Clinical trials: In-Vitro Fertilization
Minor Intra-uterine Abnormalities
The Impact of Treating Minor Uterine Cavity Abnormalities Diagnosed by Office Hysteroscopy in Unselected In Vitro Fertilization (IVF) Cases
This is a comparative, controlled trial to evaluate the impact of treating undetected, asymptomatic, predefined minor uterine cavity abnormalities on the success of IVF treatment.
- Trial name
- NCT00830401
- Testing
- Treatment of predefined abnormality by hysteroscopic surgery, Ofloxacinum/Doxycycline
- Where
- Netherlands
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Infertility
PGS Using Microarray in IVF Patients With Repeated Implantation Failure
This project intends to use preimplantation genetic screening (PGS) with the microarray technique to determine the chromosome composition of fertilized eggs, so that only chromosomally normal embryos are transferred during IVF.
- Trial name
- NCT02265614
- Testing
- PGS
- Where
- Sweden
- Volunteers
- 130 people
- Sponsor
- IVF Research Sweden
Infertility, Endometritis
Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization
Chronic endometritis is a persistent inflammation of the endometrium. Chronic endometritis is asymptomatic or little symptomatic.
- Conditions
- Infertility, Endometritis, Abortion, Spontaneous
- Trial name
- NCT01762098
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Clinique Ovo
in Vitro Fertilization
Transfer of Frozen Embryos in Natural Cycle: Evaluation of Impact of Spontaneous Versus HCG-triggered Ovulation on Pregnancy Rate
The purpose of the study is to evaluated whether there is a difference in pregnancy rate when transferring frozen embryos between patietns having spontaneously ovulated versus those triggered to voulate with HCG.
- Trial name
- TECNAT (NCT03428165)
- Testing
- HCG
- Where
- 2 sites in France
- Volunteers
- 103 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Infertility
Correlating Time-Lapse Parameters With aCGH Testing in IVF Treatment (aCGH Study)
The purpose of this research study protocol is to collect imaging data on embryos followed to blastocyst stage (Day 5-6) and correlate Eeva parameters with array - Comparative Genomic Hybridization (aCGH) results and ongoing…
- Trial name
- NCT02141685
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Progyny, Inc.
Infertility
Stress Management for Couples Undergoing In Vitro Fertilization (IVF)
The investigators are trying to determine stress management strategies in couples undergoing In Vitro Fertilization (IVF).
- Trial name
- NCT01714882
- Testing
- Stress Management & Resiliency Training, Stress Management DVD
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Amit Sood
Infertility (IVF Patients)
Study of Abnormally Fertilized Embryos
The goal of this observational study is to determine the diploidy rate of haploid and triploid embryos from in vitro fertilization (IVF) cycles.
- Trial name
- SAFE (NCT06940973)
- Testing
- Parental samples, PGT-A, TE rebiopsies and spent blastocyst media collection
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Igenomix
Hypo-responder, Infertility (IVF Patients)
Optimal Stimulation of Hypo-responders Undergoing in Vitro Fertilization (IVF)
Stimulation is a key step of in vitro fertilization (IVF). Typically, injectable gonadotropins are used for stimulation, and their dose is individually determined to avoid hypo- as well as hyper-response.
- Conditions
- Hypo-responder, Infertility (IVF Patients), OVARIAN STIMULATION
- Trial name
- NCT07121751
- Testing
- use of combination of recombinant FSH and recombinant LH, higher dose recFSH, unchanged dose
- Where
- 4 sites in Hungary
- Volunteers
- 150 people
- Sponsor
- Dunamenti REK Istenhegyi IVF Center
Infertility
Comparative Study of Two Embryo Culture Systems
The centre for Medically-Assisted Procreation (MAP) of Dijon CHU has two high-technology embryo culture systems, with incubation characteristics that are potentially superior to those provided by classical culture systems.
- Trial name
- INCUBATE (NCT02722252)
- Testing
- Embryoscope, Embryo culture system without incorporated camera
- Where
- France
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Infertility
Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders
This is a prospective, randomized clinical trial to compare the efficiency and safety of mild stimulation and controlled ovarian stimulation protocol on the treatment of POR.
- Trial name
- POR (NCT01926210)
- Testing
- mild stimulation protocol, controlled ovarian stimulation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Huang Rui
In Vitro Fertilization
Comparing the Efficacy of Urinary and Recombinant Human Chorionic Gonadotropin (hCG) on Oocyte Maturity
This study is a prospective randomized clinical trial to compare the efficacy of the urinary and recombinant hCG on oocyte quality for ovulation induction in women undergoing IVF/ICSI.
- Trial name
- NCT01507376
- Testing
- recombinant hCG, urinary hCG
- Where
- Iran
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Infertility
Safety Evaluation of the HyperSperm Sperm Preparation Procedure for In Vitro Fertilization
Prospective, multicenter, randomized clinical study evaluating the safety of a novel sperm preparation method for in vitro fertilization (IVF), compared to standard sperm preparation procedures.
- Trial name
- NCT07478549
- Testing
- Standard Sperm Preparation, HyperSperm
- Where
- 2 sites in Argentina
- Volunteers
- 202 people
- Sponsor
- Fecundis Lab SL
Infertility
IMPACT OF POLYCYCLIC AROMATIC HYDROCARBONS (PAH) ON IN VITRO FERTILIZATION
The main objective of this study is to highlight a relationship between exposure to PAHs, genotoxic effect biomarkers on spermatozoa and follicular cells, as well as embryonic quality and embryo implantation rates at a given…
- Trial name
- NCT03914859
- Testing
- IN VITRO FERTILIZATION
- Where
- France
- Volunteers
- 220 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Infertility
Follicle Stimulating Hormone (FSH) Receptor Polymorphisms in In-Vitro Fertilization Cycles.
This study is being done to identify if certain sequences (patterns) of key genes (called polymorphisms) may predict a response to fertility medications.
- Trial name
- NCT01002885
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- University Reproductive Associates
Culture, ICSI, IVF
Comparison of Two Embryo Culture Media for IVF and ICSI
In this research, the two media used are Global medium and SSM medium with serum), which are routinely used in the reproduction biology unit. This study simply consists in setting up a methodology to compare these to media.
- Trial name
- NCT02586324
- Testing
- global medium, SSM
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Infertility, PCOS
Metformin in Step-down Regimen Versus Conventional Low Dose Step-up Protocol in Patients With PCOS Undergoing IVF
Because many women with Polycystic Ovary Syndrome (PCOS) are very sensitive to the use of gonadotropins, several strategies have been proposed to reduce the risk of Ovarian hyperstimulation syndrome (OHSS) and multiple…
- Trial name
- NCT01438190
- Testing
- Metformin, gonadotropins in step-down regimen
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Modena and Reggio Emilia
IVF Outcome
Trigger Timing in Ovarian Stimulations
The gonadotrophin-releasing hormone (GnRH) antagonist protocol is widely used in in vitro fertilisation (IVF) for its flexibility and ability to reduce the risk of ovarian hyperstimulation syndrome (OHSS).
- Trial name
- NCT04163133
- Testing
- 1-2 days later trigger than regular timing
- Where
- China
- Volunteers
- 834 people
- Sponsor
- Peking University Third Hospital
Infertility, Oocytes
Efficacy of a Simulator Based (PickUpSimTM) Residents' Training Program for Oocyte Retrievals
Simulation is an educational approach that has recently found an application in healthcare.acquire. Angers university hospital has decided to acquire, in December 2016, the high-fidelity Oocyte Pick up (OPU) simulator…
- Conditions
- Infertility, Oocytes, Fertilization in Vitro
- Trial name
- NCT03700255
- Testing
- PickUpSimTM simulation training program
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Infertility, Female
The Effect of the Mind/Body Program for Fertility, Hungarian Version, on Well-Being and Assisted Reproduction Outcomes
Involuntary childlessness is an emotionally stressful experience; however, psychosocial counseling is typically not available in Hungarian routine fertility care.
- Trial name
- NCT04151485
- Testing
- Mind/Body Program for Fertility (Domar et al., 2011), Fertility Support Program
- Where
- 2 sites in Hungary
- Volunteers
- 177 people
- Sponsor
- Semmelweis University
OHSS (Ovarian Hyperstimulation)
Triggering of Final Oocyte Maturation With GnRHa (Buserelin) in GnRH Antagonist Cycles
The purpose of this study is to possibly further improve the clinical outcome and explore the incidence of OHSS in patients, who have final oocyte maturation with GnRHa (Buserelin) in GnRH antagonist IVF/ICSI cycles
- Trial name
- NCT00627406
- Testing
- Buserelin and Pregnyl, Pregnyl
- Where
- Denmark
- Volunteers
- 384 people
- Sponsor
- Regionshospitalet Viborg, Skive