Clinical trials: In-hospital Cardiac Arrest
Cardiac Arrest, Cardiopulmonary Resuscitation
Circulation Improving Resuscitation Care (CIRC)
During resuscitation of out of hospital cardiac arrest patients the use of a mechanical chest compression device Autopulse will improve survival compared to manual compressions.
- Trial name
- CIRC (NCT00597207)
- Testing
- AutoPulse, Manual
- Where
- 5 sites in United States, Austria and 1 more
- Volunteers
- 4,231 people
- Sponsor
- Zoll Medical Corporation
Heart Arrest, Out-Of-Hospital
Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest
Phase II double blind (participants and investigator) placebo controlled randomized (1:1) clinical trial of inhaled nitric oxide (iNO) 20 ppm administered over 12h beginning as soon as possible but within 4 h of return of…
- Trial name
- iNOOHCA (NCT03079102)
- Testing
- Nitric Oxide, Nitrogen
- Where
- 5 sites in United States
- Volunteers
- 57 people
- Sponsor
- Cameron Dezfulian
Out-of-hospital Cardiac Arrest
CPR Quality Between Flexible Stretcher and Standard Stretcher in OHCA
This study aims to compare the quality of emergency medical services cardiopulmonary resuscitation between flexible stretcher and standard stretcher during ambulance transport to hospital among out-of-hospital cardiac arrest…
- Trial name
- ASIA-CPR (NCT02527694)
- Testing
- Flexible EMS stretcher cart, mechanical CPR
- Where
- South Korea
- Volunteers
- 49 people
- Sponsor
- Seoul National University Hospital
Cardiac Arrest
Mild Versus Moderate Therapeutic Hypothermia in Out-of-hospital Cardiac Arrest Patients
This trial is currently a single-center, randomized, double-blind investigator initiated prospective clinical trial initiated at the University of Ottawa Heart Institute (UOHI).
- Trial name
- CAPITALCHILL (NCT02011568)
- Testing
- Therapeutic Hypothermia
- Where
- Canada
- Volunteers
- 389 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Cardiac Arrest, Heart Arrest
ECPR for Refractory Out-Of-Hospital Cardiac Arrest
In the U.S. alone, over 300,000 people per year have sudden out-of-hospital cardiac arrest (OHCA), and less than 1 out of 10 survive.
- Conditions
- Cardiac Arrest, Heart Arrest, Sudden Cardiac Arrest, Cardiopulmonary Arrest
- Trial name
- EROCA (NCT03065647)
- Testing
- Expedited Transport With Mechanical CPR
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Cardiac Arrest
Pragmatic Airway Resuscitation Trial
The primary objective of the trial is to determine if 72-hour survival after out-of-hospital cardiac arrest (OHCA) is improved with initial endotracheal intubation (ETI) over initial laryngeal tube (LT) airway management…
- Trial name
- PART (NCT02419573)
- Testing
- Endotracheal Intubation, Laryngeal Tube (King)
- Where
- 6 sites in United States
- Volunteers
- 3,004 people
- Sponsor
- University of Alabama at Birmingham
Cardiac Arrest
Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest
The purpose of this study is to assess the feasibility of hemofiltration in patients resuscitated from cardiac arrest. Cardiac arrest is the loss of mechanical activity of the heart including the loss of detectable pulse, or…
- Trial name
- NCT01509040
- Testing
- Standard Care, Low Volume Hemofiltration, High Volume Hemofiltration
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Washington
Cardiac Arrest
Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial
Cardiac arrest is a sudden, unexpected loss of heart function. Therapeutic hypothermia, in which the body's temperature is lowered and maintained several degrees below normal for a period of time, has been used to successfully…
- Trial name
- THAPCA-OH (NCT00878644)
- Testing
- Therapeutic Hypothermia, Therapeutic Normothermia
- Where
- 34 sites in United States, Canada
- Volunteers
- 295 people
- Sponsor
- University of Michigan
Out of Hospital Cardiac Arrest
Dispatcher-Activated Neighborhood Access Defibrillation and Cardiopulmonary Resuscitation
The hypothesis of this study is Dispatcher-Activated Neighborhood Access Defibrillation and Cardiopulmonary Resuscitation (NAD-CPR) would improve survival of out-of-hospital cardiac arrest (OHCA).
- Trial name
- NCT02010151
- Testing
- NAD-CPR
- Where
- South Korea
- Volunteers
- 3,194 people
- Sponsor
- Seoul National University Hospital
Out of Hospital Cardiac Arrest
Continuous Chest Compressions vs AHA Standard CPR of 30:2
The primary aim of the trial is to compare survival to hospital discharge after continuous chest compressions (CCC) versus standard American Heart Association (AHA) recommended cardiopulmonary resuscitation (CPR) with interrupted…
- Trial name
- CCC (NCT01372748)
- Testing
- Standard CPR, Continuous chest compressions
- Where
- 7 sites in United States, Canada
- Volunteers
- 23,711 people
- Sponsor
- University of Washington
Cardiac Arrest, Shock
Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest
This study is to evaluate whether thiamine can increase oxygen consumption and lower lactate in patients who initially survive an in-hospital cardiac arrest.
- Conditions
- Cardiac Arrest, Shock, Lactic Acidosis, Thiamin Deficiency
- Trial name
- NCT02974257
- Testing
- Thiamine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Beth Israel Deaconess Medical Center
Out-Of-Hospital Cardiac Arrest, Pneumonia
Ceftriaxone to PRevent pneumOnia and inflammatTion aftEr Cardiac arresT (PROTECT)
Randomized-controlled trial and microbiome assessment to understand the risk-to-benefit ratio of prophylactic antibiotics (Ceftriaxone) vs placebo in patients with pneumonia and inflammation after cardiac arrest outside the…
- Trial name
- PROTECT (NCT04999592)
- Testing
- Standard of care without prophylaxis, Antibiotic prophylaxis
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- David J. Gagnon
Escalation of Care, Cardiopulmonary Arrest
Early Warning System for Clinical Deterioration on General Hospital Wards
The goal is to develop a two-tiered monitoring system to improve the care of patients at risk for clinical deterioration on general hospital wards (GHWs) at Barnes-Jewish Hospital (BJH).
- Conditions
- Escalation of Care, Cardiopulmonary Arrest, Respiratory Arrest, Severe Sepsis
- Trial name
- NCT01280942
- Testing
- EWS Nursing Alerts, Wireless Remote Sensor
- Where
- United States
- Volunteers
- 20,031 people
- Sponsor
- Washington University School of Medicine
Cardiac Arrest, Sudden Cardiac Death
Hemodynamic Effects of Standard Cardiopulmonary Resuscitation (CPR), Active Compression Decompression CPR With an Inspiratory Impedance Device, and Standard CPR With an Intrathoracic Pressure Regulator During Out-of-hospital Cardiac Arrest
More than 300,000 Americans experience out-of-hospital cardiac arrest annually, with overall survival rates averaging less than 5%.
- Trial name
- NCT01325870
- Testing
- ACD-CPR, ITPR, S-CPR
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Advanced Circulatory Systems
Heart Arrest, Out-Of-Hospital
Calcium for Out-of-Hospital Cardiac Arrest
This is an investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of calcium during adult out-of-hospital cardiac arrest.
- Trial name
- COCA (NCT04153435)
- Testing
- Calcium Chloride, Sodium chloride 0.9%
- Where
- Denmark
- Volunteers
- 397 people
- Sponsor
- Lars Wiuff Andersen
Heart Arrest, Death, Sudden, Cardiac
ResQ Trial: Impact of an ITD and Active Compression Decompression CPR on Survival From Out-of-Hospital Cardiac Arrest
The purpose of this study is to determine whether performing active compression decompression cardiopulmonary resuscitation (ACD-CPR) with an impedance threshold device (ITD) compared to conventional standard cardiopulmonary…
- Conditions
- Heart Arrest, Death, Sudden, Cardiac, Cardiopulmonary Resuscitation, Cardiac Arrest
- Trial name
- ResQ (NCT00189423)
- Testing
- Use of an impedance threshold device (ITD) during the performance of active compression decompression CPR (ACD-CPR), Standard cardiopulmonary resuscitation (S-CPR)
- Where
- 7 sites in United States
- Volunteers
- 1,653 people
- Sponsor
- Advanced Circulatory Systems
Cardiac Arrest
Microcirculatory Perfusion in Patients With Coma After Out-of-hospital Cardiac Arrest
The hypothesis is: In patients after an out of hospital cardiac arrest, treated with therapeutic hypothermia (33°C) will be found significantly more microcirculatory abnormalities, compared to the same group of patients treated…
- Trial name
- NCT01850485
- Testing
- microcirculation by SDF and NIRS, in 33 and 36 degrees
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Frisius Medisch Centrum
Out-Of-Hospital Cardiac Arrest
Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest
In this clinical study, a total of 1500 patients with out-of-hospital cardiac arrest in Seattle/King County will be enrolled. This will be a randomized clinical trial and patients will receive either two different doses of IV…
- Trial name
- SNOCAT (NCT03452917)
- Testing
- sodium nitrite 45 mg, sodium nitrite 60 mg
- Where
- United States
- Volunteers
- 1,502 people
- Sponsor
- University of Washington
Out of Hospital Cardiac Arrest
Effects of a New Dispatcher-Assisted Basic Life Support Training Program
Despite aggressive cardiopulmonary resuscitation (CPR) training, the outcome of cardiac arrest is not good. The problem is method of education.
- Trial name
- HEROS (NCT02142387)
- Testing
- BLS CPR program with dispatcher assisted CPR simulation
- Where
- South Korea
- Volunteers
- 18,822 people
- Sponsor
- Seoul National University Hospital
Post-Resuscitation Syndrome, Critical Illness
Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest
This retrospective observational cohort study aims to identify early predictors of short- and mid-term mortality in adult patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest.
- Conditions
- Post-Resuscitation Syndrome, Critical Illness, Cardiac Arrest, Hypoxic-Ischemic Encephalopathy
- Trial name
- PROM-ROSC (NCT07020091)
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Ahmet Düzgün