Clinical trials: In-Vitro Fertilization
Reproductive Techniques, Assisted, DNA Methylation
First Live Birth Rate With eSET After Preimplantation Methylome Screening (PIMS) Versus Conventional In-vitro Fertilization
To determine whether using DNA methylome to select embryos can increase the live birth rate.
- Trial name
- NCT05442125
- Testing
- Using DNA methylome to select embryos, Using morphologic score to select embryos
- Where
- 28 sites in China, Thailand
- Volunteers
- 1,146 people, healthy volunteers welcome
- Sponsor
- Shandong University
Trisomy 21, 18 and 13 Screening
T21,18 and 13 Screening by Cell Free Fetal DNA in Low Risk Patients
The purpose of this study is to evaluate the performance of non invasive screening in a population of pregnant women with and without in vitro fertilisation (IVF) concomitantly to regular first trimester trisomy 21 (T21)…
- Trial name
- DEPOSA (NCT02424474)
- Testing
- Genetic NIPT, Regular serum screening
- Where
- France
- Volunteers
- 933 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pregnancy Complication
Vitamin D During In Vitro Fertilisation (IVF) - A Prospective Randomized Trial
During IVF treatment women will be randomized into supplementation with a high or a low dose of Vitamin D Main outcome Laboratory pregnancy, live pregnancy at 12 weeks, Baby take home rate, OHSS Secondary outcome: 1.
- Trial name
- Delivery (NCT01019785)
- Testing
- Ergocalciferol
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Karolinska University Hospital
Infertility
Follicle Stimulating Hormone (FSH) Receptor Polymorphisms in In-Vitro Fertilization Cycles.
This study is being done to identify if certain sequences (patterns) of key genes (called polymorphisms) may predict a response to fertility medications.
- Trial name
- NCT01002885
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- University Reproductive Associates
Ovulation, Ovulation Inhibition
Can Ibuprofen Delay Ovulation in Natural Cycle-IVF?
During natural cycle in vitro fertilisation, no gonadotropin stimulation is used to stimulate oocyte production. Ovulation is induced with HCG (human chorionic gonadotropin) and the follicle is retrieved 36 hours later.
- Conditions
- Ovulation, Ovulation Inhibition, Ovulation Inhibition/Drug Effects, Pregnancy
- Trial name
- Ibudelay (NCT02571543)
- Testing
- Ibuprofen
- Where
- Switzerland
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
In Vitro Fertilization, Intracytoplasmic Sperm Injection
Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes in Polycystic Ovary Syndrome Patients.
This prospective, non-randomised, open-label, clinical trial is conducting on polycystic ovary syndrome (PCOS) subjects to compare the effects of two pituitary suppression regimens; GnRH Agonist-Long Protocol and GnRH…
- Conditions
- In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility, Polycystic Ovary Syndrome
- Trial name
- NCT04727671
- Testing
- Triptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin
- Where
- Syria
- Volunteers
- 50 people
- Sponsor
- Damascus University
Culture Media, DNA
Cell-free DNA: a Non-invasive Test for Assessing Embryo Quality
In the present project we propose to deeply characterize nuclear and/or mitochondrial DNA in embryo culture medium, in order to investigate whether both cell-free nucleic acid types may provide additional, reliable, predictive…
- Trial name
- NCT01397136
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Infertility
Ovulation Triggering 2 vs 3 Follicles
Poor responders in in-vitro fertilization (IVF) cycles represent a major challenge for fertility specialists. Although poor responders tend to have sub-optimal fertility treatment outcomes, many of these patients wish to attempt…
- Trial name
- NCT06290921
- Testing
- Ovulation triggering
- Where
- Canada
- Volunteers
- 405 people
- Sponsor
- Clinique Ovo
Infertility
Next Generation Sequencing Screening for Embryonic Ploidy Status
To evaluate the benefits of using next generation sequencing to assess embryonic aneuploidy. All viable blastocysts will be biopsied and cryopreserved for future transfer.
- Trial name
- nexgen (NCT02032264)
- Testing
- Comprehensive Chromosome Screening, Morphologically Best
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Syndrome, Russell Silver
Silver Russell Syndrome, Parental Fertility and Assisted Reproductive Technology
Silver Russell Syndrome (SRS) is a rare imprinting disorder (about 1/16000). Parental imprinting is an epigenetic regulation phenomenon leading to the monoallelic expression of some genes.
- Trial name
- SRS-AMP (NCT06878716)
- Where
- France
- Volunteers
- 125 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fertility Issues
Effect of Collaborative Infertility Counseling on Coping Strategies and Marital Satisfaction
Effect of collaborative infertility counseling on coping strategies and marital satisfaction among women undergoing in vitro fertilization: a randomized control trial
- Trial name
- NCT05658848
- Testing
- Collaborative infertility counseling
- Where
- Egypt
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Port Said University
Endometrioma, Infertility
Ethanol Sclerotherapy Prior to ART
The goal of this randomized controlled trial is to assess the impact of ethanol sclerotherapy on ART cycle outcomes. The main questions it aims to answer are: 1.
- Conditions
- Endometrioma, Infertility, Sclerotherapy, ART
- Trial name
- START (NCT05962775)
- Testing
- Ethanol Sclerotherapy for Endometrioma
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ankara University
Infertility
Comapring Luteal Phase Support in IVF Patients Who Are at High Risk for Developing OHSS
The purpose of this study is to compare two luteal support protocols in In vitro fertilization patients (IVF) and are at risk of developing ovarian hyperstimulation syndrome (OHSS).
- Trial name
- NCT02827656
- Testing
- Decapeptyl, hCG luteal support
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Clinical Pregnancy Rate, Ovulation Induction
Follicular Long GnRH Agonist Versus Antagonist Protocol in PCOS Women Undergoing in Vitro Fertilization
Pituitary down regulation is widely used during in vitro fertilization (IVF) procedures. It can suppress the spontaneous luteinizing hormone (LH) surge, and can also make follicles growth evenly.
- Conditions
- Clinical Pregnancy Rate, Ovulation Induction, IVF
- Trial name
- NCT02496754
- Testing
- GnRH-a, GnRH-anta
- Where
- China
- Volunteers
- 1,266 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Infertility
Stress Reduction During In Vitro Fertilization
The goal of this study is to determine the effect of Healing Touch (HT) on the stress, anxiety, and self-efficacy experiences of women undergoing in vitro fertilization (IVF) in a randomized, controlled design.
- Trial name
- NCT00788502
- Testing
- Healing Touch, Desensitization Therapy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Stanford University
Supervision of Pregnancy Resulting From In-vitro Fertilization
Optimal Planning of a Day 3 Cryopreserved(Frozen)-Thawed Embryo Transfer in a Natural Cycle With hCG Administration or After Spontaneous LH Peak?
The aim of the study is to determine whether spontaneous LH peak is superior to human chorionic gonadotropin before a transfer of a day 3 frozen embryo.
- Trial name
- PLUS (NCT02145819)
- Testing
- hCG, LH peak
- Where
- Belgium
- Volunteers
- 240 people
- Sponsor
- Universitair Ziekenhuis Brussel
In Vitro Fertilization
Preimplantation Genetic Screening in Women Over 35 Year
In view of insufficient evidence to routinely use Preimplantation Genetic Screening (PGS) to improve success rates after IVF, we test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate…
- Trial name
- NCT00593671
- Testing
- Preimplantation genetic screening after embryo biopsy
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Infertility, Female, Infertility
Oral Dydrogesterone (OD) Versus Micronized Vaginal Progesterone (MVP) for Luteal Phase Support (LPS) in IVF/ICSI
Female inability to conceive a child. The purpose of this prospective randomized, double-blinded, double dummy, two-arm cross-over study is to investigate the difference on histological, transcriptional and immunological level in…
- Conditions
- Infertility, Female, Infertility, Genital Diseases, Male, Genital Diseases, Female
- Trial name
- NCT03677336
- Testing
- Dydrogesterone Oral Tablet, Micronized progesterone
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Infertility, Male
Effect of Ejaculatory Abstinence on Semen Parameters in Male Factor Infertility Patients
The purpose of this study is to compare semen parameters with in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) when male factor infertility patients abstain from ejaculation more than 48 hours (routine care)…
- Trial name
- NCT04206800
- Testing
- Ejaculatory abstinence less than 24 hours
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Boston IVF
Fertilization in Vitro
Post-Marketing Surveillance of the Safety and Efficacy of Orgalutran (Ganirelix)®
The purpose of this post-marketing surveillance is to identify problems and questions regarding the safety and efficacy of Orgalutran (Ganirelix)® when used for the prevention of premature luteinizing hormone (LH) surges in women…
- Trial name
- NCT01304511
- Testing
- Orgalutran
- Volunteers
- 711 people
- Sponsor
- Organon and Co