Clinical trials: Implementation Science
Mental Health, Substance Abuse
Reducing Stigma Toward Mental Illness and Substance Use Issues in Primary Health Care in Chile
This research project aims to determine the effectiveness of a comprehensive anti-stigma intervention in reducing stigmatizing attitudes and behaviours among Primary Health Care (PHC) providers toward individuals with mental…
- Conditions
- Mental Health, Substance Abuse, Stigmatization
- Trial name
- NCT05578066
- Testing
- Developing teams of Local Leaders, Analysis of Internal Policies, Procedures and Protocols, Raising Awareness
- Where
- Chile
- Volunteers
- 16 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Implementation Science, Diet, Food, and Nutrition
Sustainability Via Active Garden Education Wellness Implementation Strategies in Early Care and Education
This project compares four SAGE implementation strategies to evaluate effectiveness in implementation, sustainability, cost, and child health outcomes.
- Conditions
- Implementation Science, Diet, Food, and Nutrition, Child Care, Motor Behavior
- Trial name
- SAGE WISE (NCT07228819)
- Testing
- SAGE Basic, SAGE e-support, SAGE in-person support
- Where
- United States
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Palliative Therapy, Implementation Science
Clinical Surveillance Tool to Screen for Unmet Palliative Needs Among Patients in the Final Year of Life
One of the most important obstacles to improving end-of-life care is the inability of clinicians to reliably identify those who are approaching the end-of-life.
- Conditions
- Palliative Therapy, Implementation Science, Screening, Terminal Care
- Trial name
- HOMR (NCT04171830)
- Testing
- modified Hospital One-year Mortality Risk (mHOMR)
- Where
- 13 sites in Canada
- Volunteers
- 3,536 people
- Sponsor
- Ottawa Hospital Research Institute
Suicide, Primary Care
Implementing Suicide Prevention Into Primary Care in Nepal
Suicide remains a major contributor to global mortality, with particularly high and persistent rates in low-resourced settings such as South Asia.
- Trial name
- NCT07362056
- Testing
- Suicide Prevention Package (PSuPP)
- Where
- Nepal
- Volunteers
- 147 people
- Sponsor
- Yale University
Adolescent HIV Infection, Transition to Adult Care
Scale-up of an Evidence-based Adolescent Transition Package to Support Transitional Care Among Youth Living With HIV
Ending the HIV epidemic for youth living with HIV will require implementation and optimization of evidence-based interventions that address barriers to treatment.
- Conditions
- Adolescent HIV Infection, Transition to Adult Care, Implementation Science, Implementation Strategies
- Trial name
- ATTACH-Scale (NCT06924073)
- Testing
- ATP-Youth Enhanced Strategy (ATP-YES)
- Where
- 25 sites in Kenya
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- University of Washington
Implementation Science, Women Health
REmote Virtual Inspiration: Vitality and Energy
REVIVE is a randomized controlled trial designed to evaluate the effects of a remotely delivered seated Tai Chi/Qigong (TCQ) intervention on cardiometabolic health, stress, sleep, and psychological well-being among women with…
- Conditions
- Implementation Science, Women Health, Disability Physical, Meditation
- Trial name
- REVIVE (NCT07675681)
- Testing
- Accesible Tai Chi/Qigong (TCQ), Health Education Videos (HEV)
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Arizona State University
Fatty Liver, Nonalcoholic, Weight Loss
Feasibility of Immersive Virtual Reality Dietician Program in Metabolic-dysfunction Associated Steatotic Liver Disease
Metabolic-dysfunction associated steatotic liver disease, often referred to as "fatty liver disease", is a leading cause of liver failure.
- Conditions
- Fatty Liver, Nonalcoholic, Weight Loss, Virtual Reality, Implementation Science
- Trial name
- NCT06215131
- Testing
- In-person dietary weight loss counseling, Virtual reality dietary weight loss counseling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center
Tuberculosis, Latent Tuberculosis
Options for Delivering Isoniazid-Rifapentine (3HP) for TB Prevention (3HP Options Implementation Trial)
The Options for Delivering Isoniazid-Rifapentine (3HP) for TB Prevention (3HP Options Implementation Trial) study will be a three-arm, open-label, parallel, randomized trial.
- Conditions
- Tuberculosis, Latent Tuberculosis, HIV/AIDS
- Trial name
- NCT03934931
- Testing
- Streamlined weekly DOT visits, Weekly DOT visit reminders, Cost reimbursement DOT
- Where
- Uganda
- Volunteers
- 1,656 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Lung Cancer, Medication Adherence
Implementation Strategies for Monitoring Adherence in Real Time
The objective of this project is to identify effective strategies to help patients with lung cancer manage side effects and achieve optimal adherence to oral targeted therapies.
- Conditions
- Lung Cancer, Medication Adherence, Symptoms and Signs
- Trial name
- iSMART (NCT04347161)
- Testing
- Conversational Agent/Chatbot, Usual Care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Implementation Science
Leveraging Telepsychology and Behavioral Economics to Increase Fidelity to CBT
The goal of this study is to develop and test a telehealth tool intended to support community mental health clinicians to deliver cognitive behavioral therapy (CBT). The main aims of the study are to: 1.
- Trial name
- BENEFITS (NCT06601062)
- Testing
- Tele-BE
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Mental Health, Parenting Stress
SBIR/ STTR Family Check-up Online
The Family Check-Up Online, a digital health intervention, was designed to improve child mental health through family-centered intervention.
- Conditions
- Mental Health, Parenting Stress, Academic Achievement, Parenting Skills
- Trial name
- NCT06876246
- Testing
- Family Check-Up Online, FCU Online with Telehealth Coaching
- Where
- United States
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Survivorship, Cancer
ONLOOP Trial: Evaluating a New Surveillance and Support System for Survivors of Childhood Cancer in Ontario
The treatments that aim to cure cancer in children can lead to "late effects" such as second cancers and heart disease. Screening tests can help find late effects, but most adult survivors of childhood cancer do not complete…
- Conditions
- Survivorship, Cancer, Heart Diseases, Secondary Cancer
- Trial name
- NCT05832138
- Testing
- ONLOOP program
- Volunteers
- 900 people
- Sponsor
- The Hospital for Sick Children
Posttraumatic Stress Disorder (PTSD), Substance Use Disorders (SUD)
Project COMET: Massed Prolonged Exposure for PTSD and SUD
The goal of this clinical trial is to learn if Massed Prolonged Exposure Therapy (M-PE) can improve PTSD symptoms and reduce substance use in adults receiving intensive outpatient (IOP) treatment for substance use disorder (SUD).
- Conditions
- Posttraumatic Stress Disorder (PTSD), Substance Use Disorders (SUD), Comorbidity, Trauma and Stressor Related Disorders
- Trial name
- PROJECT COMET (NCT06968832)
- Testing
- Massed Prolonged Exposure Therapy (M-PE), Standard outpatient SUD care
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Rutgers, The State University of New Jersey
Drug Use Disorders, Illicit Drug Use
Addressing Barriers to Care for Substance Use Disorder Pilot Study
The Addressing Barriers to Care for Substance Use Disorder Pilot (ABC-SUD Pilot) was a randomized pilot study that preceded a larger trial.
- Conditions
- Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders
- Trial name
- ABCSUD Pilot (NCT06317987)
- Testing
- Care Navigation
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Kaiser Permanente
Recurrent Urinary Tract Infection
EHR-integrated rUTI Texting Platform
The goal of this clinical trial is to compare a texting platform to usual care for managing recurrent urinary tract infections (UTI).
- Trial name
- Urotrust (NCT06035601)
- Testing
- EHR-integrated texting platform (Urotrust), Usual care
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HIV Pre-exposure Prophylaxis, Stigma, Social
Adapting an Adolescent Friendly PrEP Program for Uasin Gishu County-Kenya
The purpose of this study is to examine the implementation ( e.g. training, reach, acceptability) of a a youth friendly pre-exposure prophylaxis (PrEP) peer mentorship program for Adolescents and Young Adults (AYA).
- Trial name
- NCT05545449
- Testing
- PrEP Peer Mentor Program
- Where
- Kenya
- Volunteers
- 5 people
- Sponsor
- Indiana University
Cancer, Exercise
From Exercise Oncology Research to Clinical Practice
Building on previous research that shows the benefits of exercise, this study aims to find out how best to implement exercise in real-world settings.
- Conditions
- Cancer, Exercise, Implementation of Evidence Based Programs, Cost Effectiveness
- Trial name
- PAC ICare (NCT07635589)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Melanie Keats
Polypharmacy, Insomnia
MIDAS Cluster Randomized Controlled Trial of Implementation Strategies to Optimize Use of Medications in VA Clinical Settings
Scientific advances are constantly leading to better treatments. However, it is quite challenging for healthcare systems, including VA, to ask very busy providers to change the way they practice.
- Conditions
- Polypharmacy, Insomnia, Anticoagulants
- Trial name
- MIDAS cRCT (NCT05065502)
- Testing
- Academic Detailing (AD), LEAP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- VA Office of Research and Development
Obesity, Child
Scaling up Building Healthy Families
Evidence-based interventions for childhood obesity (EBI-CO) can improve children's weight status, but families in rural areas and small cities have limited access to the interdisciplinary healthcare teams recommended to deliver…
- Trial name
- NCT07404839
- Testing
- Building Healthy Families Program
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Utah
Perinatal Depression
Perinatal Mental Health Screening and Early Community Intervention Using Digital Clinical Pathways (MATTER Project)
The MATTER project is a digital, community-based perinatal mental health screening and early intervention program implemented in primary care and hospital settings in the Alentejo region, Portugal.
- Trial name
- MATTER (NCT07659977)
- Where
- Portugal
- Volunteers
- 1,500 people
- Sponsor
- Universidade Nova de Lisboa