Clinical trials: In-Vitro Fertilization
Fertilization in Vitro
Optimizing the Technique of Embryo Transfer in IVF Using Better Imaging Guidance
This trial seeks to improve ultrasound imaging during embryo transfer in IVF by using a small, high resolution ultrasound probe used routinely for cardiac imaging in children.
- Trial name
- NCT03062098
- Testing
- ultrasound imaging
- Where
- Israel
- Sponsor
- Rambam Health Care Campus
Infertility
Optimizing the Temperature for Embryo Culture in In Vitro Fertilization
Many human and animal studies over the past 40 years have revealed that ovaries and Fallopian tubes have a lower temperature than core body temperature, especially around the time of ovulation and early embryo development.
- Trial name
- NCT01506089
- Testing
- 36 degrees Celsius
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Complications Associated With Artificial Fertilization, Disorder of Endocrine Ovary
Cabergoline and Hydroxyethyl Starch in Ovarian Hyperstimulation Syndrome Prevention
The purpose of this study is to assess whether, in GnRH agonist in vitro fertilization (IVF) cycles, where there is a risk of ovarian hyperstimulation syndrome (OHSS), the addition of cabergoline to the hydroxyethyl starch…
- Trial name
- NCT01530490
- Testing
- Cabergoline and Hydroxyethyl Starch, Hydroxyethyl Starch
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospital de Cruces
Vitamin D Deficiency, Infertility
Vitamin D Deficiency of Couples and Infertility
Between March 2016 and March 2017, we performed a large retrospective, non-interventional, single-center cohort study and measured 25(OH)D3 plasma levels prior to ovarian stimulation in couples who underwent IVF/ICSI.And we…
- Conditions
- Vitamin D Deficiency, Infertility, Couples, In-vitro Fertilization
- Trial name
- NCT03305510
- Testing
- vitamin D is below 20ng/ml
- Volunteers
- 1,500 people
- Sponsor
- Tongji Hospital
ICSI
Luteal Phase Support With Estradiol In Poor Responders Undergoing In Vitro Fertilization
The role of progesterone (P) supplementation in the luteal phase of in vitro fertilization (IVF) cycles is well established world-wide , but the influence of the luteal phase estradiol level on implantation is not clearly defined…
- Trial name
- NCT03788681
- Testing
- Estradiol Valerate
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Ain Shams University
Infertility
Study Comparing Outcomes Between Conventional IVF and a "Freeze-all"-Strategy in Assisted Reproductive Technology
The purpose of this study is to compare conventional fresh embryo transfer with a "freeze all and transfer later strategy" in assisted reproductive technology in terms of ongoing pregnancy rates, live birth rates as well as…
- Trial name
- NCT02746562
- Testing
- Freeze all
- Where
- 2 sites in Denmark
- Volunteers
- 424 people
- Sponsor
- Anja Bisgaard Pinborg
Infertility
ICSI Versus Conventional IVF in Non-male Factor Couples
Conventionally, ICSI was initially developed and has been shown to be an effective treatment for male factor infertility. It is increasingly being used for patients without a male factor diagnosis, despite the lack of clinical…
- Trial name
- NCT03428919
- Testing
- ICSI, IVF
- Where
- Vietnam
- Volunteers
- 1,064 people
- Sponsor
- Mỹ Đức Hospital
Subfertility, Assisted Reproduction
Role of Follicular Output Rate in the Prediction of in Vitro Fertilization and Intracytoplasmic Sperm Injection in Women With Unexplained Infertility
300 women with unexplained infertility who are already decided to be treated with ICSI will be recruited from Cairo university hospitals and Dar Al-Teb subfertility centre.
- Trial name
- NCT02154958
- Where
- 2 sites in Egypt
- Volunteers
- 300 people
- Sponsor
- Cairo University
Infertility
Next Generation Sequencing Screening for Embryonic Ploidy Status
To evaluate the benefits of using next generation sequencing to assess embryonic aneuploidy. All viable blastocysts will be biopsied and cryopreserved for future transfer.
- Trial name
- nexgen (NCT02032264)
- Testing
- Comprehensive Chromosome Screening, Morphologically Best
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Infertility
Eeva™ Continued Access Study: Assessing the Usability of Eeva in a Clinical Setting
User questionnaire of Eeva System usability and reports of device malfunctions.
- Trial name
- CAS (NCT01617993)
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- Progyny, Inc.
Infertility
Protocol to Minimize Injections and Blood Draws for Women Undergoing in Vitro Fertilization
The purpose of the study is to evaluate the safety and efficacy of nasal gonadotropins (Menopur) in women undergoing IVF. The purpose of this study is also to report and monitor any and all side effects of the nasal Menopur.
- Trial name
- NCT02865681
- Testing
- Menopur, Synarel, HCG trigger
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- New Hope Fertility Center
Clinical Pregnancy Rate, Ovulation Induction
Follicular Long GnRH Agonist Versus Antagonist Protocol in PCOS Women Undergoing in Vitro Fertilization
Pituitary down regulation is widely used during in vitro fertilization (IVF) procedures. It can suppress the spontaneous luteinizing hormone (LH) surge, and can also make follicles growth evenly.
- Conditions
- Clinical Pregnancy Rate, Ovulation Induction, IVF
- Trial name
- NCT02496754
- Testing
- GnRH-a, GnRH-anta
- Where
- China
- Volunteers
- 1,266 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
In Vitro Fertilization, Psychological Stress
Does Emotional Support Decrease In Vitro Fertilization Stress?
In vitro fertilization for infertility has been associated with a significant amount of treatment related stress for patients. In addition,stress levels increase between embryo transfer and pregnancy test, during this waiting…
- Trial name
- NCT01406028
- Testing
- Phone calls
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Brigham and Women's Hospital
Infertility
Maximal Stimulation and Delayed Fertilization for Diminished Ovarian Reserve: a Randomized Pilot Study
The purpose of the study is (A) to determine if the following novel approach improves the live birth rate with In-Vitro Fertilization (IVF) for women with a poor prognosis due to diminished ovarian reserve: ovarian stimulation…
- Trial name
- NCT01921166
- Testing
- clomiphene plus gonadotropins, Leuprolide flare
- Volunteers
- 23 people
- Sponsor
- Wake Forest University Health Sciences
Primary Ovarian Insufficiency, Female Infertility Due to Diminished Ovarian Reserve
Effect of Testosterone Treatment on Embryo Quality
The purpose of this study is to determine the effect of treatment with trans-dermal testosterone cream compared to placebo on measures of ovarian reserve, oocyte and embryo quality, and pregnancy rates among women with evidence…
- Trial name
- NCT01662466
- Testing
- Testosterone cream (0.5mg per gram), DHEA
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Center for Human Reproduction
Infertility, Female, Endometrial Diseases
Effect of Different Ovarian Stimulation Protocols on Endometrial Receptivity
This study will assess the change in endometrial gene expression signature on the day of embryo transfer according to the type of exogenous gonadotropins administered.
- Trial name
- NCT03755973
- Testing
- CFA, rFSH, Fixed daily rFSH dosing protocol of 200-300 IU
- Where
- Portugal
- Volunteers
- 24 people
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
Infertility, Female
Assessment of Blood and Follicular Fluid Immune Cell Constitution in Patients Undergoing in Vitro Fertilization
The etiology of infertility in the majority of patients with poor response to ovarian stimulation remains unknown. This study will investigate the role of immune cells (T cells, B cells, dendritic cells and NK cells), that…
- Trial name
- NCT01083745
- Where
- Israel
- Sponsor
- Hillel Yaffe Medical Center
Supervision of Pregnancy Resulting From In-vitro Fertilization
Optimal Planning of a Day 3 Cryopreserved(Frozen)-Thawed Embryo Transfer in a Natural Cycle With hCG Administration or After Spontaneous LH Peak?
The aim of the study is to determine whether spontaneous LH peak is superior to human chorionic gonadotropin before a transfer of a day 3 frozen embryo.
- Trial name
- PLUS (NCT02145819)
- Testing
- hCG, LH peak
- Where
- Belgium
- Volunteers
- 240 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility; In Vitro Fertilization; Embryo Development
Day-3 vs Day-5 Assisted Hatching: Impact on Blastocyst Morphology and PGT-A Outcomes
This randomized controlled trial compared assisted hatching (AH) performed on Day 3 versus Day 5 in patients undergoing IVF-ICSI with preimplantation genetic testing for aneuploidy (PGT-A).
- Trial name
- AH-PGTA (NCT07154875)
- Testing
- Laser-Assisted Hatching
- Where
- Vietnam
- Volunteers
- 141 people
- Sponsor
- Hoang Minh Ngan
Infertility, In Vitro Fertilization
Injection of Day 2 Embryo Culture Supernatant Into the Uterine Cavity Didn't Improve Implantation and Pregnancy Rates
Forty-five infertile women undergoing in vitro fertilization treatment were managed by uterine cavity injection of day 2 embryo culture supernatant before day 3 embryo transfer.
- Trial name
- NCT00730496
- Testing
- uterine cavity injection of day 2 embryo culture supernatant
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shen-Zhen City Maternity and Child Healthcare Hospital