Clinical trials: In-Vitro Fertilization
Unexplained Infertility
ICSI Versus Conventional IVF in Couples With Unexplained Infertility
This multicenter, open-label, parallel-group, randomized controlled trial aims to compare the live birth rate, fertilization outcomes, other pregnancy outcomes and safety between ICSI and conventional IVF among couples with…
- Trial name
- ICSI/IVF-UI (NCT07294027)
- Testing
- ICSI, IVF
- Where
- 7 sites in China
- Volunteers
- 848 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Female Infertility
Single Dose FSH-GEX™ in Healthy Volunteers
The aim of the current study was the pharmacokinetic and pharmacodynamic characterization of a single dose administration of four doses of FSH-GEX™ in healthy pituitary-suppressed female volunteers, in comparison with two…
- Trial name
- NCT01354886
- Testing
- FSH-GEX™, Gonal-f, Bravelle
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Glycotope GmbH
Infertility
TICON-Day 3, Time Lapse Versus Conventional Method in Day 3 Embryo Culture and Assessment
The main purpose of the study was to evaluate the overall clinical value of GERI+ as an integrated embryo culture and assessment system, providing an undisturbed culture environment, continuous monitoring of embryo development…
- Trial name
- TICON (NCT03164551)
- Testing
- GERI+ incubator, Conventional incubator
- Where
- 17 sites in Canada, Denmark and 5 more
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
Oocyte Cryopreservation: Evaluation of an Oocyte Freezing and Thawing Technique
Over the past several decades, considerable effort has been expended toward the successful cryopreservation of various human cells.
- Trial name
- Slow-freeze (NCT00713869)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- West Coast Fertility Centers
Infertility, In Vitro Fertilization
Exploring the Effect of Footbaths on Increasing the Success Rates in Vitro Fertilization
To evaluate the effectiveness of warm-water footbaths in enhancing pregnancy rates during IVF and to explore the underlying mechanisms involved.
- Trial name
- NCT06624683
- Testing
- Intelligent footbath basin
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Polycystic Ovary Syndrome, In Vitro Fertilization
Polycystic Ovary Syndrome (PCOS) and In Vitro Fertilization (IVF): A Comparison Between Standard Long Protocol Versus an Antagonist Protocol Starting on Day 1
The aim of this study is to compare two different IVF-stimulation protocols in patients affected by PCOS: the use of a Gonadotropin-releasing hormone (GnRH) - antagonist starting on day 1 of controlled ovarian hyperstimulation…
- Trial name
- NCT00883766
- Testing
- Controlled ovarian hyperstimulation for IVF with a long agonist protocol, Controlled ovarian hyperstimulation for IVF with an antagonist protocol
- Where
- Spain
- Volunteers
- 172 people
- Sponsor
- Fundacion Dexeus
Infertility
Perifollicular Vascularity Assessment in in-Vitro Fertilization
On February 2004, a law (n. 40/2004) regulating assisted reproduction techniques (ARTs) was approved in Italy. This law aimed to regulate the treatment of infertility in Italy, contains several restrictions, such as the…
- Trial name
- NCT00458380
- Testing
- Controlled ovarian stimulation, perifollicular vascularity assessment, IVF, embryo transfer.
- Where
- Italy
- Volunteers
- 116 people
- Sponsor
- University Magna Graecia
Infertility, Male
Selection of Non Apoptotic Human Sperm for in Vitro Fertilization by Using Magnetic Activated Cell Sorting (MACS)
This clinical study has been organised to help improve the embryo quality in couples having high rate of sperm showing apoptotic signs.
- Trial name
- MACS-HS (NCT03988361)
- Testing
- Magnetic Activated Cell Sorting
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
In Vitro Fertilization
Follow-up Study of Frozen-thawed Embryo Transfer (FTET) Cycles After Cryopreservation of Embryos in Clinical Trial P05787 (P05716)
To collect the outcome of frozen-thawed embryo transfer cycles after the embryos are cryopreserved up to at least 1 year in Trial P05787 (NCT00696800), in order to estimate the cumulative pregnancy rate for each treatment group.
- Trial name
- NCT00702273
- Testing
- 150 µg Corifollitropin Alfa, 200 IU RecFSH/Follitropin beta (Days 1 to 7), 200 IU RecFSH/Follitropin beta (Days 8 to hCG)
- Volunteers
- 344 people
- Sponsor
- Organon and Co
Infertility
Vaginal Progesterone Versus Progesterone in Oil in Donor Egg Recipient In Vitro Fertilization Cycles Utilizing Vitrified Donor Eggs
The aim of this study is to evaluate both pharmaceutical therapy and advanced treatment techniques for infertile patients requiring in-vitro fertilization utilizing donor eggs.
- Trial name
- NCT01465373
- Testing
- Endometrin, Progesterone in Oil
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fertility Centers of Illinois
Infertility, Pregnancy Outcome, Live Birth
in Vitro Fertilization (IVF) Media Protein and Live Birth Rates
Human conception in vivo occurs in a complex milieu that includes proteins. It has been speculated that the addition of proteins more complex than human serum albumin to culture media may improve IVF outcomes.
- Conditions
- Infertility, Pregnancy Outcome, Live Birth, In Vitro Fertilization
- Trial name
- SSS (NCT00708383)
- Testing
- 10% SSS embryo culture medium protein supplementation, 0.5% HSA embryo culture medium protein supplementation
- Where
- 2 sites in United States
- Volunteers
- 538 people
- Sponsor
- Texas Health Resources
Recurrent Pregnancy Loss, Infertility, Female
Effects of PGS2.0 in Patients With Unexplained RPL
50%-60% of the known causes of recurrent pregnancy loss(RPL) are associated with embryonic aneuploidy, such that preimplantation genetic screening (PGS) on embryos acquired by assisted reproductive treatment should improve the…
- Trial name
- NCT03214185
- Testing
- IVF/ICSI, PGS 2.0, Conventional embryo morphology evaluation
- Where
- China
- Volunteers
- 710 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Infertility, Female
The Role of Erzhi Tiangui Formula in Expected POR Women Undergoing IVF-ET
This randomized controlled trial aims to determine whether Erzhi Tiangui Formula can optimize the reproductive outcomes of elderly patients with expected poor ovarian response, and to provide a new approach to traditional Chinese…
- Trial name
- NCT05698550
- Testing
- Erzhi Tiangui Granule
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Infertility, Female
Multicenter, Randomized, Open Label, Parallel Study to Evaluate the Efficacy & Safety of IVF-M HP Inj. vs. Menopur® Inj.
The objective of this study was to demonstrate the non-inferiority of IVFM HP Inj. by evaluating its efficacy versus Menopur® Inj.
- Trial name
- NCT02458768
- Testing
- IVF-M HP Inj., Menopur® Inj.
- Volunteers
- 112 people
- Sponsor
- LG Life Sciences
Progesterone, Fertilization in Vitro
Cut-Off Progesterone Values Deleterious for In Vitro Fertilization and Fresh Embryo Transfer
At which deleterious cut off value of progesterone on day of HCG (P-hCG) in our IVF program should fresh embryo transfer (ET) be cancelled?
- Conditions
- Progesterone, Fertilization in Vitro, Infertility, Pregnancy
- Trial name
- NCT02323347
- Testing
- Progesterone
- Volunteers
- 1,901 people
- Sponsor
- Fundacion Dexeus
Infertility, In Vitro Fertilization
Effect of Antioxydant-enriched Media on Blastocyst Euploidy Rates.
One of the most sensible factors in IVF culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species (ROS) caused by the artificial environment.
- Trial name
- GX (NCT06261671)
- Testing
- antioxidants-enriched culture medium (Gx)
- Where
- United Arab Emirates
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility
International Pilot Study for Dual Non-invasive Assesment of Embryo Development
Choosing the best embryo is one of the major challenges for achieving success in in vitro fertilization (IVF). Traditionally, embryo evaluation has been based on morphological quality (how the embryo looks like) and chromosomal…
- Trial name
- PANDORA (NCT06524648)
- Testing
- niPGT-A
- Where
- 8 sites in Austria, Spain and 1 more
- Volunteers
- 200 people
- Sponsor
- Igenomix
Infertility
Use of Nitric Oxide Metabolites for Predicting Embryo Quality in In-Vitro Fertilization (IVF)
Improvements in In-Vitro Fertilization (IVF) outcomes have largely been due to the generation of excess embryos allowing for multiple embryo transfer.
- Trial name
- NCT00788619
- Testing
- Transfer of embryos on day 3 or day 5 after fertilization., Day 5 transfer
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Primary or Secondary Infertility
Impact of Local Biopsy to the Endometrium Prior to Controlled Ovarian Stimulation on Clinical Pregnancy
In vitro fertilization (IVF) is the only available solution for many couples with various forms of infertility. The embryo implantation step in the IVF procedure is a complex multistage process and represents the majority of the…
- Trial name
- NIDABRECHE (NCT01064193)
- Testing
- biopsy, IVF
- Where
- 3 sites in France
- Volunteers
- 190 people
- Sponsor
- University Hospital, Bordeaux
Polycystic Ovary Syndrome
Role of Melatonin Supplementation in Follicular Fluid of in Vitro Fertilization (IVF) Patients With Polycystic Ovarian Syndrome
To evaluate the effects of melatonin supplementation on the main in vitro fertilization (IVF) outcomes during ovarian stimulation in patients with Polycystic ovarian syndrome (PCOS).
- Trial name
- NCT01540747
- Testing
- Myo-inositol + folic acid + melatonin, Myo-inositol + folic acid
- Where
- Italy
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre