Clinical trials: Increased Intracranial Pressure Disorders
ALS (Amyotrophic Lateral Sclerosis), FTD
Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches
Diagnosis of ALS/FTD disease spectrum is challenging because it largely relies on clinical symptoms. Identifying novel biomarkers is essential for a paradigm shift towards a more precise biological-based diagnosis.
- Conditions
- ALS (Amyotrophic Lateral Sclerosis), FTD, Neuropathic, Psychiatric Disorders
- Trial name
- SPECTRALS (NCT06856850)
- Where
- 4 sites in Italy
- Volunteers
- 230 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Traumatic Brain Injury, Intracranial Hypertension
Optic Nerve Ultrasound in Severe Traumatic Injury
Prospective study of diagnostic accuracy of optic nerve sheath diameter measurement (index study) in traumatic brain injury with simultaneous invasive intracranial pressure monitoring as the reference standard.
- Trial name
- ONUS-TBI (NCT02618226)
- Testing
- Optic nerve ultrasound
- Where
- India
- Volunteers
- 117 people
- Sponsor
- University of Michigan
Benign Intracranial Hypertension
Axial Length and Central Corneal Thickness in Benign Intracranial Hypertension
Patients in for treatment of benign intracranial hypertension will undergo two tests that are not routinely performed for these patients: central corneal thickness and axial length of the eye.
- Trial name
- NCT02541994
- Testing
- Pachette3, Lenstar-Think
- Volunteers
- 5 people
- Sponsor
- Ochsner Health System
Idiopathic Intracranial Hypertension
Venous Sinus Stenting With the River Stent in IIH
The objective of the study is to show that stenting the transverse-sigmoid sinus with the River stent is safe and has probable benefit to relieve clinical symptoms in subjects with idiopathic intracranial hypertension (IIH).
- Trial name
- NCT03556085
- Testing
- Venous sinus stenting (Serenity River)
- Where
- 6 sites in United States
- Volunteers
- 39 people
- Sponsor
- Serenity Medical, Inc.
Brain Injury Traumatic Severe, Intracranial Hemorrhage, Hypertensive
Multiomic Analysis of Traumatic Brain Injury and Hypertension Intracranial Hemorrhage Lesion Tissue
The goal of this experimental observation study is to figure out differently expressed biomarkers in lesion tissues in traumatic brain injury or hypertension intracranial hemorrhage patients.
- Trial name
- MOSS-THINK (NCT05778110)
- Testing
- Type of disease
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Hydrocephalus
Comparison of Optic Nerve Sheath Diameter on Retrobulbar Ultrasound Before and After Drainage of Cerebrospinal Fluid in Patient With Hydrocephalus
Studies in patients with intracranial hypertension have shown a good relationship between optic nerve sheath diameter measured by retrobulbar ultrasound and invasively measured intracranial pressure.
- Trial name
- NCT01863329
- Testing
- retrobulbar ultrasound
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Yonsei University
Increase Intra Cranial Pressure, Traumatic Brain Injury
Diagnostic Accuracy of the Optic Nerve Deformability Index and Optic Nerve Sheath Diameter as a Noninvasive Predictor of Intracranial Pressure
The study will be carried out on 50 patients, dichotomized into high and normal ICP groups, and we will assess both ONSD and DI in all patients.
- Trial name
- NCT06884319
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Idiopathic Intracranial Hypotension, Venous Sinus Stenosis
Stent Implantation Versus Medical Therapy for Idiopathic IntracraniaL Hypertension (SIMPLE)
The aim of this study is to assess the efficacy of stent implantation versus medical therapy on idiopathic intracranial hypertension with venous sinus stenosis.
- Trial name
- NCT05707442
- Testing
- Stent Implantation, Acetazolamide-based medical therapy, Weight loss
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Hypertension
Sonography of the Optic Nerve Sheath Diameter for Detection of Elevated Intracranial Pressure (ICP)
In this study the invistigators chose to measure the optic nerve sheath diameter by sonography for diagnosis of elevated intracranial pressure (ICP) in comparison to brain computed tomograhy (CT) as the reference gold standard…
- Trial name
- NCT03529370
- Testing
- optic nerve ultrasound
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- National Heart Institute, Egypt
Acute Brain Injury, Pupillary Reflex Impaired
Outcome pRognostication of Acute Brain Injury With the NeuroloGical Pupil indEx
The use of quantitative, automated, infrared technology for pupillary examination has long been used in ophthalmology and anesthesiology research.
- Trial name
- ORANGE (NCT04490005)
- Testing
- pupillometry
- Where
- 14 sites in United States, Belgium and 6 more
- Volunteers
- 118 people
- Sponsor
- University of Milano Bicocca
Intracranial Pressure Increase
SVP Detection Using Machine Learning
This diagnostic study will use 410 retrospectively captured fundal videos to develop ML systems that detect SVPs and quantify ICP.
- Trial name
- SVP-ML (NCT05731765)
- Testing
- Machine Learning Model
- Where
- United Kingdom
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- King's College London
Acute Liver Failure, Intracranial Hypertension
Hypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure
Treatment options in patients with high intracranial pressure due to acute liver failure are limited. This study intends to evaluate the effect of prophylactic hypothermia on preventing high intracranial pressure and compromised…
- Trial name
- NCT00670124
- Testing
- Hypothermia by the use of Blanketrol II, Cincinnati Sub-Zero
- Where
- 4 sites in United States, Denmark and 1 more
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Idiopathic Intracranial Hypertension
Outcome of Cerebral Venous Sinuses Stenting on Idiopathic Intracranial Hypertension
The aim of the work is to asses the positive effect of stenotic sinus segment stenting on idiopathic intracranial hypertension with headache and papilloedema.
- Trial name
- NCT05308823
- Testing
- Stent
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Al-Azhar University
Idiopathic Intracranial Hypertension
Exploratory Study on the Efficacy and Safety of Semaglutide for Idiopathic Intracranial Hypertension Treatment
This study aims to investigate the safety and efficacy of semaglutide in patients with Idiopathic intracranial hypertension.
- Trial name
- NCT06361823
- Testing
- Semaglutide, Low calorie diet
- Volunteers
- 74 people
- Sponsor
- Capital Medical University
Intracranial Hypertension, Increased Intracranial Pressure
Bedside Ultrasound Measurement of Optic Nerve Sheath Diameter for Detecting Raised Intracranial Pressure
Raised intracranial pressure (ICP) is a serious medical emergency that requires prompt recognition to prevent brain damage. While invasive pressure monitoring and brain CT scans are commonly used, bedside transorbital…
- Conditions
- Intracranial Hypertension, Increased Intracranial Pressure, Brain Edema, Traumatic Brain Injury
- Trial name
- NCT07799714
- Volunteers
- 85 people
- Sponsor
- Assiut University
Intracranial Pressure Increase
Posterior Fossa Intracranial Pressure (ICP) Measurement: Clinical Study
In modern medicine, doctors attempt to monitor all physiological variables to assess their evolution and to decide, based on their changes, the therapeutic attitudes to adopt.
- Trial name
- Postfossa ICP (NCT04675216)
- Testing
- Posterior fossa intracranial pressure measurement
- Where
- 2 sites in Spain
- Volunteers
- 12 people
- Sponsor
- University of Valencia
Traumatic Brain Injury, Acute Brain Injuries
Automated Measurement of Optic Nerve Sheath Diameter
Optic Nerve Ultrasound (ONUS) is a promising non-invasive tool for the detection of raised Intracranial Pressure (ICP). Variability in the optimal Optic Nerve Sheath Diameter (ONSD) threshold corresponding to elevated ICP in…
- Conditions
- Traumatic Brain Injury, Acute Brain Injuries, Intracranial Hypertension
- Trial name
- NCT02786706
- Testing
- Optic nerve ultrasound
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Michigan