Clinical trials: Incisional Pain
Postoperative Pain, Surgery
Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery
The purpose of this study is to determine whether a continuous infusion of local anesthesia with a catheter in the surgical wound reduces patient consumption of opiates by 30% in the 48-hour postoperative period following surgery…
- Conditions
- Postoperative Pain, Surgery, Postoperative Complications
- Trial name
- CATROP-2007 (NCT01075646)
- Testing
- ropivacaine, saline solution
- Where
- Spain
- Volunteers
- 225 people
- Sponsor
- Hospital Universitari de Bellvitge
Postoperative Pain
PAIN - Postoperative Analgesia INvestigation
The purpose of this study is to assess the efficacy of the intraoperative injection of prolonged acting (liposomal) bupivacaine in postoperative pain control after truncal surgical incisions.
- Trial name
- PAIN (NCT02111746)
- Testing
- Exparel, Bupivacaine hydrochloride, Patient Controlled Analgesia (PCA)
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiovascular Surgery, Pain, Postoperative
Sternal Block With Liposomal Bupivacaine vs. Saline Prior to Incision in Cardiac Surgery
The purpose of this study is to find out what effects (good and bad) that the study medicine called "liposomal bupivacaine" has on subjects that are undergoing a sternotomy.
- Conditions
- Cardiovascular Surgery, Pain, Postoperative, Block
- Trial name
- NCT04333095
- Testing
- Liposomal bupivacaine, Normal Saline Flush, 0.9% Injectable Solution_#1
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Baylor Research Institute
Pain, Postoperative
Trans-incisional vs Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy
This is a prospective, double-blinded, randomized controlled study comparing the efficacy of trans-incisional rectus sheath block to laparoscopic guided rectus sheath block for pediatric single-incision laparoscopic…
- Trial name
- NCT02494336
- Testing
- Trans-incisional rectus sheath block, Laparoscopic guided rectus sheath block, Ropivacaine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Johns Hopkins All Children's Hospital
Pain, Postoperative
Bilateral Paravertebral Blockade (T7-10) vs. Incisional Local Anesthetic Administration for Pediatric Patients
The objective of this study is to assess the efficacy of paravertebral nerve blocks, single shot, with ropivacaine 0.5% for postoperative pain control after elective laparoscopic cholecystectomy as compared with incisional…
- Trial name
- NCT01380834
- Testing
- control group, treatment group
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mihaela Visoiu
Fibroid Uterus, Pain, Postoperative
Pre-incisional Wound INfiltration and Hypogastric PLEXus Block Using Ropivacaine in Laparoscopic Myomectomy
The purpose of this study is to assess an impact of laparoscopic superior hypogastric plexus (SHP) block combined with preemptive troacar site infiltration on postoperative pain intensity following laparoscopic myomectomy.
- Trial name
- WINPLEX (NCT06429163)
- Testing
- Troacar site infiltration, Superior hypogastric plexus block
- Where
- Russia
- Volunteers
- 207 people
- Sponsor
- Saint Petersburg State University, Russia
Pain, Inflammation
Immunomodulation, IL-1 Inhibition, and Postoperative Incisional Pain
The investigators hypothesize that perioperative administration of anakinra will reduce incisional pain by lowering the concentration of inflammatory mediators in surgical wounds.
- Trial name
- NCT01466764
- Testing
- Anakinra, Normal Saline
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Stanford University
Cesarean Section, Wound Complications
Cesarean Trial of Staples vs. Sutures
To determine whether the rate of wound complications differs based on method of closure of skin incision (staples vs. suture) after cesarean delivery.
- Conditions
- Cesarean Section, Wound Complications, Patient Satisfaction, Pain Measurement
- Trial name
- CROSS (NCT01211600)
- Testing
- Staples, Suture
- Where
- 2 sites in United States
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Pain, Postoperative, Femur Fracture
Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures
The purpose of this study is to determine the efficacy and safety of a peri-incisional multimodal injection for post-operative pain control following operative management of femur fractures.
- Trial name
- NCT02793947
- Testing
- Ropivacaine, Epinephrine, Morphine
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Iowa
Abscess, Pain
Efficacy of Intranasal Fentanyl at Reducing Pain During Abscess Incision and Drainage (I&D) in Children
Children can develop abscesses (a collection of pus under their skin) that require a physician to cut it open to let the pus drain out. This is a painful procedure.
- Trial name
- NCT01549002
- Testing
- Intranasal Fentanyl, Intravenous Morphine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
Ventral Hernia, Umbilical Hernia
Does a Transabdominal Plane Block Decrease Patient Pain After Ventral Hernia Repair?
The purpose of this study is to determine if a Transabdominal Plane Block will decrease patient pain and pain medication use after a laparoscopic ventral (ventral, umbilical, incisional) hernia repair with mesh.
- Conditions
- Ventral Hernia, Umbilical Hernia, Incisional Hernia, Postoperative Complications
- Trial name
- NCT02007096
- Testing
- Transabdominal Plane Block, Non Transabdominal Plane Block
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pain, Postoperative
Pre-incision Versus Post-incision Local Anesthetic During Robotic Sacrocolpopexy
Obtaining Likest-pain scale score on postoperative day one after injection of local anesthetic into incision sites of a laparoscopic/robotic-assisted sacrocolpopexy
- Trial name
- CLAPPS (NCT04996251)
- Testing
- Bupivacaine Injection
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Hernia, Ventral Hernia
Prospective Clinical Evaluation of High-Purity Type I Collagen in Select High-Risk Hernia Repair Scenarios
This prospective, single-arm clinical study evaluates the safety, feasibility, and early clinical outcomes of High-Purity Type I Collagen (HPTC; Surgicoll-Mesh®) when used as a biologic reinforcement in selected hernia repair…
- Conditions
- Hernia, Ventral Hernia, Incisional Hernia, İnguinal Hernia
- Trial name
- NCT07360691
- Testing
- High-Purity Type I Collagen Mesh
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Surgical Wound, Bilateral Total Knee Arthroplasty
Evaluating Edema and Range of Motion Using Negative Pressure Therapy vs. Standard Surgical Dressing in Bilateral TKA
This study will compare the effects of closed incision negative pressure dressing vs. standard of care silver dressing on lower limb swelling after bilateral primary total knee arthroplasty.
- Conditions
- Surgical Wound, Bilateral Total Knee Arthroplasty, Wounds and Injuries, Joint Diseases
- Trial name
- ENABLE (NCT04712019)
- Testing
- Closed Incision Negative Pressure Therapy (ciNPT), Standard Silver-containing Dressing
- Where
- 6 sites in United States
- Volunteers
- 10 people
- Sponsor
- Solventum US LLC
Nephrectomy, Partial Nephrectomy
Erector Spinae Plane Block (ESPB): in Patients Undergoing Surgery Through a Flank or Anterior Subcostal Incision.
Using a randomized double-blinded study design, the study goal is to evaluate the superiority of Erector Spinae Plane block (ESPB) in the peri-operative pain management of patients undergoing surgery through a flank or anterior…
- Conditions
- Nephrectomy, Partial Nephrectomy, Incision Site Discomfort
- Trial name
- NCT03691935
- Testing
- Ropivacaine, Normal saline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center
Post Operative Pain
Intermittent Bolus vs Continuous Infusion Via ESP Catheters RCT
The purpose of this prospective randomized controlled trial is to compare the effectiveness of two different delivery methods for postoperative pain management following cardiac surgery requiring median sternotomy: intermittent…
- Trial name
- NCT05642416
- Testing
- Continuous Infusion of ropivacaine, Intermittent bolus of ropivacaine
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Henry Ford Health System
Surgical Site Infection, Cosmetic Appearance of Cesarean Scar
Prospective Study on Cesarean Wound Outcomes
This study will investigate whether the placement of silver impregnated dressings beginning in the OR will improve wound healing in patients undergoing cesarean delivery compared to traditional Telfa pads.
- Conditions
- Surgical Site Infection, Cosmetic Appearance of Cesarean Scar, Post Operative Pain
- Trial name
- NCT01697748
- Testing
- Silver-impregnated dressing, Telfa pad dressing
- Where
- 3 sites in United States
- Volunteers
- 660 people
- Sponsor
- University of South Florida