Clinical trials: In-Vitro Fertilization
Fertility Disorders
Injection Free IVF
Investigation of Natural Cycle In vitro Fertilisation (NC-IVF) treatment with ovulation induction with a nasal GnRH agonist instead of regular NC-IVF treatment with subcutaneous application of hCG with the objective of increasing…
- Trial name
- NCT04850261
- Testing
- hCG Injection, Nafarelin nasal spray
- Volunteers
- healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Endometritis, in Vitro Fertilization
Chronic Endometritis and IVF
Background: Embryo quality is known to be a very important determinant to predict the implantation and pregnancy rate in IVF patients, however, the role of uterine integrity or endometrial receptivity cannot be overlooked.
- Trial name
- CEIVF (NCT02646930)
- Testing
- Endometrial biopsy
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- Duke University
Pregnancy, Miscarriage Less Than 12 Gestational Weeks
Low-Dose Aspirin in in Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) Treatments
In this study we hypothesized that low-dose aspirin therapy (100 mg daily) improves ovarian responsiveness, uterine haemodynamics and clinical pregnancy rates in unselected subjects undergoing IVF/ICSI when the treatment is…
- Conditions
- Pregnancy, Miscarriage Less Than 12 Gestational Weeks, Extrauterine Pregnancy, Preeclampsia
- Trial name
- NCT00683202
- Testing
- Acetylsalicylic acid
- Where
- Finland
- Volunteers
- 374 people
- Sponsor
- University of Oulu
Infertility, Female
Effect of Oxytocin Antagonists on Implantation Success Rates of Frozen-thawed Embryo Transfer
Uterine contraction has a negative impact on implantation and pregnancy rates. Inhibition of oxytocin receptors decreases uterine contraction frequency both on pregnant and non-pregnant women.
- Trial name
- NCT03904745
- Testing
- Atosiban
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Subfertility
Endometrial Scratching in In Vitro Fertilization Cycles With Oocyte Donation
This study is designed to evaluate the potential benefit in pregnancy rates produced by an endometrial scratching made in an IVF cycle prior to embryo transfer in patients with donated oocytes.
- Trial name
- NCT01842178
- Testing
- scratching
- Where
- Spain
- Sponsor
- Centro de Infertilidad y Reproducción Humana
Fertility Disorders, Infertility, Female
The Effect of RECO-18 on Infertile Women Undergoing in Vitro Fertilization-embryo Transfer
How to improve the fertility of infertile women has become a hot topic in the field of assisted reproduction. Animal experiment has shown that RECO-18 significantly improved the female fertility in mice, and the specific…
- Trial name
- NCT05412147
- Testing
- RECO-18, Multi-vitamins
- Volunteers
- 80 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Infertility
Ultrasound-guided Hydrosalpinx Aspiration During Egg Collection
· What we know: Hydrosalpinx and IVF About 40% of patients undergoing IVF have tubal disease and in 25%-30% of tubal disease patients there is fluid collection within the tube; hydrosalpinx.
- Trial name
- NCT00566956
- Testing
- Hydrosalpinx needle aspiration to arm 1
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Infertility, Male
The Aim of This Study is to Determine the Incidence of Alterations in Fluorescent In Situ Hybridisation (FISH) of Spermatozoa and to Evaluate the Efficacy of the Use of Annexin Columns (MACS®) in Patients With Altered FISH Undergoing In Vitro Fertilisation Techniques
250 petitions for FISH of spermatozoa were requested, determining the total and particular incidence in each of the indications collected. The effect of annexin columns was evaluated in 10 couples with altered FISH.
- Trial name
- NCT06524102
- Testing
- Magnetic Activated Cell Sorting
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Instituto de Investigación Sanitaria y Biomédica de Alicante
Infertility, Fertilization in Vitro
Low Molecular Weight Heparin in Recurrent Implantation Failure
Recurrent implantation failure is the failure to achieve a pregnancy after multiple attempts with in vitro fertilization treatment. The reason is usually obscure.
- Conditions
- Infertility, Fertilization in Vitro, Recurrent Implantation Failure
- Trial name
- NCT00750451
- Testing
- low molecular weight heparin (enoxaparine sodium), crinone 8% gel
- Where
- Turkey (Türkiye)
- Sponsor
- V.K.V. American Hospital, Istanbul
Infertility, Female
Sequential Therapy of TCM Herbs to Improve the Success Rate of IVF-ET in Diminished Ovarian Reserve Patients
In the early stage, our team found that traditional Chinese medicine (TCM) intervention aimed at Nourishing kidney and regulating blood circulation in vitro fertilization and embryo transfer(IVF-ET) can improve the clinical…
- Trial name
- NCT04842825
- Testing
- Er Zhi Wan combined with Si Wu Tang, Recombinant Human Follitropin Alfa 、Fructose 、Tetyacycline Hydrochloride Capsules、Cetrorelix Acetate Powder
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Infertility, Female, Premature Ovarian Failure
Second Step Protocol in Poor Ovarian Responder (POR)
Reduced ovarian reserve and the consequent poor ovarian response are very recurent in infertile patients, indeed a percentage of 10%-24% of couples addressed to infertility program may be classified as Poor Ovarian Responder…
- Conditions
- Infertility, Female, Premature Ovarian Failure, Fertility Disorders
- Trial name
- POR (NCT03480412)
- Testing
- Follicular Phase, Luteal Phase
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Unrecognized Condition
The Effect of Melatonin Supplementation on Cumulus Cells and IVF Outcomes
This study investigates the effects of melatonin supplementation on cumulus cell gene expression and in vitro fertilization (IVF) outcomes in women over 35 years old.
- Trial name
- NCT06546774
- Testing
- Melatonin
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Fertility Disorders
Evaluating the Usability of the Product Kinder System Trial, Home Based Hormone for In-Vitro Fertilization (IVF) Monitoring System.
In-vitro fertilisation (IVF) treatment involves women undergoing hormone stimulation (drug dosing) to produce more oocytes (eggs) to increase their chances of fertilisation.
- Trial name
- NCT05634850
- Testing
- Kinder
- Where
- Singapore
- Volunteers
- 25 people
- Sponsor
- Planet Innovation
Polycystic Ovarian Syndrome
Letrozole Combined With Gonadotropins (Gn) for Ovarian Stimulation Undergoing in Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) in Patients With Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine whether letrozole combined with gonadotropins are effective in the ovarian hyperstimulating for IVF/ICSI in patients with PCOS.
- Trial name
- NCT00894608
- Testing
- letrozole + gonadotropins, GnRHa + gonadotropins
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Yunyang Medical College
Single Embryo Transfer, Fertilization in Vitro
Advantages of Early Intrauterine Transfer of "Blank" Culture Medium Prior to 1st or 2nd Transfer of Thawed Embryo(s).
Despite technical advances in Medically Assisted Reproduction (AMP), the success of fertility treatments is sometimes limited by embryo implantation failure.
- Trial name
- TRABLAN (NCT06177613)
- Testing
- Blank culture transfer
- Where
- 7 sites in France, Reunion
- Volunteers
- 1,154 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Obesity, Infertility
Multidisciplinary Treatment of Obesity Prior to in Vitro Fertilization: Impact on Global Reproductive Outcomes (PRO-FIV Study)
The aim of the present study is to evaluate the impact of a multidisciplinary treatment of obesity prior to IVF on global reproductive outcomes and maternofetal metabolic and cardiovascular risk factors.
- Trial name
- PRO-FIV (NCT03395067)
- Testing
- Intervention group
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Hospital Clinic of Barcelona
Sterility
Low Molecular Weight Heparin to Improve Pregnancy Outcome in Patients With Recurrent Implantation Failure
The objective of this study is to determine the effect of Bemiparin, a low molecular weight heparin, on implantation rate in women with unexplained recurrent implantation failure undergoing IVF/ICSI treatment.
- Trial name
- BRIF (NCT02607319)
- Testing
- Bemiparin sodium
- Where
- Lebanon
- Volunteers
- 165 people
- Sponsor
- American University of Beirut Medical Center
Infertility, Female
Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation
The goal of this clinical trial is to evaluate a long Clomid protocol as compared to a 5-day Clomid protocol for ovarian stimulation in patients with diminished ovarian reserve undergoing ovarian stimulation for in-vitro…
- Trial name
- NCT06701071
- Testing
- Clomiphene Citrate
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Southern California
Infertility, Pregnancy
Effect of Endometrial Biopsy on in Vitro Fertilization Pregnancy Rates - a Multicenter Study
Animal and clinical studies have suggested that local tissue trauma can promote the process of an embryo implanting in the uterine cavity.
- Trial name
- EndoBx-IVF (NCT01983423)
- Testing
- Endometrial Biopsy
- Where
- 2 sites in Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Jon Havelock
Infertility, OHSS
Implantation Enhancement by Elective Cryopreservation of All Viable Embryos
A randomised controlled open-label clinical trial to compare the clinical pregnancy rates between fresh embryo transfer and elective all-embryo vitrification with thawing and transfer in a subsequent cycle in high-responders
- Trial name
- ICE (NCT02148393)
- Testing
- Vitrification with subsequent-cycle embryo thawing/transfer, Intensified luteal phase support for fresh embryo transfer, Pregnyl®
- Where
- Belgium
- Volunteers
- 212 people
- Sponsor
- Universitair Ziekenhuis Brussel