Clinical trials: In Vitro Fertilization
Polycystic Ovary Syndrome, Infertility
Live Birth After Fresh Embryo Transfer Vs Frozen-thawed Embryo Transfer in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of childbearing age. However, the optimal infertility treatment for PCOS patients is still a matter of controversy.
- Trial name
- FreFro-PCOS (NCT01841528)
- Testing
- fresh embryo transfer, frozen-thawed embryo transfer
- Where
- 14 sites in China
- Volunteers
- 1,180 people
- Sponsor
- Zi-jiang Chen
IVF Cycle, Ovarian Stimulation
Efficacy and Safety of Medication Used to Stimulate Ovulation
Individuals undergoing In Vitro Fertilization must undergo controlled ovarian hyperstimulation (COH) to produce enough quality eggs for fertility treatment.
- Conditions
- IVF Cycle, Ovarian Stimulation, Egg Retrieval, Pregnancy
- Trial name
- NCT02715336
- Testing
- Ovulation induction with hCG and Lupron (GnRH agonist)
- Where
- Canada
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- Create Fertility Center
Dietary Supplements
Effectiveness of Adjuvant Supplements Prior to in IVF
To investigate the effect of combined DHEA, CoQ10 and tocotrienol on IVF cycles in poor ovarian responders
- Trial name
- NCT05471453
- Testing
- DHEA, DHEA+CoQ10+Tocotrienol
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Infertility, Assisted Reproductive Technology
Prognostic Value of Progesterone on Oocyte Retrieval Day for In Vitro Fertilization Outcome
This observational study aims the potential role of serum progesterone levels on the day of oocyte pick-up on the probability of pregnancy, in patients undergoing antagonist IVF cycles.
- Trial name
- NCT02109900
- Testing
- Serum Progesterone Levels
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Infertility
Comparison of the Accuracy and Reliability of AMH, FSH and AFC in Predicting Ovarian Response
Serum bio-markers have different prediction values for ovarian response during ovarian stimulation in-vitro fertilization
- Trial name
- AMH FSH AFC (NCT02173444)
- Testing
- Blood test
- Where
- Vietnam
- Volunteers
- 820 people
- Sponsor
- Vietnam National University
Migraine
Migraine and Infertility
The purpose of this study is to determine the prevalence of migraine in infertile women and during in Vitro Fertilization protocol. Migraine is two to three times as common in women as in men.
- Trial name
- FERTIMIG (NCT03831659)
- Testing
- self-questionnaires
- Where
- France
- Volunteers
- 137 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility (IVF Patients)
Study of Abnormally Fertilized Embryos
The goal of this observational study is to determine the diploidy rate of haploid and triploid embryos from in vitro fertilization (IVF) cycles.
- Trial name
- SAFE (NCT06940973)
- Testing
- Parental samples, PGT-A, TE rebiopsies and spent blastocyst media collection
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Igenomix
IVF, Frozen Embryo Transfer
Lipiodol Prior to FET (LIFE)
Lipiodol® flushing is an effective fertility treatment for women with unexplained infertility. It is speculated that the treatment effect could work through a direct effect of Lipiodol® on the endometrium.
- Conditions
- IVF, Frozen Embryo Transfer, Hysterosalpingography
- Trial name
- LIFE (NCT06563908)
- Testing
- Lipiodol® uterine treatment prior to IVF/ICSI
- Volunteers
- 784 people
- Sponsor
- Mỹ Đức Hospital
Controlled Ovarian Stimulation
A Study to Assess the Efficacy and Safety of Ganirelix (Orgalutran®) Treatment in Chinese Women Undergoing Controlled Ovarian Stimulation for in Vitro Fertilization (IVF) or Intra Cytoplasmatic Sperm Injection (ICSI) (Study 38651)(P05703)
The primary purpose of this study is to assess that ganirelix is safe and well-tolerated in Chinese women and that a controlled ovarian stimulation (COS) protocol combining recombinant follicle stimulating hormone (recFSH) with…
- Trial name
- NCT00725491
- Testing
- ganirelix, triptorelin
- Volunteers
- 259 people
- Sponsor
- Organon and Co
Infertility
Efficacy and Safety of Shen Que (RN8) Moxibustion in Unexpected POR
Moxibustion of Shen Que (RN8) can increase the number of embryos available for transfer, thus improving pregnancy outcomes in women of advanced reproductive age who experience unexpected poor ovarian response.
- Trial name
- NCT05653557
- Testing
- Shen Que Moxibustion
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Preimplantation Diagnosis
RCT of niPGT for Aneuploidy and Morphology Compared With Morphology Alone in IVF
This study is to compare the efficacy in embryo selection based on morphology alone compared to morphology and non-invasive preimplantation genetic testing for aneuploidy (NIPGT-A) in infertile women undergoing in vitro…
- Trial name
- NCT04474522
- Testing
- Non-invasive Preimplantation genetic testing for aneuploidy status
- Where
- China
- Volunteers
- 517 people
- Sponsor
- The University of Hong Kong
Endometriosis, Infertility
Impact of Complete Surgery of Colorectal Deep Infiltrating Endometriosis on Fertility
The ENDOFERT Study is an open, multicenter, randomized, parallel-group, controlled trial. This study includes patients presenting colorectal DIE and infertility.
- Trial name
- ENDOFERT (NCT02948972)
- Testing
- complete surgery, In vitro fertilization without surgery
- Where
- 5 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Lille
Habitual Abortion, Recurrent Pregnancy Loss
Intravenous Immunoglobulin and Prednisolone for RPL After ART.
Recurrent pregnancy loss (RPL) affects around 5 % of women in reproductive age. The underlying cause of RPL is most often unknown, probably multifactorial, and no treatment with documented effect on chance of live birth exists.
- Conditions
- Habitual Abortion, Recurrent Pregnancy Loss, Fertility Disorders, Miscarriage
- Trial name
- RPL (NCT04701034)
- Testing
- Human Intravenous Immunoglobulins, (Privigen (R), CLS Behring), Prednisolone Tablets, Human Albumin Solution
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Aalborg University Hospital
Infertility, Genetic Diseases
Time-Lapse Incubation for Embryo Culture - Morphokinetics and Environmental Stability
Embryo culture and selection has been a continuous challenge in evolution since the birth of In Vitro Fertilization (IVF). Traditionally, embryo quality and its presumed suitability for transfer were assessed based on morphologic…
- Trial name
- NCT02657811
- Testing
- Miri, Benchtop Multi-room incubator, Miri TL, Time-Lapse incubator
- Where
- Israel
- Volunteers
- 372 people
- Sponsor
- Shaare Zedek Medical Center
Infertility
Efficiency of Comprehensive Chromosomal Testing of Trophectoderm Biopsies of Blastocysts in In Vitro Fertilization
Preimplantation embryo aneuploidy is a major source of adverse outcomes in human reproduction since it leads to implantation failure, early pregnancy loss or severe chromosomal diseases.
- Trial name
- Devit (NCT04758819)
- Testing
- Comprehensive chromosomal Testing of Trophectoderm biopsies of Blastocysts (CTTEB)
- Where
- 10 sites in France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
In Vitro Fertilization
Effect of Super-GDF9 on CAPA-IVM of COCs From Small Antral Follicles
CAPA-IVM (In Vitro Maturation) technology is an assisted reproductive method offering significant benefits in terms of safety and treatment costs, particularly for high-risk patients.
- Trial name
- sGDF-9 (NCT06766604)
- Testing
- Super-GDF9 supplementation during CAPA-IVM, Conventional CAPA-IVM
- Where
- Vietnam
- Volunteers
- 9 people
- Sponsor
- Mỹ Đức Hospital
PCOS, IVF
IVM Versus IVF in High Antral Follicle Count Patients
In vitro maturation (IVM) is postulated to be an alternative to conventional in vitro fertilization (IVF) to avoid ovarian hyperstimulation syndrome.
- Conditions
- PCOS, IVF, IVM
- Trial name
- NCT03405701
- Testing
- IVM, IVF
- Where
- Vietnam
- Volunteers
- 546 people
- Sponsor
- Mỹ Đức Hospital
Infertility/Sterility
Cetrorelix and Ganirelix Flexible Protocol for (IVF)
Recombinant gonadotropins are currently used for ovarian stimulation in women undergoing to IVF for infertility. Recently new flexible protocols have been introduced: the "single dose" and "multiple dose" protocol.
- Trial name
- IVF (NCT03477929)
- Testing
- Ganirelix Acetate, Cetrorelix Acetate
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Infertility, Male Factor Infertility
A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence
This research is being done to determine if producing sperm after an ultrashort period of abstinence (1 hour of abstinence) will be effective in improving the rates of embryos with normal chromosomes (structures that carry…
- Trial name
- NCT07062237
- Testing
- Ultrashort abstinence, Standard abstinence
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- UConn Health
Patient Education
Preimplantation Genetic Testing for Aneuploidy Counseling
Purpose: To evaluate preimplantation genetic testing counseling interventions on patients undergoing in vitro fertilization treatment.
- Trial name
- PGT-A (NCT06018454)
- Testing
- Handout on PGT-A, Handout on PGT-A and genetic counseling
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Eyup Hakan Duran