Clinical trials: Implementation, open to volunteers
Sleep Deprivation, Critical Illness
Sleep Harmonization Via Bundled Team-Based Interventions in the ICU
SHANTI-ICU compares the effectiveness of two evidence-based multicomponent ICU sleep promotion bundles on delirium and patient-reported sleep quality in critically ill adults. Bundle A is a non-pharmacologic strategy.
- Conditions
- Sleep Deprivation, Critical Illness, Sleep-Wake Disorders, Bundle Care
- Trial name
- SHANTI-ICU (NCT07840560)
- Testing
- Nighttime noise & light reduction, Clustering patient-care interactions, Non-pharmacologic sleep aids
- Where
- 8 sites in United States, Puerto Rico
- Volunteers
- 62,500 people
- Sponsor
- University of California, San Diego
Acute Kidney Injury
Effectiveness-Implementation Evaluation of Acute Kidney Injury Decision Support
Study Purpose: This study is testing an artificial intelligence (AI)-powered clinical decision support (CDS) system designed to help emergency department (ED) doctors detect and manage acute kidney injury (AKI) earlier.
- Trial name
- SMART-AKI (NCT06840210)
- Where
- United States
- Volunteers
- 200,000 people
- Sponsor
- Johns Hopkins University
Hiv, Alcohol Use, Unspecified
Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care
Despite availability of evidence-based alcohol reduction interventions (EBI), unhealthy alcohol use remains a barrier to HIV medication adherence, viral suppression and retention in HIV care and consequently HIV treatment as…
- Trial name
- NCT05241990
- Testing
- Practice Facilitation, Alcohol Stepped Care
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV, Contingency Management
J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations
The goal of this clinical trial is to compare two interventions - Health Navigation and Health Navigation Plus among individuals who have been impacted by the criminal legal system.
- Conditions
- HIV, Contingency Management, Justice Involved Populations, Status Neutral Interventions
- Trial name
- J-RISE (NCT06477588)
- Testing
- Health Navigation, Health Navigation, Employment Navigation plus Contingency Management Intervention
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Antenatal Care, Maternal Health
AI Blind-Sweep Ultrasound for Antenatal Screening by Non-Specialist Health Workers in Rural DR Congo
FS2 evaluates the diagnostic accuracy and implementation feasibility of an AI-assisted blind-sweep obstetric ultrasound (SPAQ E-con AI), operated by trained non-specialist health workers, for antenatal screening in rural…
- Conditions
- Antenatal Care, Maternal Health, Gestational Age, Placenta Praevia
- Trial name
- FS2 (NCT07677670)
- Testing
- SPAQ E-con AI blind-sweep ultrasound
- Where
- Democratic Republic of the Congo
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- SOIK Corporation Sarl
Spinal Cord Injuries, Aging
Exercise and Nutrition Education for Older Adults With Spinal Cord Injury: A Pilot Randomized Controlled Trial
Older adults living with a spinal cord injury (SCI) experience an increased burden of secondary health conditions than, coupled with age-related complications, may negatively affect physical and mental health, as well as…
- Trial name
- NCT07845851
- Testing
- Individualized Exercise Training, Nutrition Education, Behavioral Support
- Volunteers
- 24 people
- Sponsor
- Wayne State University
Cataract (Post-operative Cataract Surgery Follow-up)
Vision Center Determinants of Cataract Follow-Up in Rural India
Cataract remains the leading cause of avoidable blindness in India despite substantial expansion of surgical services over the past two decades.
- Trial name
- NCT07513402
- Testing
- Follow-Up Strengthening Intervention Framework
- Volunteers
- 150 people
- Sponsor
- Seva Canada Society
Spinal Metastases, Spinal Tumors
SBRT Technique Implementation for Spinal Metastases Irradiation
Stereotactic body radiotherapy (SBRT) is a highly precise, image-guided radiotherapy technique delivering 1-5 high-dose fractions to spinal metastases.
- Conditions
- Spinal Metastases, Spinal Tumors, Bone Metastases
- Trial name
- NCT07429422
- Testing
- Stereotactic Body Radiotherapy (SBRT) for Spinal Metastases
- Where
- 2 sites in Slovenia
- Volunteers
- 100 people
- Sponsor
- Institute of Oncology Ljubljana
This Study Evaluates Interventions to Increase Surveillance Mammography Uptake for Early Breast Cancer Detection Among Singaporean Women in Real World
Community Study to Increase Mammogram Screening Among Overdue Women
Breast cancer is the most common cancer among women in Singapore, and regular mammogram screening can detect breast cancer early when treatment is more effective.
- Trial name
- IMPLEMENT (NCT07832396)
- Testing
- Evidence-based behavioural intervention
- Where
- Singapore
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Fecal Immunochemical Test, Colorectal Cancer Screening
Implementation Intention Planning Guide for FIT Colon Cancer Screening
Fecal immunochemical tests (FIT) are a primary method of screening for colorectal cancer (CRC). Implementation intention planning involves encouraging completion or eliminating barriers for the participant to make a plan to…
- Trial name
- NCT07183046
- Testing
- Implementation Intention Guide
- Where
- 5 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Insomnia Disorder, Mild Traumatic Brain Injury
Sleep MAPP in the Polytrauma/TBI System of Care
This pilot implementation trial will evaluate the Sleep Disorder Management Assistance for Providers and Patients (Sleep MAPP) Care Pathway in one Veterans Health Administration Polytrauma/TBI System of Care clinic.
- Trial name
- Sleep MAPP (NCT07886398)
- Testing
- Sleep MAPP Care Pathway
- Where
- 2 sites in United States
- Volunteers
- 900 people
- Sponsor
- VA Office of Research and Development
Low Back Pain
Implementation of P3C-LBP in Swedish Primary Care
The goal of this observational study is to evaluate the implementation of a patient centered coordination care (P3C) pathway for the management of patients with low back pain (LBP) in primary care, in Östergötland health care…
- Trial name
- P3C-LBP (NCT06240533)
- Where
- Sweden
- Volunteers
- 300,000 people
- Sponsor
- Linkoeping University
Substance Use Disorders, Pregnancy Related
Implementation of a Patient-centered, Reproductive Planning Decision Support Tool (MyPath) Among Women With Substance Use Disorder in the Immediate Postpartum Period
This is a study to determine the effect of a novel patient-centered, reproductive planning decision support tool developed by the research team called MyPath on postpartum contraceptive decision-making among women with SUDs.
- Conditions
- Substance Use Disorders, Pregnancy Related, Contraception
- Trial name
- IMPACT (NCT04939012)
- Testing
- MyPath Intervention, Usual care
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Pittsburgh
Acute Kidney Injury, Renal Replacement Therapy
FST Analysis Supporting Timely Therapy and Risk Assessment Via Clinical Decision Support for Kids
The goal of this study is to learn whether adding a clinical decision support tool to the electronic medical record helps clinicians use the furosemide stress test in critically ill children at high risk for severe acute kidney…
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Pediatric Intensive Care Unit
- Trial name
- FAST TRACK (NCT07718464)
- Testing
- Furosemide Stress Test Clinical Decision Support Tool
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Opioid Use Disorder, Opioid Use Disorder, Severe
Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses
This study is testing whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay in treatment for opioid use disorder (OUD) than referring them to community buprenorphine…
- Conditions
- Opioid Use Disorder, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
- Trial name
- BISTRO (NCT07631598)
- Testing
- Standard of Care Referral, Low Threshold Buprenorphine
- Where
- 8 sites in United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Depression and Anxiety Symptoms
Remote Group Cognitive Behavioral Skills Training for Mexican University Students With Anxiety or Depression
The aim is to assess the effectiveness of remote group cognitive behavioral skills training for reducing symptoms of depression and anxiety among university students in Mexico.
- Trial name
- NCT07776236
- Testing
- Remote group cognitive behavioral skills training, Mood monitoring web application
- Volunteers
- 400 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Frailty, Frailty at Older Adults
Implementation of the Personalized Care Plan (PCP) Proposed at the End of Step 2 of the ICOPE Program
The ICOPE (Integrated Care for the Elderly) program is based on an integrated approach including a personalized care plan (PCP).
- Trial name
- INEPPS (NCT07379099)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- MSPU de Pins-Justaret
Cervical Cancer, Cervical Cancer Screening
Human Papillomavirus Self-sampling for Enhancing Cervical Screening During the War in Ukraine
In 2020, a cervical screening center was established in Zaporizhzhia (Ukraine), initiating a pilot project to evaluate the prevalence of HPV among women in Eastern Ukraine.
- Conditions
- Cervical Cancer, Cervical Cancer Screening, Human Papillomavirus (HPV) Infection, Cervical Intraepithelial Neoplasia
- Trial name
- NCT07275333
- Testing
- HPV Self-Sampling Kit
- Where
- Ukraine
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Human Papillomavirus
Provider Recommendation and HPV Vaccination
In the United State, there are millions of US teens who are not vaccinated against the human papillomavirus (HPV) putting them at risk of getting HPV-related cancers.
- Trial name
- HPVV (NCT05365048)
- Testing
- Local Tailoring implementation strategy, Prescribed Strategy
- Where
- United States
- Volunteers
- 301,201 people
- Sponsor
- Kaiser Permanente
Child Behavior, Life Skill Development
Improving School Climate and Children's Well-being Through the Life Skills "Feel Good" Intervention in French Schools: A Controlled Before-and-After Study
Life skills are major determinants of health that can be influenced through health promotion initiatives. Numerous educational interventions exist to foster the development of life skills.
- Conditions
- Child Behavior, Life Skill Development, School Health, School
- Trial name
- FEEL GOOD (NCT07804940)
- Testing
- FEEL GOOD
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Université Paris Cité
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