Clinical trials: Implementation, open to volunteers
Cancer
The IMPACT Implementation-Effectiveness Trial
More Canadians are surviving cancer, however, individuals with cancer live with side effects for years after treatments have ended.
- Trial name
- IMPACT (NCT06323707)
- Testing
- Exercise, Self-management e-module
- Where
- 3 sites in Canada
- Volunteers
- 129 people
- Sponsor
- McMaster University
Coverage of Vitamin A Supplementation, Coverage of Immunization
OPTIMIZING ROUTINE DELIVERY OF ESSENTIAL CHILD HEALTH AND NUTRITION PACKAGE THROUGH PRIMARY HEALTH CARE CONTACTS
The primary objective of the study is to assess whether optimization of an essential package of health and nutrition services for children under five years of age using vitamin A supplementation touch points (i.e., the…
- Conditions
- Coverage of Vitamin A Supplementation, Coverage of Immunization, Feasibility and Fidelity of Implementation
- Trial name
- NCT06949930
- Testing
- Optimized package of child essential health and nutrition services, Standard package of essential child and nutrition services
- Where
- 2 sites in Kenya, Senegal
- Volunteers
- 1,928 people, healthy volunteers welcome
- Sponsor
- Nutrition International
Physical Activity During Cancer Treatment
Effective Implementation of the Physical Activity and Motor Skills Intervention for 3-6-year-old Children With Cancer (EMPOWER)
The study examines the association of digitally provided EMPOWER - exercise intervention on 3-6-year-old child's physical activity (PA), motor performance and quality of life (QoL) during and after cancer treatment.
- Trial name
- EMPOWER (NCT07488494)
- Testing
- Digital tool for physical activity guidance and follow-up, Physical activity guidance
- Volunteers
- 40 people
- Sponsor
- Turku University Hospital
Substance Use Treatment, Perinatal Substance Use
Improving Outcomes for Early Postpartum Mothers in Outpatient MOUD Treatment
Drug overdose is a leading cause of death among postpartum women and opioid-related mortality is 4 times higher in the postpartum period when compared to the third trimester of pregnancy.
- Conditions
- Substance Use Treatment, Perinatal Substance Use, Parenting
- Trial name
- NCT07071766
- Testing
- Proud of Baby and Me
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Arkansas
Cancer-related Cognitive Impairment
Electroacupuncture for Cognitive Toxicity in Cancer Survivors: Assessing Implementation, Cost, and Effectiveness for Integration
The goal of this clinical trial is to evaluate the clinical effectiveness and understand the biological mechanisms of electroacupuncture (EA) in reducing cognitive toxicity among cancer survivors.
- Trial name
- EAST-ALIGN (NCT07583979)
- Testing
- True electroacupuncture
- Where
- Singapore
- Volunteers
- 168 people
- Sponsor
- National Cancer Centre, Singapore
Pancreaticoduodenectomy, ERAS
ERAS Program Implementation for MIPD
To evaluate the impact of an Enhanced Recovery After Surgery (ERAS) program on postoperative recovery in patients undergoing minimally invasive pancreatoduodenectomy (MIPD)
- Conditions
- Pancreaticoduodenectomy, ERAS, Minimally Invasive Surgery
- Trial name
- NCT07017361
- Testing
- Conventional, ERAS
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Seoul National University Hospital
Congenital Heart Disease
Implementation of an Accessible Healthcare Model (ACHD STRONG): Comparing Nurse and Physician Lead Healthcare Transition Education in a RE-AIM Framework
The study includes patients with congenital heart disease (CHD), as well as their support persons and their providers, who are preparing to make the transition from pediatric to adult care for their CHD.
- Trial name
- NCT07559253
- Testing
- Accessible Care Model Visit, Recruitment Interviews, Participating Patient-Support Person Interviews
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Wisconsin, Madison
Substance Abuse Disorder, Dialectical Behavior Therapy
Implementing DBT in Short-Term SUD-treatment
The main objective of the study is to provide new knowledge about the implementation of DBT-informed environmental therapy in short-term substance use disorder (SUD) inpatient treatment.
- Conditions
- Substance Abuse Disorder, Dialectical Behavior Therapy, Emotion Management Skills
- Trial name
- NCT07693439
- Testing
- DBT-informed milieu therapy, Treatment as usual
- Where
- Norway
- Volunteers
- 82 people
- Sponsor
- Helse Møre og Romsdal HF
Basal Cell Carcinoma of Skin, Optical Coherence Tomography (OCT)
Real-world Evaluation of the Implementation of LC-OCT in Daily Clinical Practice
Basal cell carcinoma (BCC) is the most common skin cancer in the Netherlands, with incidence rates continuing to rise. The current diagnostic standard combines clinical evaluation and dermoscopy, while biopsy followed by…
- Conditions
- Basal Cell Carcinoma of Skin, Optical Coherence Tomography (OCT), Neoplasms, Neoplasms, Basal Cell
- Trial name
- RELI (NCT07501780)
- Where
- Netherlands
- Volunteers
- 297 people
- Sponsor
- Maastricht University Medical Center
Autism Spectrum Disorder, Executive Functioning
Hybrid Effectiveness-Implementation Trial of an Executive Functioning Intervention for Children's Mental Health Services
This project aims to follow up on a prior project examining the impact of training therapists in an executive functioning intervention Unstuck and On Target (UOT) adapted for community mental health settings.
- Trial name
- NCT06651086
- Testing
- Unstuck and On Target, Unified Protocol for Children
- Where
- 2 sites in United States
- Volunteers
- 672 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Peritoneal Dialysis (PD), Large Language Models
Peritoneal Dialysis (PD) Specialized LLM for PD Management
This study conducted a randomized controlled trial using clinical vignettes to evaluate differences in the quality of PD management among two large language model-assisted workflows and a physician-only decision-making process…
- Trial name
- PIONEER-PD (NCT07539428)
- Testing
- Peritoneal dialysis-specialized large language model., Generalized LLM tools such as deepseek
- Where
- China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Prediabetes, Diabetes Prevention
Optimizing Implementation of the Intensive Diabetes Prevention Program
The goal of this clinical trial is to explore the effectiveness and implementation outcomes of the optimized Intensive Diabetes Prevention Program (IDPP) in District Health Centres.
- Conditions
- Prediabetes, Diabetes Prevention, Implementation Science
- Trial name
- NCT07412912
- Testing
- Standard IDPP, Optimized IDPP
- Volunteers
- 170 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke Acute, Stroke (CVA) or Transient Ischemic Attack
Evaluating the Effect of Nurse-Led Stroke Transitional Care in Tanzania
The goal of this observational study is to assess the effects of nurse-led stroke transitional care in stroke survivors, caregivers and healthcare providers who participate in nurse-led stroke transitional care program to improve…
- Trial name
- NCT07319312
- Testing
- Nurse-led stroke transitional care program
- Where
- Tanzania
- Volunteers
- 130 people
- Sponsor
- Shandong University
Homelessness, Opioid Education and Naloxone Distribution (OEND)
Homeless Overdose Prevention- Expansion
Homeless Overdose Prevention - Expansion (HOPE), tests implementation of overdose education and naloxone distribution (OEND), a program that targets homeless experienced Veterans at risk for overdose, including Veterans in…
- Conditions
- Homelessness, Opioid Education and Naloxone Distribution (OEND), Substance Use Disorder
- Trial name
- HOPE (NCT07716202)
- Testing
- Homeless Overdose Prevention- Expansion (HOPE) - Low Intensity, Homeless Overdose Prevention- Expansion (HOPE) - High Intensity
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- VA Office of Research and Development
COPD, Emphysema
Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD
Sarcopenia, or skeletal muscle loss, impacts up to 40% of COPD patients and is a major cause for morbidity and mortality. Despite the high clinical significance of sarcopenia in COPD, the diagnosis remains elusive because…
- Conditions
- COPD, Emphysema, Sarcopenia
- Trial name
- NCT07059637
- Testing
- Multidisciplinary clinic evaluation, COPD standard of care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The Cleveland Clinic
Hepatitis B, HIV
Integrating Hepatitis B Elimination Into the HIV Program in Zambia
The goal of this study is to develop an integrated HBV-HIV service care model in Zambia by working with people living with HBV, healthcare workers, policy makers and other key stakeholders to co-design an intervention.
- Conditions
- Hepatitis B, HIV, Implementation Science
- Trial name
- INTEGRATE B (NCT07875218)
- Testing
- Integrated HBV/HIV Service Delivery Model
- Where
- Zambia
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Pulmonary Embolism
Nudging Provider Adoption of Clinical Decision Support: Implementation of an EHR-Agnostic Pulmonary Embolism Risk Prediction Tool
The purpose of this study is to examine the impact of the nudge implementation strategy (CDS tool + Nudge) on adoption of guideline-concordant CT ordering for pulmonary embolism (PE) in 10 EDs.
- Trial name
- NCT07249385
- Testing
- Clinical Decision Support (CDS) tool with Nudges
- Where
- 3 sites in United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Breast Cancer
Design and Pilot Implementation of a Chatbot to Support Breast Cancer Screening Among Black Women
Black women are more likely than White women to be diagnosed at later stages and to die from breast cancer. Increasing breast cancer screening rates could help improve early detection of and survival from breast cancer.
- Trial name
- NCT07858825
- Testing
- Chatbot
- Volunteers
- 873 people, healthy volunteers welcome
- Sponsor
- University of Washington
Aortic Stenosis
Transfemoral Transcatheter Aortic Valve Implementation at Hospital Without On-site Cardiac Surgery: Early Clinical Outcome in Patients With Prohibitive Surgical Risk.
Study design: single arm, interventional and multicenter study. The objectives are evaluate Safety and efficacy of TAVI in Department of Cardiology without on site cardiac Surgery for symptomatic severe aortic valve stenosis by…
- Trial name
- NCT05886517
- Testing
- Transfemoral transcatheter aortic valve implementation
- Where
- 4 sites in Italy, Spain
- Volunteers
- 200 people
- Sponsor
- AUSL Romagna Rimini
Lung Cancer
Digital Health Implementation Strategies to Improve Lung Cancer Screening Among Safety-Net Clinics
The long-term goal of this program of research is to increase the reach of Lung Cancer Screening (LCS) among low-resource healthcare settings and populations.
- Trial name
- LUNG-IS (NCT07716280)
- Testing
- Text Messages (TM+), Chat bot (CA), Video
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Utah
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