Clinical trials: In-Vitro Fertilization
Fertilization in Vitro, Infertility
The Impact of the Timing of Trigger on IVF Success
The aim of this study is to examine the length of ovarian stimulation with the timing of trigger in an IVF cycle and its potential to impact patient outcomes.
- Conditions
- Fertilization in Vitro, Infertility, Embryonic Development
- Trial name
- NCT02990949
- Testing
- Timing of trigger
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Colorado Center for Reproductive Medicine
Oocyte Retrieval, Pain
Oocyte Retrieval and Virtual Reality (REVPO)
The aim of the study is to ass wether or not the use of virtual reality during oocyte retrieval provides a better pain relief for patients, compared to a standard analgesic procedure.
- Conditions
- Oocyte Retrieval, Pain, Fertilization in Vitro
- Trial name
- REVPO (NCT04935658)
- Testing
- Hypnotic relaxation induced by virtual reality (device), local anesthesia
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pregnancy, Live Birth
Folic Acid and Zinc Supplementation Trial (FAZST)
The overarching goal of this trial is to determine if an intervention comprising folic acid and zinc dietary supplementation improves semen quality and indirectly fertility outcomes (i.e., live birth rate) among couples trying to…
- Conditions
- Pregnancy, Live Birth, Spontaneous Abortion
- Trial name
- FAZST (NCT01857310)
- Testing
- 5 mg folic acid and 30 mg elemental zinc
- Where
- 4 sites in United States
- Volunteers
- 2,370 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Endometriosis, In Vitro Fertilization Implantation Failure
The In Vitro Fertilization - Lipiodol Uterine Bathing Effect Study
The hypothesis of this study is that Lipiodol uterine bathing improves the success rate of in vitro fertilization (IVF) for women with endometriosis or recurrent IVF implantation failure.
- Trial name
- NCT00894946
- Testing
- Lipiodol + IVF, IVF
- Where
- New Zealand
- Volunteers
- 350 people
- Sponsor
- University of Auckland, New Zealand
Polycystic Ovary Syndrome, Obesity
Liraglutide and Metformin Combination on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With PCOS, Obesity and Infertility
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and one of the leading causes of infertility.
- Conditions
- Polycystic Ovary Syndrome, Obesity, Infertility, Female
- Trial name
- NCT05952882
- Testing
- Liraglutide + Metformin, Metformin
- Volunteers
- 188 people
- Sponsor
- Mỹ Đức Hospital
Oocyte Retrieval, Adverse Events
The Use of Virtual Reality Technology During Oocyte Retrieval for in Vitro Fertilization
Ultrasound-guided oocyte retrieval (OR) is a short, but oftentimes painful procedure, during which the follicles are punctured trans-vaginally to obtain oocytes for in vitro fertilization (IVF).
- Conditions
- Oocyte Retrieval, Adverse Events, Procedural Anxiety, Pain Intensity
- Trial name
- NCT06733701
- Testing
- VR-based intervention (VRReliever Software V0.3.4 fromXRHealth), VR headset without any scenery
- Volunteers
- 50 people
- Sponsor
- Mount Sinai Hospital, Canada
Infertility, In Vitro Fertilization Protocols
Evaluation of Granulosa Cells Function After IVF Protocols
This study is intended to evaluate ovarian cells after being submitted do different in vitro fertilization protocols. The investigators will analyze hormones secretion and intracellular mechanisms of these cells comparing the…
- Trial name
- NCT01946022
- Testing
- randomization between the two GnRH analogues (agonist and antagonist)
- Where
- 2 sites in Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Infertility
Timing of Estrogen Support During the Luteal Phase of in Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) Cycle
To test the hypothesis that adding estradiol (E2) to progesterone supplementation later in the luteal phase of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles, rather than earlier in the luteal phase…
- Trial name
- NCT01367912
- Testing
- estradiol tablet
- Where
- Turkey (Türkiye)
- Volunteers
- 301 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Infertility, Male
Effect of Ejaculatory Abstinence on Semen Parameters in Male Factor Infertility Patients
The purpose of this study is to compare semen parameters with in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) when male factor infertility patients abstain from ejaculation more than 48 hours (routine care)…
- Trial name
- NCT04206800
- Testing
- Ejaculatory abstinence less than 24 hours
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Boston IVF
Metabolic Syndrome, Diabetes
Metabolic Phenotyping of Individuals Born Following Assisted Reproduction Techniques
This study is to compare the effects of high fat overfeeding on metabolic risk factors in children born though assisted reproduction technologies (ART) versus children conceived naturally (controls).
- Trial name
- IMPART (NCT01230632)
- Testing
- high fat overfeeding
- Where
- Australia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Female Infertility, Embryo Development
Day-4 Embryo Defragmentation: Blastocyst Rate and clInical Outcomes
Background: Embryo fragmentation is one of the main morphological parameters assessed during in vitro culture in assisted reproductive technology (ART).
- Conditions
- Female Infertility, Embryo Development, In Vitro Fertilization
- Trial name
- DEBRIS (NCT07500337)
- Testing
- Mechanical embryo defragmentation at Day 4 (morula stage), Standard embryo culture without intervention
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- Momo Fertilife
Female Infertility Due to Diminished Ovarian Reserve
Alpha-Lipoic Acid Supplementation and IVF Outcomes in Women of Advanced Maternal Age
Female fertility declines with advancing age, largely because of deteriorating oocyte quality driven by mitochondrial dysfunction and oxidative stress within the ovarian microenvironment.
- Trial name
- NCT07685431
- Testing
- Alpha-Lipoic Acid (ALA)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Veterans General Hospital.
In Vitro Fertilisation (IVF) Treatment
Effect of Oxytocin Antagonist on Reduction of Uterine Contractions
The main purpose of this clinical research trial was to evaluate the effects of barusiban compared to placebo on uterine contractions on luteal phase uterine contractions in oocyte donors supplemented with progesterone.
- Trial name
- EFFORT (NCT01043120)
- Testing
- Barusiban
- Where
- 5 sites in Belgium, Czechia and 1 more
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
IVF Failure
Sildenafil Citrate of in Vitro Fertilization After Multiple IVF Failures Attributed to Poor Endometrial Development
The aim of this study is to evaluate the effect of sildenafil citrate on endometrial development in women with history of recurrent implantation failure after IVF
- Trial name
- NCT03044561
- Testing
- Sildenafil Citrate
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Unrecognized Condition
The Effect of Melatonin Supplementation on Cumulus Cells and IVF Outcomes
This study investigates the effects of melatonin supplementation on cumulus cell gene expression and in vitro fertilization (IVF) outcomes in women over 35 years old.
- Trial name
- NCT06546774
- Testing
- Melatonin
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Infertility
Mild Versus Conventional Ovarian Stimulation for Poor Responders Undergoing In Vitro Fertilisation
The investigators will examine the balance between IVF success in terms of outcome parameters, using a mild ovarian stimulation protocol, opposing it to the conventional stimulation regimens in poor responders undergoing IVF.
- Trial name
- NCT01319708
- Testing
- mild ovarian stimulation, conventional ovarian stimulation
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- National and Kapodistrian University of Athens
Women Infertility
Myo-inositol/D-chiro-inositol Ratio in Follicular Fluid
Considering the importance assumed by follicular microenvironment for a proper oocyte development, this study is a prospective observational clinical trial which aims to evaluate whether the embryo blastocyst quality may be…
- Trial name
- NCT03055442
- Testing
- Dosage of myo-inositol, Dosage of D-chiro-inositol
- Where
- Greece
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Lo.Li.Pharma s.r.l
Cancer, Cancer in Pregnancy
ProspectiveFemaleAYA - Late Effects of Cancer Therapies on Gonadal Function, Fertility, Efficiency of Fertility Preservation Procedures and Pregnancy Outcomes
In the past two decades, the evidence-based knowledge on the prevalence and risk factors for gonads impairment, including infertility, following cancer and numerous cancer treatment regimen has significantly increased.
- Conditions
- Cancer, Cancer in Pregnancy, Infertility, In Vitro Fertilisation (IVF) Treatment
- Trial name
- FemFertilAYA (NCT07622420)
- Volunteers
- 3,000 people
- Sponsor
- Karolinska Institutet
Low Ovarian Reserve, Poor Ovarian Response
Ovulation Trigger Strategies in Low Ovarian Reserve (TRIGGERBEST)
This study aims to compare different ovulation triggering strategies in women with low ovarian reserve undergoing fresh in vitro fertilization (IVF) cycles.
- Trial name
- TRIGGERBEST (NCT07816562)
- Testing
- Human chorionic gonadotropin (hCG), Follitropin delta, Triptorelin
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Fertility Preservation
Oocyte Vitrification for In Vitro Fertilization (IVF) Patients and Women With Fertility Threatening Conditions
Vitrification is a method of cryopreserving tissue for future use. It is widely used to preserve extra, good quality embryos generated from infertility treatments.
- Trial name
- NCT01448460
- Volunteers
- 8 people
- Sponsor
- University of Louisville