Clinical trials: In-Hospital Cardiac Arrest
Altered Mental Status, Sepsis
Pre-hospital Ventilation Clinical Study
This study will collect and characterize ventilator use during patient care with a ZOLL 731 Series ventilator in a pre-hospital setting.
- Conditions
- Altered Mental Status, Sepsis, Heart Failure, Hemorrhage
- Trial name
- NCT05604430
- Testing
- 731 Series Ventilator
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- Zoll Medical Corporation
Cardiac Arrest, Cardiopulmonary Arrest
NEURESCUE Device as an Adjunct to Cardiac Arrest
The NEURESCUE device is the first intelligent balloon catheter for aortic occlusion, an emergency technique that supercharges blood flow to the heart and brain within one minute from deployment.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest, Cardiovascular Diseases
- Trial name
- ARISE-EU (NCT05146661)
- Testing
- NEURESCUE device
- Where
- 2 sites in Germany
- Volunteers
- 10 people
- Sponsor
- neurescue
Cardiac Arrest
Hypothermia After In-hospital Cardiac Arrest
ILCOR Recommendations "On the basis of the published evidence to date, the Advanced Life Support (ALS) Task Force of the International Liaison Committee on Resuscitation (ILCOR) made the following recommendations in October 2002…
- Trial name
- HACAinhospital (NCT00457431)
- Testing
- Mild therapeutic hypothermia
- Where
- Germany
- Volunteers
- 249 people
- Sponsor
- University Hospital Schleswig-Holstein
Cardiac Arrest
Targeted Temperature Management at 33°C Versus Controlled Normothermia for In-hospital Cardiac Arrest
The IH-TTM trial is designed to determine whether survival with a favorable neurological outcome is improved by induced hypothermia at 33°C in comatose critically ill patients admitted after resuscitated in-hospital cardiac…
- Trial name
- IH-TTM (NCT07086703)
- Testing
- Induced hypothermia at 33°C, Control normothermia
- Where
- 31 sites in Belgium, France and 1 more
- Volunteers
- 788 people
- Sponsor
- Nantes University Hospital
Cardiac Arrest
Microcirculatory Perfusion in Patients With Coma After Out-of-hospital Cardiac Arrest
The hypothesis is: In patients after an out of hospital cardiac arrest, treated with therapeutic hypothermia (33°C) will be found significantly more microcirculatory abnormalities, compared to the same group of patients treated…
- Trial name
- NCT01850485
- Testing
- microcirculation by SDF and NIRS, in 33 and 36 degrees
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Frisius Medisch Centrum
Out-Of-Hospital Cardiac Arrest, Cardiac Arrest
Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest
Comatose patients resuscitated from Out-of-Hospital Cardiac Arrest (OHCA) often develop a complicated systemic inflammatory response and have a poor prognosis with neurological damage being the most common cause of death.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Cardiac Arrest, Cardiac Arrest With Successful Resuscitation, Post Cardiac Arrest Syndrome
- Trial name
- STEROHCA (NCT04624776)
- Testing
- Methylprednisolone, Isotonic saline
- Where
- 2 sites in Denmark
- Volunteers
- 158 people
- Sponsor
- Christian Hassager
Out of Hospital Cardiac Arrest, Brain Injury
Therapeutic Hypothermia and eArly Waking
Unconscious survivors of cardiac arrest who are treated with intravenous therapeutic hypothermia for 24 hours will be assessed after 12 hours for appropriateness to be woken early and extubated whilst continuing to receive…
- Trial name
- THAW (NCT03065946)
- Testing
- Early wakening
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Out-Of-Hospital Cardiac Arrest, Acute Coronary Syndrome
Cangrelor in Comatose Survivors of OHCA Undergoing Primary PCI
The main objective of the trial is to find out if 4-hour continuous infusion of parenteral P2Y12 inhibitor cangrelor at the start of primary percutaneous coronary intervention (PCI) immediately and effectively suppresses platelet…
- Trial name
- Cangrelor OHCA (NCT04005729)
- Testing
- Cangrelor 50 MG
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Out-of-hospital Cardiac Arrest (OHCA)
Application of Transesophageal Echocardiography in Pre-hospital Cardiac Arrest Patients
The Use of Point-of-Care Ultrasound (POCUS), Transthoracic Echocardiography (TTE), and Transesophageal Echocardiography (TEE) in Cardiac Arrest and Acute Coronary Syndrome Patients Studies have shown that POCUS can rapidly change…
- Trial name
- TAPCAP (NCT06672315)
- Testing
- transesophageal echocardiography
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Jen-Tang Sun
Cardiac Arrest, Cardiopulmonary Arrest
NEURESCUE Device as an Adjunct to In-Hospital Cardiac Arrest (ARISE)
The NEURESCUE device is the first intelligent catheter for aortic balloon occlusion, an emergency technique that supercharges blood flow to the heart and brain within one minute from deployment.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest, Cardiovascular Diseases
- Trial name
- ARISE (NCT05444049)
- Testing
- NEURESCUE device
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- neurescue
Mental Health, Stress Disorder, Post Traumatic
Psychological Stress and Support Needs of Volunteer First Responders After Smartphone-based Cardiac Arrest Alerts
Out-of-hospital cardiac arrest is a serious emergency. In many areas, trained volunteers are alerted by a smartphone app to help before emergency services arrive.
- Trial name
- BRAVE (NCT07607808)
- Testing
- Structured Debriefing
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Aachen
Heart Arrest
Patient Acuity Rating: a Tool to Prevent In-Hospital Cardiac Arrest
The purpose of this study is to evaluate the accuracy of medical personnel in their ability to predict the likelihood of non-intensive care (ICU), ward patients to clinically deteriorate (defined as a cardiac arrest, unplanned…
- Trial name
- PAR (NCT01082991)
- Testing
- Preemptive Rapid Response Team intervention
- Where
- United States
- Sponsor
- University of Chicago
Heart Arrest, Out-Of-Hospital, CardioPulmonary Resuscitation
Ventilation in Cardiac Arrest Resuscitation Study
Out-of-hospital cardiac arrest (OHCA) is a major public health problem, with around 40,000 victims each year in France. Their survival rate remains dramatically low, at less than 10%.
- Conditions
- Heart Arrest, Out-Of-Hospital, CardioPulmonary Resuscitation, Basic Cardiac Life Support
- Trial name
- VECARS (NCT05992454)
- Testing
- EOLIFE
- Where
- France
- Volunteers
- 120 people
- Sponsor
- French Defence Health Service
Cardiac Arrest
Arterial Pressure and Stress-Dose Steroids in Cardiac Arrest.
Early stress-dose steroids are of uncertain efficacy in cardiac arrest. The current authors plan to conduct a pertinent mediation analysis using prospectively collected data from 2 prior randomized clinical trials of in-hospital…
- Trial name
- NCT02785224
- Testing
- Vasopressin Steroids Epinephrine
- Where
- 3 sites in Greece
- Sponsor
- University of Athens
Heart Arrest
Thrombolysis Using Tenecteplase (Metalyse®) in Cardiac Arrest - The TROICA Trial
The general aim of this study is to compare the efficacy and safety of tenecteplase to standard treatment during cardiopulmonary resuscitation in patients suffering from out-of-hospital cardiac arrest.
- Trial name
- NCT00157261
- Testing
- tenecteplase
- Where
- 68 sites in Austria, Belgium and 7 more
- Volunteers
- 1,050 people
- Sponsor
- Boehringer Ingelheim
Cardio Respiratory Arrest, Cardiac Death
Ventilation in Cardiac Arrest
Over the last decades, research in cardiopulmonary resuscitation was primarily focused on uninterrupted chest compressions to restore sufficient circulation.
- Conditions
- Cardio Respiratory Arrest, Cardiac Death, Ventilation Therapy; Complications, Apnea
- Trial name
- VICA (NCT04657393)
- Testing
- mechanical ventilation
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Out-Of-Hospital Cardiac Arrest
Epidemiology, Management, Prognosis and Medical Cost Analysis of IHCA and OHCA
The study is a retrospective analysis of Taiwan national health insurance in cardiac arrest patients. The factors related to the outcomes of cardiac arrest patients were analyzed.
- Trial name
- NCT03684616
- Testing
- Statin
- Where
- Taiwan
- Volunteers
- 100,000 people
- Sponsor
- National Taiwan University Hospital
Cardiac Arrest
Effects of Laryngeal Tube Ventilation on no Flow Time During Out of Hospital Cardiac Arrest
International recommendations stress on the importance of no flow time reduction in cardiac arrest management. In fact, no flow time is an independent factor of morbidity and mortality.
- Trial name
- FLOWERS (NCT01295749)
- Testing
- laryngeal tube ventilation and continuous chest compression
- Where
- 2 sites in France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Grenoble
Cardiac Arrest, Brain Injuries
A Combined Microdialysis and FDG-PET Study for Detection of Brain Injury After Cardiac Arrest
Brain injury remains the leading cause of death in comatose patients resuscitated from OHCA. One of the most challenging aspects in the treatment of a post-cardiac arrest patient is the assessment of the extent of brain damage.
- Trial name
- COMA-PROTECT (NCT04774055)
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Out-of-Hospital Cardiac Arrest
Resuscitative Balloon Occlusion of the Aorta in Non-traumatic Out of Hospital Cardiac Arrest
The primary aim of this study is to investigate the feasibility and complications of inserting a REBOA-catheter to patients suffering from non-traumatic out-of-hospital cardiac arrest, by anesthesiologist working in the…
- Trial name
- REBOA (NCT03534011)
- Testing
- Resuscitative Balloon Occlusion of the Aorta, REBOA catheter
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Norwegian University of Science and Technology