Clinical trials: Incomplete Spinal Cord Injury (SCI)
Incomplete Spinal Cord Injury (SCI), ASIA C and D Classification of SCI
Effect of Hybrid Functional Electrical Stimulation and Augmented Reality-Based Gait Training on Gait Parameters Among Incomplete Spinal Cord Injury Patients
The goal of this clinical trial is to determine whether combining Functional Electrical Stimulation (FES) with Augmented Reality (AR)-based gait training can improve walking ability in individuals with incomplete spinal cord…
- Conditions
- Incomplete Spinal Cord Injury (SCI), ASIA C and D Classification of SCI, Gait Dysfunction
- Trial name
- FES AR SCI (NCT07263581)
- Testing
- Functional Electrical Stimulation (FES) and Augmented Reality (AR), Conventional Overground Gait Training (COGT)
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Cervical Spinal Cord Injury
Incomplete Cervical SCI Without Instability
A multicenter, international, prospective, observational case series patient cohort with incomplete cervical SCI without instability will be enrolled to obtain information and data that could inform the feasibility of…
- Trial name
- NCT05653206
- Testing
- Nonsurgical treatment, Surgical treatment
- Where
- 10 sites in United States, Brazil and 4 more
- Volunteers
- 50 people
- Sponsor
- AO Foundation, AO Spine
Psychological Well-Being, Spinal Cord Injuries
Self-Management Program for AIS D SCI
About 25-51% of adults with acquired spinal cord injury (SCI) have "AIS D" SCI, the lowest severity grade of neurologic injury. Veterans with AIS D SCI generally have better outcomes in mobility, community integration, and…
- Trial name
- SCISM-D (NCT05800717)
- Testing
- SCI Self-Management for AIS D
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Incomplete Spinal Cord Injury (SCI)
Effect of Antigravity Treadmill Training on Cardiorespiratory Fitness and Lower Limb Function in Incomplete Spinal Cord Injury
This study aims to investigate the effect of locomotor training using an antigravity treadmill on cardiorespiratory fitness and lower limb function in patients with incomplete spinal cord injury.
- Trial name
- Antigravity (NCT07653529)
- Testing
- Antigravity Treadmill for gait training, gait training and balance exercise
- Volunteers
- 60 people
- Sponsor
- Middle East University
Spinal Cord Injuries
Patient-therapist INTERaction During RObotic GAIT Rehabilitation After Spinal Cord Injury
INTERROGAIT will disentangle the role of Physical Therapist - Patient (Pht-Pt) interaction in robotic assisted gait rehabilitation in spinal cord injury patients.
- Trial name
- INTERROGAIT (NCT06531304)
- Testing
- Lokomat Robot Assisted Gait Training
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Incomplete Spinal Cord Injury
Powered Exoskeleton Combined With Functional Electrical Stimulation in Clinical Practice
After partial spinal cord injury, gait deficits may be present and often remain even after intensive rehabilitation. New robotic technologies have recently emerged to help augment the extent of rehabilitation.
- Trial name
- NCT04568928
- Testing
- OLTP/PE + FES
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Laval University
Acute Spinal Cord Injury (SCI), Spinal Cord Diseases
NG004 in Incomplete Spinal Cord Injury Patients
This is a randomized, double-blind, placebo controlled, multicenter trial of NG004 in patients with acute traumatic incomplete cervical SCI.
- Conditions
- Acute Spinal Cord Injury (SCI), Spinal Cord Diseases, Spinal Cord Injuries, Trauma Nervous System
- Trial name
- SPROUT-2 (NCT07840196)
- Testing
- NG004
- Where
- 10 sites in Germany, Switzerland
- Volunteers
- 120 people
- Sponsor
- NovaGo Therapeutics AG
Spinal Cord Injury
Comparison of Post-pinal Cord Injury (SCI) Locomotor Training Techniques
Background: Body weight supported (BWS) locomotor training improves overground walking ability in individuals with motor-incomplete spinal cord injury (SCI).
- Trial name
- NCT01095380
- Testing
- Locomotor training
- Volunteers
- 74 people
- Sponsor
- University of Miami
Spinal Cord Injuries
Arm and Leg Cycling for Accelerated Recovery From SCI
The purpose of this study is to examine the ability of simultaneous motorized upper and lower extremity cycling training to regulate spinal movement patterns in order to potentially restore functional abilities (i.e., walking) in…
- Trial name
- NCT05619146
- Testing
- Motor-assisted arms and legs cycling
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Effects of Rimonabant on Walking Abilities in Incomplete Spinal Cord Injury
Randomized placebo-controlled safety and feasibility study with crossover design (3 arms). Placebo or Rimonabant 2.5mg or Rimonabant 5mg will be administered for 5 days.
- Trial name
- RIMOFATSCI-1 (NCT05398913)
- Testing
- Rimonabant
- Where
- Spain
- Volunteers
- 8 people
- Sponsor
- Hospital Nacional de Parapléjicos de Toledo
Spinal Cord Injuries
Locomotor Training With Exoskeleton EKSO-GT in Patients With Incomplete Motor Spinal Cord Injury in a Hospital Setting
The aim of this observational, non-controlled, non-profit study is to describe the responses to rehabilitative training with the robotic exoskeleton EKSO-GT in patients with incomplete motor Spinal Cord Injury (AIS C or D).
- Trial name
- NCT02600013
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Spinal Cord Injury, Incomplete Spinal Cord Injury
Tele-rehabilitation Using TDCS Combined with Exercise in People with Spinal Cord Injury
This study aims to explore the effect of trans cranial direct current stimulation (tDCS) combined with self-exercise at home for 1 month training (3 sessions/week, for 4 weeks).
- Trial name
- NCT06079138
- Testing
- Transcranial direct current stimulation (Active), Telerehabilitation exercise
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Spinal Cord Injury
Deep Brain Stimulation in Patients With Incomplete Spinal Cord Injury for Improvement of Gait
Spinal cord injuries are anatomically mostly incomplete, showing tissue bridges of the spinal cord at the injury site. Of the 60% functionally incomplete patients, about half face a life in the wheelchair.
- Trial name
- DBS-SCI (NCT03053791)
- Testing
- Deep brain stimulation in mesencephalic locomotor region, Implantation of a Deep brain stimulation system
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- University of Zurich
Spinal Cord Injuries
Augmenting Reactive Stepping With FES After SCI
Up to 25 individuals living with chronic incomplete spinal cord injury (iSCI) who can stand but have limited ability to elicit a step without physical assistance or upper limb (U/L) support will be recruited for this study.
- Trial name
- NCT04309448
- Testing
- Perturbation-based balance training with functional electrical stimulation
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University Health Network, Toronto
Spinal Cord Injuries (SCI)
RTsMS and Body Weight-support Treadmill Training After Incomplete Spinal Cord Injury
The aim of this study is to assess the feasibility of combining rTsMS with BWSTT for gait and sensorimotor recovery in individuals with incomplete spinal cord injury.
- Trial name
- NCT06886308
- Testing
- Repetitive trans-spinal magnetic stimulation
- Where
- Brazil
- Volunteers
- 6 people
- Sponsor
- Universidade Federal de Pernambuco
Spinal Cord Injuries (SCI), Spinal Cord Injury
mSCI: Mobile Health App for Veterans With SCI and Caregivers
Caregivers of persons with Spinal Cord Injury (SCI) face increased risk of psychological distress, health problems, reduced quality of life, relationship strain, and restrictions in social and work participation.
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Spinal Cord Injuries (Complete and Incomplete), Family Caregivers
- Trial name
- NCT07269977
- Testing
- iMHERE 2.0. A mobile health App designed to support veterans with SCI manage their self care, and their caregivers
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Incomplete Spinal Cord Injury
Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury
Spinal cord injury (SCI) affects ~42,000 Veterans. The VA provides the single largest network of SCI care in the nation. The lifetime financial burden of SCI can exceed $3 million. A major cost of SCI is impaired mobility.
- Trial name
- AGILE SCI (NCT04340063)
- Testing
- Gait training performed on a treadmill, Gait training performed in a Movement Amplification Environment
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Brain-Controlled Spinal Stimulation Walking Therapy After Incomplete Spinal Cord Injury (SCI)
The purpose of this research is to test the effectiveness of a new therapy, called Brain-Computer Interface (BCI)-Transcutaneous Spinal Cord Stimulation (TSCS), for improving walking in people with an incomplete spinal cord…
- Trial name
- NCT06406855
- Testing
- Brain-Computer Interface-Triggered Transcutaneous Spinal Cord Stimulation (BCI-tSCS) System
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Miami
Spinal Cord Injuries
Daily Intermittent Hypoxia and Task-Specific Upper Limb Training in Persons With Chronic Incomplete SCI
The purpose of this research study is to investigate the effectiveness of a combinatorial therapy of breathing low oxygen in short bursts-acute intermittent hypoxia (AIH) and upper limb training on arm strength and function, and…
- Trial name
- NCT03262766
- Testing
- Acute Intermittent Hypoxia (AIH), Upper extremity training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Shirley Ryan AbilityLab