Clinical trials: In-Vitro Fertilization
Infertility
An Observational Study of Cetrotide® Gonadotropin-releasing Hormone Antagonist (GnRH Antagonist) With GONAL-f® in Assisted Reproductive Technologies (ART)
This is a multicentric, prospective, observational study on the use of Cetrotide to control the endogenous gonadotrophin levels in Gonal-f stimulated ART treatment cycles in the Asia-Pacific region.
- Trial name
- NCT01109654
- Testing
- Cetrorelix acetate and Follitropin alfa
- Where
- Singapore
- Volunteers
- 2,175 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
Eeva™ Pregnancy Investigational Clinical Study: A Postmarket Follow-Up Study
The purpose of this postmarket study is to gather data to evaluate the impact of using Eeva with traditional morphology grading on clinical pregnancy rates.
- Trial name
- EPIC (NCT01671644)
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 104 people
- Sponsor
- Progyny, Inc.
Male Infertility, Sperm DNA Fragmentation
Microfluidics Versus Density Gradient Centrifugation for Sperm Preparation in IVF
This randomized controlled trial aimed to compare the effectiveness of microfluidic sperm sorting and density gradient centrifugation (DGC) in reducing sperm DNA fragmentation index (DFI) and improving clinical outcomes in IVF.
- Conditions
- Male Infertility, Sperm DNA Fragmentation, In Vitro Fertilization (IVF)
- Trial name
- MCvsDGC (NCT07004309)
- Testing
- Microfluidic sperm sorting, Density Gradient Centrifugation
- Where
- Vietnam
- Volunteers
- 119 people
- Sponsor
- Hanoi Medical University
Intrauterine Abnormalities in Infertility
SIGnificance of Routine Hysteroscopy Prior to a First 'in Vitro Fertilization'(IVF) Treatment Cycle
BACKGROUND: Despite the numerous advances in the field of in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI), there still exists a maximum implantation rate per embryo transferred of about 30%.
- Trial name
- inSIGHT (NCT01242852)
- Testing
- Office hysteroscopy (in combination with a 'Saline Infusion Sonography'(SIS))
- Where
- Netherlands
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Infertility
Corifollitropin Alfa Versus Recombinant Follicle Stimulating Hormone (FSH) in Ovarian Stimulation of Women Undergoing in Vitro Fertilisation
The use of corifollitropin alfa is superior in terms of pregnancy outcome parameters as compared to recombinant follicle stimulating hormone (FSH) during ovarian stimulation protocols in women undergoing in vitro fertilisation.
- Trial name
- NCT01319695
- Testing
- corifollitropin alfa, recombinant follicle stimulating hormone (FSH)
- Where
- 2 sites in Greece
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Diminished Ovarian Reserve, Female Infertility
Hippo-Related Competing Endogenous RNA (ceRNA) Network Dysregulation and In Vitro Fertilization (IVF) Outcomes in Women With Diminished Ovarian Reserve
Diminished Ovarian Reserve (DOR) is an important cause of female infertility and is associated with poor ovarian response and lower pregnancy rates during In Vitro Fertilization (IVF).
- Conditions
- Diminished Ovarian Reserve, Female Infertility, In Vitro Fertilization
- Trial name
- DOR-HIPPO-IVF (NCT07658846)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Infertility, Obesity
Weight Management Intervention for Obese Women and the Live Birth Outcome of in Vitro Fertilization (IVF)
The primary aim of the study is to evaluate if weight management intervention for obese women (BMI≥30<35 kg/m2) prior to IVF improves the outcome assessed as live birth per participating woman, as compared to women where no…
- Trial name
- NCT01566929
- Testing
- Low calorie diet treatment
- Where
- 9 sites in Denmark, Iceland and 1 more
- Volunteers
- 317 people
- Sponsor
- Sahlgrenska University Hospital
Infertility, Infertility, Female
GnRH Agonist at Embryo Transfer: IVF Outcomes
In ART (assisted reproductive technology) cycles, embryos are transferred to a woman's uterus after in-vitro fertilization (IVF) in a laboratory.
- Conditions
- Infertility, Infertility, Female, Infertility, Male
- Trial name
- GRAET (NCT03544073)
- Testing
- Saline Solution for Injection, Leuprolide Acetate
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Maimonides Medical Center
Infertility
Clinical Tolerance and Equivalence of hCG-IBSA vs Recombinant Human Chorionic Gonadotrophin in Women Undergoing In Vitro Fertilisation
The purpose of the study is to evaluate the clinical equivalence and the general tolerability of two different subcutaneous hCG preparations (hCG-IBSA, IBSA vs Ovitrelle, Serono) when administered to patients undergoing IVF.
- Trial name
- NCT00335569
- Testing
- hCG-IBSA
- Where
- 4 sites in Switzerland
- Volunteers
- 144 people
- Sponsor
- IBSA Institut Biochimique SA
Infertility
Acupuncture Versus Placebo Acupuncture During In Vitro Fertilization (IVF) Embryo Transfer
During IVF treatment, acupuncture at the time of embryo transfer may improve the pregnancy rate. This study aims to compare IVF pregnancy between two groups of patients that received either acupuncture or sham acupuncture…
- Trial name
- NCT00913354
- Testing
- Acupuncture (Carbo®)
- Where
- Denmark
- Volunteers
- 635 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infertility
Double ABCX Theory Based Cognitive Psychotherapy Combined Progressive Muscle Relaxation Intervention on Women Undergoing IVF-ET
The in vitro fertilization and embryo transfer(IVF-ET) is a therapy to help the infertile couples. The mental health status of couple under IVF-ET, commonly seen in depression and anxiety, is found to be closely related to the…
- Trial name
- NCT03931187
- Testing
- Cognitive progressive muscular relaxation therapy
- Where
- China
- Volunteers
- 67 people
- Sponsor
- Central South University
Infertility, Female, Ovarian Reserve
hCG Priming in Women With Diminished Ovarian Reserve
The aim of this randomized controlled trial is to further examine the possible effects of low dose human chorionic gonadotropin (hCG) priming for eight weeks in women with diminished ovarian reserve (DOR) undergoing in vitro…
- Conditions
- Infertility, Female, Ovarian Reserve, In Vitro Fertilization (IVF)
- Trial name
- NCT07108621
- Testing
- Choriongonadotropin alfa (hCG)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Kristine Loessl
IVF Cycle, Ovarian Stimulation
Efficacy and Safety of Medication Used to Stimulate Ovulation
Individuals undergoing In Vitro Fertilization must undergo controlled ovarian hyperstimulation (COH) to produce enough quality eggs for fertility treatment.
- Conditions
- IVF Cycle, Ovarian Stimulation, Egg Retrieval, Pregnancy
- Trial name
- NCT02715336
- Testing
- Ovulation induction with hCG and Lupron (GnRH agonist)
- Where
- Canada
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- Create Fertility Center
Infertility, In Vitro Fertilization
Nordic Luveris Study
To study whether addition of human LH hormone (Luveris) during the final days of stimulation with recombinant FSH (Gonal-f) for controlled ovarian stimulation will be of benefit for patients undergoing in vitro fertilisation.
- Trial name
- NCT00553293
- Testing
- recombinant luteinizing hormone (Luveris), recombinant follicle stimulating hormone (Gonal-f)
- Where
- Denmark
- Volunteers
- 526 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infertility
Eeva 12-well Dish Study
The purpose of this study is to demonstrate that the Eeva™ System is compatible with the Eeva 12-well Dish.
- Trial name
- NDS (NCT01635036)
- Testing
- In-vitro fertilization using Eeva
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Progyny, Inc.
Infertility, Pregnancy, Multiple
Correlation Between Oocyte and Embryo Mechanical Properties on Embryo Development and Clinical Pregnancy After In Vitro Fertilization
The purpose of this study is to determine whether oocyte and embryo mechanical properties measured during in vitro fertilization can predict embryo development outcomes and clinical pregnancy.
- Trial name
- EMECH (NCT02530892)
- Testing
- EmbryoHug
- Where
- 3 sites in United States, China and 1 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Stanford University
Fertility Disorders
Menopur And Rekovelle Combination Study
This study proposes to evaluate the effect of adding HP-hMG (Menopur) to follitropin delta in a "mixed protocol" regimen, using an individualized, fixed dose of follitropin delta based on the established algorithm, combined with…
- Trial name
- MARCS (NCT03483545)
- Testing
- Follitropin delta and HP-hMG
- Where
- 4 sites in Canada
- Volunteers
- 160 people
- Sponsor
- Dr François Bissonnette
Other Complications Associated With Artificial Fertilization
Efficacy of Luteinizing Hormone (LH) Activity in Low Responder Patients With Transdermal Testosterone
The investigators have previously demonstrated the utility of transdermal testosterone in in vitro fertilization (IVF) low responder patients.
- Trial name
- NCT01291212
- Testing
- Testosterone and FSHr-LHr, testosterone and FSHr alone
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Infertility, Polycystic Ovary Syndrome
GnRH Antagonist Versus GnRH Agonist in Polycystic Ovary Syndrome During in Vitro Fertilization - Embryo Transfer
GnRH (Gonadotropin-releasing hormone) antagonists in IVF (in vitro fertilization) has been accomplished by several randomized controlled trials compared with conventional GnRH agonist long protocol in polycystic ovary syndrome…
- Trial name
- NCT01402336
- Testing
- GnRH antagonist (Cetrorelix), Conventional GnRH agonist (Triptorelin)
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
IVF-ET
Impact of Expressive Touching During Embryo Transfer
Infertile individuals report psychiatric symptoms and that their levels of anxiety and depression are significantly higher than in fertile controls .Thus,this study aimed to determine the effect of expressive touching during…
- Trial name
- NCT06590636
- Testing
- Expressive touching
- Where
- Palestinian Territories
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University