Clinical trials: In-vitro Fertilization
Ovarian Stimulation
Antagonist/Letrozole in Poor Responders
Failure to respond to controlled ovarian hyperstimulation (COH) is still a major concern in assisted reproduction and there is no consensus on the ovarian stimulation choice regime for poor responders.
- Trial name
- NCT00823004
- Testing
- letrozole, oral contraceptive (Marvelone), GnRH agonist (buserelin)
- Where
- Iran
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yazd Research & Clinical Center for Infertility
Infertility, Diminished Ovarian Reserve
The LUTEAL Trial: Luteal Stimulation vs. Estrogen Priming Protocol
Ovarian reserve defines the quantity and quality of the ovarian primordial follicular pool. Diminished ovarian reserve (DOR) indicates a reduction in the quantity of ovarian follicular pool to less than expected for age.
- Conditions
- Infertility, Diminished Ovarian Reserve, IVF
- Trial name
- NCT04447872
- Testing
- Timing of injectable gonadotropins
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Northwell Health
In Vitro Fertilization, Polycystic Ovary Syndrome
Comparative Study of Long-acting and Short Acting Triptorelin in PCOS Patients Who Underwent IVF/ICSI
To test whether long-acting Triptorelin on pituitary down-regulation can improve the clinical pregnancy rate and reduces the incidence of ovarian hyperstimulation syndrome (OHSS) in infertile high-risk patients with polycystic…
- Trial name
- NCT02477566
- Testing
- Long-acting Triptorelin, Short-acting Triptorelin
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nanjing University
In Vitro Fertilization, Controlled Ovarian Stimulation
N680S Polymorphism of the FSHR Gene and Its Relationship With the Type of Gonadotropin Used in COS
This project wants to determinate whether there is a relationship between the N680S polymorphism genotype of the FSHR gene and the nature of the FSH used in controlled ovarian stimulation.
- Trial name
- NCT04122729
- Where
- 12 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Angelini Farmacéutica
in Vitro Fertilization, Ovulation Induction
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
Background of the study: Milder stimulation protocols have the advantage of being less expensive and more patient-friendly. Moreover, recent evidence suggests that mild stimulation protocols lead to lower embryo aneuploidy rates…
- Trial name
- LITE (NCT00823472)
- Testing
- Mild stimulation
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
IVF Outcomes, Stress Levels
Virtual Reality Use in Assisted Reproductive Technology
The study will examine the effect of exposure to virtual reality on stress levels and pregnancy rates, in infertile women undergoing in vitro fertilization embryo transfer
- Trial name
- NCT04394962
- Testing
- Virtual reality
- Where
- Canada
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Dr cliff Librach
Breast Cancer, Infertility
RCT of Fixed vs Titrated Letrozole in Breast Cancer Patient Undergoing IVF
The purpose of this study is to compare two different ways to administer Letrozole to determine their effectiveness in blocking estrogen production during ovarian stimulation in patients with breast cancer prior to…
- Trial name
- NCT01035099
- Testing
- Letrozole
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Weill Medical College of Cornell University
Infertility
Comparison of Transfers of Fresh and Thawed Embryos in High Responder Patients
This study tests the hypothesis that controlled ovarian stimulation impairs endometrial receptivity in high responders.
- Trial name
- NCT00963079
- Testing
- Embryo cryopreservation, Fresh blastocyst transfer
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
Sterility
Benefits of Hysteroscopy Prior to Performing a Cycle of in Vitro Fertilization/Intracytoplasmic Sperm Injection
This is a prospective randomized open-label trial. Women scheduled for their first or second in-vitro fertilization/intracytoplasmatic Sperm Injection (IVF/ICSI) cycle and with no abnormality detected in transvaginal ultrasound…
- Trial name
- NCT03173404
- Testing
- Hysteroscopy
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Infertility
Impact of Physician Contact on Patient Anxiety During the Waiting Period After Embryo Transfer
This will be a randomized controlled trial to compare if physician contact within the period from embryo transfer to serum pregnancy test decreases anxiety levels for first-time IVF patients.
- Trial name
- NCT04190732
- Testing
- Physician phone call
- Where
- United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Boston IVF
Controlled Ovarian Stimulation, Infertility
Study to Examine Effect of Recombinant Luteinizing Hormone (r-Lh) and Recombinant Human Chorionic Gonadotropin (r-hCG) for Ovarian Stimulation in Assisted Reproduction Techniques (ART)
The study is a prospective, randomised, controlled, and non-blinded multi-center pilot study to evaluate endocrine efficacy of recombinant luteinizing hormone versus recombinant human chorionic gonadotropin administered during…
- Trial name
- NCT01339299
- Testing
- recombinant luteinizing hormone (r-LH), recombinant human chorionic gonadotropin (r-hCG)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Regionshospitalet Viborg, Skive
Embryo Implantation
Laser Acupuncture Before and After Embryo Transfer Improves IVF Outcomes
This study evaluated whether laser acupuncture at the time of embryo transfer (following in vitro fertilization) improves implantation rates.
- Trial name
- NCT02815371
- Testing
- Needle Acupuncture, Laser Acupuncture
- Where
- 2 sites in United States
- Volunteers
- 803 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Male Infertility, Sperm DNA Fragmentation
Microfluidics Versus Density Gradient Centrifugation for Sperm Preparation in IVF
This randomized controlled trial aimed to compare the effectiveness of microfluidic sperm sorting and density gradient centrifugation (DGC) in reducing sperm DNA fragmentation index (DFI) and improving clinical outcomes in IVF.
- Conditions
- Male Infertility, Sperm DNA Fragmentation, In Vitro Fertilization (IVF)
- Trial name
- MCvsDGC (NCT07004309)
- Testing
- Microfluidic sperm sorting, Density Gradient Centrifugation
- Where
- Vietnam
- Volunteers
- 119 people
- Sponsor
- Hanoi Medical University
Culture, ICSI, IVF
Comparison of Two Embryo Culture Media for IVF and ICSI
In this research, the two media used are Global medium and SSM medium with serum), which are routinely used in the reproduction biology unit. This study simply consists in setting up a methodology to compare these to media.
- Trial name
- NCT02586324
- Testing
- global medium, SSM
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Thyroid Diseases
An Assessment of Aspirin Plus Prednisone Treatment for Euthyroid Women With Thyroid Autoimmunity
Thyroid autoimmunity(TAI) per se have adverse effect on pregnancy outcomes，and aspirin and prednisone were used frequently in antithyroid antibodies(ATA) positive infertile women in clinical practice, but the impact of these…
- Trial name
- NCT04943146
- Testing
- Prednisone 10 MG+aspirin 100MG
- Where
- 2 sites in China
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Subfertility
GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET
The objectives of this study are to compare the efficacy of the dual trigger group vs the hCG trigger group on the live birth rate in women undergoing IVF and the efficacy of the agonist in LP group vs the placebo group on the…
- Trial name
- NCT04064840
- Testing
- IVF: Decapeptyl and hCG, FET: Decapeptyl, IVF: hCG and normal saline
- Where
- China
- Volunteers
- 784 people
- Sponsor
- The University of Hong Kong
Complications Associated With Artificial Fertilization, Placenta; Implantation
Effect of Assisted Hatching on Vitrified Embryo Transfer Clinical Outcome
The objective of study is to assess the possible impact of assisted hatching on the implantation, pregnancy rate and delivery rate after transfer of vitrified-warmed human embryos.
- Conditions
- Complications Associated With Artificial Fertilization, Placenta; Implantation, Pregnancy
- Trial name
- VitHatSZMC (NCT02124291)
- Testing
- Mechanical Assisted Hatching
- Where
- Israel
- Volunteers
- 18 people
- Sponsor
- Shaare Zedek Medical Center
Infertility
Effectiveness of Intracytoplasmic Sperm Injection and Laser Assisted Hatching on in Vitro Fertilization Outcomes of Patients With Different Causes of Infertility
To determine the association of factors affecting the clinical pregnancy and live birth rates in patients undergoing in vitro fertilization (IVF) who received intracytoplasmic sperm injection (ICSI) and/or laser assisted hatching…
- Trial name
- NCT02026661
- Where
- Taiwan
- Volunteers
- 375 people
- Sponsor
- Far Eastern Memorial Hospital
Infertility, IVF
PICSI RCT in Couples With a Previous Poor Fertilisation Cycle in IVF
Poor fertilisation plays a significant role in poor artificial reproductive technique outcomes. Male factor infertility accounts for a large portion of such cases.
- Trial name
- NCT05017740
- Testing
- ICSI, PICSI
- Where
- Singapore
- Volunteers
- 47 people
- Sponsor
- KK Women's and Children's Hospital
Infertility
Sequential vs. Monophasic Media Impact Trial (SuMMIT)
To evaluate the impact of two FDA approved culture media on potential of human embryos resulting from IVF (sequential \& monophasic media).
- Trial name
- SuMMIT (NCT01917240)
- Testing
- Comprehensive Chromosome Screening
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Reproductive Medicine Associates of New Jersey