Clinical trials: Incision Infection
Surgical Site Infection, Post-Op Complication
Perioperative Immunonutrition in Patients Undergoing Gynecologic or General Elective Surgery (PURPOSE)
The objective of the implementation pilot is to assess the practicality of introducing a perioperative immunonutrition protocol into a hospital environment as well as a true measure of impact on the rate of surgical site…
- Trial name
- PURPOSE (NCT04057092)
- Testing
- Dietary Supplement INergy-FLD
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Abscess
Antibiotic Therapy After Incision and Drainage for Abscess
Background: Skin abscesses are a growing problem in the general pediatric population around the world. While the standard treatment for an abscess/boil is incision and drainage, many physicians also prescribe antibiotics, despite…
- Trial name
- NCT00900510
- Testing
- Incision and drainage, Trimethoprim/Sulfamethoxazole (Bactrim)
- Where
- United States
- Sponsor
- Wake Forest University
Antibiotic Side Effect, Eyelid; Wound
Topical Antibiotic Prophylaxis for Eyelids
The investigators propose a prospective randomized control trial testing the hypothesis that routine topical antibiotic prophylaxis does not significantly reduce the rate of infection after eyelid surgery.
- Conditions
- Antibiotic Side Effect, Eyelid; Wound, Eyelid Diseases, Surgical Wound Infection
- Trial name
- NCT03199911
- Testing
- Topical Antibiotic Product, Topical Non-Antibiotic Ointment
- Where
- United States
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Appendicitis
A Randomized Controlled Trial on Wound Irrigation in Open Appendectomy.
A large retrospective study compared wound irrigation with antiseptic solution, with antimicrobial agent, and with normal saline in patients undergoing open appendectomy and concluded an evident superiority of antibiotic wound…
- Trial name
- NCT04332809
- Testing
- saline-gentamicin irrigation, saline irrigation
- Where
- Egypt
- Volunteers
- 208 people
- Sponsor
- Mansoura University
Surgical Wound Infection, Cesarean Section
Effect of Intranasal Mupirocin on Rate of Staphylococcus Aureus Surgical Site Infection Following Cesarean Sections
The investigators believe that irradication of nose colonization of staphyloccocus aureus will reduce the incidence of surgical site infections after cesarean section.
- Conditions
- Surgical Wound Infection, Cesarean Section, Staphylococcus Aureus
- Trial name
- NCT01152593
- Testing
- Mupirocin
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Hillel Yaffe Medical Center
Diabetic Foot Infection, Surgical Wound
Optimal Antibiotics for Operated Diabetic Foot Infections
Diabetic foot problems, especially infections (DFI), require multiple resources including iterative surgeries and amputations, long-lasting antibiotic therapies, education, off-loading and eventually revascularization and…
- Conditions
- Diabetic Foot Infection, Surgical Wound, Antibiotic Side Effect, Infection
- Trial name
- NCT04081792
- Testing
- Antibiotic therapy
- Where
- Switzerland
- Volunteers
- 643 people
- Sponsor
- Balgrist University Hospital
Abscess
The LOOP Trial in Treatment of Skin Abscesses
This prospective, randomized controlled trial enrolled a convenience sample of adults and children presenting to two Level 1 trauma centers over 12-months with subcutaneous skin abscesses necessitating drainage.
- Trial name
- NCT03398746
- Testing
- LOOP Technique, Standard incision and drainage
- Volunteers
- 217 people
- Sponsor
- Orlando Regional Medical Center
Surgical Site Infection, Skin Cancer
Cyanoacrylate Skin Adhesive After Mohs Surgery or Wide Local Excision
This study will compare surgical site infection after linear repair with or without cyanoacrylate skin adhesive following Mohs micrographic surgery or wide local excision.
- Conditions
- Surgical Site Infection, Skin Cancer, Wound Healing
- Trial name
- NCT07844681
- Testing
- Cyanoacrylate Skin Adhesive, Fast Gut Running Epidermal Suture Closure, Vicryl Rapide Running Epidermal Suture Closure
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Minnesota
Nosocomial Infection, Respiratory Tract Infection
Prevention of Nosocomial Infection by Decontamination of the Naso- and Oropharynx With Chlorhexidine (NONI Trial)
Does chlorhexidine gluonate, a simple broad-spectrum antimicrobial agent with virtually no adverse-effects lower the incidence of NI after cardiac surgery, especially with respect to LTI and SSI?
- Conditions
- Nosocomial Infection, Respiratory Tract Infection, Surgical Site Infection
- Trial name
- NCT00272675
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Surgical Wound Infection
Supplemental Postoperative Oxygen and Wound Infection in Morbidly Obese Patients
The investigators propose to test the hypothesis that the incidence of major complications related to infection or inadequate healing is reduced in morbidly obese patients given 80% inspired oxygen during, and for 12-18 hours…
- Trial name
- NCT00315822
- Testing
- 80% oxygen, 30% oxygen
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- The Cleveland Clinic
ExtraCorporeal Life Support (ECLS), Wound Infection
Investigating the Impact of Cold Atmospheric Plasma Treatment on Wound Healing at Cannulation Sites in Patients Following Extracorporeal Life Support
This study aims to evaluate a new wound treatment called cold atmospheric plasma (CAP) for patients receiving extracorporeal life support (ECLS).
- Conditions
- ExtraCorporeal Life Support (ECLS), Wound Infection, Surgical Site Infection, Delayed Wound Healing
- Trial name
- NCT07501897
- Testing
- Cold Atmospheric Plasma (CAP) Therapy, Standard wound care
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- National Taiwan University Hospital
Surgical Wound Infection, Thyroid Nodule
Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral Thyroidectomy
Transoral endoscopic thyroid surgery is a emerging surgical technique for thyroid surgery. This study to investigate the need for postoperative antibiotics in transoral endoscopic thyroid surgery.
- Trial name
- POTO (NCT03295955)
- Testing
- Amoxicillin Clavulanate
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Orthopaedics Wound Dressings
Comparative Efficacy of Advanced and Traditional Wound Dressings in Post-Operative Orthopedic Care
Title: Comparative Efficacy of Advanced and Traditional Wound Dressings in Post-Operative Orthopedic Care: A Randomized Controlled Trial Objective: The primary objective of this study is to evaluate and compare the efficacy of…
- Trial name
- NCT06540040
- Testing
- Aquacel Ag, OPSITE, MEPILEX POST OP BORDER
- Where
- India
- Volunteers
- 320 people
- Sponsor
- Nidhi Srivastava
Spine Infection
Effectiveness of Povidone-Iodine Versus Chlorhexidine Gluconate Solutions in Reducing Microbial Contamination in Spinal Surgery Wounds During Intraoperative Soaking.
This study aims to assess the efficacy of intraoperative wound irrigation with iodine-containing and chlorhexidine-containing solutions in reducing bacterial colonization during spine surgery, and to determine which solution is…
- Trial name
- NCT06284174
- Testing
- Povidone-iodine solution; chlorhexidine gluconate
- Where
- Taiwan
- Volunteers
- 105 people
- Sponsor
- National Cheng-Kung University Hospital
Surgical Site Infection, Superficial Surgical Site Infection
Clipping Versus No Hair Removal and the Risk of Surgical Site Infections
The objective of this study is to determine whether hair clipping is non-inferior to no hair removal in preventing superficial, deep, and organ space surgical site infections (SSI) in patients undergoing various general surgical…
- Conditions
- Surgical Site Infection, Superficial Surgical Site Infection, Deep Surgical Site Infection, Organ/Space Surgical Site Infection
- Trial name
- NCT00975377
- Testing
- Hair clipping
- Where
- United States
- Volunteers
- 1,678 people
- Sponsor
- Gundersen Lutheran Medical Foundation
Wound Closure Technique, Wound Dehiscence, Surgical
Comparison of Cosmetic Outcome and Patient Satisfaction Between Staples and Suture Technique for Wound Closure Following Upper Limb Surgeries
Surgical wound closure is an essential component of postoperative care that influences wound healing, infection rates, cosmetic appearance, and patient satisfaction.
- Trial name
- NCT07633977
- Testing
- Staples, Sutures
- Where
- Nepal
- Volunteers
- 80 people
- Sponsor
- Kathmandu University School of Medical Sciences
Peritonitis, Postoperative Complications
Intravenous Immunoglobulin in Combination Therapy With Antibacterial Agents for SSI of the Lower Digestive Tract
The purpose of this study is to assess the clinical usefulness of IVIG in combination therapy with antibacterial agents for severe peritonitis after lower digestive tract surgery.
- Trial name
- NCT00511212
- Testing
- intravenous immunoglobulin
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Multicenter Clinical Study Group of Osaka, Colorectal Cancer Treatment Group
Surgical Site Infection, Surgical Wound Infection
ROSSINI 2 - Reduction of Surgical Site Infection Using Several Novel Interventions
ROSSINI 2 is a phase III, multi-arm, multi-stage (MAMS) pragmatic, blinded (patient and outcome assessor), multicentre, randomised controlled trial (RCT) with an internal pilot, to evaluate the use of several in-theatre…
- Conditions
- Surgical Site Infection, Surgical Wound Infection, Surgery--Complications, Surgery
- Trial name
- ROSSINI 2 (NCT03838575)
- Testing
- 2% alcoholic chlorhexidine skin prep (SKIN PREP), Iodophor Antimicrobial Incise Drapes (DRAPE), Gentamicin-impregnated implants/ sponges (SPONGE)
- Where
- 2 sites in United Kingdom
- Volunteers
- 6,610 people
- Sponsor
- University of Birmingham
Abscess, Cellulitis
Aquacel Versus Iodoform Gauze for Filling Abscess Cavity Following Incision and Drainage
This study compares Aquacel against routine Iodoform packing for packing abscess cavities after incision and drainage. It is hypothesized that Aquacel will produce speedier healing of the abscess.
- Trial name
- NCT00984022
- Testing
- Type of dressing - Iodoform, Type of dressing - Aquacel
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Valleywise Health
Surgical Site Infection
Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery
The purpose of the study is to assess the effectiveness of a single dose of preoperative antibiotic in reducing surgical site infections in certain dermatological procedures.
- Trial name
- NCT04580472
- Testing
- Cephalexin
- Where
- United States
- Volunteers
- 574 people
- Sponsor
- Carilion Clinic