Clinical trials: Incretin Effect
GLP-1, Obesity &Amp; Overweight
Effect of a Dietary Supplement on Hormones Involved in Appetite Regulation in Overweight and Obese Adults
Obesity is a chronic condition linked to numerous health risks and affects more than one billion people worldwide. While pharmacological treatments such as incretin-based therapies are available, they may have side effects, are…
- Conditions
- GLP-1, Obesity &Amp; Overweight, Dietary Supplement
- Trial name
- NCT07240246
- Testing
- Intervention: Dietary Supplement with Plant Extracts
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- FFoQSI - Austrian Competence Centre for Feed and Food Quality, Safety & Innovation
Overweight , Obesity, Adults
Study to Assess the Effect and Safety of ALV-100 on Maintenance of Weight Loss
A study of ALV-100 to assess efficacy, safety and tolerability among participants with overweight or obesity who have previously achieved a body weight reduction of ≥10% while treated with incretin-based therapies.
- Trial name
- PRESERVE (NCT07837973)
- Testing
- ALV-100
- Where
- 20 sites in United States
- Volunteers
- 220 people
- Sponsor
- Alveus Therapeutics, Inc.
Obesity
Effects of Intravenous Infusions of Gut Hormones on Appetite and Metabolism.
The purpose of this study is to investigate the effects of intravenous infusion of two gastrointestinal hormones, PYY3-36 and GLP-1, alone and in combination, on appetite in healthy obese men.
- Trial name
- INGEAR-1 (NCT00940134)
- Testing
- PYY 3-36, GLP-1, saline infusion
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Type 1 Diabetes Mellitus
Incretin Hormones in Type 1 Diabetes Mellitus;Effect of Metformin Treatment
Investigators aim is to conduct an RCT to study the effect of adjunct metformin treatment to insulin monotherapy in patients with type 1 diabetes, targeting the intestinal incretin secretion.
- Trial name
- INCREDIBLE-M (NCT04177303)
- Testing
- Metformin
- Where
- Greece
- Volunteers
- 44 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Diabetes Mellitus, Type 2, Diabetes
The Effect of Simple Basal Insulin Titration, Metformin Plus Liraglutide for Type 2 Diabetes With Very Elevated HbA1c - The SIMPLE Study
The aim of this clinical trial is to assess and compare the effect of insulin detemir in combination with liraglutide and metformin versus insulin detemir in combination with insulin aspart and metformin in subjects with very…
- Trial name
- SIMPLE (NCT01966978)
- Testing
- Metformin, Detemir, Liraglutide
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- University of Texas Southwestern Medical Center
Cystic Fibrosis Related Diabetes, Cystic Fibrosis
Ivacaftor (Kalydeco) and Insulin in Cystic Fibrosis (CF)
This study is aimed at better understanding the impact of ivacaftor upon insulin and incretin secretion and glucose tolerance in patients with Cystic Fibrosis with a glycine (G551D) mutation.
- Trial name
- NCT02039986
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospital of Philadelphia
Diabetes Mellitus, Type 2
Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
The purpose of this study is to investigate the efficacy and safety of retatrutide compared with semaglutide in participants with Type 2 Diabetes and inadequate glycemic control with metformin with or without sodium-glucose…
- Trial name
- NCT06260722
- Testing
- Retatrutide, Semaglutide
- Where
- 77 sites in United States, Argentina and 3 more
- Volunteers
- 1,250 people
- Sponsor
- Eli Lilly and Company
Neonatal Diabetes
Effect of Food Composition on Postprandial Insulin Secretion in Neonatal Diabetes
Neonatal diabetes is diagnosed before 6 months of age and causes high blood glucose levels due to the pancreas not secreting insulin. Neonatal diabetes can be caused by a change in a DNA region called the KCNJ11 gene.
- Trial name
- FoND (NCT02921906)
- Testing
- High protein meal, High carbohydrate meal, Paracetamol
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Caloric Restriction, Body Composition
Long-Term Effects of Semaglutide on Body Composition and Performance in Running
Semaglutide, a GLP-1 receptor agonist, has demonstrated significant weight-loss effects in people with obesity and/or type 2 diabetes, but its impact on exercise performance among lean, fit athletes remains unknown.
- Conditions
- Caloric Restriction, Body Composition, Performance
- Trial name
- NCT07874932
- Testing
- Semaglutide (SEMA)
- Where
- Denmark
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Type 2 Diabetes
A Study of the Effects of Sitagliptin (MK0431) and Metformin on Incretin Hormone Concentrations (0431-050)(COMPLETED)
This study will determine the effect of concomitant administration of sitagliptin and metformin on post-meal incretin hormone concentrations in healthy adults.
- Trial name
- NCT00975052
- Testing
- sitagliptin phosphate, Comparator: metformin, Comparator: sitagliptin and metformin
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type 2
Efficacy and Safety of Vildagliptin Compared to Placebo on the Incretin Effect in Patients With Type 2 Diabetes Treated With Metformin
This mechanistic study will evaluate the effect of vildagliptin on glucose-stimulated insulin secretion to improve the incretin effect in patients with type 2 diabetes.
- Trial name
- NCT00396071
- Testing
- vildagliptin
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 22 people
- Sponsor
- Novartis Pharmaceuticals
Postprandial Lipaemia, Postprandial Incretins
Effects of Dietary Proteins on Postprandial Lipaemia and Incretin Responses in Obese Subjects
The purpose of this study is to determine the effects of dietary protein on blood lipids and gut hormones after a fat-rich meal.
- Conditions
- Postprandial Lipaemia, Postprandial Incretins, Postprandial Inflammation
- Trial name
- NCT00809874
- Testing
- Casein, Whey Isolate, Whey Hydrolysate
- Where
- Denmark
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Type 2 Diabetes Mellitus
Effect of Sitagliptin on Incretin Effect in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to assess the effect of the DPP-4 inhibitor sitagliptin on the incretin effect in patients with type 2 diabetes mellitus.
- Trial name
- NCT00551590
- Testing
- Sitagliptin tablet, Saline infusion, Exendin(9-39) infusion
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Diabetes, Coronary Artery Disease
Epicardial Fat and Clinical Outcomes After Coronary Artery Bypass Grafting in Diabetics vs. Non Diabetics
Cardiovascular disease (CVD) is a group of diseases including both the heart and blood vessels, thereby including coronary heart disease (CHD). To date, diabetics have a higher incidence and prevalence of multivessels CHD.
- Trial name
- NCT03360981
- Testing
- Incretins
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Diabetes Mellitus
Effect of Smoking on Postprandial Gastric Emptying, Glucose Tolerance and Secretion of Gut and Pancreatic Hormones
The study aims to evaluate the effect of smoking on postprandial responses such as plasma glucose, secretion of gut - and pancreatic hormones and gastric emptying in healthy, heavy smoking men.
- Trial name
- SmokinGLP-1 (NCT02497651)
- Testing
- Liquid mixed meal, Skin Biopsy
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Type 2 Diabetes, Obesity
Splanchnic Blood Redistribution After Incretin Hormone Infusion and Obesity Surgery
Obesity is a worldwide problem and leads to multiple metabolic and endocrinological problems. Bariatric surgeries are a growing field as a treatment choice for morbid obesity (BMI > 35 kg/m2).
- Trial name
- GIP-PET (NCT01880827)
- Testing
- Roux-en-Y, GIP-infusion, GLP-1
- Where
- Finland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Chronic Pancreatitis, Type 2 Diabetes Mellitus
The Incretin Effect in Patients With Chronic Pancreatitis
The phenomenon that oral glucose elicits a higher insulin response than does intravenous (iv) glucose, even at identical plasma glucose (PG) profiles (isoglycemia), is called the incretin effect.
- Trial name
- NCT00638573
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Type 2 Diabetes, Postprandial Lipemia
Differential Effects of Protein Quality on Postprandial Lipemia in Response to a Fat-Rich Meal in Type 2 Diabetes: Comparison of Whey, Casein, Gluten, and Cod Protein
Enhanced and prolonged postprandial triglyceride responses involve increased cardiovascular risk in type 2 diabetes. It has been demonstrated that dietary fat and carbohydrates profoundly influence postprandial…
- Trial name
- NCT00817973
- Testing
- Casein, Whey, Cod
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Aarhus University Hospital
Diabetes Mellitus, Obesity
Effects of Jeju Red Horsehead Fish-based, High Protein Diet on Satiety and Incretin Hormones in Diabetes Patients
The aim of our study is to investigate the effects of high-protein diet on satiety and incretin hormones in patients with diabetes.
- Trial name
- NCT01678742
- Testing
- High-protein diet, Standard diet
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jeju National University Hospital
Type 2 Diabetes Mellitus
A Cohort Study of Incretin-based Therapy Combined With Insulin in Type 2 Diabetic Patients for 5 Years
The use of dipeptidyl-peptidase 4 (DPP-4) inhibitors and glucagon like peptide 1 (GLP1) analogues for the treatment of diabetic mellitus (DM) type 2 is growing (1,2).
- Trial name
- NCT01681550
- Testing
- Incretin-based therapy
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Nagaoka Red Cross Hospital