Clinical trials: In-Hospital Cardiac Arrest
Sudden Death, Out-Of-Hospital Cardiac Arrest
Head-to-pelvis Computed Tomography Evaluation of Sudden Death Survivors
Out-of-hospital arrest can occur from multiple etiologies. In patients without an obvious reason for the sudden-death event, diagnostic evaluation is not clear.
- Trial name
- NCT03111043
- Testing
- Head to pelvis CT scan
- Where
- 2 sites in United States
- Volunteers
- 104 people
- Sponsor
- University of Washington
Cardiac Arrest
Non-invasive Neurological Evaluation During CPR
Cardiac arrest remains a leading cause of death, currently affecting >250,000 Europeans outside the hospital each year. Manual cardiopulmonary resuscitation (CPR) provides between 15 to 30 % of normal blood flow to the heart and…
- Trial name
- Neuro-E-CPR (NCT02684955)
- Testing
- Cerebral spectroscopy, Pupillometry
- Where
- 2 sites in France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Grenoble
Heart Arrest, Out-Of-Hospital, Opioid Overdose
Naloxone for Opioid Associated Out of Hospital Cardiac Arrest
The investigator's long-term goal is to conduct Naloxone for Opioid Associated out of Hospital Cardiac Arrest (NOPACA), a randomized, double blind, controlled trial to determine the efficacy of naloxone vs.
- Conditions
- Heart Arrest, Out-Of-Hospital, Opioid Overdose, Naloxone
- Trial name
- NOPACA (NCT06251609)
- Testing
- Naloxone 2 MG, Saline 2ml
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of California, San Francisco
Out-of-Hospital Cardiac Arrest, Blood Pressure
Blood Pressure and OXygenation Targets After OHCA
This study compares two blood pressure targets and two oxygenation targets in the post-resuscitation care of comatose out-of-hospital cardiac arrets patients.
- Conditions
- Out-of-Hospital Cardiac Arrest, Blood Pressure, Hemodynamic Instability
- Trial name
- BOX (NCT03141099)
- Testing
- Low normal MAP, High normal MAP, Low normal PaO2.
- Where
- 2 sites in Denmark
- Volunteers
- 802 people
- Sponsor
- Jesper Kjaergaard
Out-of-hospital Cardiac Arrest
Save Hearts in Arizona Registry and Education (SHARE) Project
Evaluation of the impact of bystander CPR, prehospital resuscitation protocols, and hospital post-resuscitation protocols for out-of-hospital cardiac arrest patients in the state of Arizona.
- Trial name
- SHARE (NCT01999036)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- University of Arizona
Virtual Reality, Heart Arrest
Traumatic Cardiac Arrest and Trauma SimVR Training
The goal of this single-center, prospective, randomized, controlled trial is to evaluate the effectiveness of using virtual reality technology to provide learners with skills and knowledge in the management of traumatic cardiac…
- Trial name
- Trauma SimVR (NCT06445764)
- Testing
- e-learning, Virtual reality training
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cardiac Arrest
Pre-Hospital Cooling in Cardiac Arrest Patients
Type of study: Pilot prospective nonrandomized feasibility clinical study. Aim of the study: To assess the feasibility of pre-hospital therapeutic mild hypothermia in patients successfully resuscitated from out-of-hospital…
- Trial name
- PRE-COOL (NCT00915421)
- Testing
- Induction of therapeutic mild hypothermia
- Where
- 2 sites in Czechia
- Volunteers
- 40 people
- Sponsor
- Emergency Medical Service of the Central Bohemian Region, Czech Republic
Cardiac Arrest, Cardiac Arrest Circulatory
Resuscitative TEE Collaborative Registry
The general objective of this study is to evaluate the clinical impact and safety of focused, point-of-care transesophageal echocardiography (TEE) used during the evaluation of critically-ill patients in the emergency and…
- Conditions
- Cardiac Arrest, Cardiac Arrest Circulatory, Cardiac Arrest, Out-Of-Hospital, Shock
- Trial name
- rTEECoRe (NCT04972526)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
Cardiac Arrest, Coma
Out-of-Hospital Intubation With Metal Single Use Laryngoscope Blades
New single use laryngoscope metal blades are available for intubation. This type of blade is safer than the reusable ones concerning the interhuman cross infection risk.
- Conditions
- Cardiac Arrest, Coma, Major Trauma, Respiratory Distress
- Trial name
- LAMETA (NCT00644722)
- Testing
- MacIntosh Green Lite (metal single use laryngoscope blades), MacIntosh Green Spec II (metal reusable laryngoscope blades)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Henri Mondor University Hospital
Out-of-Hospital Cardiac Arrest, Death, Sudden, Cardiac
The Use of Mobile Phones in Out of Hospital Cardiac Arrest to Increase Bystander CPR
Death from cardiac disease is one of the most common causes of death in the western world. The majority of these deaths takes place outside hospital as sudden cardiac death.
- Conditions
- Out-of-Hospital Cardiac Arrest, Death, Sudden, Cardiac, Heart Diseases, Ventricular Fibrillation
- Trial name
- RUMBA (NCT01789554)
- Testing
- MLS dispatch for bystander CPR
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Karolinska Institutet
Basic Life Support
Pedagogical Aspects on Training in Basic Life Support
Cardio vascular disease (CVD) including out-of-hospital cardiac arrest (OHCA) is still the leading cause of death in a global perspective.
- Trial name
- NCT03618888
- Testing
- Instructor-led training, Self-learning training
- Where
- Sweden
- Volunteers
- 2,623 people, healthy volunteers welcome
- Sponsor
- University of Boras
Cardiac Arrest, Out-Of-Hospital, Hypotension and Shock
BCG Biosensor and Non- and Invasive Monitoring During Emergency Medicine Cases, a Prospective Feasibility Study
In a out of hospital emergency medicine study the investigators will measure hemodynamic effects of implemented treatments for patients with cardiac arrest, hypotension, and intensive care transports.
- Trial name
- NCT04891380
- Testing
- LUCAS 2 Active Decompression 2, Hypotension, Intensive care transport
- Where
- Norway
- Volunteers
- 183 people
- Sponsor
- Oslo University Hospital
Out-of-Hospital Cardiac Arrest, Pulmonary Ventilation
CAvent-Ventilation During Advanced Cardiopulmonary Resuscitation in Out-of-hospital Cardiac Arrest- an Observational Study
The aim of this observational study is to investigate how ventilations is given during cardiopulmonary resuscitation (CPR) given by advanced life support providers (ALS).
- Trial name
- CAvent (NCT04237727)
- Testing
- Fluxmed GrH portable pneumotachograph
- Where
- 5 sites in Netherlands, Sweden
- Volunteers
- 241 people
- Sponsor
- Uppsala University
Cardiac Arrest
Develop, Implement and Assess Effectiveness of Early Warning Score (EWS) for Moneragala District General Hospital
Rationale: Early detection and timely interventions are important determinants of clinical outcome in people with acute illness.
- Trial name
- EWS (NCT02523456)
- Testing
- Training, Introduce EWS
- Where
- Sri Lanka
- Volunteers
- 18,000 people
- Sponsor
- Ministry of Health, Sri Lanka
Out-of-Hospital Cardiac Arrest (Simulated)
Simulation and Feasibility Study of Drone-Delivered AED for Out-of-Hospital Cardiac Arrest
Background: Survival after out-of-hospital cardiac arrest (OHCA) depends heavily on early defibrillation. Reducing the time from cardiac arrest to defibrillation is a key factor in improving survival.
- Trial name
- NCT07508774
- Testing
- Drone-Based AED Delivery System, Standard Ground Ambulance Response Pathway Simulation
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ye Sheng
Heart Arrest, Out-Of-Hospital, CardioPulmonary Resuscitation
Ventilation in Cardiac Arrest Resuscitation Study
Out-of-hospital cardiac arrest (OHCA) is a major public health problem, with around 40,000 victims each year in France. Their survival rate remains dramatically low, at less than 10%.
- Conditions
- Heart Arrest, Out-Of-Hospital, CardioPulmonary Resuscitation, Basic Cardiac Life Support
- Trial name
- VECARS (NCT05992454)
- Testing
- EOLIFE
- Where
- France
- Volunteers
- 120 people
- Sponsor
- French Defence Health Service
Cardiopulmonary Arrest
REBOA in Nontraumatic OHCA
The investigators propose a multicenter randomized controlled trial in South Korea and Taiwan to observe the clinical effects of REBOA on nontraumatic out-of-hospital-cardiac-arrest (OHCA) patients.
- Trial name
- REBOA (NCT06031623)
- Testing
- REBOA
- Where
- South Korea
- Volunteers
- 234 people
- Sponsor
- Seoul National University Hospital
In-hospital Cardiac Arrest
Coverage and Validity of the Swedish Registry of Cardiopulmonary Resuscitation Regarding In-hospital Cardiac Arrest
The study will have an observational retrospective cross-sectional design. Patient records and hospital administrative systems at 10 hospitals in Sweden will be searched using ICD-codes to find all patients treated for an…
- Trial name
- NCT05184972
- Where
- Sweden
- Volunteers
- 1,109 people
- Sponsor
- Dalarna University
Out-Of-Hospital Cardiac Arrest (OHCA)
NEUROprotection Via optimizINg Cerebral Blood Flow afTer cArdiaC arresT (NEURO-INTACT) Study
This single-center proof of concept study aims to assess the efficacy of a blood pressure strategy targeting person- and time-specific cerebral blood flow compared with standard-of-care using neuron-specific enolase as a…
- Trial name
- NCT05679739
- Testing
- Individualized blood pressure strategy
- Where
- Singapore
- Volunteers
- 49 people
- Sponsor
- National University Hospital, Singapore
Cardiac Arrest, Pediatric ALL
Pediatric In-Hospital Cardiac Arrest International Registry (PACHIN)
: An intrahospital CA data recording protocol has been designed following the Utstein model. Database is hosted according to European legislation regarding patient data protection. It is drafted in English and Spanish.
- Conditions
- Cardiac Arrest, Pediatric ALL, In-hospital Cardiac Arrest
- Trial name
- PACHIN (NCT04675918)
- Testing
- Cardiac arrest
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Jimena del Castillo