Clinical trials: Inappropriate Prescribing
Multimorbidity, Polypharmacy
OPTImization of Medication by Transdisciplinary Assessment of Drug Treatment in Elderly Hospitalized Patients
This study is being done to find out if a multi-faceted intervention designed to optimize medication in hospitalized older people with multiple chronic medical conditions exposed to multiple medications can reduce unplanned…
- Trial name
- OPTIMATE (NCT05387096)
- Testing
- Definitive multi-faceted intervention consisting of several components
- Where
- 3 sites in Belgium, Ireland
- Volunteers
- 642 people
- Sponsor
- University College Cork
Polypharmacy
A Digital Tool to Help Doctors and Pharmacists Prescribe Medicines More Safely for Older Adults in Oman
This is a prospective, multi-phase interventional study evaluating the clinical utility and efficacy of POLYMED-a bilingual (Arabic/English) web-based, explainable-AI medication risk calculator-on optimizing geriatric medication…
- Trial name
- POLYMED (NCT07840222)
- Testing
- OPIP Score Calculator (Oman Potentially Inappropriate Prescribing Risk Score)
- Volunteers
- 400 people
- Sponsor
- Oman Ministry of Health
Low-Value Care
EVOLV-Rx VA: Evaluating Opportunities to Decrease Low-Value Prescribing in Community Living Centers
The investigators developed EVOLV-Rx (Evaluating Opportunities to Decrease Low-Value Prescribing), a novel clinical support tool to detect 18 evidence-based and clinically useful low-value prescribing practices in older adults.
- Trial name
- NCT07166107
- Testing
- EVOLV-Rx dashboard
- Where
- 3 sites in United States
- Volunteers
- 1,161 people
- Sponsor
- VA Office of Research and Development
Medication Adherence, Inappropriate Prescribing
Carefully seLected and Easily Accessible at No Charge Medications
This trial evaluates the effect of providing primary care patients with free and convenient access to a set of essential medicines.
- Conditions
- Medication Adherence, Inappropriate Prescribing, Diabetes, Hypertension
- Trial name
- CLEAN-Meds (NCT02744963)
- Testing
- Free and convenient medicine access
- Where
- 3 sites in Canada
- Volunteers
- 784 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Prescribing, Off-Label
CMO Letter to Reduce Inappropriate Antibiotic Prescribing Winter 2019/2020
This trial aims to reduce inappropriate prescription of antibiotics and broad spectrum antibiotics by general practitioners (GPs) in England.
- Trial name
- NCT04051281
- Testing
- Letter
- Where
- United Kingdom
- Volunteers
- 2,963 people
- Sponsor
- Public Health England
Biological Markers, Inappropriate Prescribing
Big Data Analysis of the Use of bIomarkers Concentration
The investigators conducted a retrospective analysis of all measured concentrations performed in a large subset of laboratories located in the French Brittany from February 2010 the 17th to August 2015 the 30th, in adults over 20…
- Trial name
- rUBIDIuM (NCT03254472)
- Testing
- Measured concentrations of biomarkers
- Where
- France
- Volunteers
- 585,745 people
- Sponsor
- Hospital Avicenne
Internal Medicine
Polypharmacy Among Internal Medicine Patients
The World Health Organisation Patient Safety Challenge: Medication Without Harm has brought our attention to the importance of medication-related harm as a global public health issue.
- Trial name
- NCT05756400
- Where
- Iceland
- Volunteers
- 85,942 people
- Sponsor
- University of Iceland
Inappropriate Prescribing
Ensuring Clinical Appropriateness and Safety of Pharmacological Therapies in Nursing Home Residents
The goal of this clinical study is to evaluate whether a structured, clinical pharmacology team-led medication review improves the appropriateness and safety of medication prescribing in elderly nursing home (NH) residents.
- Trial name
- NCT07407387
- Testing
- Multi-Component Intervention on Medication Prescribing
- Where
- Switzerland
- Volunteers
- 219 people
- Sponsor
- Lugano Istituti Sociali
Alzheimer Disease
A Pilot Study to Reduce Inappropriate Anticholinergic Prescribing in the Elderly
This will be an eight-week, prospective, placebo-controlled, randomized trial to evaluate a patient-centered team (pharmacist-physician) intervention to improve medication appropriateness and reduce the use of inappropriate…
- Trial name
- NCT02172612
- Testing
- Arm 1 Education Session
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Daniela Moga
End-Of-Life, Inappropriate Prescribing
Effectiveness of a Person-centred Prescription Model at the End of Life
This study's main objective is to investigate whether the application of an adapted person-centred prescription model during a hospital stay would reduce the use of inappropriate or futile regular medications in older people at…
- Conditions
- End-Of-Life, Inappropriate Prescribing, Deprescriptions, Palliative Medicine
- Trial name
- NCT05454644
- Testing
- Person-Centred Prescription Model
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Matia Foundation
Increased Drug Resistance, Infectious Diseases
Reducing Inappropriate Antibiotic Prescribing by Primary Care Clinicians
Hypotheses and Specific Aims: The continued emergence of antibiotic-resistance in the outpatient setting underlines the need to responsibly manage antimicrobial prescribing.
- Trial name
- NCT01099943
- Testing
- Intervention: Education, Decision Support Tools
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Colorado, Denver
Physician's Practice Patterns
Electronic Prescription Data to Improve Primary Care Prescribing
This is a randomised controlled study to evaluate the effect of providing prescribing feedback that includes individual patient data to General Practitioners (GP) in Scotland on high risk or low quality prescribing.
- Trial name
- EPIPP (NCT02512198)
- Testing
- Prescription Data Feedback to GP Practices
- Where
- United Kingdom
- Volunteers
- 236 people
- Sponsor
- University of Dundee
Inappropriate Prescribing, Primary Health Care
Deprescribing in Primary Health Care
Medications can help older adults but can also harm them. Frail older adults tend to have many health problems that require treatment, but are also at risk of harm from the medications prescribed.
- Conditions
- Inappropriate Prescribing, Primary Health Care, Polypharmacy
- Trial name
- NCT03903484
- Testing
- Deprescribing toolbox and intervention
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Inappropriate Prescribing
Reducing Inappropriate Prescribing for Psychiatric Patients Using Nurse-led Medication Reviews
The purpose of this study is to investigate the effect of nurse-led medication reviews on the frequency, type and potential severity of PIP in psychiatric patients
- Trial name
- NCT02052505
- Testing
- Medication review
- Where
- 2 sites in Denmark
- Volunteers
- 411 people
- Sponsor
- Aalborg University
Drug-Related Side Effects and Adverse Reaction, Digoxin Overdose
Introducing Electronic Alerts to Reduce Inappropriate Digoxin Prescribing in Older Adults
The intervention consists of introducing computerized alerts into the electronic medical record of the CSAPG (MIRA software), which are triggered when a physician prescribes digoxin at a dose higher than the recommended amount…
- Trial name
- Aldigo (NCT07008144)
- Testing
- Digoxin alarm
- Where
- 2 sites in Spain
- Volunteers
- 5,954 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Potentially Inappropriate Medications
PIM Incidence in Older Cardiovascular Patients During COVID-19 Pandemics
The aim of the study is to assess the incidence of potentially inappropriate medication (PIM) administration, polypharmacy, and potential drug-drug-interactions (PDDIs) in cardiovascular patients enrolled in the reimbursement…
- Trial name
- PIM-BARS (NCT05336565)
- Testing
- Electronic medical record analysis
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Medication Therapy Management
Impact of a Mobile Geriatric Team With a Pharmacist on the Optimisation of Prescriptions in Elderly Inpatients
In patients aged 75 years and older, polypathology is frequent and often associated with polypharmacy. This polypharmacy coupled with a lack of proactive elderly care can sometimes lead to hospitalisation.
- Trial name
- PHARMOG (NCT04151797)
- Testing
- Medication therapy management
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Toulouse
Acute Respiratory Tract Infection
Evaluation of an Algorithm to Reduce Antibiotic Prescribing for Acute Bronchitis
Inappropriate use of antibiotics to treat patients with acute bronchitis is a significant factor contributing to the selection of antimicrobial drug resistant pathogens, which threaten the effectiveness of available therapies to…
- Trial name
- NCT00981994
- Testing
- Decision Support for ARI Management
- Volunteers
- 3,300 people
- Sponsor
- University of Pennsylvania
Dementia
Optimizing Prescribing of Antipsychotics in Long-Term Care
Inappropriate antipsychotic prescribing is a key quality indicator by which clinical outcomes might be monitored and improved in LTC.
- Trial name
- OPAL (NCT03557593)
- Testing
- Educational
- Sponsor
- Queen's University
Geriatric Disorder
Inappropriate Prescribing of Proton-pump Inhibitor is it Associated With the Burden of Comorbidities in Older Patients?
Proton pump inhibitors (PPIs) are one of the most frequently prescribed classes of drugs in the world and the most effective drugs available to reduce gastric acid secretion.
- Trial name
- IPP SA (NCT02841852)
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Nantes University Hospital