Clinical trials: Implementation Research, open to volunteers
HIV, Smoking
A Patient-Oriented Research Mentoring Program in Tobacco Dependence and Implementation Science Research
The objective of this trial is to evaluate the effectiveness of "nudges" to clinicians, patients, or both in increasing referral to, and engagement with, tobacco use treatment services (TUTS) for HIV patients versus usual care.
- Conditions
- HIV, Smoking, Tobacco Use, Nicotine Dependence
- Trial name
- NCT05852860
- Testing
- Clinician Nudge, Patient Nudge
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Cancer
The Research of French PaRole OncO : A Peer Supported Program for Cancer Patients
Peer support is a valuable mode of accompaniment between individuals who are facing or have faced similar challenging life experiences.
- Trial name
- PROOF (NCT06817655)
- Testing
- PaRole OncO France : Individual peer support
- Where
- 2 sites in France
- Volunteers
- 720 people
- Sponsor
- Hospices Civils de Lyon
Vitreoretinal Lymphoma
Multicentre Implementation and Validation of a Molecular Diagnostic for VitreoRetinal Lymphoma
The goal of this observational study is to gain new insights into the changes in proteins, genes and other molecular biological substances in the aqueous humour, vitreous humour, blood serum and, in rare cases, retina/choroid…
- Trial name
- DecodeVRL (NCT05841914)
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Vinodh Kakkassery, MD
Chronic Obstructive Pulmonary Disease
Developing an Intervention to Optimize Virtual Care Adoption for COPD Management
VA is a leader in virtual care (VC), including the patient portal, mobile apps, and telehealth programs. VC has great utility for managing chronic conditions like chronic obstructive pulmonary disease (COPD).
- Trial name
- VC-OPTIONS (NCT05986214)
- Testing
- VC-OPTIONS
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Stress-related Problem, Depression, Anxiety
Harlem Strong Mental Health Coalition
Addressing health disparities, especially in the face of coronavirus pandemic, requires an integrated multi-sector equity-focused, community-based approach.
- Conditions
- Stress-related Problem, Depression, Anxiety, Mental Health Wellness
- Trial name
- NCT05833555
- Testing
- MH task-sharing training, Supervision, Learning Collaborative
- Where
- 2 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- City University of New York, School of Public Health
Pediatric Cancer
Multisite Implementation of COMPRENDO
COMPRENDO (ChildhOod Malignancy Peer Research NavigatiOn) is a multi-site randomized clinical trial (RCT) that uses a Hybrid Type 1 design, to test the effects of a clinical intervention on patient-level outcomes, while exploring…
- Trial name
- COMPRENDO (NCT06055296)
- Testing
- COMPRENDO Peer Navigation Intervention
- Where
- 4 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Prostate Cancer, Risk Assessment
PROstate Cancer Risk Calculator for ACTionable Clinical Decision-making in Nigeria
This study is a pilot trial that builds on findings from the validation of prostate cancer risk calculators in Nigerian men. The goal of the overall study is to improve the early detection of prostate cancer in a high-risk…
- Conditions
- Prostate Cancer, Risk Assessment, Clinical Decision Support Systems, Predictive Value of Tests
- Trial name
- PROACT (NCT07733440)
- Testing
- (a) Training and (b) Supported risk assessment
- Where
- Nigeria
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University
PTSD Symptoms, Violence Prevention
IPV Prevention Among FDP
Forcibly displaced women and their male partners experience compounding social and structural vulnerabilities to intimate partner violence (IPV) and mental health challenges, yet rigorous studies or examples of evidence-based…
- Conditions
- PTSD Symptoms, Violence Prevention, Depression and Anxiety Symptoms
- Trial name
- NCT07775677
- Testing
- EA$E-US, ongoing standard of care
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- George Mason University
Anxiety, Anxiety Disorders
Implementation of a Just-In-Time Adaptive Intervention for Adolescent Anxiety
The goal of this clinical trial is to evaluate a smartphone based just-in-time adaptive intervention (JITAI) tool to deliver somatic behavioral recommendations for anxiety management among youth.
- Conditions
- Anxiety, Anxiety Disorders, Anxiety Disorder of Childhood
- Trial name
- NCT06946823
- Testing
- Just-In-Time Adaptive Intervention for Adolescent Anxiety
- Volunteers
- 50 people
- Sponsor
- Trustees of Dartmouth College
Delirium, Neurocognitive Disorders
Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders
The goal of this clinical trial is to compare the Hospital Elder Life Program (HELP) with a family-augmented version of HELP (FAM-HELP), that includes family members and care partners, for the prevention of delirium in older…
- Conditions
- Delirium, Neurocognitive Disorders, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- ENHANCE (NCT05929703)
- Testing
- HELP, FAM-HELP
- Where
- 7 sites in United States
- Volunteers
- 1,900 people
- Sponsor
- University of Michigan
Implementation Research, Help Seeking
Teen Helpline Motivational Interviewing Study
The proposed study will establish a foundation for research within peer-delivered helplines for teens. It aims to evaluate the impact of a Motivational Interviewing training at peer-to-peer helpline.
- Trial name
- MI (NCT07639736)
- Testing
- Motivational Interviewing Training
- Where
- United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Intracerebral Hemorrhage, Intracerebral Haemorrhage
International Care Bundle Evaluation in Cerebral Hemorrhage Research
Spontaneous intracerebral haemorrhage (ICH) accounts for approximately 10-15% of all strokes but stands for 50% of stroke-related morbidity and mortality.
- Conditions
- Intracerebral Hemorrhage, Intracerebral Haemorrhage, Intraventricular Hemorrhage, Stroke
- Trial name
- I-CATCHER (NCT06429332)
- Testing
- Reversal of Oral anticoagulation within 30 minutes, Early intensive blood pressure lowering, Treatment of pyrexia
- Where
- 54 sites in United States, Australia and 6 more
- Volunteers
- 3,500 people
- Sponsor
- Region Skane
Loneliness, Social Isolation
Evaluating and Implementing The CONNECT Program - a Group-Based Telehealth Intervention to Reduce Social Isolation, Loneliness, and Mental Health Symptoms in Adults Ages 55+, Compared to Routine Community-Based Programming
Older adults in Canada are experiencing increasing levels of social isolation, loneliness, and mental health challenges, including anxiety and depression - trends that have worsened during and following the COVID-19 pandemic.
- Conditions
- Loneliness, Social Isolation, Depression Disorders, Anxiety
- Trial name
- NCT07107906
- Testing
- The CONNECT Program, Community Participation as Usual (Service as Usual)
- Where
- Canada
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Built Environment
Neighborhood Connect
The study is evaluating the effectiveness of an implementation strategy called Neighborhood Connect, which is designed to support residents' engagement in activities that improve the attractiveness, safety and livability of…
- Trial name
- NCT07780825
- Testing
- Neighborhood Connect
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Exposure to Environmental Pollution, Exposure to Household Air Pollution
Applied Implementation Research for Clean Cooking in Cambodia
The goal of this study is to learn how to help families in Cambodia switch to using electric induction stoves instead of traditional stoves that burn wood or charcoal.
- Trial name
- AIR-C3 (NCT06942715)
- Testing
- Electric Induction Cookstoves
- Where
- Cambodia
- Volunteers
- 6,150 people, healthy volunteers welcome
- Sponsor
- Emory University
HIV, Cervical Cancer
ACCESS: Accelerating Cervical Cancer Elimination Through the Integration of Screen-and-treat Services
While there has been a significant increase in the uptake of antiretroviral therapy among women living with HIV (WLHIV) in many low- and-middle income countries (LMICs), the coverage of cervical cancer screening and treatment…
- Trial name
- ACCESS (NCT06128304)
- Testing
- Core Implementation strategies, Core+ Enhanced Implementation Strategies
- Where
- 2 sites in United States, Nigeria
- Volunteers
- 2,436 people
- Sponsor
- University of California, San Diego