Disease, Depression Disorders, Diabetes, COPD
- Trial name
- myCare Start-I (NCT07036471)
- Testing
- myCare Start
- Where
- Switzerland
- Volunteers
- 1,600 people
- Sponsor
- University of Geneva, Switzerland
Advanced Care Planning
Implementing a Nurse-led Advance Care Planning (ACP) Intervention in Residential Care Homes
The goal of this cluster randomized controlled trial is to examine the effectiveness of a nurse-led advance care planning (ACP) intervention on improving ACP discussion uptake in residential care homes (RCHs).
- Trial name
- NCT06238063
- Testing
- Nurse-led Advance Care Planning (ACP) Intervention
- Where
- Hong Kong
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
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