Clinical trials: Improve Physical Activity
Sedentary Lifestyle
Exercise Effects on Brain Health and Learning From Minutes to Months
Given the accelerating growth of older adults worldwide and the decline in cognitive function with aging, therapeutics that remediate age-related cognitive decline are needed more than ever.
- Trial name
- EXTEND (NCT03114150)
- Testing
- Cardiorespiratory fitness training, Functional fitness training
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Michelle W. Voss
Oxidative Stress, Dyslipidemias
Effects of Octacosanol During Taekwondo Training
Taekwondo players undergo rapid reductions of body weight prior to their competition in order to gain a size advantage over the opponent.
- Trial name
- NCT03557476
- Testing
- Octacosanol
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Kosin University
Rheumatoid Arthritis
Weight Loss and Exercise To Improve Rheumatoid Arthritis Cardiovascular Risk
This is a small exploratory, randomized, controlled trial. Twenty-six older (ages 60-80 yr.), obese (BMI 28-40 kg/m2) persons with rheumatoid arthritis (RA) (seropositive or erosive) will be randomized to 16 weeks of a counseling…
- Trial name
- SWET/CHAT (NCT04356183)
- Testing
- SWET: Supervised Weight loss and Exercise Training, CHAT: Counseling Health As Treatment
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Sedentary Lifestyle
Way to Be Active IV (Framing vs Incentives)
Employers are increasingly looking for opportunities to motivate sedentary employees to become more physically active. Workplace walking programs have had mixed success and typically show most improvement among participants that…
- Trial name
- NCT02030080
- Testing
- Financial incentives, Teams, Framing of feedback
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- University of Pennsylvania
Chronic Pain, Obesity
A Mobile Intervention to Reduce Pain and Improve Health (MORPH)
Chronic pain contributes to declining health and function in older adults; effects that are intensified by obesity and sedentary (sitting) behavior.
- Conditions
- Chronic Pain, Obesity, Sedentary Lifestyle
- Trial name
- NCT03377634
- Testing
- MORPH
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Wake Forest University Health Sciences
Stroke
A Study in Chinese Patients to Compare How Tenecteplase and Alteplase Given After a Stroke Improve Recovering of Physical Activity
This study is open to Chinese adults who had an ischaemic stroke, which means that blood vessels in the brain are blocked. To resolve blood clots, people in the study get either tenecteplase or alteplase within 4 hours and 30…
- Trial name
- ORIGINAL (NCT04915729)
- Testing
- tenecteplase, alteplase
- Where
- 55 sites in China
- Volunteers
- 1,489 people
- Sponsor
- Boehringer Ingelheim
Mechanical Low Back Pain, Chronic Low Back Pain
Spinal Control During Functional Activities to Improve Low Back Pain Outcomes
Exercise is one of the primary interventions used with people with chronic, mechanical low back pain. It is unknown, however, which exercise is best for which person, which exercises a person will adhere to and for how long, and…
- Trial name
- LBP (NCT02027623)
- Testing
- Motor skill training, Strength and flexibility exercise
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Washington University School of Medicine
Peripheral Arterial Disease
Exercise and Weight Loss in PAD
This study is designed to examine the added benefits of weight loss to an exercise program in older obese Veterans with peripheral arterial disease.
- Trial name
- Action3 (NCT02607033)
- Testing
- Exercise, Weight Loss
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- VA Office of Research and Development
Motor Activity, Health Behavior
Targeting Physical Activity to Improve Cardiovascular Health in Type 2 Diabetes
This study plans to learn more about physical activity and physical function in sedentary older adults with type 2 diabetes.
- Conditions
- Motor Activity, Health Behavior, Diabetes Mellitus, Type 2
- Trial name
- NCT02473926
- Testing
- Physical Activity, Questionnaires
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Colorado, Denver
Osteoarthritis
Mobile Motivational Physical Activity Targeted Intervention
More than 50% of older persons with osteoarthritis (OA) experience disrupted sleep and insomnia symptoms of difficulty falling asleep, awakening during the night, and awakening too early and being unable to fall back to sleep.
- Trial name
- MobMPATI (NCT03160287)
- Testing
- Motivaltional interviews and infrequent motivational text messages
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Washington
Type 1 Diabetes
Coin2Dose: Behavioral Economics to Promote Insulin BOLUS Activity and Improve HbA1c in Teens
Our objective is to test the feasibility, acceptability, and initial efficacy of using behavioral economics incentives (BEI) in a novel, semi-automated intervention to target daily insulin BOLUS scores in adolescents with…
- Trial name
- Coin2Dose (NCT05280184)
- Testing
- Coin2Dose
- Where
- 2 sites in United States
- Volunteers
- 173 people
- Sponsor
- Nemours Children's Clinic
Hip Fracture, Frailty
Starting a Testosterone and Exercise Program After Hip Injury
This study is a randomized controlled double-blinded multi-center clinical trial enrolling female hip fracture patients who are 65 and older.
- Conditions
- Hip Fracture, Frailty, Sarcopenia
- Trial name
- STEP-HI (NCT02938923)
- Testing
- Testosterone, Supervised exercise training, Home exercise program
- Where
- 8 sites in United States
- Volunteers
- 129 people
- Sponsor
- Washington University School of Medicine
Physical Activity, Acute Coronary Syndrome
Evaluating Increasing Physical Activity After Acute Coronary Syndrome
This study will use a randomized, controlled trial to test the effectiveness of a home-based physical activity program using wearable devices and financial incentives.
- Trial name
- NCT02531022
- Testing
- Financial incentive, Daily feedback
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Multiple Sclerosis
Study of Behavioral Modification Program and Mirabegron to Improve Urinary Urgency in Multiple Sclerosis
The purpose of this study is to determine if treatment with Mirabegron will improve urinary urgency control beyond that achieved with pelvic floor exercises alone
- Trial name
- MIRROR (NCT02086188)
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Theodore R. Brown, MD MPH
Diabetes Mellitus, Type 2
FAMS Mobile Health Intervention for Diabetes Self-care Support
This study evaluates a family-focused mobile phone-delivered intervention, called FAMS (Family-focused Add-on for Motivating Self-care), in supporting adults with type 2 diabetes in their self-management relative to a control…
- Trial name
- NCT02481596
- Testing
- REACH + FAMS, REACH, Helpline & A1c results
- Where
- United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Aging, Sarcopenia
Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health
What are the effects of resistance exercise (RE) alone or RE plus low intensity physical activity (LPA) breaks in sedentary time (ST) on skeletal muscle health in older adults? What are the effects of resistance exercise (RE)…
- Conditions
- Aging, Sarcopenia, Disability Physical, Cardiovascular Diseases
- Trial name
- REALPA (NCT03771417)
- Testing
- Exercise Intervention
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Louisiana State University and A&M College
Cerebral Palsy, Central Nervous System Diseases
Power Training Combined With Interval Treadmill Training
Ambulatory children with cerebral palsy (CP) experience walking limitations which negatively influence their ability to physically participate in day to day life.
- Conditions
- Cerebral Palsy, Central Nervous System Diseases, Brain Damage, Chronic
- Trial name
- PT³ (NCT03625570)
- Testing
- Power training combined with interval treadmill training, Strength training combined with traditional treadmill training
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Physiological Stress
Exercise and Stress Management Post Autologous and Allogeneic Transplant (BMT CTN 0902)
This is a Phase III, randomized, unblinded, multicenter, prospective comparative study. The purpose of this study is to test whether exercise or stress management training delivered to autologous and allogeneic hematopoietic cell…
- Trial name
- NCT01278927
- Testing
- Exercise, Stress Management, Exercise and Stress Management
- Where
- 19 sites in United States
- Volunteers
- 711 people
- Sponsor
- Medical College of Wisconsin
Spinal Cord Injuries, Paraplegia
Multimodal Exercises to Improve Leg Function After Spinal Cord Injury
Many people with spinal cord injury (SCI) retain at least some movement below their injury, but their muscles often have a 'mind of their own'.
- Conditions
- Spinal Cord Injuries, Paraplegia, Paraparesis
- Trial name
- NCT01740128
- Testing
- Robotic body weight supported treadmill training, Harness-supported multimodal balance training
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- VA Office of Research and Development
Geriatric, Exercise Adherence
Adherence for Exercise Rehabilitation in Older People Trial
Exercise is an effective treatment modality for many chronic conditions. The effectiveness of prescribed exercise can be limited by adherence to exercise programmes.
- Trial name
- AERO (NCT03643432)
- Testing
- Exercise adherence intervention, Usual Care
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Oxford University Hospitals NHS Trust