Clinical trials: In-stent Restenosis
In-Stent Carotid Artery Restenosis
Carotid Endarterectomy vs. Repeated Carotid Angioplasty and Stenting for In-Stent Restenosis
Patients with in-stent restenosis in carotid artery indicated to carotid intervention will be randomized into repeated carotid percutaneous transluminal angioplasty with or without stenting or carotid endarterectomy with stent…
- Trial name
- CERCAS (NCT05390983)
- Testing
- Carotid endarterectomy with stent removal
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Ostrava
Coronary Stenosis, Coronary Artery Stenosis
A Study to EXhibit Percutaneous Coronary Artery Dilatation With Non-Slip Element Balloon
The objective of this study is to evaluate safety and effectiveness of the Lacrosse NSE ALPHA coronary dilatation catheter during PCI in subjects with stenotic coronary arteries.
- Conditions
- Coronary Stenosis, Coronary Artery Stenosis, In-stent Restenosis
- Trial name
- EXPANSE-PTCA (NCT04985773)
- Testing
- Lacrosse NSE ALPHA coronary dilatation catheter
- Where
- 10 sites in United States
- Volunteers
- 200 people
- Sponsor
- Infraredx
In-stent Restenosis
Role of Novel Biomarkers Associated With In-stent Restenosis After Percutaneous Coronary Intervention
To study the relation between ISR and neutrophil-to-lymphocyte ratio (NLR), novel biomarkers (high-sensitivity CRP (hs-CRP), bone morphogenetic protein-2 (BMP-2) and other risk factors (age, sex, smoking, hypertension, diabetes…
- Trial name
- NCT06148441
- Testing
- bone morphogenetic protein-2 (BMP-2)
- Volunteers
- 100 people
- Sponsor
- Assiut University
Coronary Artery Disease, In Stent Restenosis
Sirolimus-Coated Balloon Versus Paclitaxel-Coated Balloon for the Treatment of Coronary In-Stent Restenosis
This is a prospective, multicenter, randomized controlled clinical trial, which plans to enroll 260 subjects.
- Trial name
- SIBLINT ISR (NCT04240444)
- Testing
- drug-coated balloon Catheter
- Where
- 16 sites in China
- Volunteers
- 260 people
- Sponsor
- B. Braun Medical International Trading Company Ltd.
In-stent Restenosis, Major Adverse Cardiovascular Events
Effect of Evolocumab on Chronic Total Occlusions (EVOLO-CTO)
The purpose of this study is to evaluate the effect of proprotein convertase subtilisin/kexin type-9 (PCSK9) inhibitors added to regular statin therapy on target lesion failure (TLF) and arteriosclerosis progression in patients…
- Trial name
- NCT05623995
- Testing
- PCSK9 inhibitor, Statin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Lin Zhao
Stent Restenosis
Clinical Study of Tongxinluo Capsule in Preventing and Treating Restenosis After Intracranial and External Arterial Stenting
Intrastent restenosis is a common complication after intracranial and extracranial arterial stenting and an important cause of recurrent ischemic stroke.
- Trial name
- NCT06112028
- Testing
- Tongxinluo capsule, Primary therapy
- Volunteers
- 200 people
- Sponsor
- Yanbin Li
Coronary Artery Disease, In-stent Restenosis
Safety and Efficacy of Paclitaxel Coated PTCA Balloon Catheter With a Shellac Plus Vitamin E Excipient (GENOSS® DCB) in Patients With Coronary In-stent Restenosis (ISR): A Prospective, Multi-center, Observational Study
The SFRGENISTA study aims to evaluate the long-term efficacy and safety of a paclitaxel-coated balloon catheter containing shellac and vitamin E excipients (Genoss® DCB) in patients with coronary in-stent restenosis (ISR).
- Trial name
- SFRGENISTA (NCT06104007)
- Testing
- Genoss® DCB
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Hospital
Angiotensin Converting Enzyme rs (1799752) Gene Polymorphism and Development of In-Stent Restenosis in Patients With Stable Coronary Artery Diseases
Angiotensin Converting Enzyme rs (1799752) Gene Polymorphism and Development of In-Stent Restenosis in Patients With Stable Coronary Artery Diseases in Sohag Hospital University.
One of the most common medical approaches to the treatment of coronary artery disease (CAD) is the percutaneous coronary intervention (PCI) which became frequent due to high efficiency and safety of this procedure.
- Trial name
- NCT06055673
- Testing
- DNA extraction AND Real- time polymerase chain reaction analysis to POLYMORPHISM OF in in-stent restenosis (ISR) in CAD
- Where
- Egypt
- Volunteers
- 182 people
- Sponsor
- Sohag University
Mesenteric Ischemia, Bowel; Ischemic
Copenhagen Mesenteric Stent Study - A Randomized Trial of Stent Versus Covered Stent Treatment for Chronic Mesenteric Ischemia
Chronic mesenteric ischemia (CMI) is often caused by narrowings in the arteries providing blood to the intestines. Endovascular stent placement is considered the preferred treatment for this condition.
- Conditions
- Mesenteric Ischemia, Bowel; Ischemic, Superior Mesenteric Atherosclerosis, Mesenteric Artery Stenosis
- Trial name
- COMESS (NCT05244629)
- Testing
- BMS vs. CS
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Stent Restenosis, Coronary Artery Disease
Effect of Exercise Training in Coronary Artery Disease Patients After Stenting
To determine the effects of exercise training on ankle-brachial index and Quality of Life in coronary artery disease patients after stenting.
- Trial name
- NCT05315193
- Testing
- Structured In-patient and Home plan, Conventional Therapy
- Where
- Pakistan
- Volunteers
- 73 people
- Sponsor
- Riphah International University
Stent Restenosis, Coronary Artery Disease
Exercise Training in Coronary Artery Disease Patients After Stenting
To determine the effect of exercise training on cardiac outcomes in coronary artery disease patients after Stenting. There is a need to develop strategies, not only to prevent restenosis but also to improve patients' functional…
- Trial name
- NCT05591365
- Testing
- Structured In-Patient and Home plan, Conventional Therapy
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Peripheral Artery Disease, Restenosis of Peripheral Vascular Stent
Hemostatic Endothelial Dysfunction in Patients With Peripheral Artery Disease
The study is aimed at evaluating the role of the activity of the key hemostatic parameters of endothelial dysfunction (nitric oxide II (NO) metabolites, plasmin activator inhibitor-1 (PAI-1), von Willebrand factor (vWF)…
- Conditions
- Peripheral Artery Disease, Restenosis of Peripheral Vascular Stent, Restenosis, Vascular Graft, Endothelial Dysfunction
- Trial name
- NCT04391374
- Testing
- an arterial reconstructive procedure
- Volunteers
- 167 people
- Sponsor
- Ryazan State Medical University
In-stent Arterial Restenosis
Paclitaxel-coated or Uncoated AngioSculpt Scoring Balloon Catheter
The purpose of this study is to examine the treatment of coronary Bare Metal Stent restenosis with a drug coated AngioSculpt scoring balloon.
- Trial name
- NCT01495533
- Testing
- uncoated AngioSculpt(R), Drug coated AngioSculpt(R)
- Where
- 3 sites in Brazil, Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital, Saarland
In-stent Restenosis Lesion
Comparison of the Efficacy of Paclitaxel-releasing Balloon Catheter System Versus the Everolimus-Eluting Stent System for Treatment of In-Stent Restenosis Lesions - Harmonizing Optimal Strategy for Treatment of In-Stent Restenosis Lesions (The HOST-ISR Trial) -
In-stent restenosis (ISR) lesions are considered one of the toughest lesions that interventional cardiologists encounter in the drug eluting stent (DES) era.
- Trial name
- NCT01093300
- Testing
- Paclitaxel-eluting balloon catheter, Everolimus-eluting stent
- Where
- South Korea
- Volunteers
- 264 people
- Sponsor
- Seoul National University Hospital
In-stent Restenosis
Morphological Parameters of In-stent RESTenosis Assessed and Identified by OCT
The statistical risk of intrastent stenosis has fallen considerably with the emergence of latest generation coated stents (drug-eluting stents: DES).
- Trial name
- RESTO (NCT04268875)
- Testing
- Optical Coherence Tomography (OCT)
- Where
- 27 sites in Belgium, France and 1 more
- Volunteers
- 307 people
- Sponsor
- University Hospital, Clermont-Ferrand
In-stent Coronary Artery Restenosis, Coronary Artery Restenosis
Resveratrol Excipient Paclitaxel Coated Balloon for Coronary Treatment
The objective of this study is to establish reasonable assurance of safety and effectiveness to support an FDA premarket approval (PMA) application for the SeQuent® Please ReX™ Drug Coated PTCA Balloon Catheter as indicated.
- Conditions
- In-stent Coronary Artery Restenosis, Coronary Artery Restenosis, In-stent Restenosis
- Trial name
- RESPECT-ISR (NCT05093244)
- Testing
- SeQuent Please ReX, Plain old balloon angioplasty (POBA)
- Sponsor
- B. Braun Medical Inc.
Coronary Restenosis, Coronary Stent Occlusion
Restenosis in Coronary Stents And Cutaneous HEaLing
Case control study of patients with and without restenosis to demonstrate the link between in-stent restenosis and an excessive skin healing.
- Conditions
- Coronary Restenosis, Coronary Stent Occlusion, Skin Scarring, Keloid
- Trial name
- RACHEL (NCT04915391)
- Testing
- Skin biopsy and blood sample for inflammation markers, RNA and proteins
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Coronary Artery Disease, In-stent Restenosis
CT-FFR-guided Strategy for In-stent Restenosis
This study will be a prospective, randomized clinical trial to compare standard practice guided by usual care testing to CT-FFR-guided management in patients with in-stent restenosis.
- Trial name
- NCT05611190
- Testing
- CT-FFR, Usual Care
- Volunteers
- 294 people
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
Femoropopliteal Artery Occlusion, Atherosclerosis Obliterans
Lesion Preparation in Femoropopliteal Artery Occlusion Disease
Peripheral arterial disease (PAD) carries a significant global health burden, and can limit functional capacity and quality of life.
- Conditions
- Femoropopliteal Artery Occlusion, Atherosclerosis Obliterans, Lesion; Vascular, In-stent Restenosis
- Trial name
- CIVILIAN (NCT05473884)
- Testing
- lesion preparation devices, conventional balloon
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Shanghai Pudong Hospital
In-stent Restenosis
In-stent Restenosis and Pericoronary Fat Attenuation Index
This study aims to investigate the predictive value of fat attenuation index (FAI) and related radiomics characteristics of pericoronary fat in patients after percutaneous coronary intervention (PCI) for the occurrence of…
- Trial name
- NCT05512832
- Where
- China
- Volunteers
- 126 people
- Sponsor
- RenJi Hospital