Clinical trials: In-Hospital Cardiac Arrest
Out of Hospital Cardiac Arrest
Developing a Digital Handover Application for Paramedics to Provide a Personalized Approach to Pre-hospital Stratification for Out of Hospital Cardiac Arrest
A prospective study validating the role of the MIRACLE2 score in patients with resuscitated out of hospital cardiac arrest in a pre-hospital setting.
- Trial name
- RAPID-MIRACLE (NCT05185063)
- Testing
- Point of Care blood test
- Volunteers
- 500 people
- Sponsor
- King's College London
Heart Arrest, Cardiac Arrest
Resuscitation Outcomes in the Netherlands
The Resuscitation Outcomes in the Netherlands - study assesses one-year survival and quality of life after In-Hospital Cardiac Arrest(IHCA).
- Conditions
- Heart Arrest, Cardiac Arrest, Cardiac Arrest as A Complication of Care, Outcome, Fatal
- Trial name
- ROUTiNE (NCT03120507)
- Where
- 12 sites in Netherlands
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Altered Mental Status, Sepsis
Pre-hospital Ventilation Clinical Study
This study will collect and characterize ventilator use during patient care with a ZOLL 731 Series ventilator in a pre-hospital setting.
- Conditions
- Altered Mental Status, Sepsis, Heart Failure, Hemorrhage
- Trial name
- NCT05604430
- Testing
- 731 Series Ventilator
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- Zoll Medical Corporation
Cardiac Arrest
Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest
Recent studies have suggested that arginine-vasopressin could be more effective in the treatment of cardiac arrests. The last published study did not outline obvious improvements in the prognosis of all cardiac arrests but…
- Trial name
- NCT00127907
- Testing
- epinephrine (1 mg/1 mL), arginine-vasopressin (40 UI/2 mL)
- Where
- France
- Volunteers
- 2,416 people
- Sponsor
- Hospices Civils de Lyon
Out-of-Hospital Cardiac Arrest
Arizona Prehospital CPR Quality Improvement Project
The quality of cardiopulmonary resuscitation (CPR) provided to patients with out-of-hospital cardiac arrest (OHCA) is often suboptimal.
- Trial name
- NCT01258244
- Testing
- Audiovisual Feedback
- Where
- 2 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Valleywise Health
In-hospital Cardiac Arrest
National Cardiac Arrest Survey
The aim of this study is to describe incidence of "in-hospital" deaths and outcomes after attempted cardiac arrest resuscitation, availability of resuscitation equipment and medical staff training in state Hospitals of Sri Lanka.
- Trial name
- NCAS (NCT02368392)
- Testing
- Exposure for cardiac arrests
- Where
- Sri Lanka
- Volunteers
- 537 people
- Sponsor
- Ministry of Health, Sri Lanka
Pain, Out-of-hospital Cardiac Arrest (OHCA)
Pain After Cardiac Arrest and Resuscitation (PAINCARE)
The PAINCARE substudy is an observational cohort substudy nested within the international STEPCARE trial, which evaluates sedation, temperature, and mean arterial pressure strategies after out-of-hospital cardiac arrest.
- Trial name
- PAINCARE (NCT07564778)
- Where
- 3 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Out-Of-Hospital Cardiac Arrest
Out-of-hospital Cardiac Arrest Epidemiology and Outcomes in Kaunas 2016-2021
Out-of-hospital cardiac arrest rate is common problem, because of high mortality rate. It is not clear incidence rate, epidemiology and outcomes in Lithuania and Kaunas city included.
- Trial name
- NCT04784117
- Testing
- Dispatcher protocol change
- Where
- 2 sites in Lithuania
- Volunteers
- 1,500 people
- Sponsor
- Lithuanian University of Health Sciences
Resuscitation, Emergency Department
The Association Between Post-resuscitation Time Series Management in the Emergency Department and Short-term Outcomes for Out-of-hospital Cardiac Arrest Patients
This study examines the impact of emergency department (ED) management on short-term outcomes of nontraumatic adult out-of-hospital cardiac arrest (OHCA) patients.
- Conditions
- Resuscitation, Emergency Department, Outcome
- Trial name
- NCT06165081
- Where
- Taiwan
- Volunteers
- 6,000 people
- Sponsor
- National Taiwan University Hospital
Cardiac Arrest
Kneeling Posture With a Kneeling Stool During Cardiopulmonary Resuscitation in Hospital
To perform chest compression (CC) in the kneeling posture in hospital, we designed a stage with stairs, named the 'kneeling stool', on which a CC performer kneels beside a patient on a bed.This work is the validation study to…
- Trial name
- NCT02043028
- Testing
- Chest compression with a step stool, Chest compression with a kneeling stool
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hanyang University
Heart Arrest, Out-Of-Hospital, Computed Tomography
Head Computed Tomography for Predicting Neurological Outcome After Cardiac Arrest
The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) joint guidelines for post-resuscitation care recommend a multimodal approach to prognostication of neurological outcome.
- Conditions
- Heart Arrest, Out-Of-Hospital, Computed Tomography, Unconsciousness, Neurologic Deficits
- Trial name
- NCT03913065
- Testing
- CT
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Lund University
Out-Of-Hospital Cardiac Arrest After Initial Successful Resuscitation, Out of Hospital Cardiac Arrest
RESTORE-ZG: Return of Effective Spontaneous Circulation Resuscitation Evaluation Canton of Zug
This study looked at cardiac arrest that happens outside a hospital. Cardiac arrest means the heart suddenly stops pumping blood. When this happens, a person collapses and needs help right away.
- Conditions
- Out-Of-Hospital Cardiac Arrest After Initial Successful Resuscitation, Out of Hospital Cardiac Arrest, Out of Hospital Setting, Defibrillation
- Trial name
- RESTORE-ZG (NCT07750119)
- Testing
- Prehospital resuscitation care
- Where
- Switzerland
- Volunteers
- 240 people
- Sponsor
- Felix Brinkmann
Out-of-hospital Cardiac Arrest (OHCA)
Execution of Prehospital Transesophageal Echocardiography During Cardiopulmonary Resuscitation in Patients With Out-of-hospital Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) remains a major global public health challenge. Despite continuous advancements in resuscitation strategies, overall survival rates remain low.
- Trial name
- EXECT-CPR-2 (NCT07909642)
- Testing
- Transesophageal Echocardiography-Guided Chest Compression, Conventional Cardiopulmonary Resuscitation
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- Far Eastern Memorial Hospital
Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation
PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)
The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation, Death, Sudden, Cardiac, Therapeutic Hypothermia
- Trial name
- PRECEDENCE (NCT07421882)
- Testing
- CarbonCool® Cooling Vest
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore General Hospital
Cardiac Arrest
Therapeutic Hypothermia After the Return of Spontaneous Circulation
The purpose of this study is to determine if induced therapeutic hypothermia (ITH) in the pre-hospital setting of a four county emergency medical system (EMS) that serves both urban and rural communities improves meaningful…
- Trial name
- NCT01617291
- Testing
- Induced therapeutic hypothermia
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of California, San Francisco
Cardiac Arrest With Successful Resuscitation
Gasping Improves Long-term Survival After Out-of-hospital Cardiac Arrest
The aim of our retrospective clinical study was to examine the association between agonal breathing, return of spontaneous circulation (ROSC), and long-term survival.
- Trial name
- NCT02998749
- Volunteers
- 584 people
- Sponsor
- Charles University, Czech Republic
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
Early Initiation of Extracorporeal Life Support in Refractory OHCA
Despite adequate conventional cardiopulmonary resuscitation (CCPR) and attempted defibrillation, a considerable number of patients in cardiac arrest fail to achieve sustained return of spontaneous circulation.
- Conditions
- Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Sudden Cardiac Death
- Trial name
- INCEPTION (NCT03101787)
- Testing
- Extracorporeal cardiopulmonary resuscitation (ECPR)
- Where
- 10 sites in Netherlands
- Volunteers
- 134 people
- Sponsor
- Maastricht University Medical Center
Resuscitation, Cardiopulmonary
Effect of Early High-dose Epoetin Alfa During Cardiac Arrest (Pilot Study)
The purpose of this study is to test the possible neuroprotective effect of early high dose erythropoietin alpha after out of hospital cardiac arrest (OHCA).
- Conditions
- Resuscitation, Cardiopulmonary, Cardiac Arrest
- Trial name
- NCT00719498
- Testing
- Epo-alpha
- Volunteers
- 20 people
- Sponsor
- Janssen Cilag S.A.S.
Out-Of-Hospital Cardiac Arrest
Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest
Patients admitted to intensive care unit (ICU) following an out-of-hospital cardiac arrest (OHCA) have a high morbidity and mortality rate, primarily due to ischemia-reperfusion (I/R) syndrome leading to anoxic-ischemic brain…
- Trial name
- RIPOST-CA (NCT06473207)
- Testing
- Remote ischemic post conditioning sessions
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Out-of-hospital Cardiac Arrest (OHCA)
Cerebral Near Infrared Spectroscopy in Out-of-Hospital Cardiac Arrest and Neurological Prognosis
Out-of-hospital cardiac arrest (OHCA) prognosis remains poor : 7% of patients surviving without neurological impairment. 65% of patients dying after hospital admission were neurologically impaired.
- Trial name
- NISOHCA (NCT06972329)
- Testing
- Cerebral Near infrared spectroscopy (NIRSc).
- Where
- 6 sites in France
- Volunteers
- 542 people
- Sponsor
- Central Hospital, Nancy, France