Clinical trials: Incretin Effect
Type 2 Diabetes, Healthy
Effect of Pioglitazone and Exenatide on Body Weight and Beta Cell Function
Pioglitazone, a drug used in treatment of type 2 diabetes has been shown to improve insulin sensitivity in skeletal muscle, liver, and fat cells.
- Conditions
- Type 2 Diabetes, Healthy, Impaired Glucose Tolerance
- Trial name
- PIO-EX (NCT00845182)
- Testing
- Pioglitazone, Exenatide, Pioglitazone and Exenatide
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
GLP-1, Gut Microbiota
Effects of Sucralose in Gut Intestinal Microbiota and Postprandial GLP-1
Recently, it has been proposed that the consumption of non-nutritive sweeteners, including sucralose, it's not harmless and is related with metabolic effects.
- Conditions
- GLP-1, Gut Microbiota, Insulin Resistance
- Trial name
- NCT06094894
- Testing
- sucralose
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Type 2 Diabetes
Antidiabetic Effects of Adding a DPP-4 Inhibitor to Pre-Existing Treatment With an Incretin Mimetic in Patients With T2D
Objectives: To quantify differences in control of glycemia (primary objective) and the secretion of endogenous incretin hormones (secondary objective) comparing sitagliptin or placebo added to pre-existing therapy with…
- Trial name
- NCT01937598
- Testing
- Mixed meal test, Liraglutide, Sitagliptin
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Michael A. Nauck
Type 2 Diabetes Mellitus
Effect of Incretin-related Drugs on Dietary Intake in Japanese Patients With Type 2 Diabetes Mellitus
It is well known that incretin, particular GLP-１enhances satiety and reduces energy intake in controlling appetite and dietary in humans (Flint A, et al. Gutzwiller JP et al.).
- Trial name
- NCT01568125
- Testing
- Incretin-related drugs
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Nagaoka Red Cross Hospital
Obesity
Analysing Differences in Glycaemic Control Immediately Post Obesity SurgEry (The ADIPOSE Study)
It is well established that bariatric (weightloss) surgery affords considerable improvement in glycaemic control (control of blood sugar), and in many cases may lead to a complete resolution of type 2 diabetes.
- Trial name
- ADIPOSE (NCT01515059)
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Leicester
Diabetes Mellitus, Type 2
Effects of Dapagliflozin on the Incretin Sensitivity of the Pancreatic Beta Cell
To investigate the effect of dapagliflozin on the incretin sensitivity of the pancreatic beta cell.
- Trial name
- NCT02420392
- Testing
- Dapagliflozin
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Insulin Resistance, Glucose Intolerance
Is Insulin Resistance and/or Glucose Intolerance Pathogenetic in the Development of a Reduced Incretin Effect
The purpose of this study is to examine whether there is a causal relationship between insulin resistance and/or glucose intolerance in the development of a defect incretin effect.
- Trial name
- NCT00784745
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diabetes Mellitus, Type 2
The Role of Endogenous Glucagon-like Peptide 1 (GLP-1) in Type 2 Diabetes Mellitus (T2DM)
The purpose of the study is to determine the contribution of endogenous Glucagon-like peptide 1 (GLP-1) to the postprandial secretion of insulin and glucagon and the incretin effect in healthy subjects and patients with type 2…
- Trial name
- DFG_5 (NCT01449019)
- Testing
- exendin(9-39)amide, saline, duodenal meal
- Where
- 2 sites in Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Sarcopenia
Characterizing the Incretin Effect of Amino Acids and Defining GLP-1 Role on Skeletal Muscle
This study has two protocols the aims of which are: 1. To identify age-related effects of AA on incretin secretion and whether and to what extent AA exhibit a true incretin effect (gut- mediated increases in plasma insulin) in…
- Trial name
- Incretin (NCT02370745)
- Testing
- GLP-1, Insulin Actrapid, Oral amino acids
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Obesity
Effect of Gastric Bypass Surgery on Energy Metabolism
The purpose of this study is to investigate the short term and long term effects of Roux-en-Y gastric bypass (RYGB) surgery on energy expenditure, gastrointestinal and appetite regulating hormone levels, and appetite sensation.
- Trial name
- ERGEM (NCT00939679)
- Testing
- Roux-en-Y gastric bypass surgery, low calorie diet (1,000 kcal/day)
- Where
- 2 sites in Denmark
- Volunteers
- 32 people
- Sponsor
- University of Copenhagen
Type2 Diabetes, Obesity, Morbid
Effect of RYGB on Alpha- and Beta Cell Function and Sensitivity to Incretins in Patients With Type 2 Diabetes
The aim of the study is to investigate the effect of Roux-en-Y gastric bypass (RYGB) on pancreatic alpha and beta-cell function and for the sensitivity of incretin hormones in patients with pre-operative type 2 diabetes.
- Trial name
- BETASIN (NCT04782999)
- Testing
- Oral Glucose Tolerance Test, Hyperglycemic clamp with infusion of saline, GLP-1 or GIP
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Hvidovre University Hospital
Overweight and Obesity
Evaluation of Libramed in Obesity Treatment
Randomized, double-blind, placebo-controlled study aimed at evaluating the effects of a 3-months treatment with Policaptil Gel Retard on postprandial incretin hormones release and satiety in obese women
- Trial name
- ELOT (NCT03537235)
- Testing
- Libramed
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Aboca Spa Societa' Agricola
Diabetes Mellitus, Type 2
Pioglitazone Incretin Study
Incretin hormones are hormones produced by the gut in response to food intake. These hormones help the body to control the metabolism of glucose (sugar).
- Trial name
- NCT00656864
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Vermont
Insulin Resistance, Microvascular Disease
The Vascular Effects of Vildagliptin in Insulin Resistant Individuals
Animal models have demonstrated that incretins have a glucose-independent effect on vascular perfusion, and there is limited evidence that incretins may enhance endothelial function in healthy subjects.
- Trial name
- NCT01122641
- Testing
- Vildagliptin
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Glucose and Lipid Metabolism, Incretin Hormones Plasma Levels
Effects of Aleurone-enriched Products on Cardiovascular Risk Factors
Very few studies have evaluated the effect of aleurone-enriched grains on cardiovascular risk factors. Price et al.(2010) have shown that 4-week supplementation of aleurone-enriched products (27 g/day of aleurone) increased…
- Conditions
- Glucose and Lipid Metabolism, Incretin Hormones Plasma Levels, Inflammation, Oxidative Stress and Endothelial Function
- Trial name
- NCT02150356
- Testing
- Aleurone, Control
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Federico II University
Gestational Diabetes
The Incretin Effect in Patients With Gestational Diabetes Mellitus
The aim of this study is to evaluate the reduced incretin effect observed in patients with T2DM in relation to reversibility. The incretin effect will be measured by means of OGTT and iIVGTT in 12 women with GDM during pregnancy…
- Trial name
- NCT01307995
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Incretin Effect
Quantification of the Incretin Effect in Healthy Subjects and Patients With Type 2 Diabetes
Patients with T2DM lac a sufficient incretin response after oral glucose intake. It has only been tested using 50g of glucose. We don't know if patients with T2DM are capable of regulating the incretin effect like healthy people…
- Trial name
- NCT00529048
- Testing
- Oral Glucose Tolerance Test, Isoglycemic clamp, Gastric emptying rate
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Diabetes, Hyperglycemia
Insulin Secretion in Diabetes Before and After Glycemic Control
The objective of this project is to understand defects in insulin secretion that contribute to abnormal glucose metabolism in patients with diabetes.
- Trial name
- NCT00469833
- Testing
- insulin glargine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Diabetes Mellitus, Type 2
To Compare the Effects of Non-nutritive Sweeteners Intake in Subjects With T2DM
ABSTRACT Introduction: There is no current data about the effects of non-nutritive sweeteners (NNS) about important factors, such as the energy intake, appetite and its relationship in people with diabetes when tasting sweet.
- Trial name
- NCT03680482
- Testing
- Intervention ingest a 48 mg of sucralose, Intervention ingest a 96 mg of stevia
- Volunteers
- 17 people
- Sponsor
- University of Chile
Type 1 Diabetes, Hypoglycemia
Dipeptidyl Peptidase-4 Inhibitors and Alpha-cell Recovery
Hypoglycaemia is a well-known complication of insulin treated diabetes. The counterregulatory response to hypoglycaemia, with glucagon as the most important mediator, is initially diminished within a few years of onset of Type 1…
- Trial name
- DARE (NCT01272583)
- Testing
- Sitagliptin
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)